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1. Full Text Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp
by Qiu, Xiangguo and Qiu, Xiangguo and Wong, Gary and Wong, Gary and Audet, Jonathan and Audet, Jonathan and Bello, Alexander and Bello, Alexander and Fernando, Lisa and Fernando, Lisa and Alimonti, Judie B and Alimonti, Judie B and Fausther-Bovendo, Hugues and Fausther-Bovendo, Hugues and Wei, Haiyan and Wei, Haiyan and Aviles, Jenna and Aviles, Jenna and Hiatt, Ernie and Hiatt, Ernie and Johnson, Ashley and Johnson, Ashley and Morton, Josh and Morton, Josh and Swope, Kelsi and Swope, Kelsi and Bohorov, Ognian and Bohorov, Ognian and Bohorova, Natasha and Bohorova, Natasha and Goodman, Charles and Goodman, Charles and Kim, D and Kim, Do and Pauly, Michael H and Pauly, Michael H and Velasco, Jesus and Velasco, Jesus and Pettitt, James and Pettitt, James and Olinger, Gene G and Olinger, Gene G and Whaley, Kevin and Whaley, Kevin and Xu, Bianli and Xu, Bianli and Strong, James E and Strong, James E and Zeitlin, Larry and Zeitlin, Larry and Kobinger, Gary P and Kobinger, Gary P
Nature, ISSN 0028-0836, 2014, Volume 514, Issue 7520, pp. 47 - 53
Without an approved vaccine or treatments, Ebola outbreak management has been limited to palliative care and barrier methods to prevent transmission. These... 
ANTIBODIES | CHALLENGE | MEDIATED PROTECTION | HEMORRHAGIC-FEVER | MULTIDISCIPLINARY SCIENCES | POSTEXPOSURE PROTECTION | INFECTION | Guinea | Macaca mulatta - immunology | Molecular Sequence Data | Antibodies, Monoclonal - therapeutic use | Male | Ebolavirus - immunology | Macaca mulatta - virology | Antibodies, Neutralizing - immunology | Antibodies, Neutralizing - therapeutic use | Hemorrhagic Fever, Ebola - virology | Female | Hemorrhagic Fever, Ebola - immunology | Hemorrhagic Fever, Ebola - drug therapy | Antibodies, Monoclonal - immunology | Amino Acid Sequence | Guinea Pigs | Antibodies, Viral - therapeutic use | Enzyme-Linked Immunosorbent Assay | Viremia - drug therapy | Cross Reactions - immunology | Hemorrhagic Fever, Ebola - blood | Sequence Alignment | Animals | Viremia - virology | Viral Envelope Proteins - chemistry | Immunization, Passive | Antibodies, Viral - immunology | Viral Envelope Proteins - immunology | Viremia - immunology | Monoclonal antibodies | Physiological aspects | Medicine, Experimental | Medical research | Ebola virus infections | Research | Studies | Ebola virus | Infections | Vaccines | Experiments | nonhuman primates | Ebola | ZMapp | post-exposure therapy
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2. Full Text A Recombinant Vesicular Stomatitis Virus Ebola Vaccine
by Regules, Jason A and Beigel, John H and Paolino, Kristopher M and Voell, Jocelyn and Castellano, Amy R and Hu, Zonghui and Muñoz, Paula and Moon, James E and Ruck, Richard C and Bennett, Jason W and Twomey, Patrick S and Gutiérrez, Ramiro L and Remich, Shon A and Hack, Holly R and Wisniewski, Meagan L and Josleyn, Matthew D and Kwilas, Steven A and Van Deusen, Nicole and Mbaya, Olivier Tshiani and Zhou, Yan and Stanley, Daphne A and Jing, Wang and Smith, Kirsten S and Shi, Meng and Ledgerwood, Julie E and Graham, Barney S and Sullivan, Nancy J and Jagodzinski, Linda L and Peel, Sheila A and Alimonti, Judie B and Hooper, Jay W and Silvera, Peter M and Martin, Brian K and Monath, Thomas P and Ramsey, W. Jay and Link, Charles J and Lane, H. Clifford and Michael, Nelson L and Davey, Richard T and Thomas, Stephen J and rVSV G-ZEBOV-GP Study Grp and rVSVΔG-ZEBOV-GP Study Group
The New England Journal of Medicine, ISSN 0028-4793, 01/2017, Volume 376, Issue 4, pp. 330 - 341
This final report updates preliminary data on an attenuated, replication-competent, recombinant vesicular stomatitis virus–based vaccine candidate designed to... 
NONHUMAN-PRIMATES | IMMUNIZATION | CHALLENGE | MEDICINE, GENERAL & INTERNAL | PROTECTION | GLYCOPROTEINS | VECTORS | NEUROVIRULENCE | MARBURG VIRUSES | Vesicular stomatitis Indiana virus | Double-Blind Method | Enzyme-Linked Immunosorbent Assay | Hemorrhagic Fever, Ebola - prevention & control | Viral Envelope Proteins - isolation & purification | Viremia | Humans | Middle Aged | Ebola Vaccines - administration & dosage | Male | Recombinant Proteins | Ebolavirus - genetics | Antibodies, Viral - blood | Ebola Vaccines - adverse effects | Seroconversion | Ebolavirus - immunology | Ebolavirus - isolation & purification | Vaccines, Attenuated - immunology | Adult | Ebola Vaccines - immunology | Female | Hemorrhagic Fever, Ebola - immunology | Ebola virus | Placebos | Stomatitis | Care and treatment | Usage | Vaccines | Headache | Immunization | Vaccination | Prophylaxis | Clinical trials | Fatigue | Outbreaks | Myalgia | Disease prevention | Pain | Immunogenicity | Enzyme-linked immunosorbent assay
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3. Full Text Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses
by Martines, Roosecelis Brasil and Ng, Dianna L and Greer, Patricia W and Rollin, Pierre E and Zaki, Sherif R
The Journal of Pathology, ISSN 0022-3417, 01/2015, Volume 235, Issue 2, pp. 153 - 174
Ebola viruses and Marburg viruses include some of the most virulent and fatal pathogens known to humans. These viruses cause severe haemorrhagic fevers, with... 
Ebola virus | pathogenesis | pathology | Marburg virus | haemorrhagic fever | electron microscopy | immunohistochemistry | filovirus | autopsy | Haemorrhagic fever | Immunohistochemistry | Pathology | Autopsy | Pathogenesis | Filovirus | Electron microscopy | VIRAL HEMORRHAGIC-FEVER | DENDRITIC CELLS | CYNOMOLGUS MACAQUES | ELECTRON-MICROSCOPY | GUINEA-PIGS | ACUTE RESPIRATORY SYNDROME | NIEMANN-PICK C1 | FILOVIRUS ENTRY | ONCOLOGY | DC-SIGN | RHESUS MACAQUES | Predictive Value of Tests | Prognosis | Marburg Virus Disease - immunology | Marburg Virus Disease - virology | Humans | Virulence | Ebolavirus - pathogenicity | Marburgvirus - pathogenicity | Ebolavirus - genetics | Ebolavirus - immunology | Virus Internalization | Hemorrhagic Fever, Ebola - diagnosis | Hemorrhagic Fever, Ebola - virology | Marburgvirus - immunology | Pathology, Molecular - methods | Hemorrhagic Fever, Ebola - immunology | Viral Tropism | Marburg Virus Disease - epidemiology | Marburg Virus Disease - pathology | Risk Factors | Hemorrhagic Fever, Ebola - transmission | Hemorrhagic Fever, Ebola - pathology | Hemorrhagic Fever, Ebola - epidemiology | Virology - methods | Ebolavirus - isolation & purification | Marburg Virus Disease - transmission | Marburgvirus - genetics | Host-Pathogen Interactions | Animals | Biopsy | Marburgvirus - isolation & purification | Marburg Virus Disease - diagnosis | Virulence (Microbiology) | Health aspects | Marburg virus disease
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4. Full Text Safety and Immunogenicity of Novel Adenovirus Type 26– and Modified Vaccinia Ankara–Vectored Ebola Vaccines: A Randomized Clinical Trial
by Milligan, Iain D and Gibani, Malick M and Sewell, Richard and Clutterbuck, Elizabeth A and Campbell, Danielle and Plested, Emma and Nuthall, Elizabeth and Voysey, Merryn and Silva-Reyes, Laura and McElrath, M. Juliana and De Rosa, Stephen C and Frahm, Nicole and Cohen, Kristen W and Shukarev, Georgi and Orzabal, Nicola and van Duijnhoven, Wilbert and Truyers, Carla and Bachmayer, Nora and Splinter, Daniel and Samy, Nathaly and Pau, Maria Grazia and Schuitemaker, Hanneke and Luhn, Kerstin and Callendret, Benoit and Van Hoof, Johan and Douoguih, Macaya and Ewer, Katie and Angus, Brian and Pollard, Andrew J and Snape, Matthew D
JAMA, ISSN 0098-7484, 04/2016, Volume 315, Issue 15, pp. 1610 - 1623
IMPORTANCE: Developing effective vaccines against Ebola virus is a global priority. OBJECTIVE: To evaluate an adenovirus type 26 vector vaccine encoding Ebola... 
ANTIBODIES | RESPONSES | CHALLENGE | IMMUNITY | MEDICINE, GENERAL & INTERNAL | VIRUS | PROTECTION | DOUBLE-BLIND | VACCINATION | Single-Blind Method | Enzyme-Linked Immunosorbent Assay | Humans | Middle Aged | Viral Proteins - immunology | Ebola Vaccines - administration & dosage | Male | Vaccines, Synthetic - immunology | Healthy Volunteers | Ebola Vaccines - adverse effects | Ebolavirus - immunology | Immunization, Secondary | Immunity, Humoral | Vaccines, Synthetic - adverse effects | Marburgvirus - immunology | Vaccinia - immunology | Adult | Ebola Vaccines - immunology | Female | T-Lymphocytes - immunology | Hemorrhagic Fever, Ebola - immunology | Vaccines, Synthetic - administration & dosage | Genetic Vectors | Immunity, Cellular | Ebola virus infections | Care and treatment | Glycoproteins | Research | Adenoviruses | Viruses | Immunization | Side effects | Vaccines
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5. Full Text Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe
by Agnandji, Selidji T and Huttner, Angela and Zinser, Madeleine E and Njuguna, Patricia and Dahlke, Christine and Fernandes, José F and Yerly, Sabine and Dayer, Julie-Anne and Kraehling, Verena and Kasonta, Rahel and Adegnika, Akim A and Altfeld, Marcus and Auderset, Floriane and Bache, Emmanuel B and Biedenkopf, Nadine and Borregaard, Saskia and Brosnahan, Jessica S and Burrow, Rebekah and Combescure, Christophe and Desmeules, Jules and Eickmann, Markus and Fehling, Sarah K and Finckh, Axel and Goncalves, Ana Rita and Grobusch, Martin P and Hooper, Jay and Jambrecina, Alen and Kabwende, Anita L and Kaya, Gürkan and Kimani, Domtila and Lell, Bertrand and Lemaître, Barbara and Lohse, Ansgar W and Massinga-Loembe, Marguerite and Matthey, Alain and Mordmüller, Benjamin and Nolting, Anne and Ogwang, Caroline and Ramharter, Michael and Schmidt-Chanasit, Jonas and Schmiedel, Stefan and Silvera, Peter and Stahl, Felix R and Staines, Henry M and Strecker, Thomas and Stubbe, Hans C and Tsofa, Benjamin and Zaki, Sherif and Fast, Patricia and Moorthy, Vasee and Kaiser, Laurent and Krishna, Sanjeev and Becker, Stephan and Kieny, Marie-Paule and Bejon, Philip and Kremsner, Peter G and Addo, Marylyn M and Siegrist, Claire-Anne
The New England Journal of Medicine, ISSN 0028-4793, 04/2016, Volume 374, Issue 17, pp. 1647 - 1660
In this set of four phase 1 studies, a recombinant vesicular stomatitis virus (rVSV)–based Ebola vaccine induced Ebola virus–specific immune responses and was... 
IMMUNITY | MEDICINE, GENERAL & INTERNAL | MARBURG VIRUS | PROTECTS NONHUMAN-PRIMATES | VSV | INFECTION | VESICULAR STOMATITIS-VIRUS | Double-Blind Method | Hemorrhagic Fever, Ebola - prevention & control | Viremia | Humans | Middle Aged | Ebola Vaccines - administration & dosage | Male | Virus Shedding | Recombinant Proteins | Antibodies, Viral - blood | Ebola Vaccines - adverse effects | Ebolavirus - immunology | Ebolavirus - isolation & purification | Exanthema - etiology | Dermatitis - etiology | Vesiculovirus | Arthritis - etiology | Adult | Ebola Vaccines - immunology | Female | Viral Envelope Proteins - immunology | Hemorrhagic Fever, Ebola - immunology | Membrane Glycoproteins - immunology | Ebola virus | Clinical trials | Ebola virus infections | Care and treatment | Usage | Research | Urine | Immunization | Arthritis | Vaccines | Joint diseases | Fever | Studies | Stomatitis | Pain | Immunogenicity | Replication | Skin | Safety | Saliva | Public health | Age
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6. Full Text A Monovalent Chimpanzee Adenovirus Ebola Vaccine Boosted with MVA
by Ewer, Katie and Rampling, Tommy and Venkatraman, Navin and Bowyer, Georgina and Wright, Danny and Wright, Edward and Lambe, Teresa and Imoukhuede, Egeruan B and Payne, Ruth and Fehling, Sarah Katharina and Strecker, Thomas and Biedenkopf, Nadine and Krähling, Verena and Tully, Claire M and Edwards, Nick J and Bentley, Emma M and Samuel, Dhanraj and Labbé, Geneviève and Jin, Jing and Gibani, Malick and Minhinnick, Alice and Wilkie, Morven and Poulton, Ian and Lella, Natalie and Roberts, Rachel and Hartnell, Felicity and Bliss, Carly and Sierra-Davidson, Kailan and Powlson, Jonathan and Berrie, Eleanor and Tedder, Richard and Roman, Francois and De Ryck, Iris and Nicosia, Alfredo and Sullivan, Nancy J and Stanley, Daphne A and Mbaya, Olivier T and Ledgerwood, Julie E and Schwartz, Richard M and Siani, Loredana and Colloca, Stefano and Folgori, Antonella and Di Marco, Stefania and Cortese, Riccardo and Becker, Stephan and Graham, Barney S and Koup, Richard A and Levine, Myron M and Volkmann, Ariane and Chaplin, Paul and Pollard, Andrew J and Draper, Simon J and Ballou, W. Ripley and Lawrie, Alison and Gilbert, Sarah C and Hill, Adrian V.S
The New England Journal of Medicine, ISSN 0028-4793, 04/2016, Volume 374, Issue 17, pp. 1635 - 1646
In this phase 1 study involving 76 healthy volunteers in England, a single dose of a monovalent chimpanzee adenovirus vaccine elicited immune responses to... 
T-Lymphocytes - physiology | Adenoviruses, Simian - immunology | Hemorrhagic Fever, Ebola - prevention & control | Humans | Middle Aged | B-Lymphocytes - physiology | Ebola Vaccines - administration & dosage | Male | Pan troglodytes | Antibodies, Viral - blood | Ebolavirus - immunology | Young Adult | Animals | Immunization, Secondary | Adult | Ebola Vaccines - immunology | Female | Hemorrhagic Fever, Ebola - immunology | Immunity, Cellular | Vaccinia | Cytokines - blood | Ebola virus | Research | T cells | Adenoviruses | Immunization | CD8 antigen | Vaccination | Antibodies | Outbreaks | Lymphocytes T | Vaccines | Monkeys & apes | Studies | Stomatitis | Lymphocytes B | Virions
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7. Full Text Human Ebola virus infection results in substantial immune activation
by Anita K. McElroy and Rama S. Akondy and Carl W. Davis and Ali H. Ellebedy and Aneesh K. Mehta and Colleen S. Kraft and G. Marshall Lyon and Bruce S. Ribner and Jay Varkey and John Sidney and Alessandro Sette and Shelley Campbell and Ute Ströher and Inger Damon and Stuart T. Nichol and Christina F. Spiropoulou and Rafi Ahmed
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2015, Volume 112, Issue 15, pp. 4719 - 4724
Four Ebola patients received care at Emory University Hospital, presenting a unique opportunity to examine the cellular immune responses during acute Ebola... 
SEE COMMENTARY | Ebola infection | Human immune response | Immune activation | T cells | Plasmablasts | NONHUMAN-PRIMATES | plasmablasts | DENDRITIC CELLS | MULTIDISCIPLINARY SCIENCES | immune activation | MARBURG VIRUSES | CHALLENGE | LYMPHOCYTE APOPTOSIS | IN-VITRO | T-CELL RESPONSES | HEMORRHAGIC-FEVER | KIKWIT | human immune response | VACCINES | Tumor Necrosis Factor-alpha - metabolism | Ebolavirus - metabolism | Immunoglobulin G - blood | Immunity, Humoral - immunology | Humans | Precursor Cells, B-Lymphoid - metabolism | Viral Proteins - immunology | Precursor Cells, B-Lymphoid - immunology | Interferon-gamma - metabolism | Viral Proteins - metabolism | Ebolavirus - immunology | CD4-Positive T-Lymphocytes - immunology | Lymphocyte Activation - immunology | Flow Cytometry | Immunoglobulin G - immunology | Hemorrhagic Fever, Ebola - virology | Tumor Necrosis Factor-alpha - immunology | CD8-Positive T-Lymphocytes - metabolism | Hemorrhagic Fever, Ebola - immunology | Enzyme-Linked Immunosorbent Assay | CD4-Positive T-Lymphocytes - metabolism | Immunophenotyping | Hemorrhagic Fever, Ebola - blood | Immunity, Cellular - immunology | Interferon-gamma - immunology | CD8-Positive T-Lymphocytes - immunology | Complications and side effects | Ebola virus infections | Care and treatment | Immune response | Research | Biological Sciences
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8. Full Text Host genetic diversity enables Ebola hemorrhagic fever pathogenesis and resistance
by Rasmussen, Angela L and Okumura, Atsushi and Ferris, Martin T and Green, Richard and Feldmann, Friederike and Kelly, Sara M and Scott, Dana P and Safronetz, David and Haddock, Elaine and LaCasse, Rachel and Thomas, Matthew J and Sova, Pavel and Carter, Victoria S and Weiss, Jeffrey M and Miller, Darla R and Shaw, Ginger D and Korth, Marcus J and Heise, Mark T and Baric, Ralph S and De Villena, Fernando Pardo-Manuel and Feldmann, Heinz and Katze, Michael G
Science, ISSN 0036-8075, 11/2014, Volume 346, Issue 6212, pp. 987 - 991
Existing mouse models of lethal Ebola virus infection do not reproduce hallmark symptoms of Ebola hemorrhagic fever, neither delayed blood coagulation and... 
COAGULATION | GUINEA-PIGS | OUTBREAK | VIRUS INFECTION | MAP | MULTIDISCIPLINARY SCIENCES | Genetic Predisposition to Disease | Liver - pathology | Neovascularization, Physiologic - genetics | Liver - metabolism | Mice, Inbred C57BL | Endothelium, Vascular - physiopathology | Capillary Permeability - genetics | Receptor, TIE-2 - genetics | Hemorrhagic Fever, Ebola - blood | Liver - blood supply | Lymphocyte Activation - immunology | Animals | Host-Pathogen Interactions - genetics | Alleles | Blood Coagulation - genetics | Hemorrhagic Fever, Ebola - genetics | Hemorrhagic Fever, Ebola - immunology | Mice | Disease Models, Animal | Prevention | Genetic research | Ebola virus infections | Genetic aspects | Research | Virus research | Biological diversity | Ebola virus | Genetic diversity | Drug resistance | Pathogenesis | Hemorrhage | Fever | Panels | Viral diseases | Coagulation | Genetics | Viruses
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9. Full Text Ebola Vaccine — An Urgent International Priority
by Kanapathipillai, Rupa and Henao Restrepo, Ana Maria and Fast, Patricia and Wood, David and Dye, Christopher and Kieny, Marie-Paule and Moorthy, Vasee
The New England Journal of Medicine, ISSN 0028-4793, 12/2014, Volume 371, Issue 24, pp. 2249 - 2251
With the Ebola epidemic in West Africa continuing to grow, the World Health Organization convened an urgent meeting on September 29 and 30 to assess the... 
MEDICINE, GENERAL & INTERNAL | Hemorrhagic Fever, Ebola - prevention & control | Humans | Epidemics - prevention & control | Hemorrhagic Fever, Ebola - immunology | Hemorrhagic Fever, Ebola - epidemiology | Clinical Trials, Phase I as Topic | Ebola Vaccines | Ebolavirus - immunology | Ebola virus | Studies | Epidemics | Vaccines | Public health
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10. Full Text Structures of protective antibodies reveal sites of vulnerability on Ebola virus
by Charles D. Murin and Marnie L. Fusco and Zachary A. Bornholdt and Xiangguo Qiu and Gene G. Olinger and Larry Zeitlin and Gary P. Kobinger and Andrew B. Ward and Erica Ollmann Saphire
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2014, Volume 111, Issue 48, pp. 17182 - 17187
Ebola virus (EBOV) and related filoviruses cause severe hemorrhagic fever, with up to 90% lethality, and no treatments are approved for human use. Multiple... 
Ebola virus | Polysaccharides | Cocktails | Antibodies | Monoclonal antibodies | Primates | Viruses | Infections | Glycoproteins | Epitopes | EM | Ebola | ZMapp | NONHUMAN-PRIMATES | NEUTRALIZING ANTIBODIES | MULTIDISCIPLINARY SCIENCES | POSTEXPOSURE PROTECTION | GUINEA-PIGS | CHALLENGE | MEDIATED PROTECTION | HEMORRHAGIC-FEVER | MUCIN-LIKE DOMAIN | antibodies | GLYCOPROTEIN | MONOCLONAL-ANTIBODIES | Protein Structure, Tertiary | Cell Line | Binding Sites, Antibody - immunology | Ebolavirus - metabolism | Viral Proteins - immunology | Models, Molecular | Antibody Affinity - immunology | Microscopy, Electron | Ebolavirus - immunology | Epitopes - immunology | Glycoproteins - immunology | Animals | Antibody Specificity - immunology | Hemorrhagic Fever, Ebola - virology | Antibodies, Viral - chemistry | Antibodies, Viral - immunology | Epitopes - chemistry | Hemorrhagic Fever, Ebola - immunology | Immunoglobulin Fab Fragments - immunology | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Proteins | Protein research | Host-virus relationships | Research | Structure | Virus research | Health aspects | Index Medicus | Biological Sciences
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