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Nature, ISSN 0028-0836, 2014, Volume 512, Issue 1, pp. 78 - 81
Myeloproliferative neoplasms (MPNs) are diseases caused by mutations in the haematopoietic stem cell (HSC) compartment. Most MPN patients have a common... 
TYROSINE KINASE JAK2 | JAK2-V617F | ACTIVATING MUTATION | POLYCYTHEMIA-VERA | BONE | MULTIDISCIPLINARY SCIENCES | Neuroprotective Agents - therapeutic use | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Sympathetic Nervous System - drug effects | Humans | Hematopoietic Stem Cells - pathology | Myeloproliferative Disorders - pathology | Sympathetic Nervous System - physiopathology | Adrenergic beta-3 Receptor Agonists - pharmacology | Neuroprotective Agents - pharmacology | Interleukin-1beta - metabolism | Neoplastic Stem Cells - pathology | Female | Sympathetic Nervous System - pathology | Schwann Cells - drug effects | Hematopoietic Stem Cells - drug effects | Nerve Fibers - pathology | Mesenchymal Stromal Cells - drug effects | Stem Cell Niche | Janus Kinase 2 - genetics | Nerve Fibers - drug effects | Schwann Cells - pathology | Myeloproliferative Disorders - drug therapy | Receptors, Adrenergic, beta-3 - metabolism | Disease Progression | Neoplasms - drug therapy | Nestin - metabolism | Adrenergic beta-3 Receptor Agonists - therapeutic use | Animals | Mice | Mesenchymal Stromal Cells - pathology | Neoplasms - pathology | Complications and side effects | Development and progression | Health aspects | Peripheral nerve diseases | Hematopoietic stem cells | Myeloproliferative disorders | Tumors | Studies | Mutation | Kinases | Rodents | Stem cells | Apoptosis
Journal Article
Cell Stem Cell, ISSN 1934-5909, 09/2016, Volume 19, Issue 3, pp. 370 - 382
Journal Article
Leukemia, ISSN 0887-6924, 07/2011, Volume 25, Issue 7, pp. 1080 - 1094
The Ras/Raf/mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway is often implicated in sensitivity and resistance to... 
targeted therapy | Ras | therapeutic sensitivity | Raf | resistance | ERK | ABROGATE CYTOKINE DEPENDENCY | INITIATION-FACTOR 4E | ACUTE MYELOID-LEUKEMIA | KINASE INHIBITOR PROTEIN | DRUG-INDUCED APOPTOSIS | BONE-MARROW MICROENVIRONMENT | ONCOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | CHRONIC LYMPHOCYTIC-LEUKEMIA | MURINE HEMATOPOIETIC-CELLS | HEMATOLOGY | SIGNAL-REGULATED KINASE | ras Proteins - genetics | MAP Kinase Signaling System - physiology | Mitogen-Activated Protein Kinase Kinases - genetics | Apoptosis - drug effects | raf Kinases - antagonists & inhibitors | Humans | Neoplasm Proteins - physiology | Mitogen-Activated Protein Kinase Kinases - physiology | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Molecular Targeted Therapy | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - genetics | Gene Expression Regulation, Leukemic - genetics | raf Kinases - physiology | MAP Kinase Signaling System - genetics | Drug Design | Antineoplastic Agents - pharmacology | Extracellular Signal-Regulated MAP Kinases - physiology | Neoplasm Proteins - genetics | raf Kinases - genetics | ras Proteins - physiology | Cell Division - genetics | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | ras Proteins - antagonists & inhibitors | Gene Expression Regulation, Leukemic - drug effects | Leukemia - drug therapy | Cell Division - drug effects | Phosphatidylinositol 3-Kinases - genetics | Drug Resistance, Neoplasm - genetics | MAP Kinase Signaling System - drug effects | Models, Biological | Phosphatidylinositol 3-Kinases - physiology | Apoptosis - physiology | Drug Resistance, Neoplasm - physiology | Drug Resistance, Neoplasm - drug effects | Chemotherapy | Extracellular signal-regulated kinases | Leukemia | Physiological aspects | Genetic aspects | Research | Drug therapy | Health aspects | Mitogen-activated protein kinases | Cancer
Journal Article
Emerging Infectious Diseases, ISSN 1080-6040, 07/2009, Volume 15, Issue 7, pp. 1068 - 1076
Azoles are the mainstay of oral therapy for aspergillosis. Azole resistance in Aspergillus has been reported infrequently. The first resistant isolate in... 
SYSTEM | INFECTIOUS DISEASES | INVASIVE ASPERGILLOSIS | ITRACONAZOLE RESISTANCE | HIGH-RESOLUTION | CROSS-RESISTANCE | ANTIFUNGAL AGENTS | IN-VITRO SUSCEPTIBILITY | MECHANISMS | MUTATIONS | IMMUNOLOGY | CYP51A GENE | Aspergillus fumigatus - drug effects | Humans | Fungal Proteins - drug effects | Azoles - therapeutic use | Fungal Proteins - genetics | Pyrimidines - pharmacology | Aspergillus fumigatus - genetics | Disease Progression | Itraconazole - pharmacology | Antifungal Agents - therapeutic use | Itraconazole - therapeutic use | Triazoles - pharmacology | Cytochrome P-450 Enzyme System - drug effects | Pyrimidines - therapeutic use | Treatment Failure | Voriconazole | Cytochrome P-450 Enzyme System - genetics | Drug Resistance, Fungal | Amino Acid Substitution | Aspergillosis - drug therapy | Evolution, Molecular | Triazoles - therapeutic use | Lung diseases, Obstructive | Care and treatment | Methionine | Mycoses | Transplantation | Drug resistance | Hematopoietic stem cells | Endowments | Algorithms | Codon | Evolutionary biology | Amphotericin B | Gene mutations | Triazoles | Analysis | Antiparasitic agents | Cross infection | Nosocomial infections | Health aspects | Itraconazole | Aspergillus | population genetics | antifungal drug resistance | sterol 14-alpha demethylase CYP51A | Aspergillus fumigatus | azoles
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 10/2013, Volume 210, Issue 11, pp. 2465 - 2476
Journal Article
Science, ISSN 0036-8075, 4/2008, Volume 320, Issue 5873, pp. 226 - 230
The toxicity of ionizing radiation is associated with massive apoptosis in radiosensitive organs. Here, we investigate whether a drug that activates a... 
Crypts | Stem cells | Irradiation | Agonists | Reports | Radiotherapy | Radiation protection | Small intestine | Endothelial cells | Tumors | Apoptosis | ADAPTIVE IMMUNITY | TUMOR-NECROSIS-FACTOR | TOLL-LIKE RECEPTOR-5 | FLAGELLIN | INDUCED APOPTOSIS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | FACTOR-KAPPA-B | MICE | IONIZING-RADIATION | CANCER | Gamma Rays | Whole-Body Irradiation | Apoptosis - drug effects | Apoptosis - radiation effects | Hematopoietic System - drug effects | Molecular Sequence Data | Radiation-Protective Agents - administration & dosage | NF-kappa B - metabolism | Macaca mulatta | Toll-Like Receptor 5 - agonists | Peptides - administration & dosage | Flagellin - pharmacology | Salmonella enterica | Radiation Injuries, Experimental - prevention & control | Peptides - toxicity | Flagellin - chemistry | Hematopoietic System - radiation effects | Radiation-Protective Agents - pharmacology | Intestine, Small - radiation effects | Chemotherapy, Adjuvant | Amino Acid Sequence | Toll-Like Receptor 5 - metabolism | Peptides - chemistry | Signal Transduction | Radiation-Protective Agents - chemistry | Radiation Dosage | Neoplasms, Experimental - radiotherapy | Mice, Inbred ICR | Peptides - pharmacology | Radiation-Protective Agents - toxicity | Radiation Tolerance - drug effects | Animals | Intestine, Small - cytology | Intestine, Small - drug effects | Mice | Neoplasms, Experimental - drug therapy | Cell receptors | Ionizing radiation | Rodents | Physiological aspects | Environmental aspects | Primates | Influence | Models | Research | Properties | Cellular biology | Toxicity | Radiation | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 11/2010, Volume 116, Issue 20, pp. 4158 - 4167
Journal Article
Blood, ISSN 0006-4971, 03/2010, Volume 115, Issue 11, pp. 2251 - 2259
Journal Article