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Nature Reviews Clinical Oncology, ISSN 1759-4774, 05/2013, Volume 10, Issue 5, pp. 256 - 266
The promise of targeting epigenetic abnormalities for cancer therapy has not been realized for solid tumours, although increasing evidence is demonstrating its... 
CELL LUNG-CANCER | HISTONE DEACETYLASE INHIBITOR | PHASE-II TRIAL | POLYCYTHEMIA-VERA | DNA METHYLATION | ONCOLOGY | SUBEROYLANILIDE HYDROXAMIC ACID | GERMLINE EPIMUTATION | ESSENTIAL THROMBOCYTHEMIA | MYELODYSPLASTIC SYNDROMES | CHRONIC MYELOMONOCYTIC LEUKEMIA | Hematologic Neoplasms - therapy | Humans | Histone Deacetylase Inhibitors - administration & dosage | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | DNA (Cytosine-5-)-Methyltransferases - antagonists & inhibitors | Promoter Regions, Genetic - drug effects | Dose-Response Relationship, Drug | Enzyme Inhibitors - administration & dosage | Neoplasms - therapy | Molecular Targeted Therapy - trends | Multicenter Studies as Topic | Neoplasms - genetics | Antineoplastic Agents - pharmacology | Epigenesis, Genetic - drug effects | Drug Therapy, Combination | Molecular Targeted Therapy - methods | Myelodysplastic Syndromes - drug therapy | Drug Administration Schedule | Enzyme Inhibitors - pharmacology | Clinical Trials as Topic | Combined Modality Therapy | Genetic Therapy - trends | DNA, Neoplasm - drug effects | Enzyme Inhibitors - therapeutic use | Forecasting | Neoplasms - drug therapy | Animals | Hematologic Neoplasms - drug therapy | Histone Deacetylase Inhibitors - pharmacology | Hematologic Neoplasms - genetics | Histone Deacetylase Inhibitors - therapeutic use | Myelodysplastic Syndromes - genetics | DNA, Neoplasm - genetics | DNA Methylation - drug effects | Drug Screening Assays, Antitumor | Genetic Therapy - methods | Epigenetic inheritance | Care and treatment | Genetic aspects | Research | Gene expression | Tumors
Journal Article
Nature, ISSN 0028-0836, 10/2017, Volume 550, Issue 7674, pp. 128 - 132
The dynamic and reversible acetylation of proteins, catalysed by histone acetyltransferases (HATs) and histone deacetylases (HDACs), is a major epigenetic... 
ANDROGEN RECEPTOR | ACETYLATION | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | ACETYLTRANSFERASES P300 | EXPRESSION | SMALL-MOLECULE INHIBITOR | Catalytic Domain - drug effects | p300-CBP Transcription Factors - antagonists & inhibitors | Prostatic Neoplasms, Castration-Resistant - enzymology | Histone Acetyltransferases - chemistry | Humans | Receptors, Androgen - metabolism | Crystallography, X-Ray | Male | Antineoplastic Agents - therapeutic use | Hematologic Neoplasms - enzymology | Hematologic Neoplasms - pathology | Cell Lineage - drug effects | Heterocyclic Compounds, 4 or More Rings - pharmacology | Prostatic Neoplasms, Castration-Resistant - pathology | Heterocyclic Compounds, 4 or More Rings - therapeutic use | Biocatalysis - drug effects | Histone Acetyltransferases - metabolism | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | p300-CBP Transcription Factors - chemistry | Binding, Competitive | Enzyme Inhibitors - pharmacology | Heterocyclic Compounds, 4 or More Rings - chemistry | Models, Molecular | Neoplasms - enzymology | Prostatic Neoplasms, Castration-Resistant - drug therapy | Antineoplastic Agents - chemistry | Mice, SCID | Enzyme Inhibitors - therapeutic use | Acetyl Coenzyme A - metabolism | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | p300-CBP Transcription Factors - metabolism | Animals | Histone Acetyltransferases - antagonists & inhibitors | Cell Line, Tumor | Hematologic Neoplasms - drug therapy | Protein Conformation | Cell Proliferation - drug effects | Mice | Neoplasms - pathology | Care and treatment | Chemical inhibitors | Usage | Transferases | Binding proteins | Health aspects | Tumors | Histone deacetylase | Transcription factors | Molecular structure | Transcription | Peptides | Androgen receptors | Amino acids | Event-related potentials | Selectivity | Catalytic activity | Kinases | Experiments | Crystallography | Proteins | CREB-binding protein | Castration | Xenografts | Coenzyme A | Acetylation | Catalysis | Inhibition | Crystal structure | Hematology | Feasibility studies | Cyclic AMP response element-binding protein | Histone acetyltransferase | Inhibitors | Microscopy | Natural products | Regulatory mechanisms (biology) | Epigenetics | Ligands | Prostate cancer | Prostate | Cancer | INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2012, Volume 13, Issue 9, pp. 879 - 886
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 10/2012, Volume 30, Issue 29, pp. 3633 - 3639
Journal Article
Drug Resistance Updates, ISSN 1368-7646, 2016, Volume 29, pp. 90 - 106
Abstract We herein review various pharmacological and clinical aspects of pegylated liposomal doxorubicin (PLD), the first nanomedicine to be approved for... 
Infectious Disease | Hematology, Oncology and Palliative Medicine | Liposome | Anthracyclines | Chemotherapy | Drug delivery | Nanomedicine | ADVANCED BREAST-CANCER | STERICALLY STABILIZED LIPOSOMES | SOFT-TISSUE SARCOMAS | PROLONGED CIRCULATION TIME | T-CELL LYMPHOMA | OVARIAN-CANCER | KAPOSIS-SARCOMA | RANDOMIZED PHASE-III | GLYCOL-COATED LIPOSOMES | PHARMACOLOGY & PHARMACY | POLYETHYLENE-GLYCOL | Antibiotics, Antineoplastic - pharmacology | Liposomes - administration & dosage | Sarcoma, Kaposi - metabolism | Theranostic Nanomedicine - trends | Humans | Ovarian Neoplasms - pathology | Male | Hematologic Neoplasms - pathology | Breast Neoplasms - metabolism | Sarcoma, Kaposi - drug therapy | Multiple Myeloma - drug therapy | Doxorubicin - analogs & derivatives | Drug Compounding | Female | Ovarian Neoplasms - metabolism | Antibiotics, Antineoplastic - pharmacokinetics | Ovarian Neoplasms - drug therapy | Hematologic Neoplasms - metabolism | Polyethylene Glycols - pharmacology | Drug Administration Schedule | Polyethylene Glycols - pharmacokinetics | Clinical Trials as Topic | Multiple Myeloma - metabolism | Breast Neoplasms - drug therapy | Doxorubicin - pharmacokinetics | Sarcoma, Kaposi - pathology | Multiple Myeloma - pathology | Breast Neoplasms - pathology | Hematologic Neoplasms - drug therapy | Doxorubicin - pharmacology | Medical colleges | Usage | Sarcoma | Multiple myeloma | Adjuvant treatment | Jewish schools | Permeability | Ovarian cancer | Analysis | Lymphomas | Health aspects | Cancer | Drugs | Medical research | Drug delivery systems | Vehicles | Medicine, Experimental | Nanotechnology
Journal Article