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PLoS ONE, ISSN 1932-6203, 09/2012, Volume 7, Issue 9, pp. e45285 - e45285
A role for the NADPH oxidases NOX1 and NOX2 in liver fibrosis has been proposed, but the implication of NOX4 is poorly understood yet. The aim of this work was... 
GROWTH-FACTOR-BETA | OXIDATIVE STRESS | TGF-BETA | INDUCED APOPTOSIS | ADENINE-DINUCLEOTIDE PHOSPHATE | MULTIDISCIPLINARY SCIENCES | FIBROGENESIS | DIFFERENTIATION | MESENCHYMAL TRANSITION | UP-REGULATION | Liver - virology | Hepatitis C, Chronic - pathology | Liver - enzymology | Gene Expression - drug effects | Apoptosis - drug effects | ATP Binding Cassette Transporter, Sub-Family B - deficiency | Carbon Tetrachloride | Humans | NADPH Oxidases - metabolism | Hepatitis C, Chronic - virology | Myofibroblasts - enzymology | Liver Cirrhosis - enzymology | Liver Cirrhosis - chemically induced | Liver - drug effects | Cell Transdifferentiation - drug effects | Hepatitis C, Chronic - enzymology | STAT3 Transcription Factor - deficiency | NADPH Oxidases - genetics | Hepacivirus - physiology | Hepatic Stellate Cells - virology | Myofibroblasts - virology | Hepatocytes - drug effects | STAT3 Transcription Factor - genetics | Hepatic Stellate Cells - drug effects | Cyclin-Dependent Kinase Inhibitor p16 - deficiency | Hepatic Stellate Cells - enzymology | Cyclin-Dependent Kinase Inhibitor p16 - genetics | NADPH Oxidase 4 | Myofibroblasts - drug effects | Mice, Knockout | Transforming Growth Factor beta - pharmacology | Animals | Liver Cirrhosis - virology | Signal Transduction - drug effects | Biopsy | Hepatocytes - virology | Liver Cirrhosis - pathology | Mice | ATP Binding Cassette Transporter, Sub-Family B - genetics | Hepatocytes - enzymology | Oxidases | Care and treatment | Liver diseases | Research | Gene expression | Liver cells | Animal models | Biomedical research | Mesenchyme | Liver | Carbon tetrachloride | Viruses | Activation | Metastasis | Experiments | NAD(P)H oxidase | Hepatitis | Genotype & phenotype | Cell activation | NOX4 protein | Rodents | Hepatology | Gastroenterology | CYBB protein | Fibroblasts | Growth factors | Medical research | Stellate cells | Patients | Pulmonary fibrosis | Hepatocytes | Cell death | Fibrosis | Hepatitis C virus | Hepatitis C | Cancer | Apoptosis | Bile | Index Medicus | Malalties del fetge | Cèl·lules hepàtiques
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2007, Volume 282, Issue 14, pp. 10678 - 10689
Journal Article
Gastroenterology, ISSN 0016-5085, 2014, Volume 147, Issue 5, pp. 1094 - 1105.e25
Background & Aims Direct-acting antivirals that target nonstructural protein 5A (NS5A), such as daclatasvir, have high potency against the hepatitis C virus... 
Gastroenterology and Hepatology | Viral Replication | Viral Replication Factory | Drug Mechanism | Chronic Hepatitis C | DOMAIN | NONSTRUCTURAL PROTEIN 5A | CRYSTAL-STRUCTURE | LIVER-DISEASES | VIRAL GENOME | CELL-LINES | CULTURE | IN-VITRO | POTENT | BMS-790052 | GASTROENTEROLOGY & HEPATOLOGY | Minor Histocompatibility Antigens | Humans | Protein Multimerization | Drug Resistance, Viral | Imidazoles - chemistry | Hepacivirus - genetics | Structure-Activity Relationship | Protease Inhibitors - pharmacology | Viral Nonstructural Proteins - chemistry | Transfection | Time Factors | Antiviral Agents - chemistry | Drug Design | Molecular Structure | Binding Sites | Cell Membrane - drug effects | Hepatocytes - drug effects | Hepacivirus - drug effects | Virus Replication - drug effects | Antiviral Agents - pharmacology | Protease Inhibitors - chemistry | Viral Nonstructural Proteins - genetics | Cell Membrane - ultrastructure | Imidazoles - pharmacology | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Host-Pathogen Interactions | Cell Membrane - enzymology | Hepacivirus - enzymology | Cell Line, Tumor | Hepatocytes - ultrastructure | Hepatocytes - virology | Cell Membrane - virology | Protein Conformation | Viral Nonstructural Proteins - metabolism | Molecular Docking Simulation | Mutation | Viral Nonstructural Proteins - antagonists & inhibitors | Hepatocytes - enzymology | Virus diseases | RNA | Hepatitis C virus | Health aspects | Index Medicus | Abridged Index Medicus
Journal Article
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 02/2013, Volume 344, Issue 2, pp. 388 - 396
Journal Article
Journal Article
The Journal of Immunology, ISSN 0022-1767, 10/2008, Volume 181, Issue 7, pp. 4926 - 4935
Journal Article
Gastroenterology, ISSN 0016-5085, 2014, Volume 146, Issue 5, pp. 1373 - 1385.e11
Background & Aims Positive-sense RNA viruses remodel intracellular membranes to generate specialized membrane compartments for viral replication. Several RNA... 
Gastroenterology and Hepatology | Viral Replication | Phosphatidylinositol 4-Phosphate | Lipid Kinase | Lipid Transfer Proteins | Keywords | COMPLEX | ACTIVATION | 4-Phosphate | RNA REPLICATION | LIPID RAFT | Phosphatidylinositol | IN-VITRO | HEPATITIS-C VIRUS | III ALPHA | CELL-CULTURE | INFECTION | GASTROENTEROLOGY & HEPATOLOGY | Phosphatidylinositol Phosphates - metabolism | Receptors, Steroid - metabolism | Humans | Hepacivirus - genetics | Hepacivirus - pathogenicity | Viral Proteins - metabolism | 1-Phosphatidylinositol 4-Kinase - metabolism | Transfection | Biological Transport | RNA Interference | HEK293 Cells | Cell Membrane - drug effects | Hepacivirus - drug effects | Virus Replication - drug effects | RNA, Viral - biosynthesis | Viral Proteins - genetics | 1-Phosphatidylinositol 4-Kinase - antagonists & inhibitors | Genotype | Cholesterol - metabolism | Host-Pathogen Interactions | Cell Membrane - enzymology | Hepacivirus - enzymology | Phenotype | Receptors, Steroid - genetics | Hepacivirus - growth & development | Viral Nonstructural Proteins - metabolism | Protein Kinase Inhibitors - pharmacology | HeLa Cells | RNA | Phospholipids | Hepatitis C virus | Hepatitis C | Phosphotransferases | Cholesterol | Protein binding | Index Medicus | Abridged Index Medicus | viral replication | lipid transfer proteins | lipid kinase | phosphatidylinositol 4-phosphate
Journal Article
Clinical & Experimental Immunology, ISSN 0009-9104, 12/2015, Volume 182, Issue 3, pp. 323 - 331
Journal Article
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 03/2011, Volume 39, Issue 3, pp. 510 - 521
Boceprevir (SCH 503034), a protease inhibitor, is under clinical development for the treatment of human hepatitis C virus infections. In human liver... 
METABOLISM | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | NS3 PROTEASE | ALDO-KETO REDUCTASES | CARBONYL REDUCTION | NEUROSTEROIDS | SUPERFAMILY | PHARMACOLOGY & PHARMACY | AGENTS | DEHYDROGENASE | HIV-INTEGRASE INHIBITOR | Liver - enzymology | Proline - metabolism | Stereoisomerism | Humans | Drugs, Investigational - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | Urea - chemistry | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Drugs, Investigational - chemistry | Serine Proteinase Inhibitors - chemistry | Cytochrome P-450 CYP3A - genetics | Urea - analogs & derivatives | 3-Hydroxysteroid Dehydrogenases - metabolism | Hydroxysteroid Dehydrogenases - metabolism | Urea - metabolism | Molecular Structure | Oligopeptides - chemistry | Recombinant Proteins - metabolism | Oxidation-Reduction | Proline - analogs & derivatives | Subcellular Fractions - drug effects | Enzyme Inhibitors - pharmacology | Serine Proteinase Inhibitors - metabolism | Hydroxysteroid Dehydrogenases - genetics | Oligopeptides - metabolism | Subcellular Fractions - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Proline - chemistry | Hepacivirus - enzymology | Hydroxyprostaglandin Dehydrogenases - antagonists & inhibitors | Cytochrome P-450 CYP3A Inhibitors | Aldo-Keto Reductase Family 1 Member C3 | Cytochrome P-450 CYP3A - metabolism | Biotransformation - drug effects | Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Kinetics | 3-Hydroxysteroid Dehydrogenases - genetics | Viral Nonstructural Proteins - antagonists & inhibitors | Subcellular Fractions - enzymology | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2014, Volume 9, Issue 6, pp. e100207 - e100207