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Nature, ISSN 0028-0836, 05/2017, Volume 545, Issue 7655, pp. 439 - 445
Developmental pathways that orchestrate the fleeting transition of endothelial cells into haematopoietic stem cells remain undefined. Here we demonstrate a... 
PROGENITOR CELLS | MAINTENANCE | REGENERATION | MULTIDISCIPLINARY SCIENCES | VASCULAR NICHE | HEMOGENIC ENDOTHELIUM | SELF-RENEWAL | GENERATION | INDUCTION | DIFFERENTIATION | FIBROBLASTS | Clone Cells - cytology | Humans | Transcriptome | Male | Cellular Reprogramming | DNA-Binding Proteins - metabolism | Cell Self Renewal | Hematopoietic Stem Cells - immunology | Aging - genetics | Hematopoiesis | Trans-Activators - genetics | Cell Differentiation | Adaptive Immunity | Proto-Oncogene Proteins - metabolism | Cell Line | Clone Cells - transplantation | Core Binding Factor Alpha 2 Subunit - metabolism | Endothelial Cells - metabolism | Mice, Inbred C57BL | Proto-Oncogene Proteins c-fos - metabolism | Hematopoietic Stem Cell Transplantation | Proto-Oncogene Proteins - genetics | Hematopoietic Stem Cells - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Endothelium - cytology | Transcription Factors - metabolism | Cell Lineage | Animals | T-Lymphocytes - cytology | Endothelial Cells - cytology | Hematopoietic Stem Cells - cytology | Proto-Oncogene Proteins c-fos - genetics | T-Lymphocytes - immunology | Trans-Activators - metabolism | Mice | Core Binding Factor Alpha 2 Subunit - genetics | Physiological aspects | Physiological research | Research | Immunocompetent cells | Stem cells | Endothelium
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 08/2019, Volume 10, Issue 1, pp. 3577 - 14
Haematopoietic stem cells are generated from the haemogenic endothelium (HE) located in the floor of the dorsal aorta (DA). Despite being integral to arteries,... 
TRANSITION | PROGENITORS | DISTINCT FUNCTIONS | PATHWAY | MULTIDISCIPLINARY SCIENCES | GENOME-WIDE ANALYSIS | HEMOGENIC ENDOTHELIUM | RUNX1 EXPRESSION | RECEPTOR | HEMATOPOIETIC STEM | AORTIC ENDOTHELIUM | Genes | Stem cells | Differentiation (biology) | Aorta | Runx1 protein | Zebrafish | Cell differentiation | Hematopoietic stem cells | Pluripotency | Arteries | Mutants | Endothelium
Journal Article
Developmental Dynamics, ISSN 1058-8388, 09/2012, Volume 241, Issue 9, pp. 1454 - 1464
Journal Article
Journal Article
Cell Reports, ISSN 2211-1247, 05/2018, Volume 23, Issue 8, pp. 2467 - 2481
Understanding the pathways guiding the development of definitive hematopoiesis with lymphoid potential is essential for advancing human pluripotent stem cell... 
hematopoiesis | human pluripotent stem cells | T cells | hematopoietic stem cells | ETS1 | hemogenic endothelium | MAPK/ERK signaling
Journal Article
Cell Reports, ISSN 2211-1247, 04/2017, Volume 19, Issue 1, pp. 10 - 19
Journal Article
Development (Cambridge), ISSN 0950-1991, 03/2015, Volume 142, Issue 6, pp. 1050 - 1061
Journal Article
Seminars in Cell and Developmental Biology, ISSN 1084-9521, 12/2011, Volume 22, Issue 9, pp. 1036 - 1047
► The bipotential hemangioblast paradigm has shifted to “hemogenic endothelium”. ► Hematopoietic stem cell (HSC) embryonic origins can be trac