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Nature (London), ISSN 1476-4687, 2015, Volume 525, Issue 7570, pp. 538 - 542
.... Here we use primary mouse haematopoietic stem and progenitor cells immortalized with the fusion protein MLL-AF9 to generate several single-cell clones that demonstrate resistance, in vitro... 
SELECTIVE-INHIBITION | ACCURATE | CHROMATIN | MECHANISM | MULTIDISCIPLINARY SCIENCES | ACUTE MYELOID-LEUKEMIA | DRUG-RESISTANCE | MUTATIONS | SEQUENCING DATA | CANCER | DISCOVERY | Chromatin - metabolism | Transcription, Genetic - drug effects | Clone Cells - drug effects | Neoplastic Stem Cells - drug effects | Epigenesis, Genetic | Humans | Leukemia, Myeloid, Acute - metabolism | Molecular Targeted Therapy | Neoplastic Stem Cells - metabolism | Leukemia, Myeloid, Acute - drug therapy | Neoplastic Stem Cells - pathology | Gene Expression Regulation, Neoplastic - drug effects | Hematopoietic Stem Cells - drug effects | Benzodiazepines - pharmacology | Leukemia, Myeloid, Acute - pathology | Cells, Cultured | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Hematopoietic Stem Cells - metabolism | Clone Cells - metabolism | beta Catenin - metabolism | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Clone Cells - pathology | Wnt Signaling Pathway - drug effects | Genes, myc - genetics | Hematopoietic Stem Cells - cytology | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Mice | Cell Cycle Proteins | Drug Resistance, Neoplasm - drug effects | Leukemia, Myeloid, Acute - genetics | Proteins | Leukemia | Cloning | Cell cycle | Stem cells | Epigenetics | Apoptosis
Journal Article
Bioimpacts, ISSN 2228-5660, 12/2018, Volume 8, Issue Suppl 1, pp. S1 - S129
Journal Article
Nature (London), ISSN 1476-4687, 2010, Volume 466, Issue 7308, pp. 829 - 834
The cellular constituents forming the haematopoietic stem cell (HSC) niche in the bone marrow are unclear, with studies implicating osteoblasts, endothelial and perivascular cells... 
PROGENITOR CELLS | OSTEOBLAST | OSTEOPONTIN | MICROENVIRONMENT | MULTIDISCIPLINARY SCIENCES | SELF-RENEWAL | RECEPTOR | DIFFERENTIATION | NEURAL CREST | COOPERATION | EXPRESSION | Chondrocytes - cytology | Nestin | Multipotent Stem Cells - metabolism | Parathyroid Hormone - pharmacology | Cell Lineage - drug effects | Chondrocytes - drug effects | Mesenchymal Stromal Cells - cytology | Multipotent Stem Cells - drug effects | Sympathetic Nervous System - physiology | Cell Division | Stromal Cells - drug effects | Osteoblasts - cytology | Hematopoietic Stem Cells - drug effects | Mesenchymal Stromal Cells - drug effects | Gene Expression Regulation - genetics | Osteoblasts - drug effects | Stromal Cells - metabolism | Cells, Cultured | Mesenchymal Stromal Cells - metabolism | Mice, Transgenic | Hematopoietic Stem Cells - metabolism | Stem Cell Niche - cytology | Nerve Tissue Proteins - metabolism | Granulocyte Colony-Stimulating Factor - pharmacology | Animals | Chemokine CXCL12 - metabolism | Cell Differentiation - drug effects | Multipotent Stem Cells - cytology | Hematopoietic Stem Cells - cytology | Stem Cell Niche - metabolism | Mice | Stem Cell Niche - drug effects | Osteoblasts - metabolism | Intermediate Filament Proteins - metabolism | Mesenchymal Stem Cell Transplantation | Stromal Cells - cytology | Cell Movement | Physiological aspects | Genetic aspects | Research | Bone marrow cells | Gene expression | Osteoblasts | Hematopoietic stem cells | Studies | Proteins | Bone marrow | Rodents | Stem cells
Journal Article
Stem cells (Dayton, Ohio), ISSN 1066-5099, 09/2013, Volume 31, Issue 9, pp. 1785 - 1794
ABSTRACT A patient with βE/β0‐thalassemia major was converted to transfusion‐independence 4.5 years ago by lentiviral gene transfer in hematopoietic stem cells while showing a myeloid... 
Human induced pluripotent stem cells Gene therapy Hematopoietic stem cells Thalassemia β‐Globin expression | Human induced pluripotent stem cells Gene therapy Hematopoietic stem cells Thalassemia β-Globin expression | VECTOR INTEGRATION | INTEGRATION SITES | Hematopoietic stem cells | IPS CELLS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | ENGRAFTMENT | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | Thalassemia beta-Globin expression | IN-VIVO | Human induced pluripotent stem cells | GENE-THERAPY | GENERATION | DIFFERENTIATION | Gene therapy | SELECTION | HEMATOLOGY | beta-Thalassemia - pathology | Mutagens - toxicity | Humans | Erythroid Cells - cytology | Globins - metabolism | Lentivirus - metabolism | Virus Integration - drug effects | Adult | Induced Pluripotent Stem Cells - cytology | Induced Pluripotent Stem Cells - metabolism | Hematopoietic Stem Cells - drug effects | Transduction, Genetic | Induced Pluripotent Stem Cells - drug effects | Erythroid Cells - metabolism | Genetic Vectors - metabolism | Hematopoietic Stem Cell Transplantation | Hematopoietic Stem Cells - metabolism | Gene Expression Regulation - drug effects | Globins - genetics | Regeneration - drug effects | Animals | Erythroid Cells - drug effects | Cell Differentiation - drug effects | Hematopoietic Stem Cells - cytology | Mice
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2009, Volume 106, Issue 38, pp. 16281 - 16286
.... CD133, a surface glycoprotein linked to organ-specific stem cells, was described as a marker of cancer-initiating cells in different tumor types... 
Chemotherapy | Cell growth | Population growth | Lungs | Stem cells | Cell lines | Heterologous transplantation | Tumors | Lung neoplasms | Cancer | CXCR4 | ABC transporters | Cancer stem cells | Chemoresistance | Xenografts | POPULATION | xenografts | MARKER | PROSPECTIVE IDENTIFICATION | MULTIDISCIPLINARY SCIENCES | MELANOMAS | BRAIN-TUMORS | chemoresistance | GROWTH | cancer stem cells | AC133 | EXPRESSION | HEMATOPOIETIC STEM | ANTIGEN | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Immunohistochemistry | Lung Neoplasms - drug therapy | Neoplastic Stem Cells - drug effects | Humans | Lung Neoplasms - metabolism | Middle Aged | Glycoproteins - metabolism | Drug Resistance, Neoplasm | Lung Neoplasms - pathology | Male | Antineoplastic Agents - therapeutic use | Neoplasm Proteins - metabolism | Antigens, CD - metabolism | Flow Cytometry | Peptides - metabolism | Neoplastic Stem Cells - metabolism | ATP-Binding Cassette Transporters - metabolism | Biomarkers, Tumor - metabolism | Neoplastic Stem Cells - pathology | Female | Antineoplastic Agents - pharmacology | Tumor Cells, Cultured | Carcinoma, Non-Small-Cell Lung - pathology | Cell Survival - drug effects | Carcinoma, Non-Small-Cell Lung - metabolism | Cisplatin - pharmacology | Mice, SCID | AC133 Antigen | Receptors, CXCR4 - metabolism | Xenograft Model Antitumor Assays | Animals | Cisplatin - therapeutic use | Tumor Burden - drug effects | Survival Analysis | Cell Line, Tumor | Mice | Carcinoma, Non-Small-Cell Lung - drug therapy | Biological Sciences
Journal Article
Cell stem cell, ISSN 1934-5909, 09/2012, Volume 11, Issue 3, pp. 346 - 358
.... In this study, we show that this expansion begins with overproliferation within a compartment of normally quiescent long-term hematopoietic stem cells (LT-HSCs... 
PROGENITOR CELLS | INTERNAL TANDEM DUPLICATION | CONSTITUTIVE ACTIVATION | ACUTE MYELOGENOUS LEUKEMIA | GENE-EXPRESSION | SELF-RENEWAL | C-KIT | ACUTE MYELOID-LEUKEMIA | PROGNOSTIC-SIGNIFICANCE | MYELODYSPLASTIC SYNDROME | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Niacinamide - analogs & derivatives | Small Molecule Libraries - pharmacology | Neoplastic Stem Cells - drug effects | Hematopoietic Stem Cells - pathology | Male | Bone Marrow Neoplasms - genetics | RNA, Messenger - metabolism | Promoter Regions, Genetic - genetics | Side-Population Cells - drug effects | fms-Like Tyrosine Kinase 3 - genetics | Neoplastic Stem Cells - metabolism | Side-Population Cells - metabolism | Bone Marrow - metabolism | Neoplastic Stem Cells - pathology | Female | Gene Expression Regulation, Neoplastic - drug effects | Homeostasis - drug effects | Tandem Repeat Sequences - genetics | Bone Marrow - drug effects | Gene Duplication - drug effects | Hematopoietic Stem Cells - drug effects | RNA, Messenger - genetics | Hematopoietic Stem Cell Transplantation | Hematopoietic Stem Cells - metabolism | Enzyme Activation - drug effects | Side-Population Cells - pathology | fms-Like Tyrosine Kinase 3 - metabolism | Gene Knock-In Techniques | Phenotype | Animals | Bone Marrow Neoplasms - pathology | Signal Transduction - drug effects | Bone Marrow - pathology | Cell Compartmentation - drug effects | Cell Proliferation - drug effects | Mice | Phenylurea Compounds - pharmacology | Niacinamide - pharmacology | Cell Cycle - drug effects | Homeostasis - genetics
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2008, Volume 105, Issue 18, pp. 6620 - 6625
The mechanisms by which bone marrow (BM)-derived stem cells might contribute to angiogenesis and the origin of neovascular endothelial cells (ECs) are controversial... 
Angiogenesis | Transgenic animals | Blood cells | Stem cells | Blood vessels | Progenitor cells | Endothelial cells | Hematopoietic stem cells | Tumors | Endothelium | Progenitor | Differentiation | Stem cell | Cancer | PROGENITOR CELLS | RECRUITMENT | differentiation | MYOCARDIAL-INFARCTION | angiogenesis | NITRIC-OXIDE SYNTHASE | ANGIOGENIC SWITCH | MULTIDISCIPLINARY SCIENCES | progenitor | TRANSPLANTATION | stem cell | HEMATOPOIETIC STEM-CELLS | IN-VIVO | cancer | NEOVASCULARIZATION | BLOOD | Organ Specificity - drug effects | Neovascularization, Pathologic | Endothelium, Vascular - drug effects | Receptor, TIE-1 - metabolism | Parabiosis | Neoplasms, Experimental | Bone Marrow Cells - drug effects | Vascular Endothelial Growth Factor A - pharmacology | Genes, Reporter | Bone Marrow Cells - pathology | Proteoglycans - metabolism | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Neoplasms - blood supply | Cell Movement - drug effects | Collagen - metabolism | Animals | Stem Cells - drug effects | Stem Cells - pathology | Blood Circulation - drug effects | Endothelium, Vascular - pathology | Cell Proliferation - drug effects | Mice | Laminin - metabolism | Endothelial Cells - pathology | Neoplasms - pathology | Drug Combinations | Endothelial Cells - drug effects | Bone marrow | Vascular endothelium | Properties | Growth | Health aspects | Biological Sciences
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2006, Volume 355, Issue 12, pp. 1253 - 1261
Journal Article
Nature (London), ISSN 1476-4687, 2018, Volume 553, Issue 7687, pp. 171 - 177
Haematopoietic stem cells renew blood. Accumulation of DNA damage in these cells promotes their decline, while misrepair of this damage initiates malignancies... 
REPLICATION | FANCONI-ANEMIA PATHWAY | MULTIDISCIPLINARY SCIENCES | MICE | HOMOLOGOUS RECOMBINATION | DNA-REPAIR | IDENTIFICATION | EXPRESSION | BONE-MARROW FAILURE | GENOME | PROGRESSION | Acetaldehyde - metabolism | Fanconi Anemia Complementation Group D2 Protein - genetics | Fanconi Anemia - metabolism | Ethanol - administration & dosage | Hematopoietic Stem Cells - pathology | Male | Fanconi Anemia Complementation Group D2 Protein - deficiency | Tumor Suppressor Protein p53 - genetics | DNA Breaks, Double-Stranded - drug effects | DNA End-Joining Repair | Gene Deletion | Genomic Instability - drug effects | Fanconi Anemia - pathology | Female | Alcohol Dehydrogenase - deficiency | Fanconi Anemia - genetics | Recombinational DNA Repair - drug effects | Alcohol Dehydrogenase - metabolism | Hematopoietic Stem Cells - drug effects | Cell Survival - drug effects | Ethanol - metabolism | Mice, Inbred C57BL | Tumor Suppressor Protein p53 - metabolism | Hematopoietic Stem Cell Transplantation | Hematopoietic Stem Cells - metabolism | Ku Autoantigen - metabolism | Genes, p53 - genetics | Tumor Suppressor Protein p53 - deficiency | Whole Genome Sequencing | Ethanol - pharmacology | Animals | Fanconi Anemia Complementation Group D2 Protein - metabolism | Alcohol Dehydrogenase - genetics | Mice | Mutation | Aldehydes | Health aspects | Chromosomes | Hematopoietic stem cells | Alcohols | Recombination | Dehydrogenases | Cell survival | Ethanol | p53 Protein | DNA damage | Alcohol | Transplantation | Genomes | Chromosome rearrangements | DNA repair | Gene sequencing | Acetaldehyde | Genomic instability | Mutagenesis | Clonal deletion | Stem cells | Cell cycle | Alcoholic beverages | Damage accumulation | Deoxyribonucleic acid--DNA
Journal Article