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PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 3, pp. e18330 - e18330
TRAIL is a promising therapeutic agent for human malignancies. TRAIL often requires mitochondrial dysfunction, referred to as the Type II death receptor... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Humans | Zinc Finger Protein Gli2 | bcl-2 Homologous Antagonist-Killer Protein - genetics | Hedgehog Proteins - metabolism | Immunoblotting | BH3 Interacting Domain Death Agonist Protein - genetics | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Promoter Regions, Genetic - genetics | TNF-Related Apoptosis-Inducing Ligand - pharmacology | Bcl-2-Like Protein 11 | Chromatin Immunoprecipitation | Hedgehog Proteins - genetics | RNA Interference | Kruppel-Like Transcription Factors - metabolism | Veratrum Alkaloids - pharmacology | Apoptosis Regulatory Proteins - genetics | Electrophoretic Mobility Shift Assay | Inhibitor of Apoptosis Proteins - metabolism | Membrane Proteins - metabolism | Nuclear Proteins - genetics | BH3 Interacting Domain Death Agonist Protein - metabolism | bcl-2-Associated X Protein - genetics | Proto-Oncogene Proteins - metabolism | Cell Line | Membrane Proteins - genetics | bcl-2-Associated X Protein - metabolism | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Signal Transduction - genetics | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | X-Linked Inhibitor of Apoptosis Protein - genetics | Apoptosis Regulatory Proteins - metabolism | Transcription Factors - metabolism | Signal Transduction - drug effects | X-Linked Inhibitor of Apoptosis Protein - metabolism | Cell Line, Tumor | Zinc Finger Protein GLI1 | Kruppel-Like Transcription Factors - genetics | Biochemistry | Cell death | Health aspects | Analysis | Cancer cells | Cancer | Bax protein | Toxicity | Cytotoxicity | XIAP protein | Metastasis | Neoplasms | Proteins | Signal transduction | Hepatitis | Mitochondria | Hepatology | Gastroenterology | Tumor necrosis factor-TNF | Inhibition | Cholangiocarcinoma | Immunoglobulins | Mortality | Pharmacology | siRNA | Chemical compounds | Signaling | Glioma | Hedgehog protein | Pancreatic cancer | Ligands | BIM protein | Apoptosis | Tumors | Index Medicus
Journal Article
Nature (London), ISSN 1476-4687, 07/2016, Volume 535, Issue 7613, pp. 517 - 522
Journal Article
Journal Article
Development, ISSN 0950-1991, 10/2007, Volume 134, Issue 20, pp. 3677 - 3689
The Hedgehog (Hh) family of secreted proteins is involved both in developmental and tumorigenic processes... 
Development | Hedgehog | Phosphorylation | Costal2 | Drosophila | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Drosophila melanogaster - embryology | Drosophila melanogaster - physiology | Embryo, Nonmammalian - anatomy & histology | Receptors, G-Protein-Coupled - metabolism | Homeodomain Proteins - metabolism | Embryo, Nonmammalian - metabolism | Hedgehog Proteins - metabolism | Drosophila Proteins - metabolism | DNA-Binding Proteins - metabolism | Multiprotein Complexes - metabolism | Hedgehog Proteins - genetics | RNA Interference | Smoothened Receptor | Kinesin - genetics | Drosophila melanogaster - anatomy & histology | Binding Sites | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Protein-Serine-Threonine Kinases - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Serine - metabolism | Homeodomain Proteins - genetics | Kinesin - metabolism | Transcription Factors - metabolism | Phenotype | Animals | Signal Transduction - physiology | Receptors, G-Protein-Coupled - genetics | Drosophila Proteins - genetics | Index Medicus | Drosophila Proteins | Signal Transduction | Multiprotein Complexes | Protein-Serine-Threonine Kinases | Serine | Receptors, G-Protein-Coupled | Cellular Biology | Hedgehog Proteins | Life Sciences | Homeodomain Proteins | Embryo, Nonmammalian | Transcription Factors | Drosophila melanogaster | Kinesin | DNA-Binding Proteins | Cell Behavior
Journal Article
Journal Article
Developmental cell, ISSN 1534-5807, 06/2013, Volume 25, Issue 6, pp. 636 - 644
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 1/2011, Volume 108, Issue 4, pp. 1456 - 1461
.... We have identified sister of open brain (sopb), a null allele of mouse Intraflagellar transport protein 122 (Ift122... 
Hedgehogs | Phenotypes | Neurons | Gene expression regulation | Physiological regulation | Genetic mutation | Embryos | Cells | Regulator genes | Cilia | Kinesin 2 | Cytoplasmic dynein 2 | Axoneme | Neural patterning | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Immunohistochemistry | Receptors, G-Protein-Coupled - metabolism | Zinc Finger Protein Gli2 | Zinc Finger Protein Gli3 | Hedgehog Proteins - metabolism | Male | Green Fluorescent Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Embryo, Mammalian - metabolism | In Situ Hybridization | Hedgehog Proteins - genetics | Gene Expression Regulation, Developmental | Kruppel-Like Transcription Factors - metabolism | Mice, Mutant Strains | Smoothened Receptor | Cilia - ultrastructure | Female | Intracellular Signaling Peptides and Proteins - genetics | Fibroblasts - metabolism | Green Fluorescent Proteins - metabolism | Microscopy, Electron, Scanning | Signal Transduction | Mice, Inbred C57BL | Cells, Cultured | Nerve Tissue Proteins - genetics | Blotting, Western | Cilia - metabolism | Mice, Inbred C3H | Cilia - genetics | Nerve Tissue Proteins - metabolism | Proteins - genetics | Animals | Proteins - metabolism | Embryo, Mammalian - embryology | Embryo, Mammalian - cytology | Fibroblasts - cytology | Mice | Receptors, G-Protein-Coupled - genetics | Kruppel-Like Transcription Factors - genetics | Microscopy, Fluorescence | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Carrier proteins | Flagella (Microbiology) | Proteins | Signal transduction | Rodents | Index Medicus | Biological Sciences | neural patterning | cytoplasmic dynein 2 | axoneme | kinesin 2
Journal Article