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Journal Article
Clinical Immunology, ISSN 1521-6616, 2016, Volume 163, pp. 60 - 65
Abstract Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a monogenic autoimmune disease characterized by early-onset... 
Allergy and Immunology | Autoimmunity | IPEX | Mutation | FOXP3 | Primary immunodeficiency | X-LINKED SYNDROME | ENTEROPATHY | STABILITY | IMMUNOLOGY | IMMUNE DYSREGULATION | DIMER | SEQUENCE | DISEASE | REGULATORY T-CELLS | POLYENDOCRINOPATHY | IMMUNODYSREGULATION | Eczema - genetics | Eczema - immunology | Immune System Diseases - genetics | Humans | Diabetes Mellitus, Type 1 - congenital | Infant | Male | Meningoencephalitis - immunology | Thrombocytopenia - genetics | Immunoglobulin E - immunology | Diarrhea - immunology | Eosinophilia - genetics | Fatal Outcome | Hepatomegaly - immunology | Genetic Diseases, X-Linked - genetics | Diabetes Mellitus, Type 1 - immunology | Dimerization | Hemorrhage - genetics | Sepsis - immunology | Splenomegaly - genetics | Growth Disorders - immunology | Hemorrhage - immunology | Splenomegaly - immunology | Thrombocytopenia - immunology | Immune System Diseases - immunology | Leukocytosis - immunology | Meningoencephalitis - genetics | Diabetes Mellitus, Type 1 - genetics | Models, Molecular | Klebsiella Infections - genetics | Hepatomegaly - genetics | Forkhead Transcription Factors - genetics | Sepsis - genetics | Lung Diseases - immunology | Genetic Diseases, X-Linked - immunology | Immune System Diseases - congenital | Thymus Gland - abnormalities | Lung Diseases - genetics | Eosinophilia - immunology | Diarrhea - genetics | Klebsiella Infections - immunology | Phenylalanine - genetics | Hydrophobic and Hydrophilic Interactions | Growth Disorders - genetics | Leukocytosis - genetics | Index Medicus
Journal Article
Journal of Periodontology, ISSN 0022-3492, 10/2014, Volume 85, Issue 10, pp. 1416 - 1423
Journal Article
Immunology, ISSN 0019-2805, 03/2010, Volume 129, Issue 3, pp. 363 - 374
P>Little is known of how the Toll-like receptor (TLR) system can modulate the function of non-parenchymal liver cells (NPC) as a major component of the innate... 
Innate immunity | Sinusoidal endothelial cells | Toll-like receptor | Kupffer cells | TOLERANCE | TRAUMA-HEMORRHAGE | IMMUNOLOGY | REPLICATION | innate immunity | HEPATITIS-C VIRUS | SINUSOIDAL ENDOTHELIAL-CELLS | sinusoidal endothelial cells | LIPOPOLYSACCHARIDE | MICE | UP-REGULATION | T-CELLS | Tumor Necrosis Factor-alpha - metabolism | Interferon-alpha - pharmacology | Interferon-beta - immunology | Gene Expression - genetics | Dendritic Cells - immunology | Culture Media, Conditioned - pharmacology | Antigens, CD - metabolism | CD4-Positive T-Lymphocytes - immunology | Histocompatibility Antigens Class I - metabolism | Liver - immunology | Lymphocyte Activation - immunology | Gene Expression - immunology | Antibodies - immunology | Toll-Like Receptor 4 - agonists | Dendritic Cells - drug effects | Histocompatibility Antigens Class II - metabolism | Kupffer Cells - metabolism | Toll-Like Receptor 3 - genetics | Toll-Like Receptors - metabolism | Interleukin-6 - metabolism | Dendritic Cells - metabolism | Interferon-alpha - metabolism | Virus Replication - drug effects | Poly I-C - pharmacology | Endothelial Cells - metabolism | Mice, Inbred C57BL | Toll-Like Receptor 4 - genetics | Virus Replication - immunology | Toll-Like Receptor 3 - agonists | Encephalomyocarditis virus - immunology | Toll-Like Receptor 3 - metabolism | Toll-Like Receptor 4 - metabolism | Toll-Like Receptors - agonists | Interferon-alpha - immunology | Kupffer Cells - drug effects | Antibodies - pharmacology | Endothelial Cells - immunology | Immunity, Innate - immunology | Animals | Interferon-beta - metabolism | Interferon-beta - pharmacology | Toll-Like Receptors - genetics | T-Lymphocytes - immunology | Liver - cytology | Mice | CD8-Positive T-Lymphocytes - immunology | Endothelial Cells - drug effects | Kupffer Cells - immunology | Medical colleges | Immune response | Dendritic cells | Interferon beta | Cross infection | Nosocomial infections | Biological response modifiers | T cells | Endothelium | Antigens | Ligands | T cell receptors | Immune system | Index Medicus | Original
Journal Article
Journal of Immunology, ISSN 0022-1767, 06/2014, Volume 192, Issue 12, pp. 5984 - 5992
Promoting hematoma absorption is a novel therapeutic strategy for intracerebral hemorrhage (ICH); however, the mechanism of hematoma absorption is unclear. The... 
TRIAL | CELLS | PHAGOCYTOSIS | CD36 DEFICIENCY | INFLAMMATION | MACROPHAGES | DISEASE | INJURY | MUTATIONS | IMMUNOLOGY | RECEPTOR 4 | CD36 Antigens - genetics | Humans | Middle Aged | Genetic Diseases, Inborn - genetics | Male | Genetic Diseases, Inborn - pathology | Phagocytosis - genetics | Hematoma, Epidural, Cranial - genetics | Brain Hemorrhage, Traumatic - pathology | Signal Transduction - immunology | Microglia - immunology | Myeloid Differentiation Factor 88 - immunology | Blood Platelet Disorders - immunology | Brain Hemorrhage, Traumatic - immunology | Microglia - pathology | Adult | Female | Retrospective Studies | Blood Platelet Disorders - genetics | Nerve Tissue Proteins - immunology | Catalase - genetics | Catalase - immunology | Genetic Diseases, Inborn - immunology | Myeloid Differentiation Factor 88 - genetics | Phagocytosis - immunology | CD36 Antigens - immunology | Toll-Like Receptor 4 - genetics | Signal Transduction - genetics | Toll-Like Receptor 4 - immunology | Nerve Tissue Proteins - genetics | Mice, Knockout | Animals | Brain Hemorrhage, Traumatic - genetics | Hydrogen Peroxide - immunology | Hematoma, Epidural, Cranial - pathology | Hematoma, Epidural, Cranial - immunology | Aged | Blood Platelet Disorders - pathology | Index Medicus | Abridged Index Medicus | Innate Immunity and Inflammation
Journal Article
The Journal of Immunology, ISSN 0022-1767, 12/2008, Volume 181, Issue 11, pp. 8027 - 8035
Bacterial LPS (endotoxin) is implicated in the pathogenesis of acute liver failure and several chronic inflammatory liver diseases. To evaluate the effect of... 
TUMOR-NECROSIS-FACTOR | CYTOSOLIC PHOSPHOLIPASE A | HEPATOCELLULAR-CARCINOMA | ACTIVATION | LETHAL HEPATIC-FAILURE | INJURY | LIPOPOLYSACCHARIDE | RECEPTOR | MICE | TNF-ALPHA | IMMUNOLOGY | Aspartate Aminotransferases - genetics | Caspase 9 - genetics | Caspase 9 - metabolism | Apoptosis - drug effects | Humans | Caspase 3 - metabolism | Liver Failure, Acute - enzymology | Apoptosis - genetics | Alanine Transaminase - blood | Mitogen-Activated Protein Kinase 9 - genetics | Necrosis - immunology | Cyclooxygenase 2 - genetics | Hepatitis - genetics | Caspase 3 - genetics | Hepatitis - metabolism | Gene Expression | Hemorrhage - genetics | Lipopolysaccharides - toxicity | Mitogen-Activated Protein Kinase 9 - metabolism | Hemorrhage - immunology | Mice, Transgenic | Aspartate Aminotransferases - immunology | Signal Transduction - genetics | Caspase 9 - immunology | Aspartate Aminotransferases - blood | Signal Transduction - drug effects | Up-Regulation - immunology | Liver Failure, Acute - immunology | Liver Failure, Acute - pathology | Mice | Necrosis - genetics | Receptors, Prostaglandin E, EP1 Subtype | Chronic Disease | Galactosamine - toxicity | Hepatocytes - enzymology | Organ Specificity - drug effects | Poly(ADP-ribose) Polymerases - immunology | Caspase 3 - immunology | Hepatocytes - pathology | Necrosis - pathology | Receptors, Prostaglandin E - genetics | Organ Specificity - immunology | Organ Specificity - genetics | Signal Transduction - immunology | Alanine Transaminase - genetics | Liver Failure, Acute - genetics | Receptors, Prostaglandin E - immunology | Alanine Transaminase - immunology | Cyclooxygenase 2 - immunology | Transgenes - genetics | Hepatitis - pathology | Mitogen-Activated Protein Kinase 9 - immunology | Up-Regulation - genetics | Hepatocytes - immunology | Up-Regulation - drug effects | Poly(ADP-ribose) Polymerases - metabolism | Animals | Apoptosis - immunology | Poly(ADP-ribose) Polymerases - genetics | Cyclooxygenase 2 - metabolism | Hemorrhage - enzymology | Hepatitis - immunology | Transgenes - immunology | Hemorrhage - pathology | Necrosis - enzymology | Receptors, Prostaglandin E - metabolism | Index Medicus | Abridged Index Medicus | Lipopolysaccharide | EP1 receptor | liver | acute hepatic failure | cyclooxygenase-2 | endotoxin
Journal Article
Journal Article
Journal of Immunology, ISSN 0022-1767, 01/2014, Volume 192, Issue 2, pp. 612 - 622
Journal Article
Journal of the American Society of Nephrology, ISSN 1046-6673, 05/2008, Volume 19, Issue 5, pp. 973 - 984
Anti-myeloperoxidase (anti-MPO) antibodies have been implicated in the pathogenesis of small-vessel vasculitis, but the molecular mechanisms by which these... 
GLOMERULONEPHRITIS | SYSTEMIC VASCULITIS | MYELOPEROXIDASE | FC-GAMMA RECEPTORS | ANTIMYELOPEROXIDASE ANTIBODIES | HOST-DEFENSE | P-SELECTIN | UROLOGY & NEPHROLOGY | ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES | ROLLING NEUTROPHILS | DEFICIENT MICE | Leukocyte Rolling - drug effects | Cell Communication - immunology | Vasculitis - metabolism | Interleukin-1beta - pharmacology | Microcirculation - metabolism | CD18 Antigens - immunology | Vasculitis - pathology | Male | Antibodies, Antineutrophil Cytoplasmic - immunology | Vasculitis - immunology | Leukocytes - immunology | Antibodies, Antineutrophil Cytoplasmic - metabolism | Receptors, IgG - genetics | Immunoglobulin G - immunology | Kidney Glomerulus - metabolism | Microcirculation - immunology | Renal Circulation - immunology | Antibodies, Monoclonal - immunology | Leukocytes - cytology | Peroxidase - immunology | Endothelial Cells - metabolism | Antibodies, Monoclonal - pharmacology | Hemorrhage - immunology | Mice, Inbred C57BL | Hemorrhage - metabolism | Kidney Glomerulus - pathology | Receptors, IgG - immunology | Leukocyte Rolling - immunology | Mice, Knockout | CD18 Antigens - metabolism | Endothelial Cells - immunology | Tumor Necrosis Factor-alpha - pharmacology | Animals | Endothelial Cells - cytology | Cell Communication - drug effects | Mice | Kidney Glomerulus - immunology | Hemorrhage - pathology | Leukocytes - metabolism | Immunoglobulin G - metabolism | Peroxidase - metabolism | Index Medicus | Basic Research
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2016, Volume 11, Issue 1, pp. e0148029 - e0148029
Background Dogs with leptospirosis show similar organ manifestations and disease course as human patients, including acute kidney injury and pulmonary... 
FIBROSIS | GROWTH-FACTOR-BETA | CHRONIC ENTEROPATHIES | NITRIC-OXIDE SYNTHASE | HAMSTERS | MULTIDISCIPLINARY SCIENCES | DISEASE | GENE-EXPRESSION | INTERROGANS | SEPSIS | KIDNEY | Interleukin-8 - genetics | Leukocytes, Mononuclear - metabolism | RNA, Messenger - immunology | Interleukin-1alpha - immunology | Arachidonate 5-Lipoxygenase - genetics | Humans | Tumor Necrosis Factor-alpha - genetics | Hemorrhage - mortality | Male | Acute Kidney Injury - genetics | Interleukin-1beta - genetics | Acute Kidney Injury - veterinary | Lung Injury - mortality | Arachidonate 5-Lipoxygenase - immunology | Nitric Oxide Synthase Type II - immunology | Leukocytes, Mononuclear - immunology | Lung Injury - veterinary | Tumor Necrosis Factor-alpha - immunology | Female | Interleukin-1alpha - genetics | Acute Kidney Injury - immunology | Leptospirosis - immunology | Disease Models, Animal | Severity of Illness Index | Transforming Growth Factor beta - immunology | Hemorrhage - genetics | Signal Transduction | Hemorrhage - immunology | RNA, Messenger - genetics | Gene Expression Regulation | Interleukin-1beta - immunology | Disease Progression | Syndrome | Leptospirosis - genetics | Leptospirosis - veterinary | Leukocytes, Mononuclear - pathology | Acute Kidney Injury - mortality | Lung Injury - genetics | Animals | Transforming Growth Factor beta - genetics | Nitric Oxide Synthase Type II - genetics | Dogs | Survival Analysis | Hemorrhage - veterinary | Interleukin-8 - immunology | Lung Injury - immunology | Leptospirosis - mortality | Infection | Leptospirosis | Enzymes | Messenger RNA | Chronic kidney failure | Tumor necrosis factor | Transforming growth factors | Health aspects | Hemorrhage | Health care | Laboratories | Syngeneic grafts | Inflammatory response | Infections | Leukocytes | Veterinary medicine | Blood | Rodents | Physiology | Growth factors | Interleukin 8 | Injuries | Public health | Urine | Cytokines | Internal medicine | Lung diseases | Inflammation | Tumor necrosis factor-α | Gene expression | Disease control | Nitric-oxide synthase | Zoonoses | White blood cells | Nitric oxide | Interleukin 10 | Sepsis | Diagnostic systems | Kidney diseases | Index Medicus
Journal Article