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Gastroenterology, ISSN 0016-5085, 06/2018, Volume 154, Issue 8, pp. 2237 - 2251.e16
Hepatitis C virus (HCV) infections most often result in chronic outcomes, although the virus constantly produces replication intermediates, in particular... 
Escape | Rab27a | Exosomes | Virology | RESPONSES | PROTEIN | RNA | NS5A | HUMAN LIVER | CELL-CULTURE | INFECTION | GASTROENTEROLOGY & HEPATOLOGY | Humans | Hepatitis C, Chronic - virology | Hepatocytes - metabolism | Interferons - immunology | Extracellular Vesicles - metabolism | Host-Pathogen Interactions - immunology | Signal Transduction - immunology | Extracellular Vesicles - immunology | Hepacivirus - physiology | RNA, Viral - isolation & purification | Cell Line | RNA, Double-Stranded - isolation & purification | RNA, Double-Stranded - secretion | Toll-Like Receptor 3 - immunology | Virus Replication - immunology | Hepatocytes - immunology | Immunity, Innate | Toll-Like Receptor 3 - metabolism | Hepatitis C, Chronic - blood | RNA, Viral - secretion | Hepatitis C, Chronic - immunology | RNA, Double-Stranded - immunology | Interferons - metabolism | RNA, Viral - immunology | Primary Cell Culture | Dendritic cells | Hepatitis C virus | Health aspects | Analysis | Index Medicus | Abridged Index Medicus | Hepatocytes/immunology | Toll-Like Receptor 3/metabolism | Toll-Like Receptor 3/immunology | Innate immunity | Extracellular Vesicles/immunology | Hepatitis C, Chronic/blood | Extracellular Vesicles/metabolism | Life Sciences | Host-Pathogen Interactions/immunology | RNA, Double-Stranded/immunology | Immunology | Hepatitis C, Chronic/immunology | RNA, Viral/immunology | RNA, Viral/isolation & purification | Hepatitis C, Chronic/virology | Interferons/metabolism | Hépatology and Gastroenterology | Interferons/immunology | Hepacivirus/physiology | RNA, Viral/metabolism | Virus Replication/immunology | Microbiology and Parasitology | Human health and pathology | Hepatocytes/metabolism | RNA, Double-Stranded/isolation & purification | Signal Transduction/immunology | RNA, Double-Stranded/metabolism
Journal Article
Journal of Immunology, ISSN 0022-1767, 01/2014, Volume 192, Issue 2, pp. 649 - 657
Journal Article
MUCOSAL IMMUNOLOGY, ISSN 1933-0219, 03/2016, Volume 9, Issue 2, pp. 401 - 413
The C-type lectin-like receptor CD161 is expressed by lymphocytes found in human gut and liver, as well as blood, especially natural killer (NK) cells, T... 
INVARIANT T-CELLS | MAIT CELLS | SUBPOPULATION | CD161 EXPRESSION | TISSUE | SUBSETS | HUMAN NKR-P1A | DEFINES | IMMUNOLOGY | CUTTING EDGE | LYMPHOCYTES | Antigens, CD - immunology | Crohn Disease - genetics | CD8-Positive T-Lymphocytes - pathology | Tetradecanoylphorbol Acetate - pharmacology | Hepacivirus - immunology | Humans | Colitis, Ulcerative - genetics | Lectins, C-Type - immunology | Colon - immunology | Killer Cells, Natural - pathology | T-Box Domain Proteins - immunology | Lectins, C-Type - genetics | Antigens, CD - genetics | Colitis, Ulcerative - immunology | Hepatitis C - immunology | Th17 Cells - drug effects | Intestinal Mucosa - immunology | Integrin alpha Chains - immunology | Killer Cells, Natural - immunology | Adenoviridae - immunology | Hepatitis C - prevention & control | Th17 Cells - pathology | Antigens, Differentiation, T-Lymphocyte - immunology | Signal Transduction | Colon - pathology | Lymphocyte Activation | Gene Expression Regulation | Clinical Trials as Topic | Colitis, Ulcerative - pathology | Crohn Disease - immunology | NK Cell Lectin-Like Receptor Subfamily B - immunology | T-Box Domain Proteins - genetics | NK Cell Lectin-Like Receptor Subfamily B - genetics | Crohn Disease - pathology | CD8-Positive T-Lymphocytes - drug effects | Antigens, Differentiation, T-Lymphocyte - genetics | Hepatitis C - virology | Th17 Cells - immunology | Immunologic Memory | Killer Cells, Natural - drug effects | Primary Cell Culture | CD8-Positive T-Lymphocytes - immunology | Integrin alpha Chains - genetics | Intestinal Mucosa - pathology | Index Medicus | Biological Sciences | Basic Medicine | Naturvetenskap | Medical and Health Sciences | Medicin och hälsovetenskap | Biologiska vetenskaper | Medicinska och farmaceutiska grundvetenskaper | Natural Sciences | Immunologi inom det medicinska området | Immunology in the medical area
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2011, Volume 286, Issue 12, pp. 10847 - 10855
Hepatitis C virus (HCV) infection is highly efficient in the establishment of persistent infection, which leads to the development of chronic liver disease and... 
IMMUNE-SYSTEM | DENDRITIC CELLS | INFLAMMATION | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | INFECTION | SUPPRESSOR-CELLS | DIFFERENTIATION | INTERLEUKIN-6 | CANCER | T-CELLS | Hepatitis C - metabolism | Hepacivirus - immunology | Dendritic Cells - immunology | Humans | Monocytes - metabolism | Autocrine Communication - drug effects | Monocytes - immunology | Phosphatidylinositol 3-Kinases - metabolism | Hepacivirus - metabolism | Phosphatidylinositol 3-Kinases - immunology | Hepatitis C - immunology | Antibodies, Neutralizing - immunology | Inflammation - metabolism | T-Lymphocytes - metabolism | Viral Core Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Viral Core Proteins - pharmacology | Interleukin-6 - metabolism | Dendritic Cells - metabolism | Macrophages - immunology | STAT3 Transcription Factor - metabolism | Antibodies, Monoclonal, Murine-Derived - immunology | Autocrine Communication - physiology | Cells, Cultured | Antibodies, Neutralizing - pharmacology | Inflammation - immunology | Macrophages - metabolism | Proto-Oncogene Proteins c-akt - immunology | Signal Transduction - drug effects | Interleukin-6 - immunology | Signal Transduction - physiology | T-Lymphocytes - immunology | Viral Core Proteins - immunology | STAT3 Transcription Factor - immunology | Antibodies, Monoclonal, Murine-Derived - pharmacology | Index Medicus | Human APC | Immunology | Innate Immunity | STAT3 | Viral Immunology | Cellular Immune Response | Myeloid Cell | Hepatitis C Virus
Journal Article
PLoS Pathogens, ISSN 1553-7366, 2014, Volume 10, Issue 6, pp. e1004210 - e1004210
The ability of innate immune cells to sense and respond to impending danger varies by anatomical location. The liver is considered tolerogenic but is still... 
BORRELIA-BURGDORFERI | RESPONSES | INVARIANT T-CELLS | HEPATITIS-B-VIRUS | REPLICATION | VIROLOGY | RECOGNITION | RNA | DISTINCT | KUPFFER CELLS | MICROBIOLOGY | PARASITOLOGY | Leukocytes, Mononuclear - metabolism | Liver - pathology | Hepatitis B - metabolism | Coculture Techniques | Humans | Hepatitis B - virology | Liver - microbiology | Hepacivirus - pathogenicity | Monocytes - immunology | Oligoribonucleotides - pharmacology | Hepatitis C - immunology | Liver - immunology | Liver - drug effects | Pseudomonas aeruginosa - metabolism | T-Lymphocyte Subsets - drug effects | Enterococcus faecalis - immunology | Enterococcus faecalis - pathogenicity | Riboflavin - biosynthesis | Leukocytes, Mononuclear - drug effects | Monocytes - drug effects | Enterococcus faecalis - metabolism | Hepatitis C - virology | Killer Cells, Natural - drug effects | Killer Cells, Natural - metabolism | Toll-Like Receptor 8 - metabolism | Pseudomonas aeruginosa - immunology | T-Lymphocyte Subsets - immunology | Adjuvants, Immunologic - pharmacology | Hepatitis C - metabolism | Hepacivirus - immunology | Hepatitis B virus - pathogenicity | Monocytes - metabolism | Hepatitis B - immunology | Pseudomonas aeruginosa - pathogenicity | Escherichia coli - pathogenicity | Leukocytes, Mononuclear - immunology | Escherichia coli - metabolism | Killer Cells, Natural - immunology | Hepatitis B virus - immunology | Toll-Like Receptor 8 - agonists | Immunity, Innate - drug effects | Interferon-gamma Release Tests | Cells, Cultured | Hepatitis B - pathology | Escherichia coli - immunology | Up-Regulation - drug effects | Leukocytes, Mononuclear - pathology | T-Lymphocyte Subsets - metabolism | Hepatitis C - pathology | Liver diseases | Toll-like receptors | Physiological aspects | Development and progression | Interferon | Drug therapy | Health aspects | Index Medicus | Bacterial infections | Liver | Rodents | Immune system
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2014, Volume 193, Issue 2, pp. 783 - 796
Human ficolin-2 (L-ficolin/p35) is a lectin-complement pathway activator that is present in normal human plasma and is associated with infectious diseases;... 
LECTIN-COMPLEMENT PATHWAY | HOST-CELLS | DISEASE RISK | ENVELOPE GLYCOPROTEIN E2 | PROTEIN | ANTIVIRAL THERAPY | ENTRY FACTOR | N-GLYCANS | IMMUNOLOGY | DENSITY-LIPOPROTEIN RECEPTOR | INNATE IMMUNITY | Tumor Escape - genetics | Hepacivirus - immunology | Humans | Hepacivirus - genetics | Green Fluorescent Proteins - genetics | Tetraspanin 28 - immunology | Host-Pathogen Interactions - immunology | Lectins - metabolism | RNA Interference | HEK293 Cells | Viral Envelope Proteins - metabolism | Scavenger Receptors, Class B - immunology | Hepacivirus - physiology | Tetraspanin 28 - genetics | Binding, Competitive - immunology | Tumor Escape - immunology | Green Fluorescent Proteins - metabolism | Receptors, LDL - genetics | Viral Envelope Proteins - genetics | Lectins - immunology | Receptors, LDL - metabolism | Scavenger Receptors, Class B - genetics | Polysaccharides - immunology | Apolipoprotein E3 - immunology | Mannans - immunology | Receptors, LDL - immunology | Apolipoprotein E3 - metabolism | Protein Binding - immunology | Blotting, Western | Polysaccharides - metabolism | Microscopy, Confocal | Apolipoprotein E3 - genetics | Mannans - metabolism | Cell Line, Tumor | Tetraspanin 28 - metabolism | Lectins - genetics | Viral Envelope Proteins - immunology | HeLa Cells | Scavenger Receptors, Class B - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Journal of Infectious Diseases, ISSN 0022-1899, 11/2016, Volume 214, Issue 9, pp. 1438 - 1448
Background. Immune activation predicts morbidity during hepatitis C virus (HCV) infection and human immunodeficiency virus (HIV) infection, although mechanisms... 
hepatitis C | T cell | lysophospholipase D | monocyte | immunity | ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2) | human | INFECTIOUS DISEASES | LIVER FIBROSIS | MICROBIOLOGY | ANTIRETROVIRAL THERAPY | IMMUNOLOGY | HUMAN-IMMUNODEFICIENCY-VIRUS | ACUTE CORONARY SYNDROME | CLINICAL PROGRESSION | MASS-SPECTROMETRY | SPHINGOSINE 1-PHOSPHATE | phosphodiesterase 2 (ENPP2) | LYSOPHOSPHOLIPASE-D | HEPATOCELLULAR-CARCINOMA | ectonucleotide pyrophosphatase | TUMOR-ASSOCIATED ANTIGEN | Antigens, CD - immunology | Hepatitis C - drug therapy | Coinfection - drug therapy | Hepacivirus - immunology | Humans | Middle Aged | Male | HIV - immunology | Interferons - therapeutic use | Monocytes - immunology | Lysophospholipids - immunology | Lipopolysaccharide Receptors - metabolism | HIV Infections - immunology | Hepatitis C - immunology | Phosphoric Diester Hydrolases - blood | Adult | Anti-HIV Agents - therapeutic use | Female | Antigens, Differentiation, Myelomonocytic - immunology | Coinfection - immunology | HIV Infections - virology | Plasma - immunology | Lipopolysaccharide Receptors - immunology | Biomarkers - blood | Coinfection - virology | Receptors, Cell Surface - immunology | Monocytes - virology | Hepatitis C - virology | Interleukin-6 - immunology | HIV Infections - drug therapy | Aged | Care and treatment | Interferon | Research | Hepatitis C virus | HIV (Viruses) | Index Medicus | Abridged Index Medicus | Major and Brief Reports
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2012, Volume 109, Issue 16, pp. 6205 - 6210
Hepatitis C virus (HCV) infects ~2% of the world's population. It is estimated that there are more than 500,000 new infections annually in Egypt the country... 
Hepatitis | Antigens | Vaccination | Virions | Antibodies | Viruses | Glycoproteins | Infections | Epitopes | Genotypes | Cross-neutralizing antibody | Virus challenge | Antigenic determinant | Chronic viral infection | Protective determinant | chronic viral infection | DESIGN | STRATEGY | MULTIDISCIPLINARY SCIENCES | E1 GLYCOPROTEIN | virus challenge | antigenic determinant | cross-neutralizing antibody | EPITOPE | CELL-CULTURE SYSTEMS | E2 GLYCOPROTEIN | INFECTION | HUMAN MONOCLONAL-ANTIBODIES | protective determinant | VACCINES | REVEALS | Hepacivirus - immunology | Viral Hepatitis Vaccines - administration & dosage | Humans | Hepacivirus - genetics | Molecular Sequence Data | Immunoblotting | Epitopes, B-Lymphocyte - immunology | Hepatitis C Antibodies - immunology | Peptide Library | Tetraspanin 28 - immunology | Hepatitis C - immunology | Antibodies, Neutralizing - immunology | Antibody Specificity - immunology | HEK293 Cells | Hepatitis C - prevention & control | Antibodies, Monoclonal - immunology | Amino Acid Sequence | Viral Envelope Proteins - genetics | Enzyme-Linked Immunosorbent Assay | Genotype | Viral Hepatitis Vaccines - immunology | Animals | Hepatitis C - virology | Cell Line, Tumor | Viral Envelope Proteins - immunology | Mice | Viral antibodies | Physiological aspects | Hepatitis C virus | Health aspects | Vaccines | Polyclonal antibodies | Binding sites | Index Medicus | Biological Sciences
Journal Article
Journal of Immunology, ISSN 0022-1767, 03/2014, Volume 192, Issue 6, pp. 2770 - 2777
Hepatitis C virus (HCV) is a major cause of liver disease. The innate immune system is essential for controlling HCV replication, and HCV is recognized by... 
TOLL-LIKE RECEPTOR-3 | GENETIC-VARIATION | IL28B | REPLICATION | RNA | INNATE IMMUNE-RESPONSES | PATHWAY | INTERFERON-LAMBDA | RIG-I | IMMUNOLOGY | T-CELLS | Gene Expression - drug effects | Hepatitis C - metabolism | Hepacivirus - immunology | Dendritic Cells - immunology | Humans | Adaptor Proteins, Vesicular Transport - genetics | Hepacivirus - genetics | Hepatocytes - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Host-Pathogen Interactions - immunology | Hepatitis C - immunology | Flow Cytometry | RNA, Viral - genetics | Gene Expression - immunology | Adaptor Proteins, Signal Transducing - immunology | Hepacivirus - physiology | Poly I-C - immunology | RNA, Viral - metabolism | DEAD-box RNA Helicases - metabolism | Dendritic Cells - virology | Cytokines - genetics | Dendritic Cells - metabolism | Cytokines - immunology | Cell Line | DEAD Box Protein 58 | Poly I-C - pharmacology | Cytokines - metabolism | Mice, Inbred C57BL | Cells, Cultured | Hepatitis C - genetics | Adaptor Proteins, Vesicular Transport - immunology | Hepatocytes - immunology | Reverse Transcriptase Polymerase Chain Reaction | CD8 Antigens - immunology | Mice, Knockout | DEAD-box RNA Helicases - genetics | CD8 Antigens - metabolism | Animals | Adaptor Proteins, Signal Transducing - genetics | DEAD-box RNA Helicases - immunology | Hepatocytes - virology | RNA, Viral - immunology | Mice | Adaptor Proteins, Signal Transducing - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Hepatology, ISSN 0270-9139, 03/2014, Volume 59, Issue 3, pp. 828 - 838
Journal Article
Blood, ISSN 0006-4971, 11/2012, Volume 120, Issue 23, pp. 4544 - 4551
The elimination of hepatitis C virus (HCV) in > 50% of chronically infected patients by treatment with IFN-alpha suggests that plasmacytoid dendritic cells... 
TARGET | PLUS RIBAVIRIN | HEPATITIS-C VIRUS | ALPHA PRODUCTION | INTERFERON-PRODUCING CELLS | TLR9-MEDIATED ACTIVATION | HUMAN BLOOD | INFECTION | TYPE-1 | HEMATOLOGY | CULTURE | Phosphorylation | Membrane Glycoproteins - metabolism | Hepacivirus - immunology | Dendritic Cells - immunology | Humans | Lectins, C-Type - immunology | Cercopithecus aethiops | Extracellular Signal-Regulated MAP Kinases - metabolism | Interferons - immunology | Lectins, C-Type - genetics | Extracellular Signal-Regulated MAP Kinases - immunology | Hepacivirus - metabolism | Host-Pathogen Interactions - immunology | Lectins, C-Type - metabolism | Flow Cytometry | Toll-Like Receptor 7 - immunology | Viral Envelope Proteins - metabolism | Hepacivirus - physiology | Liver Neoplasms - pathology | Carcinoma, Hepatocellular - immunology | Membrane Glycoproteins - immunology | Receptors, Immunologic - immunology | Dendritic Cells - virology | Proto-Oncogene Proteins c-akt - metabolism | Dendritic Cells - metabolism | Liver Neoplasms - virology | Toll-Like Receptor 7 - metabolism | Cells, Cultured | Liver Neoplasms - immunology | Carcinoma, Hepatocellular - virology | Membrane Glycoproteins - genetics | Animals | Proto-Oncogene Proteins c-akt - immunology | Carcinoma, Hepatocellular - pathology | Cell Line, Tumor | Interferons - metabolism | Protein Binding | Ligands | Viral Envelope Proteins - immunology | Receptors, Immunologic - genetics | COS Cells | Receptors, Immunologic - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Cytokine, ISSN 1043-4666, 10/2012, Volume 60, Issue 1, pp. 138 - 142
► A decrease in the IL-I7F/IL-22 ratio is observed in chronic hepatitis C. ► IL-17F serum levels are increased in HCV patients with high ALT levels. ► Serum... 
Liver histology | Hepatitis C | Th17 | Viral load | Cytokine | Hepatitis c | CELLS | TGF-BETA | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIVER FIBROSIS | INTERLEUKIN-22 | IMMUNOLOGY | MIXED CRYOGLOBULINEMIA | CELL BIOLOGY | INHIBITION | BIOLOGY | GROWTH | Liver - virology | Liver - pathology | Hepacivirus - immunology | Humans | Middle Aged | Interleukin-17 - immunology | Hepatitis C, Chronic - virology | Male | Alanine Transaminase - blood | Viral Load | Host-Pathogen Interactions - immunology | Liver - immunology | Th17 Cells - metabolism | Interleukin-6 - blood | Interleukins - immunology | Adult | Female | Hepacivirus - physiology | Interleukin-8 - blood | Alanine Transaminase - immunology | Granulocyte-Macrophage Colony-Stimulating Factor - blood | Cytokines - blood | Cytokines - immunology | Interleukin-17 - blood | Transforming Growth Factor beta - immunology | Enzyme-Linked Immunosorbent Assay | Interleukins - blood | Hepatitis C, Chronic - blood | Transforming Growth Factor beta - blood | Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Hepatitis C, Chronic - immunology | Interleukin-6 - immunology | Th17 Cells - immunology | Aged | Interleukin-8 - immunology | Virus diseases | Interleukins | Hepatitis C virus | Health aspects | Index Medicus | Immune response | Granulocyte-macrophage colony-stimulating factor | Viremia | Liver | Helper cells | Chronic infection | Interleukin 22 | Lymphocytes T | Interleukin 6 | Serum levels | Lymphocytes | Enzyme-linked immunosorbent assay | Injuries | Interleukin 8
Journal Article