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Nature, ISSN 0028-0836, 2013, Volume 498, Issue 7455, pp. 492 - 496
Journal Article
Genetics in Medicine, ISSN 1098-3600, 03/2015, Volume 17, Issue 3, pp. 188 - 196
Purpose: The phenotypic manifestations of cerebral cavernous malformation disease caused by rare PDCD10 mutations have not been systematically examined, and a... 
cerebral cavernous malformation | vascular malformations | CCM3 | Rho kinase | PDCD10 | MANAGEMENT | MECHANISM | GCKIII PROTEINS | RHO-KINASE | MODEL | NATURAL-HISTORY | LESION | STRATEGIES | VASCULAR INTEGRITY | GENETICS & HEREDITY | Human Umbilical Vein Endothelial Cells | Prospective Studies | Stress Fibers - drug effects | Humans | Middle Aged | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Child, Preschool | Infant | Intracellular Signaling Peptides and Proteins - metabolism | Hemangioma, Cavernous, Central Nervous System - genetics | rho-Associated Kinases - antagonists & inhibitors | Young Adult | rho-Associated Kinases - metabolism | Apoptosis Regulatory Proteins - genetics | Adult | Membrane Proteins - metabolism | Child | Intracellular Signaling Peptides and Proteins - genetics | Disease Models, Animal | Proto-Oncogene Proteins - metabolism | Keratin-1 - genetics | Membrane Proteins - genetics | Central Nervous System Neoplasms - genetics | Cells, Cultured | Proto-Oncogene Proteins - genetics | Apoptosis Regulatory Proteins - metabolism | Carrier Proteins - genetics | Central Nervous System Neoplasms - pathology | Stress Fibers - metabolism | Animals | Hemangioma, Cavernous, Central Nervous System - enzymology | Hemangioma, Cavernous, Central Nervous System - pathology | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Adolescent | Central Nervous System Neoplasms - enzymology | Mice | Mutation | Cerebral cavernous malformations
Journal Article
Nature Medicine, ISSN 1078-8956, 09/2016, Volume 22, Issue 9, pp. 1033 - 1042
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 07/2015, Volume 112, Issue 27, pp. 8421 - 8426
Cerebral cavernous malformation (CCM) is a disease of the central nervous system causing hemorrhage-prone multiple lumen vascular malformations and very severe... 
Cerebral cavernous malformation | Sulindac metabolites | catenin | Endothelial cells | Vascular pathology | cerebral cavernous malformation | beta-catenin | endothelial cells | SIGNALING CONTROLS | MULTIDISCIPLINARY SCIENCES | BLOOD-BRAIN-BARRIER | EFFECTOR | CEREBRAL CAVERNOUS MALFORMATIONS | vascular pathology | PATHWAY | RAP1 | DISEASE | JUNCTIONS | GROWTH | sulindac metabolites | Immunohistochemistry | Central Nervous System Neoplasms - metabolism | Endothelial Cells - metabolism | Central Nervous System Neoplasms - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Signal Transduction - genetics | Reverse Transcriptase Polymerase Chain Reaction | Hemangioma, Cavernous, Central Nervous System - drug therapy | beta Catenin - metabolism | Hemangioma, Cavernous, Central Nervous System - genetics | Hemangioma, Cavernous, Central Nervous System - metabolism | beta Catenin - genetics | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Mice, Knockout | Intracellular Signaling Peptides and Proteins - deficiency | Sulindac - analogs & derivatives | Animals | Signal Transduction - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Central Nervous System Neoplasms - drug therapy | Intracellular Signaling Peptides and Proteins - genetics | Sulindac - pharmacology | Transforming Growth Factor beta - metabolism | Disease Models, Animal | Usage | Sulindac | Genetic aspects | Research | Drug therapy | Health aspects | Cerebrovascular disease | Biological Sciences | β-catenin | Other Medical Sciences not elsewhere specified | Other Medical Sciences | Medical and Health Sciences | Medicin och hälsovetenskap | Annan medicin och hälsovetenskap | Övrig annan medicin och hälsovetenskap
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 2761 - 16
Cerebral cavernous malformation (CCM) is a neurovascular familial or sporadic disease that is characterised by capillary-venous cavernomas, and is due to... 
STEM-CELLS | PDCD10/CCM3 | CEREBROVASCULAR MALFORMATIONS | MULTIDISCIPLINARY SCIENCES | TISSUE | PROLIFERATION | IDENTIFICATION | EMT | CONTRIBUTES | 2-HIT MECHANISM | PROGRESSION | Endothelium, Vascular - cytology | Loss of Function Mutation | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Hemangioma, Cavernous, Central Nervous System - genetics | Brain - blood supply | Cell Differentiation - genetics | Apoptosis Regulatory Proteins - genetics | Female | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Mesenchymal Stem Cells - metabolism | Disease Models, Animal | Biomarkers - metabolism | Proto-Oncogene Proteins - metabolism | Cell Line | Brain - cytology | Endothelial Cells - metabolism | Membrane Proteins - genetics | Central Nervous System Neoplasms - genetics | Proto-Oncogene Proteins - genetics | Gene Knockout Techniques | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Central Nervous System Neoplasms - pathology | Animals | Hemangioma, Cavernous, Central Nervous System - pathology | Brain - pathology | Endothelium, Vascular - pathology | Mice | Endothelial Cells - pathology | Animal models | Mesenchyme | Genes | Markers | Endothelial cells | Endothelium | Allografts | Stem cells | Tumor suppressor genes | Mutation | Null cells | Lesions | Tumors
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2010, Volume 107, Issue 28, pp. 12640 - 12645
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 01/2016, Volume 8, Issue 1, pp. 6 - 24
Cerebral cavernous malformations (CCMs) are vascular malformations located within the central nervous system often resulting in cerebral hemorrhage.... 
endothelial cells | TGFβ‐BMP | CCM | KLF4 | EndMT | Endothelial cells | TGFβ-BMP | MEDICINE, RESEARCH & EXPERIMENTAL | RHO KINASE | BLOOD-BRAIN-BARRIER | KRUPPEL-LIKE FACTORS | ENDOTHELIAL-MESENCHYMAL TRANSITION | TGF beta-BMP | SIGNALING PATHWAY | VASCULAR INTEGRITY | SHEAR-STRESS | VE-CADHERIN | GROWTH-FACTOR | TRANSCRIPTION FACTOR | Cell Proliferation | KRIT1 Protein | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Hemangioma, Cavernous, Central Nervous System - genetics | Hemangioma, Cavernous, Central Nervous System - metabolism | Bone Morphogenetic Protein 6 - genetics | RNA Interference | Kruppel-Like Transcription Factors - metabolism | HEK293 Cells | Disease Models, Animal | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Signal Transduction | Endothelial Cells - metabolism | Mice, Inbred C57BL | Bone Morphogenetic Protein 6 - antagonists & inhibitors | Proto-Oncogene Proteins - genetics | Microtubule-Associated Proteins - antagonists & inhibitors | Mitogen-Activated Protein Kinase 7 - metabolism | Disease Progression | Mice, Knockout | Animals | Bone Morphogenetic Protein 6 - metabolism | Hemangioma, Cavernous, Central Nervous System - pathology | Endothelial Cells - cytology | Smad1 Protein - metabolism | Mice | Mutation | Kruppel-Like Transcription Factors - antagonists & inhibitors | Kruppel-Like Transcription Factors - genetics | Transforming Growth Factor beta - metabolism | Brain | Bone morphogenetic proteins | Transforming growth factors | Mortality | Stem cells | Vascular Biology & Angiogenesis | Genetics, Gene Therapy & Genetic Disease | Cardiovascular System | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2010, Volume 285, Issue 16, pp. 11760 - 11764
Cerebral cavernous malformations (CCM) are vascular lesions causing seizures and stroke. Mutations causing inactivation of one of three genes, ccm1, -2, or -3,... 
ACTIVATION | FASUDIL | GTPASES | INTEGRITY | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CCM1 | KRIT1 Protein | Microtubule-Associated Proteins - genetics | Humans | rhoA GTP-Binding Protein - metabolism | Hemangioma, Cavernous, Central Nervous System - genetics | Hemangioma, Cavernous, Central Nervous System - metabolism | rho-Associated Kinases - antagonists & inhibitors | RNA Interference | rho-Associated Kinases - metabolism | Apoptosis Regulatory Proteins - genetics | Cardiac Myosins - metabolism | Amides - pharmacology | Cell Line | Proto-Oncogene Proteins - antagonists & inhibitors | Endothelial Cells - metabolism | Membrane Proteins - genetics | Carrier Proteins - antagonists & inhibitors | Proto-Oncogene Proteins - genetics | Microtubule-Associated Proteins - antagonists & inhibitors | Hemangioma, Cavernous, Central Nervous System - drug therapy | Carrier Proteins - genetics | Phenotype | Hemangioma, Cavernous, Central Nervous System - pathology | Membrane Proteins - antagonists & inhibitors | Apoptosis Regulatory Proteins - antagonists & inhibitors | Biosensing Techniques | Myosin Light Chains - metabolism | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Endothelial Cells - pathology | Endothelial Cells - drug effects | Molecular Bases of Disease | Brain | Extracellular Matrix | shRNA | Cerebral Cavernous Malformation | RhoA Biosensor | Reports | Drug Action | ROCK Inhibitor | Rho Kinase | Cell Permeabilization | RhoA
Journal Article