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PLoS ONE, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, pp. e0139271 - e0139271
Exposure to high-dose radiation results in detrimental effects on survival. The effects of combined trauma, such as radiation in combination with hemorrhage,... 
HYPOXIA-INDUCIBLE FACTOR | IRRADIATION | ERYTHROPOIETIN | ACTIVATION | COMBINED INJURY | MULTIDISCIPLINARY SCIENCES | MICE | MECHANISMS | INOS | INDUCED INCREASES | BLOOD | Body Weight | Kidney - blood supply | Kidney - pathology | Caspase 3 - metabolism | Hemorrhage - mortality | Male | MicroRNAs - metabolism | NF-kappa B - metabolism | Hematopoiesis - radiation effects | Inflammation - metabolism | Kidney - metabolism | Erythropoietin - metabolism | Anemia - etiology | Cytokines - metabolism | Thrombocytopenia - etiology | Bone Marrow Cells - cytology | Hemorrhage - complications | Water - metabolism | Bone Marrow Cells - radiation effects | Lethal Dose 50 | Radiation Injuries - complications | Thrombocytopenia - metabolism | Anemia - metabolism | Disease-Free Survival | Kidney - radiation effects | Animals | Mice | Leukopenia - etiology | Hemorrhage - pathology | Bone Marrow Cells - metabolism | Physiological aspects | Complications and side effects | MicroRNA | Radiotherapy | Hemorrhage | Health sciences | Transcription factors | Erythropoietin | Radiation | Life assessment | Caspase-3 | Blood | Interleukin 6 | Thrombopenia | Nuclear accidents & safety | Blood volume | Hematopoiesis | Bone marrow | Radiation injuries | Anesthesia | Armed forces | Injuries | Euthanasia | Spleen | Radiation effects | γ Radiation | Cell survival | Kidneys | Leukopenia | Mortality | MiRNA | Caspase | Inflammation | Exposure | Tumor necrosis factor-α | Gene expression | Trauma | Survival | Ileum | Radiation dosage | Hemopoiesis | Pathology | Depletion | Tumor necrosis factor | MicroRNAs | Hypoxia | Laboratory animals | α Radiation | Index Medicus
Journal Article
Science, ISSN 0036-8075, 11/2016, Volume 354, Issue 6313, pp. 765 - 768
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 10/2009, Volume 206, Issue 11, pp. 2483 - 2496
Journal Article
Journal Article
Cellular Physiology and Biochemistry, ISSN 1015-8987, 12/2016, Volume 40, Issue 3-4, pp. 716 - 726
Background: Exposure to ionizing radiation (IR) often causes severe damage to radiosensitive tissues, which limits the use of radiotherapy in cancer patients.... 
Original Paper | Tissues injury | HKMT | Toll like receptor 2 (TLR2) | Radioprotection | IMMUNE-RESPONSE | PHYSIOLOGY | BONE-MARROW HEMATOPOIESIS | DNA-DAMAGE | INJURY | IN-VIVO LIGANDS | RADIATION PROTECTION | CELL BIOLOGY | CYTOKINE PRODUCTION | RADIO-RESISTANCE | MICE | INNATE IMMUNITY | Inflammation - pathology | Antigens, CD34 - metabolism | Apoptosis - drug effects | Apoptosis - radiation effects | Cell Count | Th2 Cells - radiation effects | Male | NF-kappa B - metabolism | Protein Transport - drug effects | Th2 Cells - immunology | Th1 Cells - immunology | Th2 Cells - drug effects | Testis - drug effects | Testis - radiation effects | Radiation Tolerance - radiation effects | Th1 Cells - radiation effects | Mycobacterium tuberculosis - physiology | Radiation-Protective Agents - pharmacology | Radiation, Ionizing | Hematopoietic Stem Cells - drug effects | Cell Survival - drug effects | MAP Kinase Signaling System - radiation effects | Th1 Cells - drug effects | Cytokines - metabolism | Cells, Cultured | Hematopoietic Stem Cells - metabolism | Hot Temperature | Cell Survival - radiation effects | Radiation Tolerance - drug effects | Animals | MAP Kinase Signaling System - drug effects | Testis - pathology | Protein Transport - radiation effects | Radiation Injuries - pathology | Mice, Inbred BALB C | Index Medicus
Journal Article
Radiation Research, ISSN 0033-7587, 06/2018, Volume 189, Issue 6, pp. 560 - 578
Journal Article
eLife, ISSN 2050-084X, 03/2015, Volume 2015, Issue 4, pp. e05521 - e05521
Hematopoietic stem cells (HSCs) are maintained by a perivascular niche in bone marrow but it is unclear whether the niche is reciprocally regulated by HSCs.... 
LONG-TERM | OVEREXPRESSING ANGIOPOIETIN-1 | SINUSOIDAL ENDOTHELIAL-CELLS | BONE-MARROW NICHE | BIOLOGY | SELF-RENEWAL | LYMPHOID PROGENITORS | MICE | DISTINCT ROLES | RECEPTOR TYROSINE KINASE | TIE2 RECEPTOR | Gamma Rays | Stem Cell Niche - radiation effects | Receptors, Leptin - genetics | Blood Vessels - metabolism | Male | Angiopoietin-1 - metabolism | Proto-Oncogene Proteins c-kit - metabolism | Capillary Permeability - radiation effects | Regeneration - radiation effects | Blood Vessels - radiation effects | Hematopoiesis - radiation effects | Regeneration - genetics | Nestin - genetics | Female | Integrases - metabolism | Proto-Oncogene Proteins c-kit - genetics | Osteoblasts - cytology | Megakaryocytes - cytology | Megakaryocytes - metabolism | Megakaryocytes - radiation effects | Hematopoietic Stem Cells - radiation effects | Stem Cell Niche - genetics | Osteoblasts - radiation effects | Signal Transduction | Bone Marrow Cells - cytology | Stromal Cells - metabolism | Gene Expression Regulation | Hematopoiesis - genetics | Mice, Transgenic | Hematopoietic Stem Cells - metabolism | Bone Marrow Cells - radiation effects | Blood Vessels - cytology | Nestin - metabolism | Angiopoietin-1 - genetics | Animals | Hematopoietic Stem Cells - cytology | Mice | Receptors, Leptin - metabolism | Osteoblasts - metabolism | Integrases - genetics | Bone Marrow Cells - metabolism | Stromal Cells - cytology | Stromal Cells - radiation effects | Angiopoietin | Radiation | Stem cell transplantation | Osteoblasts | c-Kit protein | Experiments | Hematopoietic stem cells | Endothelial cells | Stains & staining | Regeneration | Angiogenesis | Allografts | Clonal deletion | Microscopy | Stromal cells | Rodents | Stem cells | Bone marrow | Megakaryocytes | Index Medicus
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 10/2012, Volume 264, Issue 2, pp. 202 - 211
The radioprotective effect of extracellular melanin, a naturally occurring pigment, isolated from the fungus was examined in BALB/C mice, and the probable... 
Spleen | Radioprotection | Melanin | γ-Radiation | Apoptosis | MAPKs | PATHWAYS | FUNGI | PROTECTION | INJURY | gamma-Radiation | RESPONSES | PHARMACOLOGY & PHARMACY | TOXICOLOGY | RADIOSENSITIVITY | RADIOTHERAPY | IONIZING-RADIATION | Radiation-Protective Agents | Gamma Rays | Melanins - chemistry | Liver - radiation effects | Male | Spleen - drug effects | Hematopoiesis - drug effects | Leukocytes - radiation effects | Hematopoiesis - radiation effects | Immunity - drug effects | Spectrophotometry, Infrared | Liver - drug effects | Solutions | Immunity - radiation effects | Oxidative Stress - radiation effects | Phosphorylation - drug effects | Oncogene Protein v-akt - metabolism | Magnetic Resonance Spectroscopy | Liver - metabolism | Spectrophotometry, Ultraviolet | Survival | Blotting, Western | Melanins - pharmacology | Phosphorylation - radiation effects | Animals | Spleen - metabolism | Indicators and Reagents | Leukocytes - drug effects | Spleen - radiation effects | Mice | Mice, Inbred BALB C | DNA Damage | Hypocreales - chemistry | Oxidative Stress - drug effects | Leukocytes - metabolism | Mitogen-Activated Protein Kinases - metabolism | Gamma rays | Nuclear radiation | Free radicals (Chemistry) | Index Medicus | AKT protein | OXIDATION | APOPTOSIS | BORON CHLORIDES | WHOLE-BODY IRRADIATION | PHOSPHORYLATION | COLONY FORMING UNITS | ANIMAL TISSUES | 60 APPLIED LIFE SCIENCES | MELANIN | SPLEEN | LYMPHOKINES | INFLAMMATION | LIVER | BLOOD CELLS | HEMATOPOIETIC SYSTEM | MICE
Journal Article
Nature Medicine, ISSN 1078-8956, 03/2013, Volume 19, Issue 3, pp. 295 - 304
The mechanisms that regulate hematopoietic stem cell (HSC) regeneration after myelosuppressive injury are not well understood. We identified epidermal growth... 
PROGENITOR CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | SELF-RENEWAL | FACTOR RECEPTOR | CELL BIOLOGY | STEM-CELL NUMBER | REPOPULATING CAPACITY | LETHALLY IRRADIATED MICE | EX-VIVO CULTURE | ENDOTHELIAL-CELLS | APOPTOTIC PATHWAYS | EGF RECEPTOR | Erlotinib Hydrochloride | Whole-Body Irradiation | Apoptosis - radiation effects | bcl-2 Homologous Antagonist-Killer Protein - genetics | Bone Marrow - radiation effects | Receptor, Epidermal Growth Factor - metabolism | Hematopoiesis | Radiation Injuries, Experimental - drug therapy | Hematopoietic Stem Cells - physiology | Female | Signal Transduction - radiation effects | Hematopoietic Stem Cells - radiation effects | bcl-2-Associated X Protein - genetics | Apoptosis Regulatory Proteins - biosynthesis | Mice, Inbred C57BL | Cells, Cultured | Epidermal Growth Factor - metabolism | Bone Marrow Cells - radiation effects | Mice, Knockout | Regeneration | Animals | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | Protein Kinase Inhibitors - pharmacology | Epidermal Growth Factor - pharmacology | Quinazolines - pharmacology | Tumor Suppressor Proteins - biosynthesis | Care and treatment | Epidermal growth factor | Radiation injuries | Transplantation | Research | Health aspects | Hematopoietic stem cells | Cytokines | Gene expression | Stem cells | Radiation | Index Medicus
Journal Article
Journal Article