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Journal of virology, ISSN 1098-5514, 2018, Volume 92, Issue 10, pp. e01982 - 17
Hepatitis C virus (HCV) infection causes 500,000 deaths annually, in association with end-stage liver diseases. Investigations of the HCV life cycle have... 
PROTEIN-KINASE-A | piperazinylbenzenesulfonamide | RNA REPLICATION | CD81 | PHOSPHORYLATION | MAP KINASE | SEROTONIN RECEPTORS | virus-host interaction | VIROLOGY | CELL-CULTURE SYSTEMS | tight junction protein | SIGNALING PATHWAY | IN-VIVO | hepatitis C virus | virus entry | INFECTION | protein kinase A | Cyclic AMP-Dependent Protein Kinases - metabolism | Tight Junctions - metabolism | Receptors, G-Protein-Coupled - metabolism | Humans | Protein Transport - drug effects | Sulfonamides - pharmacology | Virus Internalization - drug effects | Piperazines - pharmacology | Receptors, Serotonin - metabolism | Isoquinolines - pharmacology | Claudin-1 - metabolism | Cell Line, Tumor | Hepatocytes - virology | Tetraspanin 28 - metabolism | Hepacivirus - physiology | Protein Kinase Inhibitors - pharmacology | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Hepatocytes/virology | Protein Transport/drug effects | Cyclic AMP-Dependent Protein Kinases/metabolism | Claudin-1/metabolism | Cellular Biology | Life Sciences | Tight Junctions/metabolism | Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors | Isoquinolines/pharmacology | Tetraspanin 28/metabolism | Virus Internalization/drug effects | Pharmaceutical sciences | Hépatology and Gastroenterology | Receptors, Serotonin/metabolism | Piperazines/pharmacology | Pharmacology | Hepacivirus/physiology | Virology | Microbiology and Parasitology | Human health and pathology | Sulfonamides/pharmacology | Infectious diseases | Receptors, G-Protein-Coupled/metabolism | Protein Kinase Inhibitors/pharmacology
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2016, Volume 291, Issue 7, pp. 3254 - 3267
Hepatitis C virus (HCV) relies on host lipids and lipid droplets for replication and morphogenesis. The accumulation of lipid droplets in infected hepatocytes... 
TARGET | liver injury | OXIDATIVE STRESS | SREBP | hepatitis virus | CHOLESTEROL | INTERLEUKIN-1-BETA | BIOCHEMISTRY & MOLECULAR BIOLOGY | lipid metabolism | NLRP3 inflammasome | DROPLETS | inflammation | PATHWAY | inflammasome | FATTY-ACID | CASPASES | INFECTION | EXPRESSION | Hepatitis C, Chronic - pathology | Inflammasomes - metabolism | Cytoskeletal Proteins - antagonists & inhibitors | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Golgi Apparatus - drug effects | Humans | Hepatitis C, Chronic - virology | Non-alcoholic Fatty Liver Disease - etiology | Caspase 1 - metabolism | Host-Pathogen Interactions - drug effects | Intracellular Signaling Peptides and Proteins - metabolism | Protein Transport - drug effects | Sterol Regulatory Element Binding Protein 1 - agonists | RNA Interference | Hepacivirus - physiology | Sterol Regulatory Element Binding Protein 2 - metabolism | Endopeptidases - metabolism | Carrier Proteins - antagonists & inhibitors | Serine Endopeptidases - chemistry | Cysteine Proteinase Inhibitors - pharmacology | Cell Line, Tumor | Hepatocytes - virology | Sterol Regulatory Element Binding Protein 2 - agonists | Hepatitis C, Chronic - metabolism | Hepatitis C, Chronic - physiopathology | Hepatocytes - pathology | Golgi Apparatus - pathology | Hepatocytes - metabolism | Golgi Apparatus - virology | Caspase 1 - chemistry | Proteolysis - drug effects | Endopeptidases - chemistry | Inflammasomes - drug effects | Enzyme Induction - drug effects | Cytoskeletal Proteins - metabolism | Membrane Proteins - metabolism | Hepatocytes - drug effects | Sterol Regulatory Element Binding Protein 1 - metabolism | Hepacivirus - drug effects | Proprotein Convertases - metabolism | Proprotein Convertases - chemistry | Carrier Proteins - genetics | Carrier Proteins - metabolism | Caspase 1 - genetics | CARD Signaling Adaptor Proteins | Lipogenesis - drug effects | Golgi Apparatus - metabolism | Serine Endopeptidases - metabolism | Microbiology
Journal Article
PLoS pathogens, ISSN 1553-7374, 2013, Volume 9, Issue 4, p. e1003248
Upon recognition of viral components by pattern recognition receptors, such as the toll-like receptors (TLRs) and retinoic acid-inducible gene I (RIG-I)-like... 
RNA REPLICATION | HEPATITIS-C-VIRUS | MICROBIOLOGY | PROTEIN-SYNTHESIS | ALPHA-INTERFERON | I INTERFERON | VIROLOGY | SIGNALING PATHWAY | GENE-EXPRESSION | CYCLOOXYGENASE-2 EXPRESSION | NF-KAPPA-B | DEPENDENT ACTIVATION | PARASITOLOGY | Interleukin-1 Receptor-Associated Kinases - metabolism | RNA Helicases - metabolism | Up-Regulation | Phosphorylation | Interleukin-1 Receptor-Associated Kinases - genetics | Hepacivirus - immunology | Humans | Adaptor Proteins, Vesicular Transport - genetics | Hepacivirus - genetics | Hepacivirus - pathogenicity | JNK Mitogen-Activated Protein Kinases - metabolism | MicroRNAs - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Interferon Regulatory Factor-3 - genetics | MAP Kinase Signaling System | Hepatitis C - immunology | RNA Interference | Protein Kinase C - metabolism | HEK293 Cells | Interferon-alpha - metabolism | Toll-Like Receptor 7 - metabolism | Interferon-alpha - biosynthesis | Myeloid Differentiation Factor 88 - genetics | Proto-Oncogene Proteins c-fos - metabolism | MicroRNAs - immunology | Immune Evasion | Cell Line, Tumor | Viral Nonstructural Proteins - metabolism | MicroRNAs - genetics | RNA, Small Interfering | Serine Endopeptidases - metabolism | Myeloid Differentiation Factor 88 - metabolism | Virus diseases | Immune response | MicroRNA | Cellular control mechanisms | Research | Observations | Hepatitis C virus | Properties | Testing | Proteins | Hepatitis | Kinases | Viral infections | Immune system
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2014, Volume 9, Issue 4, p. e94460
.... It enabled us to analyze metabolism in the HCV-infected cells integrally combining metabolomics and expression arrays... 
HEPATOCELLULAR-CARCINOMA | HEPATOCYTES | LIPID DROPLET | NRF2 | RNA REPLICATION | TRANSPORTERS | MEMBRANE | MULTIDISCIPLINARY SCIENCES | SECRETION | CORE PROTEIN | CANCER | Metabolomics | Transcriptional Activation - genetics | Hepatitis C - metabolism | Humans | Desmosterol - metabolism | Viral Proteins - metabolism | Gene Knockdown Techniques | Amino Acids - metabolism | Culture Media | Hepacivirus - physiology | Transcription, Genetic | Clone Cells | NADP - metabolism | Lipid Droplets - metabolism | Fatty Acids - metabolism | Cell Line | Fatty Liver - metabolism | Biosynthetic Pathways | Cholesterol - metabolism | Nucleotides - metabolism | Triglycerides - metabolism | Intracellular Space - metabolism | NF-E2-Related Factor 2 - metabolism | Hepatitis C - virology | Hepatitis C - pathology | Phosphates | Glucose metabolism | Distribution | Physiological aspects | Genetic aspects | Hepatitis C virus | Fatty acids | Tricarboxylic acid cycle | Downstream effects | Liver | Genes | Amino acids | Viruses | Biology | Infections | Biochemistry | Biosynthesis | Cancer therapies | Proteins | Hepatitis | Liver cancer | Glucose 6 phosphate dehydrogenase | Glucose dehydrogenase | Metabolites | Pentose | Hepatology | Gastroenterology | NADP | Drug therapy | Glucosephosphate dehydrogenase | Pentose phosphate | Enzymes | Internal medicine | Metabolism | Gene expression | Cholesterol | Constraining | Steatosis | Medicine | Infectious diseases | Pharmacy | Pentose phosphate pathway | Glycolysis | Hepatitis C | Liver cirrhosis | Apoptosis
Journal Article
Journal Article
World Journal of Gastroenterology, ISSN 1007-9327, 01/2016, Volume 22, Issue 4, pp. 1461 - 1476
Journal Article
Cell (Cambridge), ISSN 0092-8674, 2014, Volume 159, Issue 5, pp. 1086 - 1095
Journal Article
Journal of Virology, ISSN 0022-538X, 09/2008, Volume 82, Issue 17, pp. 8838 - 8848
Journal Article
Hepatology (Baltimore, Md.), ISSN 0270-9139, 2012, Volume 56, Issue 6, pp. 2060 - 2070
Journal Article