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1. Full Text The Binding of Oxidized Low Density Lipoprotein (ox-LDL) to ox-LDL Receptor-1 Reduces the Intracellular Concentration of Nitric Oxide in Endothelial Cells through an Increased Production of Superoxide
by Luciano Cominacini and Anna Rigoni and Anna Fratta Pasini and Ulisse Garbin and Anna Davoli and Mario Campagnola and Antonio M. Pastorino and Vincenzo Lo Cascio and Tatsuya Sawamura
Journal of Biological Chemistry, ISSN 0021-9258, 04/2001, Volume 276, Issue 17, pp. 13750 - 13755
Oxidized low density lipoprotein (ox-LDL) has been suggested to affect endothelium-dependent vascular tone through a decreased biological activity of... 
SIGNAL-TRANSDUCTION | SYNTHASE | 2',7'-DICHLOROFLUORESCIN | DEPENDENT RELAXATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | L-ARGININE | RELAXING FACTOR | INVOLVEMENT | ATHEROSCLEROSIS | SMOOTH-MUSCLE CELLS | CORONARY-ARTERIES | Free Radical Scavengers - pharmacology | Reactive Oxygen Species - metabolism | Humans | Scavenger Receptors, Class E | Hemostatics - pharmacology | omega-N-Methylarginine - pharmacology | Aorta - metabolism | Oxygen - metabolism | Dose-Response Relationship, Drug | Probucol - pharmacology | Flow Cytometry | Thrombin - pharmacology | Chromans - pharmacology | Time Factors | Cattle | Superoxides - metabolism | Lipoproteins, LDL - metabolism | Aspirin - pharmacology | Bradykinin - pharmacology | CHO Cells | Cricetinae | Receptors, Oxidized LDL | Antibodies, Monoclonal - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Receptors, LDL - metabolism | Antioxidants - pharmacology | Imidazolines | Animals | Endothelium, Vascular - metabolism | Ascorbic Acid - pharmacology | Protein Binding | Allopurinol - pharmacology | Mice | Nitric Oxide - metabolism | Catecholamines - pharmacology
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2. Arrest of bleeding
: physiology, pharmacology, pathology
by Roskam, Jacques
1954, American lecture series, publication no. 217, 71
Hemorrhage | Hemostatics
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3. Full Text Acute management of bleeding in patients on novel oral anticoagulants
by Siegal, Deborah M and Crowther, Mark A
European Heart Journal, ISSN 0195-668X, 02/2013, Volume 34, Issue 7, pp. 489 - 500
Novel oral anticoagulants that directly inhibit thrombin (dabigatran) or factor Xa (rivaroxaban, apixaban) are currently available for prevention of venous... 
Novel oral anticoagulants | Bleeding | Management | RECOMBINANT FACTOR-VIIA | CARDIAC & CARDIOVASCULAR SYSTEMS | DIRECT THROMBIN INHIBITOR | RANDOMIZED EVALUATION | INTRACRANIAL HEMORRHAGE | ACTIVATED FACTOR-VII | FACTOR-XA INHIBITOR | DABIGATRAN ETEXILATE | VENOUS THROMBOEMBOLISM | PROTHROMBIN COMPLEX CONCENTRATE | NONVALVULAR ATRIAL-FIBRILLATION | Plasma | Anticoagulants - administration & dosage | Factor Xa Inhibitors | Thiophenes - adverse effects | Humans | Antithrombins - administration & dosage | Hemorrhage - prevention & control | Thiophenes - administration & dosage | Dabigatran | Antithrombins - pharmacology | Pyridones - administration & dosage | Rivaroxaban | Benzimidazoles - administration & dosage | Platelet Aggregation Inhibitors - administration & dosage | beta-Alanine - pharmacology | Renal Insufficiency - complications | Benzimidazoles - adverse effects | Drug Therapy, Combination | beta-Alanine - analogs & derivatives | Morpholines - adverse effects | Pyrazoles - adverse effects | Pyrazoles - pharmacology | Acute Disease | beta-Alanine - adverse effects | Administration, Oral | Morpholines - administration & dosage | Risk Factors | beta-Alanine - administration & dosage | Morpholines - pharmacology | Thiophenes - pharmacology | Anticoagulants - adverse effects | Pyrazoles - administration & dosage | Anticoagulants - pharmacology | Antithrombins - adverse effects | Blood Coagulation Tests | Benzimidazoles - pharmacology | Aged | Hemostatics - therapeutic use | Pyridones - adverse effects | Pyridones - pharmacology | Renal Dialysis
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4. Full Text Old versus new oral anticoagulants: Focus on pharmacology
by Fareed, Jawed and Thethi, Indermohan and Hoppensteadt, Debra
Annual Review of Pharmacology and Toxicology, ISSN 0362-1642, 2012, Volume 52, Issue 1, pp. 79 - 99
Since the discovery of heparin nearly a century ago, there have been large gaps in the development of anticoagulants. The discovery of warfarin was the first... 
Direct thrombin inhibitors | Factor Xa inhibitors | Vitamin K antagonists | Factor IIa inhibitors | vitamin K antagonists | DIRECT THROMBIN INHIBITOR | RIVAROXABAN BAY 59-7939 | DEEP-VEIN THROMBOSIS | factor IIa inhibitors | TOTAL KNEE ARTHROPLASTY | ATRIAL-FIBRILLATION | FACTOR-XA INHIBITOR | VENOUS THROMBOEMBOLISM | DABIGATRAN ETEXILATE | DOUBLE-BLIND TRIAL | TOTAL HIP-REPLACEMENT | PHARMACOLOGY & PHARMACY | TOXICOLOGY | factor Xa inhibitors | direct thrombin inhibitors | Pharmacogenetics | Factor Xa Inhibitors | Administration, Oral | Antithrombins - therapeutic use | Food-Drug Interactions | Humans | Heparin, Low-Molecular-Weight - adverse effects | Warfarin - adverse effects | Hemostatics - metabolism | Heparin, Low-Molecular-Weight - therapeutic use | Warfarin - therapeutic use | Vitamin K - antagonists & inhibitors | Anticoagulants - pharmacology | Antithrombins - adverse effects | Prothrombin - antagonists & inhibitors | Thrombosis - drug therapy | Thrombin - therapeutic use | Physiological aspects | Pharmacology | Anticoagulants (Medicine) | Research | Health aspects
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5. Full Text Endothelium-derived hyperpolarizing factor mediated relaxations in pig coronary arteries do not involve Gi/o proteins
by Ng, KFJ and Leung, SWS and Man, RYK and Vanhoutte, PM
Acta Pharmacologica Sinica, ISSN 1671-4083, 12/2008, Volume 29, Issue 12, pp. 1419 - 1424
Aim: Endothelium-dependent relaxations to certain neurohumoral substances are mediated by pertussis toxin-sensitive Gi/o protein. Our experiments were designed... 
CELLS | DEPENDENT RELAXATION | ANANDAMIDE | MESENTERIC-ARTERY | NATRIURETIC PEPTIDE | CHEMISTRY, MULTIDISCIPLINARY | endothelium-derived hyperpolarizing factor | Gi/o protein | pig coronary artery | L-ARGININE | pertussis toxin | PHARMACOLOGY & PHARMACY | RECEPTORS | EXPRESSION | EDHF | Endothelium-Dependent Relaxing Factors - pharmacology | Hemostatics - pharmacology | Peptide Fragments - pharmacology | Substance P - pharmacology | Apamin - pharmacology | Serotonin - pharmacology | Dose-Response Relationship, Drug | Thrombin - pharmacology | Charybdotoxin - pharmacology | Neurotransmitter Agents - pharmacology | Dinoprost - pharmacology | Bradykinin - pharmacology | Ionophores - pharmacology | Pertussis Toxin - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Ketanserin - pharmacology | Coronary Vessels - drug effects | Vasodilator Agents - pharmacology | Coronary Vessels - physiology | Enzyme Inhibitors - pharmacology | Serotonin Antagonists - pharmacology | Calcimycin - pharmacology | Neurotoxins - pharmacology | Animals | Muscle Relaxation - drug effects | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Sus scrofa | Biological Factors - pharmacology | Tocolytic agents | Swine | Tachykinins | Bradykinin | Thrombin | Indomethacin | Carbonates | Endothelium-derived relaxing factors | Peptide hormones | Arteries | Endothelium | Index Medicus
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6. Full Text Reversal of dabigatran anticoagulation ex vivo: Porcine study comparing prothrombin complex concentrates and idarucizumab
by Honickel, Markus and Treutler, Stefanie and Ryn, Joanne van and Tillmann, Sabine and Rossaint, Rolf and Grottke, Oliver
Thrombosis and Haemostasis, ISSN 0340-6245, 07/2015, Volume 113, Issue 4, pp. 728 - 740
Summary Urgent surgery or life-threatening bleeding requires prompt reversal of the anticoagulant effects of dabigatran. This study assessed the ability of... 
Coagulation and Fibrinolysis | Thrombin generation | Dabigatran | Idarucizumab | Trauma | Prothrombin complex concentrate | trauma | BERIPLEX P/N | DILUTIONAL COAGULOPATHY | BLOOD-LOSS | prothrombin complex concentrate | PIG MODEL | idarucizumab | FIBRINOGEN CONCENTRATE | ORAL ANTICOAGULANTS | MAJOR TRAUMA | PERIPHERAL VASCULAR DISEASE | HEMOSTATIC THERAPY | thrombin generation | HEMATOLOGY | FRESH-FROZEN PLASMA | Dabigatran - pharmacology | Dabigatran - administration & dosage | Administration, Oral | Tranexamic Acid - pharmacology | Male | Antithrombins - administration & dosage | Multiple Trauma - blood | Antithrombins - pharmacology | Dose-Response Relationship, Drug | Animals | Blood Coagulation - drug effects | Time Factors | Swine | Antibodies, Monoclonal, Humanized - pharmacology | Coagulants - pharmacology | Fibrinogen - metabolism | Antifibrinolytic Agents - pharmacology | Blood Coagulation Tests | Multiple Trauma - drug therapy | Blood Coagulation Factors - pharmacology | Infusions, Intravenous | Thrombin - metabolism | Disease Models, Animal
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7. Full Text Fabrication of photo-crosslinkable glycol chitosan hydrogel as a tissue adhesive
by Lu, Min and Liu, Yi and Huang, Chun-Jen and Huang, Yung-Chi and Tsai, Wei-Bor
Carbohydrate Polymers, ISSN 0144-8617, 02/2018, Volume 181, pp. 668 - 674
In this work, an gelling system composed of glycol chitosan (GC) was fabricated and evaluated regarding its tissue-adhesive, anti-bacterial and hemostatic... 
Glycol chitosan | Photochemical crosslinking | Hydrogel | Tissue adhesive | Antibacterial | Hemostasis | SEALANTS | POLYMER SCIENCE | SURGICAL APPLICATIONS | DRUG-DELIVERY | CHEMISTRY, ORGANIC | INJECTABLE CHITOSAN | HEMOSTATIC MATERIALS | IN-VITRO | BIOMEDICAL APPLICATIONS | DRESSINGS | BIOMATERIALS | CHEMISTRY, APPLIED | FIBRINOGEN | Cross-Linking Reagents - radiation effects | Staphylococcus epidermidis - drug effects | Escherichia coli - drug effects | Phenylpropionates - chemistry | Tissue Adhesives - pharmacology | Drug Carriers - toxicity | Hemostatics - pharmacology | Elastic Modulus | Hydrogels - chemical synthesis | Drug Carriers - chemistry | Gentamicins - pharmacology | Swine | Light | Phenylpropionates - toxicity | Tissue Adhesives - chemical synthesis | Chitosan - pharmacology | Hydrogels - toxicity | Chitosan - radiation effects | Phenylpropionates - radiation effects | Chitosan - chemical synthesis | Cell Line | Hemostatics - chemistry | Hemostatics - toxicity | Cross-Linking Reagents - chemistry | Cross-Linking Reagents - toxicity | Drug Carriers - chemical synthesis | Chitosan - toxicity | Organometallic Compounds - radiation effects | Drug Carriers - pharmacology | Animals | Amoxicillin - pharmacology | Chickens | Tissue Adhesives - toxicity | Drug Liberation | Anti-Bacterial Agents - pharmacology | Mice | Hemostatics - chemical synthesis | Hydrogels - pharmacology | Tissue Adhesives - chemistry | Hydrogels - chemistry | Crosslinked polymers | Glycols | Adhesives | Antibacterial agents | Analysis | Liver
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8. Full Text Progesterone inhibits in vitro fetal membrane weakening
by Kumar, Deepak, MD and Springel, Edward, MD and Moore, Robert M., MS and Mercer, Brian M., MD and Philipson, Elliot, MD and Mansour, Joseph M., PhD and Mesiano, Sam, PhD and Schatz, Fredrick, PhD and Lockwood, Charles J., MD and Moore, John J., MD
American Journal of Obstetrics and Gynecology, ISSN 0002-9378, 2015, Volume 213, Issue 4, pp. 520.e1 - 520.e9
Objective Inflammation/infection and abruption are leading causes of preterm premature rupture of the membranes. Recently, we identified granulocyte-macrophage... 
Obstetrics and Gynecology | fetal membrane | thrombin | GM-CSF | medroxyprogesterone acetate | progesterone | PPROM | TNF | weakening | RECEPTOR EXPRESSION | PREVENTION | TERM | OBSTETRICS & GYNECOLOGY | HUMAN MYOMETRIAL CELLS | DOUBLE-BLIND | PRETERM PREMATURE RUPTURE | BIRTH | PARTURITION | MOLECULAR-MECHANISMS | Humans | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology | Medroxyprogesterone Acetate - pharmacology | Progestins - pharmacology | Hemostatics - pharmacology | Pregnancy | Tumor Necrosis Factor-alpha - pharmacology | Fetal Membranes, Premature Rupture | Thrombin - pharmacology | 17-alpha-Hydroxyprogesterone - pharmacology | Female | Chorion - drug effects | Decidua - drug effects | In Vitro Techniques | Progesterone - pharmacology | Extraembryonic Membranes - drug effects | Medroxyprogesterone | Thrombin | Macrophage colony stimulating factor | Progesterone | Analysis | Aerospace engineering
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9. Full Text A multifunctional in situ–forming hydrogel for wound healing
by Du, Lina and Tong, Li and Jin, Yiguang and Jia, Junwei and Liu, Yangpu and Su, Chang and Yu, Shanjiang and Li, Xin
Wound Repair and Regeneration, ISSN 1067-1927, 11/2012, Volume 20, Issue 6, pp. 904 - 910
In this study, a multifunctional in situ–forming hydrogel (MISG) was prepared as a wound dressing designed to stop bleeding, inhibit inflammation, relieve... 
MEDICINE, RESEARCH & EXPERIMENTAL | SURGERY | GELS | ALGINATE | CHITOSAN | COPOLYMERS | RELEASE | MODEL | DELIVERY | CELL BIOLOGY | DERMATOLOGY | GROWTH | DRESSINGS | SKIN | Lidocaine - pharmacology | Temperature | Bandages | Povidone-Iodine - pharmacology | Hemostatics - pharmacology | Male | Anesthetics, Local - pharmacology | Poloxamer - pharmacology | Inflammation - drug therapy | Pain - drug therapy | Chitosan - pharmacology | Hydrogel, Polyethylene Glycol Dimethacrylate - pharmacology | Wound Healing - drug effects | Rabbits | Wounds and Injuries - pathology | Anti-Infective Agents, Local - pharmacology | Mice, Inbred C57BL | Rats | Aminocaproates - pharmacology | Rats, Sprague-Dawley | Surface-Active Agents - pharmacology | Hemorrhage - drug therapy | Animals | Wounds and Injuries - drug therapy | Mice | Care and treatment | Pain | Wound healing
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10. Full Text The ATP-gated P2X1 Receptor Plays a Pivotal Role in Activation of Aspirin-treated Platelets by Thrombin and Epinephrine
by Magnus GrenegÃ¥rd and Karin Vretenbrant-Öberg and Martina Nylander and Stéphanie Désilets and Eva G. Lindström and Anders Larsson and Ida Ramström and Sofia Ramström and Tomas L. Lindahl and Klinisk kemi and Linköpings universitet and Institutionen för klinisk och experimentell medicin and Laboratoriemedicinskt centrum and Institutionen för medicin och hälsa and Farmakologi and Östergötlands Läns Landsting and Hälsouniversitetet
Journal of Biological Chemistry, ISSN 0021-9258, 07/2008, Volume 283, Issue 27, pp. 18493 - 18504
Human platelets express protease-activated receptor 1 (PAR1) and PAR4 but limited data indicate for differences in signal transduction. We studied the... 
Receptor, PAR-1 - metabolism | Humans | Thrombin - antagonists & inhibitors | Receptors, Adrenergic, alpha-2 - metabolism | Secretory Vesicles - metabolism | Hemostatics - pharmacology | Peptide Fragments - pharmacology | Epinephrine - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Epinephrine - agonists | Dose-Response Relationship, Drug | Adrenergic alpha-2 Receptor Agonists | Receptors, Thrombin - agonists | Thrombin - pharmacology | Blood Platelets - cytology | Adenosine Triphosphate - metabolism | Thrombin - agonists | Platelet Aggregation Inhibitors - pharmacology | Platelet Aggregation - drug effects | Aspirin - pharmacology | Aspirin - agonists | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Aspirin - antagonists & inhibitors | Oligopeptides - antagonists & inhibitors | Calcium - pharmacology | Receptor, PAR-1 - agonists | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Platelet Aggregation - physiology | Purinergic P2 Receptor Agonists | Oligopeptides - agonists | Receptors, Purinergic - metabolism | Receptors, Purinergic P2X | Drug Synergism | Drug Antagonism | Purinergic Agonists | Blood Platelets - metabolism | Peptide Fragments - agonists | Peptide Fragments - antagonists & inhibitors | Receptors, Purinergic P2 - metabolism | Receptors, Thrombin - metabolism | Adrenergic alpha-Agonists - pharmacology | Adenosine Diphosphate - metabolism | Adrenergic alpha-2 Receptor Antagonists | Oligopeptides - pharmacology | Epinephrine - pharmacology | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
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11. Full Text Plasminogen associates with phosphatidylserine-exposing platelets and contributes to thrombus lysis under flow
by Whyte, Claire S and Swieringa, Frauke and Mastenbroek, Tom G and Lionikiene, Ausra S and Lance, Marcus D and van der Meijden, Paola E. J and Heemskerk, Johan W. M and Mutch, Nicola J
Blood, ISSN 0006-4971, 04/2015, Volume 125, Issue 16, pp. 2568 - 2578
The interaction of plasminogen with platelets and their localization during thrombus formation and fibrinolysis under flow are not defined. Using a novel model... 
STIMULATED PLATELETS | FACTOR-XIII | FIBRIN FORMATION | CELL-SURFACE | PROCOAGULANT RESPONSE | GLYCOPROTEIN-IB | BINDING-SITES | HEMATOLOGY | ACTIVATOR INHIBITOR | GLU-PLASMINOGEN | TISSUE FACTOR | Tyrosine - pharmacology | Fibrinolysis - drug effects | Crotalid Venoms - pharmacology | Shear Strength | Tissue Plasminogen Activator - metabolism | Rheology | Lectins, C-Type | Phosphatidylserines - metabolism | Hemostatics - pharmacology | Tyrosine - analogs & derivatives | Fibrinolytic Agents - pharmacology | Microscopy, Confocal | Thrombosis - metabolism | Flow Cytometry | Thrombin - pharmacology | Urokinase-Type Plasminogen Activator - metabolism | Blood Platelets - metabolism | Protein Binding - drug effects | Blood Platelets - drug effects | Fibrin - metabolism | Oligopeptides - pharmacology | Fibrinolysin - metabolism | Hirudins - pharmacology | Thrombosis and Hemostasis
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12. Full Text Bletilla striata: Medicinal uses, phytochemistry and pharmacological activities
by He, Xirui and Wang, Xiaoxiao and Fang, Jiacheng and Zhao, Zefeng and Huang, Linhong and Guo, Hao and Zheng, Xiaohui
Journal of Ethnopharmacology, ISSN 0378-8741, 01/2017, Volume 195, pp. 20 - 38
(Thunb.) Reichb. f. (Orchidaceae), also known as Hyacinth Orchid and Baiji (Simplified Chinese: 白及), not only has been widely used for the treatment of... 
Phenanthrenes | Polysaccharides | Wound healing | Bletilla striata | Biomaterials | CHEMISTRY, MEDICINAL | BIPHENANTHRENES | NONPOLAR CONSTITUENTS | TUBERS | ULCERATIVE-COLITIS | SPIROSTANE-STEROIDAL SAPONINS | PLANT SCIENCES | STILBENOIDS | INTEGRATIVE & COMPLEMENTARY MEDICINE | INFLAMMATION | ROOTS | PHARMACOLOGY & PHARMACY | EXPRESSION | POLYSACCHARIDE | Hemostasis - drug effects | Hemostatics - toxicity | Plant Extracts - toxicity | Plant Extracts - pharmacology | Humans | Drugs, Chinese Herbal - pharmacology | Hemostatics - pharmacology | Plant Extracts - isolation & purification | Hemostatics - isolation & purification | Polysaccharides - pharmacology | Phytochemicals - isolation & purification | Drugs, Chinese Herbal - toxicity | Animals | Phytochemicals - toxicity | Polysaccharides - toxicity | Polysaccharides - isolation & purification | Orchidaceae - chemistry | Phytotherapy | Drugs, Chinese Herbal - isolation & purification | Phytochemicals - pharmacology | Wound Healing - drug effects | Plants, Medicinal | Medical colleges | Eye diseases | Usage | Hemorrhoids | Phytochemistry | Biological products | Analysis | Index Medicus
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13. Full Text Differential Effects of Extracellular Matrix Proteins on Human Airway Smooth Muscle Cell Proliferation and Phenotype
by Hirst, Stuart J and Twort, Charles H. C and Lee, Tak H
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 09/2000, Volume 23, Issue 3, pp. 335 - 344
Mature airway smooth muscle cells are characterized by a low proliferative index and expression of contractile marker proteins such as smooth muscle... 
LUNG | CONTRACTILE | RESPIRATORY SYSTEM | LAMININ | BIOCHEMISTRY & MOLECULAR BIOLOGY | FIBRONECTIN | CULTURE | EXPRESSION | MODULATION | BRONCHIAL-ASTHMA | CELL BIOLOGY | Laminin - pharmacology | Bronchi - chemistry | Humans | Hemostatics - pharmacology | Flow Cytometry | Thrombin - pharmacology | Actins - analysis | Collagen - pharmacology | Bronchi - cytology | Myosin Heavy Chains - analysis | Fibronectins - pharmacology | Asthma - physiopathology | Proto-Oncogene Proteins c-sis | Calcium-Binding Proteins - analysis | Cell Size - drug effects | Cells, Cultured | Extracellular Matrix Proteins - pharmacology | Immunophenotyping | Biocompatible Materials - pharmacology | Cell Size - physiology |