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eLife, ISSN 2050-084X, 2013, Volume 2, pp. e01340 - e01340
The Hedgehog (Hh) signal is transduced across the membrane by the heptahelical protein Smoothened (Smo), a developmental regulator, oncoprotein and drug target... 
oxysterol | Hedgehog signaling | Zebrafish | cysteine rich domain | smoothened | MAXIMUM-LIKELIHOOD | STEM-CELLS | PROTEIN | SONIC HEDGEHOG | CYSTEINE-RICH DOMAINS | CRYSTAL-STRUCTURE | PATHWAY ACTIVITY | BIOLOGY | N-TERMINAL DOMAIN | MAMMALIAN-CELLS | PRIMARY CILIUM | Hedgehog Proteins - chemistry | Receptors, G-Protein-Coupled - metabolism | Hedgehog Proteins - metabolism | Crystallography, X-Ray | Structure-Activity Relationship | Hedgehog Proteins - genetics | Gene Expression Regulation, Developmental | Smoothened Receptor | Escherichia coli - metabolism | Binding Sites | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Protein Structure, Secondary | Signal Transduction | Zebrafish Proteins - chemistry | Sterols - chemistry | Zebrafish Proteins - metabolism | Zebrafish Proteins - antagonists & inhibitors | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Zebrafish - growth & development | Zebrafish - genetics | Animals | Escherichia coli - genetics | Zebrafish - metabolism | Embryo, Nonmammalian | Receptors, G-Protein-Coupled - antagonists & inhibitors | Protein Binding | Ligands | Mice | Receptors, G-Protein-Coupled - genetics | Zebrafish Proteins - genetics | Receptors, G-Protein-Coupled - chemistry | Wnt protein | Frizzled protein | Genes | Lipids | Biology | Hydrophobicity | Chromatography | Membrane proteins | Medicine | Proteins | Hedgehog protein | Binding sites | Crystal structure | Structure-function relationships | Index Medicus
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 7/2018, Volume 75, Issue 14, pp. 2663 - 2680
Primary cilia are sensory organelles that coordinate multiple cellular signaling pathways, including Hedgehog (HH), Wingless/Int (WNT) and Transforming Growth... 
Biomedicine, general | Biochemistry, general | TSC | LC3b | Primary cilia | TGF-β signaling | WNT5a | Hedgehog signaling | Autophagy | Cell Biology | Life Sciences | Life Sciences, general | mTOR | GLI1 EXPRESSION | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | PROTEIN-COUPLED RECEPTORS | CELL-SIZE | CELL BIOLOGY | TSC1-TSC2 COMPLEX | TGF-beta signaling | GROWTH-FACTOR-BETA | MEDIATORS | Tumor Suppressor Proteins - metabolism | Signal Transduction | Cells, Cultured | Gene Expression Regulation | Hedgehog Proteins - metabolism | Smoothened Receptor - metabolism | Smoothened Receptor - genetics | Cilia - metabolism | Mice, Knockout | Zinc Finger Protein Gli2 - metabolism | Animals | Tuberous Sclerosis Complex 2 Protein | Hedgehog Proteins - genetics | RNA Interference | Embryo, Mammalian - cytology | Tumor Suppressor Proteins - genetics | Tuberous Sclerosis Complex 1 Protein | Zinc Finger Protein Gli2 - genetics | Fibroblasts - metabolism | Tuberous sclerosis | Bone morphogenetic proteins | Protein biosynthesis | Molecular genetics | Transforming growth factors | TOR protein | Tuberous sclerosis 2 protein | Phosphorylation | Wnt protein | Transforming growth factor | Hamartin | Kinases | TSC1 protein | Sclerosis | Proteins | Signal transduction | Smad2 protein | Fibroblasts | Elongation | Cilia | Phenotypes | Rapamycin | Embryo fibroblasts | Organelles | Embryos | TSC2 protein | Signaling | Protein synthesis | Hedgehog protein | Dismantling | Index Medicus | Original
Journal Article
Journal Article
Journal Article
CELL, ISSN 0092-8674, 02/2000, Volume 100, Issue 4, pp. 423 - 434
Ci/Gli zinc finger proteins mediate the transcriptional effects of Hedgehog protein signals. In Drosophila, Ci action as transcriptional repressor or activator... 
PROTEIN-KINASE-A | VENTRAL NEURAL-TUBE | CUBITUS-INTERRUPTUS | FLOOR PLATE | SIGNALING PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | TERMINAL CLEAVAGE PRODUCT | PATTERNING ACTIVITY | TRANSCRIPTION FACTOR | GREIG CEPHALOPOLYSYNDACTYLY SYNDROME | SONIC-HEDGEHOG | CELL BIOLOGY | Phosphorylation | Humans | Repressor Proteins | Zinc Finger Protein Gli2 | Zinc Finger Protein Gli3 | Molecular Sequence Data | DNA-Binding Proteins - metabolism | Hedgehog Proteins | Gene Expression Regulation, Developmental | Base Sequence | Body Patterning | Antibodies - immunology | Transcription, Genetic | Transcription Factors - immunology | Cyclic AMP-Dependent Protein Kinases - metabolism | DNA-Binding Proteins - immunology | Trans-Activators | Nerve Tissue Proteins | Transcription Factors - genetics | Xenopus Proteins | DNA-Binding Proteins - genetics | Chick Embryo | Limb Buds - embryology | Nuclear Proteins | Kruppel-Like Transcription Factors | Transcription Factors - metabolism | Animals | Proteins - metabolism | Mice | Protein Processing, Post-Translational | COS Cells | DNA, Complementary | Vertebrates | Carrier proteins | Physiological aspects | Genetic aspects | Research | Genetic transcription | Cytochemistry | Cell migration | Extremities (Anatomy) | Gli3 gene | Hedgehog protein | Cubitus interruptus protein | Sonic hedgehog protein | Gli3 protein | Index Medicus
Journal Article
Nature Structural & Molecular Biology, ISSN 1545-9993, 06/2010, Volume 17, Issue 6, pp. 718 - 725
Synergism between the RAS and Hedgehog (HH) pathways has been suggested for carcinogenesis in the pancreas, lung and colon. We investigated the molecular... 
GLI1 EXPRESSION | SUPPRESSOR | PANCREATIC DUCTAL ADENOCARCINOMA | ONCOGENIC KRAS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ADULT MICE | INDUCTION | CELL BIOLOGY | CANCER-CELL | BIOPHYSICS | K-RAS | PATHWAY | PRIMARY CILIA | NIH 3T3 Cells | RNA, Small Interfering - genetics | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Pancreatic Neoplasms - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Zinc Finger Protein Gli2 | Zinc Finger Protein Gli3 | Hedgehog Proteins - metabolism | ras Proteins - metabolism | RNA, Messenger - metabolism | RNA, Neoplasm - metabolism | Protein-Tyrosine Kinases - genetics | Adenocarcinoma - metabolism | Hedgehog Proteins - genetics | Kruppel-Like Transcription Factors - metabolism | Base Sequence | Adenocarcinoma - genetics | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | RNA, Messenger - genetics | Paracrine Communication - genetics | Protein-Serine-Threonine Kinases - genetics | ras Proteins - antagonists & inhibitors | Nuclear Proteins - metabolism | Pancreatic Neoplasms - genetics | Proto-Oncogene Proteins - genetics | Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Cilia - metabolism | Autocrine Communication - genetics | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Animals | Models, Biological | RNA, Neoplasm - genetics | Mice | Zinc Finger Protein GLI1 | Mutation | Genes, ras | Kruppel-Like Transcription Factors - genetics | Ras genes | Pancreatic cancer | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Health aspects | Risk factors | Signal transduction | Molecular biology | Kinases | Cancer | Index Medicus
Journal Article
Nature Cell Biology, ISSN 1465-7392, 09/2017, Volume 19, Issue 10, pp. 1226 - 1236
Direct interactions between pro-and anti-apoptotic BCL-2 family members form the basis of cell death decision-making at the outer mitochondrial membrane (OMM).... 
SIGNAL | APOPTOSIS | ACTIVATION | SONIC HEDGEHOG | PATHWAY | MCL-1 | GENOMIC ANALYSIS | RESISTANCE | PROLIFERATION | MEDULLOBLASTOMA | CELL BIOLOGY | Neoplasms - metabolism | NIH 3T3 Cells | Transcription, Genetic - drug effects | Cell Proliferation | Zinc Finger Protein GLI1 - metabolism | Humans | Gene Expression Regulation, Neoplastic | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | bcl-X Protein - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Molecular Mimicry | Transfection | Neoplasms - genetics | RNA Interference | Time Factors | Tumor Suppressor Proteins - genetics | HEK293 Cells | Female | Antineoplastic Agents - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein - deficiency | Repressor Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Peptide Fragments - metabolism | Tumor Suppressor Proteins - metabolism | Signal Transduction | Cell Survival | Zinc Finger Protein GLI1 - genetics | Repressor Proteins - genetics | Genotype | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Mice, Knockout | Neoplasms - drug therapy | Phenotype | Animals | Mice, Nude | CRISPR-Cas Systems | Mice | Neoplasms - pathology | bcl-X Protein - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis | Regulators | Cell survival | Bcl-2 protein | Transcription | Decision making | Homology | Drug resistance | Gene expression | Mcl-1 protein | Proteins | Signaling | Mitochondria | DNA-binding protein | Bcl-x protein | Cell death | Feedforward | Deoxyribonucleic acid--DNA | Tumors | Cancer | Index Medicus
Journal Article
Journal Article
Nature Cell Biology, ISSN 1465-7392, 06/2009, Volume 11, Issue 6, pp. 739 - 746
Sonic hedgehog (Shh) and its main receptor, Patched (Ptc), are implicated in both neural development and tumorigenesis. Besides its classic morphogenic... 
PROTEIN | INHIBITION | GENE | MECHANISM | SONIC HEDGEHOG | NEURONAL DEATH | PRODUCT INDUCES APOPTOSIS | KAPPA-B | CASPASE ACTIVATION | CELL-DEATH | CELL BIOLOGY | RNA, Small Interfering - genetics | Caspase 9 - metabolism | Homeodomain Proteins - metabolism | Humans | Hedgehog Proteins - metabolism | Neoplasm Proteins - metabolism | CARD Signaling Adaptor Proteins - genetics | Multiprotein Complexes - metabolism | CARD Signaling Adaptor Proteins - metabolism | Hedgehog Proteins - genetics | Muscle Proteins - metabolism | Apoptosis Regulatory Proteins - genetics | Patched Receptors | Neoplasm Proteins - genetics | Cell Line | Receptors, Cell Surface - metabolism | Transcription Factors - genetics | Chick Embryo | Homeodomain Proteins - genetics | Apoptosis Regulatory Proteins - metabolism | Muscle Proteins - genetics | Transcription Factors - metabolism | Two-Hybrid System Techniques | Animals | Adaptor Proteins, Signal Transducing - genetics | LIM-Homeodomain Proteins | Signal Transduction - physiology | Apoptosis - physiology | Adaptor Proteins, Signal Transducing - metabolism | RNA, Small Interfering - metabolism | Receptors, Cell Surface - genetics | Causes of | Physiological aspects | Cell receptors | Research | Proteases | Apoptosis | Index Medicus | Caspase 9 | Signal Transduction | Multiprotein Complexes | Receptors, Cell Surface | Cellular Biology | Hedgehog Proteins | Life Sciences | Muscle Proteins | Adaptor Proteins, Signal Transducing | Apoptosis Regulatory Proteins | Homeodomain Proteins | Neoplasm Proteins | CARD Signaling Adaptor Proteins | RNA, Small Interfering | Transcription Factors | Development Biology | physiology | genetics | metabolism
Journal Article
Genes and Development, ISSN 0890-9369, 2009, Volume 23, Issue 16, pp. 1910 - 1928
Journal Article
Developmental Cell, ISSN 1534-5807, 06/2013, Volume 25, Issue 6, pp. 636 - 644
The Cubitus interruptus (Ci)/Gli family of transcription factors can be degraded either completely or partially from a full-length form (Ci155/Gli ) to a... 
MEMBRANE-FUSION | PATHWAY | AAA-ATPASE | LIGASES | DEVELOPMENTAL BIOLOGY | REPRESSOR | NF-KAPPA-B | TRANSCRIPTION FACTOR | CUBITUS-INTERRUPTUS PROTEIN | HEDGEHOG | DROSOPHILA | CELL BIOLOGY | Valosin Containing Protein | Hedgehog Proteins - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Smad Proteins, Inhibitory - genetics | Drosophila Proteins - metabolism | DNA-Binding Proteins - metabolism | Hedgehog Proteins - genetics | Cell Cycle Proteins - genetics | Cullin Proteins - metabolism | Ubiquitination - physiology | Intracellular Signaling Peptides and Proteins - genetics | Cell Cycle Proteins - metabolism | Cells, Cultured | Ubiquitin-Protein Ligases - metabolism | Adenosine Triphosphatases - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Cullin Proteins - genetics | Proteasome Endopeptidase Complex - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Signal Transduction - physiology | Adenosine Triphosphatases - genetics | Drosophila Proteins - genetics | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-Protein Ligases - genetics | Drosophila melanogaster | Protein Binding - physiology | Ubiquitin | Ligases | Children's hospitals | Adenosine triphosphatase | Stem cells | Index Medicus
Journal Article