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NEW ENGLAND JOURNAL OF MEDICINE, ISSN 0028-4793, 09/2009, Volume 361, Issue 12, pp. 1173 - 1178
Medulloblastoma is the most common malignant brain tumor in children. Aberrant activation of the hedgehog signaling pathway is strongly implicated in the... 
CELL LUNG-CANCER | MEDICINE, GENERAL & INTERNAL | GEFITINIB | SONIC HEDGEHOG | STAGE | IMATINIB | TUMOR | RESISTANCE | MICE | MUTATIONS | CHRONIC MYELOID-LEUKEMIA
Journal Article
Journal Article
Science, ISSN 0036-8075, 10/2009, Volume 326, Issue 5952, pp. 572 - 574
The Hedgehog (Hh) signaling pathway is inappropriately activated in certain human cancers, including medulloblastoma, an aggressive brain tumor. GDC-0449, a... 
Receptors | Relapse | Basal cell carcinoma | Medulloblastoma | Amino acids | Biopsies | Reports | Genetic mutation | Tumors | Resistance mechanisms | Cancer | PROTEIN-COUPLED RECEPTORS | CYCLOPAMINE | CANCER | MULTIDISCIPLINARY SCIENCES | Anilides - therapeutic use | Receptors, G-Protein-Coupled - metabolism | Humans | Brain Neoplasms - pathology | Hedgehog Proteins - metabolism | Molecular Sequence Data | Drug Resistance, Neoplasm | Antineoplastic Agents - therapeutic use | Mutation, Missense | Antineoplastic Agents - metabolism | Neoplasm Metastasis | Hedgehog Proteins - genetics | Medulloblastoma - pathology | Smoothened Receptor | Veratrum Alkaloids - pharmacology | Antineoplastic Agents - pharmacology | Patched Receptors | Medulloblastoma - genetics | Mutant Proteins - antagonists & inhibitors | Pyridines - therapeutic use | Amino Acid Sequence | Signal Transduction | Anilides - metabolism | Brain Neoplasms - genetics | Receptors, Cell Surface - metabolism | Mutant Proteins - metabolism | Hedgehog Proteins - antagonists & inhibitors | Brain Neoplasms - drug therapy | Cinnamates - pharmacology | Animals | Pyridines - metabolism | Mutant Proteins - chemistry | Anilides - pharmacology | Receptors, G-Protein-Coupled - antagonists & inhibitors | Cell Line, Tumor | Protein Conformation | Mice | Pyridines - pharmacology | Receptors, G-Protein-Coupled - genetics | Medulloblastoma - drug therapy | Receptors, G-Protein-Coupled - chemistry | Amino Acid Substitution | Receptors, Cell Surface - genetics | Gene mutations | Development and progression | Genetic aspects | Diagnosis | Drug resistance | Identification and classification | Signal transduction | Genotype & phenotype | Inhibitor drugs | Cellular biology | Brain cancer | Mutation
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 04/2011, Volume 17, Issue 8, pp. 2502 - 2511
Journal Article
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 12/2015, Volume 33, Issue 36, pp. 4284 - 4292
Journal Article
Journal Article
Journal Article
Pancreas, ISSN 0885-3177, 2016, Volume 45, Issue 3, pp. 370 - 375
Objectives In mouse models of pancreatic cancer, IPI-926, an oral Hedgehog inhibitor, increases chemotherapy delivery by depleting tumor-associated stroma.... 
Stroma | FOLFIRINOX | Hedgehog | Phase I | Pancreatic cancer | SIGNALING PATHWAYS | stroma | IDENTIFICATION | CANCER | CHEMOTHERAPY | pancreatic cancer | SHH | GROWTH | phase I | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | REQUIREMENT | Veratrum Alkaloids - administration & dosage | Leucovorin - administration & dosage | Pancreatic Neoplasms - metabolism | Nausea - chemically induced | Veratrum Alkaloids - pharmacokinetics | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Hedgehog Proteins - metabolism | Male | Diarrhea - chemically induced | Feasibility Studies | Dose-Response Relationship, Drug | Pancreatic Neoplasms - drug therapy | Organoplatinum Compounds - administration & dosage | Adenocarcinoma - metabolism | Fluorouracil - administration & dosage | Leucovorin - adverse effects | Fluorouracil - adverse effects | Camptothecin - administration & dosage | Female | Camptothecin - analogs & derivatives | Camptothecin - adverse effects | Veratrum Alkaloids - adverse effects | Kaplan-Meier Estimate | Treatment Outcome | Adenocarcinoma - drug therapy | Vomiting - chemically induced | CA-19-9 Antigen - metabolism | Signal Transduction - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Nervous System Diseases - chemically induced | Aged | Organoplatinum Compounds - adverse effects
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2012, Volume 109, Issue 20, pp. 7859 - 7864
Journal Article
Journal Article
Journal Article
Journal Article
American Journal of Surgery, The, ISSN 0002-9610, 2015, Volume 210, Issue 3, pp. 554 - 560
Journal Article