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1. Acquired haemophilia--an overlooked disorder with high morbidity
by Qvist, Evelina and Engquist, Leif and Tengborn, Lilian
Lakartidningen, ISSN 0023-7205, 02/2010, Volume 107, Issue 6, p. 328
Diagnosis, Differential | Glucocorticoids - therapeutic use | Antibodies, Monoclonal, Murine-Derived | Hemophilia A - mortality | Humans | Immunosuppressive Agents - therapeutic use | Prothrombin Time | Rituximab | Antibodies, Monoclonal - therapeutic use | Male | Antineoplastic Agents - therapeutic use | Hemophilia A - etiology | Aged | Prednisolone - therapeutic use | Hemophilia A - diagnosis | Hemophilia A - drug therapy
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2. Full Text Impact of inhibitors on hemophilia a mortality in the United States
by Walsh, Christopher E and Soucie, J. Michael and Miller, Connie H and US Hemophilia Treatment Ctr Networ and United States Hemophilia Treatment Center Network
American Journal of Hematology, ISSN 0361-8609, 05/2015, Volume 90, Issue 5, pp. 400 - 405
The previously published mortality studies are limited in hemophilia populations but suggest that there is no increased risk of mortality in factor VIII... 
PROPHYLAXIS | FINLAND | HIV | FACTOR-VIII | SURVEILLANCE | DISORDERS | DEATH | KINGDOM | HEMATOLOGY | LIFE EXPECTANCY | United States | Humans | Middle Aged | Male | Cytomegalovirus Infections - complications | Cytomegalovirus Infections - mortality | Factor VIII - antagonists & inhibitors | Adult | HIV Infections - mortality | Retrospective Studies | Child | HIV Infections - blood | Hemophilia A - mortality | Risk Factors | Hemophilia A - blood | Hemophilia A - complications | Cytomegalovirus Infections - blood | Cytomegalovirus Infections - drug therapy | Adolescent | Factor VIII - administration & dosage | HIV Infections - complications | Survival Analysis | Antibodies - blood | HIV Infections - drug therapy | Hemophilia A - drug therapy | Blood coagulation factor VIII | Health aspects | Mortality | Analysis | Hemophilia
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3. Full Text Inhibitor development and mortality in non-severe hemophilia A
by Eckhardt, C. L and Loomans, J. I and van Velzen, A. S and Peters, M and Mauser-Bunschoten, E. P and Schwaab, R and Mazzucconi, M. G and Tagliaferri, A and Siegmund, B and Reitter-Pfoertner, S. E and van der Bom, J. G and Fijnvanaat, K and Kamphuisen, P. W and Peerlinck, K and Oldenburg, J and Santagostino, E and Astermark, J and Streefkerk, N and Loomans, J. L and van Eijkelenburg, A and Jansen, A. J and Kruijt, C. C and van Tienoven, B and van Baar, A. C. G and Corten, I. W and Meijer, K and Nijziel, M. R and Dors, N and Hamulyak, K and Beckers, E and Brons, P. P and Laros-van Gorkom, B. A. P and van Heerde, W. L and Leebeek, F and Kruip, M and Cnossen, M. H and Mauser-Bunschoten, E and Fischer, K and Smiers, F. J and Hermans, C and Klamroth, R and Escuriola-Ettingshausen, C and Königs, C and Petrini, P and Holmström, M and Mäkipernaa, A and Male, C and Pabinger, I and Keenan, R. D and Liesner, R and INSIGHT Study Grp and INSIGHT Study Group and the INSIGHT Study Group
Journal of thrombosis and haemostasis, ISSN 1538-7933, 2015, Volume 13, Issue 7, pp. 1217 - 1225
The life expectancy of non-severe hemophilia A (HA) patients equals the life expectancy of the non-hemophilic population. However, data on the effect of... 
mortality | hemophilia A | neutralizing antibodies | cause of death | hemorrhage | Neutralizing antibodies | Cause of death | Hemorrhage | Mortality | Hemophilia A | MANAGEMENT | FACTOR-VIII INHIBITORS | RISK | DEATH | MILD | MUTATION | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | LIFE EXPECTANCY | Factor VIII - immunology | Autoantibodies - blood | Humans | Middle Aged | Hemorrhage - mortality | Male | Cause of Death | Young Adult | Time Factors | Adult | Retrospective Studies | Hemophilia A - diagnosis | Child | Severity of Illness Index | Hemophilia A - mortality | Risk Assessment | Europe | Hemophilia A - immunology | Hemorrhage - immunology | Risk Factors | Hemorrhage - blood | Biomarkers - blood | Hemophilia A - blood | Hemorrhage - diagnosis | Adolescent | Aged | Australia | Antibodies, Neutralizing - blood | Blood coagulation factor VIII | Health aspects | Hemophilia
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4. Full Text Mortality rates, life expectancy, and causes of death in people with hemophilia A or B in the United Kingdom who were not infected with HIV
by Darby, Sarah C and Sau, Wan Kan and Spooner, Rosemary J and Giangrande, Paul L. F and Hill, Frank G. H and Hay, Charles R. M and Lee, Christine A and Ludlam, Christopher A and Williams, Michael and UK Haemophilia Ctr Doctors
Blood, ISSN 0006-4971, 08/2007, Volume 110, Issue 3, pp. 815 - 825
Since the 1970s, mortality in the hemophilia population has been dominated by human immunodeficiency virus (HIV) and few reports have described mortality in... 
POPULATION | RISK-FACTORS | HEPATITIS | PROGNOSIS | FACTOR-VIII | SWEDISH HEMOPHILIACS | DISORDERS | ISCHEMIC-HEART-DISEASE | HEMATOLOGY | DIRECTORS | HIV Infections | Follow-Up Studies | Humans | Middle Aged | Creutzfeldt-Jakob Syndrome - complications | Child, Preschool | Hemorrhage - mortality | Infant | Male | Life Expectancy | Aged, 80 and over | Hodgkin Disease - mortality | Liver Diseases - complications | Adult | Myocardial Ischemia - mortality | Retrospective Studies | Child | Infant, Newborn | Hemophilia B - mortality | Hemophilia A - mortality | Hemorrhage - complications | United Kingdom | Hodgkin Disease - complications | Hemophilia A - complications | Hemophilia B - complications | Creutzfeldt-Jakob Syndrome - mortality | Myocardial Ischemia - complications | Adolescent | Liver Diseases - mortality | Aged
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5. Full Text Mortality and causes of death in Italian persons with haemophilia, 1990–2007
by TAGLIAFERRI, A and RIVOLTA, G. F and IORIO, A and OLIOVECCHIO, E and MANCUSO, M. E and MORFINI, M and ROCINO, A and MAZZUCCONI, M. G and FRANCHINI, M and Italian Assoc and Italian Association of Hemophilia Centers and ON BEHALF OF THE ITALIAN ASSOCIATION OF HEMOPHILIA CENTERS
Haemophilia, ISSN 1351-8216, 05/2010, Volume 16, Issue 3, pp. 437 - 446
Although a number of studies have analysed so far the causes of death and the life expectancy in haemophilic populations, no investigations have been conducted... 
haemophilia | mortality | cancer | HCV | HIV | Haemophilia | Mortality | Cancer | RATES | THERAPY | DISORDERS | LIVER-DISEASE | HEMATOLOGY | LIFE EXPECTANCY | Hemophilia A - mortality | Humans | Middle Aged | Child, Preschool | Male | Cause of Death | Hemophilia A - complications | Young Adult | Hemophilia B - complications | Life Expectancy | Hepatitis C - mortality | Adolescent | HIV Infections - complications | Adult | Female | HIV Infections - mortality | Hepatitis C - complications | Italy - epidemiology | Aged | Retrospective Studies | Child | Hemophilia B - mortality | Oncology, Experimental | Hemophilia | Research | HIV (Viruses) | Hepatitis C | Health aspects | HIV infection
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6. Full Text Mortality caused by intracranial bleeding in non-severe hemophilia A patients
by Loomans, J. I and Eckhardt, C. L and Reitter-Pfoertner, S. E and Holmström, M and van Gorkom, B. Laros and Leebeek, F. W. G and Santoro, C and Haya, S and Meijer, K and Nijziel, M. R and van der Bom, J. G and Fijnvanaat, K
Journal of thrombosis and haemostasis, ISSN 1538-7933, 2017, Volume 15, Issue 6, pp. 1115 - 1122
Background: Non-severe hemophilia (factor VIII concentration [FVIII: C] of 2-40 IU dL(-1)) is characterized by a milder bleeding phenotype than severe... 
mortality | epidemiology | hemophilia A | cohort study | intracranial hemorrhage | SURVIVAL | CRITICAL-CARE MANAGEMENT | FACTOR-VIII | RISK | DEATH | INTRACEREBRAL HEMORRHAGE | PERIPHERAL VASCULAR DISEASE | INHIBITOR DEVELOPMENT | COHORT | HEMATOLOGY | Recombinant Proteins - therapeutic use | Age Factors | Humans | Middle Aged | Child, Preschool | Infant | Male | Young Adult | Intracranial Hemorrhages - mortality | Aged, 80 and over | Adult | Child | Infant, Newborn | Factor VIII - therapeutic use | Hemophilia A - mortality | Comorbidity | Europe | Risk Factors | International Cooperation | Hemophilia A - complications | Hemorrhage - drug therapy | Phenotype | Adolescent | Aged | Australia | Hemophilia A - drug therapy | Intracranial Hemorrhages - complications | Cohort Studies | Medical research | Blood coagulation factor VIII | Mortality | Analysis | Patient outcomes | Hemophilia | Medicine, Experimental | Risk factors | Drugs | Coagulation factors | Death & dying | Bats | Data processing | Population | Death | Bleeding
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7. Full Text Cardiovascular risk assessment in haemophilia patients
by Biere-Rafi, S and Baarslag, M. A and Peters, M and Kruip, M. J. H. A and Kraaijenhagen, R. A and den Heijer, M and Büller, H. R and Kamphuisen, P. W
Thrombosis and Haemostasis, ISSN 0340-6245, 2011, Volume 105, Issue 2, pp. 274 - 278
Haemophilia patients have a reduced cardiovascular mortality, which may be the result of a lifelong deficiency of factor VIII or IX. On the other hand, the... 
Cardiovascular Disease | Haemophilia | Diabetes Mellitus | hypertension | Risk Factors | Blood Coagulation, Fibrinolysis and Cellular Haemostasis | Hypertension | Cardiovascular disease | Diabetes mellitus | Risk factors | MORTALITY | FRAMINGHAM | risk factors | PROJECT | THROMBOSIS | diabetes mellitus | DEATH | BLOOD-PRESSURE | HEART-ASSOCIATION | DISEASE | haemophilia | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Dyslipidemias - mortality | Prevalence | Prospective Studies | Dyslipidemias - complications | Humans | Middle Aged | Netherlands - epidemiology | Male | Case-Control Studies | Young Adult | Time Factors | Blood Coagulation | Aged, 80 and over | Cardiovascular Diseases - blood | Cardiovascular Diseases - mortality | Adult | Hypertension - mortality | Obesity - mortality | Hemophilia B - mortality | Cardiovascular Diseases - etiology | Hemophilia A - mortality | Risk Assessment | Obesity - complications | Hemophilia B - blood | Biomarkers - blood | Chi-Square Distribution | Hemophilia A - blood | Diabetes Complications - etiology | Diabetes Complications - mortality | Hemophilia A - complications | Hemophilia B - complications | Adolescent | Hypertension - complications | Aged
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8. Full Text Mortality and causes of death in patients with hemophilia, 1992-2001: a prospective cohort study
by Plug, I and van der Bom, J. G and Peters, M and Mauser-Bunschoten, E. P and de Goede-Bolder, A and Heijnen, L and Smit, C and Willemse, J and Rosendaal, F. R
Journal of thrombosis and haemostasis, ISSN 1538-7933, 2006, Volume 4, Issue 3, pp. 510 - 516
Clotting factor products have been safe for HIV since 1985, and for hepatitis C since 1992. Few studies have reported on mortality in the total population of... 
Life expectancy | Mortality | Viral infections | Hemophilia | hemophilia | POPULATION | UNITED-KINGDOM | SEROCONVERSION | AIDS | PREVALENCE | life expectancy | viral infections | HIV-INFECTION | mortality | SWEDISH HEMOPHILIACS | DUTCH HEMOPHILIACS | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | HEPATITIS-C | Severity of Illness Index | Hemophilia A - mortality | Prospective Studies | Humans | Middle Aged | Child, Preschool | Infant | Male | Life Expectancy - trends | Cause of Death | Hemophilia A - complications | Netherlands | Hepatitis C - mortality | Adolescent | HIV Infections - complications | Aged, 80 and over | Adult | HIV Infections - mortality | Hepatitis C - complications | Aged | Child | Infant, Newborn | Medicine, Experimental | Medical research | Patient outcomes | Analysis
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9. Full Text The incidence of factor VIII and factor IX inhibitors in the hemophilia population of the UK and their effect on subsequent mortality, 1977–99
by Darby, S. C and Keeling, D. M and Spooner, R. J. D and Wan Kan, S and Giangrande, P. L. F and Collins, P. W and Hill, F. G. H and Hay, C. R. M and UK Haemphilia CTR Doctors Org and UK Haemophilia Centre Doctors' Organisation
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 07/2004, Volume 2, Issue 7, pp. 1047 - 1054
Background: Previous studies of the development of inhibitors and their impact on mortality have been small. Objectives: To examine the development of... 
mortality | hemophilia A hemophilia B | inhibitors | Hemophilia A hemophilia B | Mortality | Inhibitors | MULTICENTER | FINLAND | UNITED-KINGDOM | EFFICACY | SAFETY | RECOMBINANT FACTOR-VIII | DISORDERS | PREVIOUSLY UNTREATED PATIENTS | DISAPPEARANCE | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | LIFE EXPECTANCY | Factor VIII - immunology | Hemophilia A - mortality | Hemophilia B - immunology | Factor IX - immunology | Hemophilia A - immunology | Humans | Child, Preschool | Male | Risk | Survival Rate | United Kingdom | Hemophilia A - epidemiology | Databases as Topic | Incidence | Isoantibodies - blood | Time Factors | Adolescent | HIV Infections - mortality | Child | Hemophilia B - epidemiology | Longitudinal Studies | Hemophilia B - mortality
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10. Full Text Coronary atherosclerosis and cardiovascular mortality in hemophilia
by FOLEY, C. J and NICHOLS, L and JEONG, K and MOORE, C. G and RAGNI, M. V
Journal of Thrombosis and Haemostasis, ISSN 1538-7933, 01/2010, Volume 8, Issue 1, pp. 208 - 211
ATHEROGENESIS | DEFECTS | RISK-FACTORS | VON-WILLEBRAND-DISEASE | PATHWAY | FACTOR-VIII | PERIPHERAL VASCULAR DISEASE | ISCHEMIC-HEART-DISEASE | DEATH | HEMATOLOGY | THROMBOGENICITY | PROTECT | Cardiovascular Diseases - etiology | Coronary Stenosis - etiology | Hemophilia A - mortality | Cross-Sectional Studies | Risk Assessment | Humans | Middle Aged | Risk Factors | Male | Cardiovascular Diseases - pathology | Case-Control Studies | Hemophilia A - pathology | Hemophilia A - complications | Young Adult | Coronary Stenosis - pathology | Autopsy | Adolescent | Cardiovascular Diseases - mortality | Adult | Aged | Coronary Stenosis - mortality | Health aspects | Mortality | Atherosclerosis | Hemophilia | atherosclerosis | hemophilia | ischemic cardiac disease | factor VIII | coronary thrombosis
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11. Full Text Incidence, mortality rates and causes of deaths in haemophilia patients in Sweden
by Lövdahl, S and Henriksson, K. M and Baghaei, F and Holmström, M and Nilsson, J.‐Å and Berntorp, E and Astermark, J and Faculty of Medicine and Medicinska fakulteten and Clinical Coagulation, Malmö and Lund University and Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG and Division of Microbiology, Immunology and Glycobiology - MIG and Lunds universitet and Klinisk koagulationsmedicin, Malmö
Haemophilia, ISSN 1351-8216, 05/2013, Volume 19, Issue 3, pp. 362 - 369
Summary Sweden has been a pioneer in the treatment of haemophilia, with the first concentrate available in the 1950s. Treatment has improved over the years to... 
mortality | viral hepatitis | Haemophilia | HIV | incidence | Viral hepatitis | Mortality | Incidence | SWEDISH HEMOPHILIACS | COHORT | HEMATOLOGY | LIFE EXPECTANCY | CARE | Hemophilia A - mortality | Humans | Middle Aged | Risk Factors | Proportional Hazards Models | Child, Preschool | Infant | Male | Hemophilia A - epidemiology | Sweden - epidemiology | Cause of Death | Young Adult | Adolescent | Aged, 80 and over | Adult | Registries | Aged | Myocardial Ischemia - mortality | Child | Infant, Newborn | Cohort Studies | Health aspects | Hemophilia | Clinical Medicine | Hematologi | Medical and Health Sciences | Hematology | Klinisk medicin | Medicin och hälsovetenskap
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12. Full Text Decreased mortality of ischaemic heart disease among carriers of haemophilia
by Šrámek, A and Kriek, M and Rosendaal, FR
The Lancet, ISSN 0140-6736, 08/2003, Volume 362, Issue 9381, pp. 351 - 354
Coagulation plays an important part in ischaemic cardiovascular disease. Results of studies have shown that extremes in hypocoagulability protect against... 
STROKE | WOMEN | MEDICINE, GENERAL & INTERNAL | MYOCARDIAL-INFARCTION | GENE | MUTATION | VENOUS THROMBOSIS | FACTOR-V | RISK | Hemophilia A - mortality | Follow-Up Studies | Humans | Middle Aged | Mortality | Netherlands - epidemiology | Male | Mothers - statistics & numerical data | Hemophilia A - blood | Cause of Death | Incidence | Blood Coagulation Factors - analysis | Survival Analysis | Aged, 80 and over | Adult | Female | Heterozygote | Aged | Hemophilia A - genetics | Myocardial Ischemia - mortality | Cohort Studies | Myocardial Ischemia - epidemiology | Physiological aspects | Netherlands | Statistics | Hemophiliacs | Cardiovascular disease | Blood | Hemophilia | Heart | Stroke | Embolisms | Calendars | Hemorrhage | Thrombosis | Coronary artery disease | Carriers | Womens health | Population | Death | Fatalities | Cardiovascular diseases | Health risk assessment | Heart diseases | Age
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13. Full Text Trends in the epidemiology, diagnosed age and mortality rate of haemophiliacs in Taiwan: a population‐based study, 1997–2009
by Chang, C.‐Y and Yeh, G.‐C and Lin, S.‐Y and Tseng, I.‐J and Tsai, C.‐H and Lee, Y.‐W
Haemophilia, ISSN 1351-8216, 07/2014, Volume 20, Issue 4, pp. 535 - 540
Summary Many studies on epidemiology and mortality in haemophiliacs have been published in Western countries. However, few have been conducted in Asian... 
haemophilia | human immunodeficiency virus | mortality | epidemiology | population‐based study | Taiwan | Population-based study | Haemophilia | Human immunodeficiency virus | Epidemiology | Mortality | population-based study | COHORT | DEATH | PREVALENCE | SPECTRUM | HEMATOLOGY | WORLD | Hemophilia B - diagnosis | Hemophilia A - mortality | Prevalence | Humans | Middle Aged | Child, Preschool | Infant | Male | Hemophilia A - epidemiology | Incidence | Young Adult | Taiwan - epidemiology | Adolescent | Age of Onset | Adult | Female | Aged | Hemophilia A - diagnosis | Child | Hemophilia B - epidemiology | Infant, Newborn | Databases, Factual | Hemophilia B - mortality | Virus diseases | Hemophilia
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14. Full Text Morbidity and mortality in ageing HIV‐infected haemophilia patients
by Putte, D. E. Fransen and Fischer, K and Roosendaal, G and Hoepelman, A. I. M and Mauser‐Bunschoten, E. P
Haemophilia, ISSN 1351-8216, 01/2013, Volume 19, Issue 1, pp. 141 - 149
Summary Over 25 years of follow‐up is now available for HIV‐infected haemophilia patients. The aim of this study was to retrospectively asses the morbidity and... 
haemophilia | highly active antiretroviral therapy | AIDS | intracranial bleeding | HIV | Intracranial bleeding | Highly active antiretroviral therapy | Haemophilia | RISK-FACTORS | MYOCARDIAL-INFARCTION | PROTEASE INHIBITOR THERAPY | CLINICAL FACTORS | FOLLOW-UP | LIVER-DISEASE | POSITIVE HEMOPHILIACS | HEPATITIS-C VIRUS | ACTIVE ANTIRETROVIRAL THERAPY | CARDIOVASCULAR-DISEASE | HEMATOLOGY | Hemophilia A - mortality | Comorbidity | Humans | Middle Aged | Kaplan-Meier Estimate | Male | Cause of Death | Hemophilia A - complications | Antiretroviral Therapy, Highly Active | Young Adult | Regression Analysis | Adolescent | HIV Infections - complications | Adult | Anti-HIV Agents - therapeutic use | HIV Infections - drug therapy | HIV Infections - mortality | Aged | Retrospective Studies | Child | Hypertension | Patient outcomes | Mortality | Hemophilia | HIV patients | HIV (Viruses) | HIV infection | Morbidity
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