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Nature, ISSN 0028-0836, 07/2012, Volume 487, Issue 7408, pp. 505 - 509
Mutationally activated kinases define a clinically validated class of targets for cancer drug therapy(1). However, the efficacy of kinase inhibitors in... 
CELL LUNG-CANCER | SURVIVAL | HETEROGENEITY | ACTIVATION | RECEPTOR TYROSINE KINASES | THERAPY | MET AMPLIFICATION | MULTIDISCIPLINARY SCIENCES | ACQUIRED-RESISTANCE | SENSITIVITY | TUMOR-CELLS | Receptor, ErbB-2 - genetics | Humans | Receptor, ErbB-2 - metabolism | Melanoma - enzymology | Phosphatidylinositol 3-Kinases - metabolism | Hepatocyte Growth Factor - pharmacology | Breast Neoplasms - metabolism | Melanoma - genetics | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cell Survival - drug effects | Melanoma - pathology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Breast Neoplasms - drug therapy | Hepatocyte Growth Factor - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Breast Neoplasms - genetics | Signal Transduction - drug effects | Breast Neoplasms - pathology | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Line, Tumor | Ligands | Protein Kinase Inhibitors - pharmacology | Quinazolines - pharmacology | Drug Resistance, Neoplasm - drug effects | Mitogen-Activated Protein Kinases - metabolism | Antimitotic agents | Physiological aspects | Antineoplastic agents | Growth factors | Health aspects | Phosphotransferases | Substance abuse treatment | Epidermal growth factor | Rodents | Biomarkers | Breast cancer | Insulin-like growth factors | Kinases | Drug resistance | Tumors | Index Medicus
Journal Article
Journal Article
Nature Neuroscience, ISSN 1097-6256, 06/2012, Volume 15, Issue 6, pp. 862 - 870
Journal Article
CELL DEATH & DISEASE, ISSN 2041-4889, 12/2017, Volume 8, Issue 12, pp. 1 - 13
Multiple target inhibition has gained considerable interest in combating drug resistance in glioblastoma, however, understanding the molecular mechanisms of... 
CELL BIOLOGY | Phosphorylation | Hepatocyte growth factor | Transforming growth factor | Glioblastoma | Extracellular signal-regulated kinase | MAP kinase | AKT protein | Gene expression | Drug resistance | Kinases | 1-Phosphatidylinositol 3-kinase | c-Met protein | Signal transduction | Molecular modelling | Glioma cells | Stem cells | Growth factors | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, pp. e92248 - e92248
Three-dimensional (3D) cell culture is gaining acceptance in response to the need for cellular models that better mimic physiologic tissues. Spheroids are one... 
CANCER-CELLS | CARCINOMA-CELLS | CROSS-TALK | GROWTH-FACTOR RECEPTOR | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | ERLOTINIB RESISTANCE | C-MET ANTIBODY | MULTICELLULAR SPHEROIDS | KINASE INHIBITORS | ANTICANCER DRUGS | Proto-Oncogene Proteins c-met - metabolism | Lung Neoplasms - drug therapy | Humans | Spheroids, Cellular - pathology | Lung Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Hepatocyte Growth Factor - pharmacology | Cell Culture Techniques - methods | Receptor, Epidermal Growth Factor - metabolism | Antineoplastic Agents - pharmacology | Spheroids, Cellular - drug effects | Phosphorylation - drug effects | Tumor Cells, Cultured | Tumor Microenvironment - drug effects | Cell Survival - drug effects | Reproducibility of Results | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Treatment Outcome | Drug Discovery | Cell Movement - drug effects | Protein Kinase Inhibitors - therapeutic use | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Ligands | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Epidermal Growth Factor - pharmacology | Epidermal growth factor | Health aspects | Lung cancer | Tumors | Monomolecular films | Cell proliferation | Drugs | Self assembly | Cell culture | Flow cytometry | Biotechnology | Phosphorylation | Lung | Systematic review | Drug development | Kinases | Tissues | Pharmaceutical industry | Growth factors | Epidermal growth factor receptors | Hepatocyte growth factor | Research & development--R&D | Tumor cells | Cultures | Pharmacology | Tumor cell lines | Chemical compounds | Spheroids | Studies | Cytometry | Self-assembly | Inhibitors | Monolayers | Mutation | Three dimensional models | Cell migration | Index Medicus | Research & development | R&D
Journal Article
Cancer Research, ISSN 0008-5472, 10/2009, Volume 69, Issue 20, pp. 8009 - 8016
The Met receptor tyrosine kinase and its ligand, hepatocyte growth factor (HGF), are overexpressed and/or activated in a wide variety of human malignancies.... 
CARCINOMA-CELLS | LUNG-CANCER | ONCOLOGY | GASTRIC-CANCER | FACTOR SCATTER FACTOR | COLORECTAL-CANCER | IN-VIVO | PROGNOSTIC-SIGNIFICANCE | MONOCLONAL-ANTIBODIES | C-MET EXPRESSION | SOMATIC MUTATIONS | Endothelium, Vascular - cytology | Proto-Oncogene Proteins c-met - metabolism | Lung Neoplasms - drug therapy | Apoptosis - drug effects | Humans | Endothelium, Vascular - drug effects | Hepatocyte Growth Factor - pharmacology | Quinolines - pharmacology | Dermis - drug effects | Neoplasms, Experimental - pathology | Receptors, Vascular Endothelial Growth Factor - metabolism | Lung Neoplasms - secondary | Umbilical Veins - drug effects | Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors | Female | Neovascularization, Pathologic - prevention & control | Phosphorylation - drug effects | Dermis - cytology | Umbilical Veins - cytology | Fibroblasts - metabolism | Lung Neoplasms - blood supply | Dermis - metabolism | Enzyme-Linked Immunosorbent Assay | Neoplasm Invasiveness | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Cells, Cultured | Cell Adhesion - drug effects | Blotting, Western | Cell Movement - drug effects | Animals | Endothelium, Vascular - metabolism | Mice, Nude | Fibroblasts - drug effects | Anilides - pharmacology | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Protein Kinase Inhibitors - pharmacology | Neoplasms, Experimental - drug therapy | Neoplasms, Experimental - blood supply | Umbilical Veins - metabolism | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 08/2013, Volume 110, Issue 32, pp. E2987 - E2996
Binding of hepatocyte growth factor (HGF) to the receptor tyrosine kinase MET is implicated in the malignant process of multiple cancers, making disruption of... 
MetMAb | HGFR | OA5D5 | Scatter factor | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | HEPATOCYTE GROWTH-FACTOR | PHARMACOKINETIC PK | DOSE-ESCALATION | SINGLE-AGENT | scatter factor | C-MET | BINDING-SITE | RECEPTOR MET | MONOCLONAL-ANTIBODIES | Proto-Oncogene Proteins c-met - metabolism | Humans | Molecular Sequence Data | Crystallography, X-Ray | Hepatocyte Growth Factor - pharmacology | Antibodies, Monoclonal, Humanized - genetics | Antibodies, Monoclonal, Humanized - pharmacology | Protein Binding - drug effects | Drug Design | Antineoplastic Agents - pharmacology | Hepatocyte Growth Factor - chemistry | Antibodies, Monoclonal - chemistry | Protein Structure, Tertiary | Amino Acid Sequence | Immunoglobulin Fab Fragments - genetics | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Antibodies, Monoclonal - pharmacology | Models, Molecular | Mice, Transgenic | Antineoplastic Agents - chemistry | Mice, SCID | Immunoglobulin Fab Fragments - pharmacology | Mice, Inbred C3H | Hepatocyte Growth Factor - metabolism | Neoplasms - drug therapy | Sequence Homology, Amino Acid | Xenograft Model Antitumor Assays | Antibodies, Monoclonal - genetics | Animals | Mice, Nude | Immunoglobulin Fab Fragments - chemistry | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Antibodies, Monoclonal - metabolism | Proto-Oncogene Proteins c-met - chemistry | Neoplasms - pathology | Antibodies, Monoclonal, Humanized - chemistry | Prescription drugs | Antigens | Phosphorylation | Monoclonal antibodies | Biochemistry | Binding sites | Tumors | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 02/2014, Volume 445, Issue 1, pp. 16 - 22
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 04/2011, Volume 17, Issue 8, pp. 2260 - 2269
Journal Article
Gastroenterology, ISSN 0016-5085, 2009, Volume 136, Issue 3, pp. 990 - 999.e4
Journal Article