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Nature, ISSN 0028-0836, 2014, Volume 506, Issue 7488, pp. 328 - 333
In acute myeloid leukaemia (AML), the cell of origin, nature and biological consequences of initiating lesions, and order of subsequent mutations remain poorly... 
BREAST-CANCER | RELAPSE | ACUTE NONLYMPHOCYTIC LEUKEMIA | MULTIDISCIPLINARY SCIENCES | ACUTE LYMPHOBLASTIC-LEUKEMIA | PANCREATIC-CANCER | DNA METHYLTRANSFERASE | CLONAL EVOLUTION | ACUTE MYELOID-LEUKEMIA | DNMT3A MUTATIONS | MYELODYSPLASTIC SYNDROMES | Clone Cells - cytology | Neoplasm Transplantation | Neoplastic Stem Cells - cytology | Neoplastic Stem Cells - drug effects | Humans | Hematopoietic Stem Cells - pathology | DNA (Cytosine-5-)-Methyltransferases - metabolism | Heterografts | Neoplastic Stem Cells - metabolism | T-Lymphocytes - metabolism | Hematopoiesis | Cell Division | Leukemia, Myeloid, Acute - drug therapy | Neoplastic Stem Cells - pathology | Female | Cell Differentiation | T-Lymphocytes - pathology | Nuclear Proteins - genetics | Hematopoietic Stem Cells - drug effects | Leukemia, Myeloid, Acute - pathology | Isocitrate Dehydrogenase - genetics | Hematopoietic Stem Cells - metabolism | Mice, SCID | Mutation - genetics | Clone Cells - metabolism | Remission Induction | Cell Lineage | DNA (Cytosine-5-)-Methyltransferases - genetics | Animals | Clone Cells - pathology | Leukemia, Myeloid, Acute - diagnosis | Hematopoietic Stem Cells - cytology | Mice, Inbred NOD | Mice | Drug Resistance, Neoplasm - drug effects | Leukemia, Myeloid, Acute - genetics | Acute leukemia | Genetic aspects | Diagnosis | Identification and classification | Hematopoietic stem cells
Journal Article
Current Opinion in Cell Biology, ISSN 0955-0674, 2013, Volume 25, Issue 2, pp. 254 - 264
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 512, Issue 1, pp. 78 - 81
Myeloproliferative neoplasms (MPNs) are diseases caused by mutations in the haematopoietic stem cell (HSC) compartment. Most MPN patients have a common... 
TYROSINE KINASE JAK2 | JAK2-V617F | ACTIVATING MUTATION | POLYCYTHEMIA-VERA | BONE | MULTIDISCIPLINARY SCIENCES | Neuroprotective Agents - therapeutic use | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Sympathetic Nervous System - drug effects | Humans | Hematopoietic Stem Cells - pathology | Myeloproliferative Disorders - pathology | Sympathetic Nervous System - physiopathology | Adrenergic beta-3 Receptor Agonists - pharmacology | Neuroprotective Agents - pharmacology | Interleukin-1beta - metabolism | Neoplastic Stem Cells - pathology | Female | Sympathetic Nervous System - pathology | Schwann Cells - drug effects | Hematopoietic Stem Cells - drug effects | Nerve Fibers - pathology | Mesenchymal Stromal Cells - drug effects | Stem Cell Niche | Janus Kinase 2 - genetics | Nerve Fibers - drug effects | Schwann Cells - pathology | Myeloproliferative Disorders - drug therapy | Receptors, Adrenergic, beta-3 - metabolism | Disease Progression | Neoplasms - drug therapy | Nestin - metabolism | Adrenergic beta-3 Receptor Agonists - therapeutic use | Animals | Mice | Mesenchymal Stromal Cells - pathology | Neoplasms - pathology | Complications and side effects | Development and progression | Health aspects | Peripheral nerve diseases | Hematopoietic stem cells | Myeloproliferative disorders | Tumors | Studies | Mutation | Kinases | Rodents | Stem cells | Apoptosis
Journal Article
Nature, ISSN 0028-0836, 09/2015, Volume 525, Issue 7570, pp. 538 - 542
Bromodomain and extra terminal protein (BET) inhibitors are first-in-class targeted therapies that deliver a newtherapeutic opportunity by directly targeting... 
SELECTIVE-INHIBITION | ACCURATE | CHROMATIN | MECHANISM | MULTIDISCIPLINARY SCIENCES | ACUTE MYELOID-LEUKEMIA | DRUG-RESISTANCE | MUTATIONS | SEQUENCING DATA | CANCER | DISCOVERY | Chromatin - metabolism | Transcription, Genetic - drug effects | Clone Cells - drug effects | Neoplastic Stem Cells - drug effects | Epigenesis, Genetic | Humans | Leukemia, Myeloid, Acute - metabolism | Molecular Targeted Therapy | Neoplastic Stem Cells - metabolism | Leukemia, Myeloid, Acute - drug therapy | Neoplastic Stem Cells - pathology | Gene Expression Regulation, Neoplastic - drug effects | Hematopoietic Stem Cells - drug effects | Benzodiazepines - pharmacology | Leukemia, Myeloid, Acute - pathology | Cells, Cultured | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Hematopoietic Stem Cells - metabolism | Clone Cells - metabolism | beta Catenin - metabolism | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Clone Cells - pathology | Wnt Signaling Pathway - drug effects | Genes, myc - genetics | Hematopoietic Stem Cells - cytology | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Mice | Drug Resistance, Neoplasm - drug effects | Leukemia, Myeloid, Acute - genetics | Proteins | Leukemia | Cloning | Cell cycle | Stem cells | Epigenetics | Apoptosis
Journal Article
Blood, ISSN 0006-4971, 12/2008, Volume 112, Issue 13, pp. 4793 - 4807
Journal Article
Journal Article
Cell Stem Cell, ISSN 1934-5909, 11/2016, Volume 19, Issue 5, pp. 613 - 627
Mesenchymal niche cells may drive tissue failure and malignant transformation in the hematopoietic system, but the underlying molecular mechanisms and... 
microenvironment | leukemia | inflammation | mesenchymal | hematopoietic stem cell | shwachman-diamond syndrome | niche | cancer | myelodysplastic syndrome (MDS) | S100A8 | PROGENITOR CELLS | OXIDATIVE DNA-DAMAGE | GENE | SBDS | MUTATIONS | SHWACHMAN-DIAMOND-SYNDROME | MYELODYSPLASTIC CELLS | STROMAL CELLS | EXPRESSION | DEFICIENCY | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Bone and Bones - pathology | Inflammation - pathology | Leukemia - pathology | Oxidative Stress | Humans | Hematopoietic Stem Cells - pathology | Precancerous Conditions - metabolism | Leukemia - metabolism | S100 Proteins - genetics | Lipomatosis - pathology | Gene Deletion | Integrases - metabolism | Precancerous Conditions - pathology | Toll-Like Receptors - metabolism | Stem Cell Niche | Pathogen-Associated Molecular Pattern Molecules - metabolism | Signal Transduction | Exocrine Pancreatic Insufficiency - pathology | Risk Factors | Tumor Suppressor Protein p53 - metabolism | Mesenchymal Stromal Cells - metabolism | S100 Proteins - metabolism | Treatment Outcome | Hematopoietic Stem Cells - metabolism | Mitochondria - metabolism | Bone Marrow Diseases - pathology | Disease Progression | Transcription Factors - metabolism | Animals | Proteins - metabolism | DNA Repair | Sp7 Transcription Factor | Mice | DNA Damage | Mesenchymal Stromal Cells - pathology | Bone and Bones - abnormalities
Journal Article