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1. Full Text Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b
by Kornfeld, Jan-Wilhelm and Baitzel, Catherina and Könner, A. Christine and Nicholls, Hayley T and Vogt, Merly C and Herrmanns, Karolin and Scheja, Ludger and Haumaitre, Cécile and Wolf, Anna M and Knippschild, Uwe and Seibler, Jost and Cereghini, Silvia and Heeren, Joerg and Stoffel, Markus and Brüning, Jens C
Nature, ISSN 0028-0836, 02/2013, Volume 494, Issue 7435, pp. 111 - 115
Insulin resistance represents a hallmark during the development of type 2 diabetes mellitus and in the pathogenesis of obesity-associated disturbances of... 
CDKN2A/B | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | CDKAL1 | MUTATIONS | PROTEINS | TCF2 | HEPATOCYTE NUCLEAR FACTOR-1-BETA | Glucose Intolerance - metabolism | Glucose Intolerance - genetics | Signal Transduction | Humans | Liver - metabolism | Gene Expression Regulation | Gene Silencing | Hepatocyte Nuclear Factor 1-beta - deficiency | MicroRNAs - biosynthesis | Glucose - biosynthesis | Obesity - genetics | Insulin - metabolism | Animals | Insulin Resistance - genetics | Glucose - metabolism | Mice | MicroRNAs - genetics | Hepatocyte Nuclear Factor 1-beta - genetics | Gluconeogenesis | Hepatocyte Nuclear Factor 1-beta - metabolism | Glucose metabolism | Obesity | Gene silencing | MicroRNA | Physiological aspects | Development and progression | Genetic aspects | Research | Gene expression | Health aspects | Rodents | Insulin resistance | Diabetes | Glucose | Metabolism | Insulin | Life Sciences | Development Biology
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2. Full Text MicroRNA-375 is induced in cisplatin nephrotoxicity to repress hepatocyte nuclear factor 1-β
by Hao, Jielu and Lou, Qiang and Wei, Qingqing and Mei, Shuqin and Li, Lin and Wu, Guangyu and Mi, Qing-Sheng and Mei, Changlin and Dong, Zheng
Journal of Biological Chemistry, ISSN 0021-9258, 03/2017, Volume 292, Issue 11, pp. 4571 - 4582
Nephrotoxicity is a major adverse effect of cisplatin-mediated chemotherapy in cancer patients. The pathogenesis of cisplatininduced nephrotoxicity remains... 
TRANSCRIPTION FACTORS | ACUTE KIDNEY INJURY | DISEASES | ROLES | BIOCHEMISTRY & MOLECULAR BIOLOGY | TARGETS | MECHANISMS | CELL APOPTOSIS | NF-KAPPA-B | CANCER | P53 | Gene Expression Regulation - drug effects | Kidney - metabolism | Animals | Cisplatin - toxicity | Kidney - drug effects | Ribonuclease III - genetics | Apoptosis - drug effects | Mice | MicroRNAs - genetics | Hepatocyte Nuclear Factor 1-beta - genetics | Antineoplastic Agents - toxicity | Mice, Knockout | Molecular Bases of Disease | kidney | NF-κB | microRNA (miRNA) | nephrotoxicity | gene regulation | apoptosis | cisplatin
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3. Full Text Hepatocyte nuclear factor 1β-associated kidney disease: More than renal cysts and diabetes
by Verhave, Jacobien C and Bech, Anneke P and Wetzels, Jack F.M and Nijenhuis, Tom
Journal of the American Society of Nephrology, ISSN 1046-6673, 02/2016, Volume 27, Issue 2, pp. 345 - 353
Hepatocyte nuclear factor 1 beta (HNF1 beta) associated disease is a recently recognized clinical entity with a variable multisystem phenotype. Early reports... 
HEPATOCELLULAR-CARCINOMA | FACTOR 1-BETA | URINARY-TRACT | HNF1B MUTATIONS | UROLOGY & NEPHROLOGY | FRAMESHIFT MUTATION | FACTOR-I | CONGENITAL-ANOMALIES | CELL CARCINOMA | HNF1-BETA MUTATIONS | FACTOR-1-BETA GENE | Renal Insufficiency, Chronic - etiology | Diabetic Nephropathies - etiology | Hepatocyte Nuclear Factor 1-beta - physiology | Humans | Middle Aged | Diabetic Nephropathies - genetics | Male | Kidney Diseases, Cystic - etiology | Young Adult | Phenotype | Renal Insufficiency, Chronic - genetics | Adult | Female | Mutation | Hepatocyte Nuclear Factor 1-beta - genetics | Up Front Matters | clinical nephrology | diabetes mellitus | cystic kidney | electrolytes | CKD | genetic renal disease
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4. Full Text Pancreatic Exocrine Duct Cells Give Rise to Insulin-Producing β Cells during Embryogenesis but Not after Birth
by Solar, Myriam and Cardalda, Carina and Houbracken, Isabelle and Martín, Mercè and Maestro, Miguel Angel and De Medts, Nele and Xu, Xiaobo and Grau, Vanessa and Heimberg, Harry and Bouwens, Luc and Ferrer, Jorge
Developmental Cell, ISSN 1534-5807, 2009, Volume 17, Issue 6, pp. 849 - 860
A longstanding unsettled question is whether pancreatic β cells originate from exocrine duct cells. We have now used genetic labeling to fate map embryonic and... 
STEMCELL | HUMDISEASE | DEVBIO | PROGENITOR CELLS | ENDOCRINE PANCREAS | NOD MICE | MOUSE PANCREAS | COMBINATION THERAPY | EPIDERMAL-GROWTH-FACTOR | IN-VIVO | ISLET REGENERATION | EMBRYONIC PANCREAS | ADULT-RATS | DEVELOPMENTAL BIOLOGY | CELL BIOLOGY | Animals | Mice, Inbred C57BL | Pancreas - cytology | Female | Male | Mice, Transgenic | Insulin-Secreting Cells - cytology | Mice | Pancreas, Exocrine - embryology | Pancreas - embryology | Hepatocyte Nuclear Factor 1-beta - genetics | Hepatocyte Nuclear Factor 1-beta - metabolism
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5. Full Text HNF1B-associated renal and extra-renal disease - An expanding clinical spectrum
by Clissold, Rhian L and Hamilton, Alexander J and Hattersley, Andrew T and Ellard, Sian and Bingham, Coralie
Nature Reviews Nephrology, ISSN 1759-5061, 02/2015, Volume 11, Issue 2, pp. 102 - 112
Heterozygous mutations in the gene that encodes the transcription factor hepatocyte nuclear factor 1β (HNF1B) represent the most common known monogenic cause... 
Phenotype | Hepatocyte Nuclear Factor 1-beta - physiology | Humans | Kidney Diseases - etiology | Mutation | Hepatocyte Nuclear Factor 1-beta - genetics | Kidney Diseases - genetics | FACTOR-I-BETA | YOUNG TYPE 5 | GLOMERULOCYSTIC KIDNEY-DISEASE | PROSTATE-CANCER RISK | GENE MUTATION | DIABETES SYNDROME | PRUNE-BELLY-SYNDROME | HEPATOCYTE NUCLEAR FACTOR-1-BETA | CLINICAL NEUROLOGY | GENOME-WIDE ASSOCIATION | HYPERECHOGENIC KIDNEYS | Physiological aspects | Development and progression | Transcription factors | Genetic aspects | Kidney diseases | Research
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6. Full Text Response to Comment on Dubois-Laforgue et al. Diabetes, Associated Clinical Spectrum, Long-term Prognosis, and Genotype/Phenotype Correlations in 201 Adult Patients With Hepatocyte Nuclear Factor 1B ( HNF1B ) Molecular Defects. Diabetes Care 2017;40:1436-1443
by Dubois-Laforgue, Danièle and Cornu, Erika and Saint-Martin, Cécile and Coste, Joël and Bellanné-Chantelot, Christine and Timsit, José
Diabetes care, ISSN 0149-5992, 01/2018, Volume 41, Issue 1, pp. e8 - e9
Phenotype | Prognosis | Genetic Association Studies | Humans | Adult | Genotype | Diabetes Mellitus, Type 2 | Mutation | Hepatocyte Nuclear Factor 1-beta - genetics
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7. Full Text Transcription factor hepatocyte nuclear factor-1β (HNF-1β) regulates microRNA-200 expression through a long noncoding RNA
by Hajarnis, Sachin S and Patel, Vishal and Aboudehen, Karam and Attanasio, Massimo and Cobo-Stark, Patricia and Pontoglio, Marco and Igarashi, Peter
Journal of Biological Chemistry, ISSN 0021-9258, 10/2015, Volume 290, Issue 41, pp. 24793 - 24805
The transcription factor hepatocyte nuclear factor-1 beta (HNF-1 beta) regulates tissue-specific gene expression in the kidney and other epithelial organs.... 
EPITHELIAL-MESENCHYMAL TRANSITION | HUMAN GENOME | RENAL CYSTS | DNA METHYLATION | GENE | POLYCYSTIC KIDNEY-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TISSUE-SPECIFIC EXPRESSION | MIR-200 FAMILY | PKD1 | FUNCTIONAL POLYCYSTIN-1 | Epithelial Cells - metabolism | Genomics | Humans | Gene Expression Regulation | Repressor Proteins - genetics | Hepatocyte Nuclear Factor 1-beta - deficiency | Kidney - cytology | RNA, Long Noncoding - genetics | Gene Knockout Techniques | Zinc Finger E-box Binding Homeobox 2 | Homeodomain Proteins - genetics | TRPP Cation Channels - genetics | Animals | Base Sequence | Mice | MicroRNAs - genetics | HeLa Cells | Mutation | Hepatocyte Nuclear Factor 1-beta - genetics | Hepatocyte Nuclear Factor 1-beta - metabolism | Molecular Bases of Disease | epithelial-mesenchymal transition (EMT) | kidney | transcription regulation | long noncoding RNA (long ncRNA, lncRNA) | microRNA (miRNA) | hepatocyte nuclear factor 1 (HNF-1) | ChIP-sequencing (ChIP-seq)
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8. Full Text Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes
by Gudmundsson, J and Sulem, P and Steinthorsdottir, V and Bergthorsson, J.T and Thorleifsson, G and Manolescu, A and Rafnar, T and Gudbjartsson, D.F and Agnarsson, B.A and Baker, A and Sigurdsson, A and Benediktsdottir, K.R and Jakobsdottir, M and Blondal, T and Stacey, S.N and Helgason, A and Gunnarsdottir, S and Olafsdottir, A and Kristinsson, K.T and Birgisdottir, B and Ghosh, S and Thorlacius, S and Magnusdottir, D and Stefansdottir, G and Kristjansson, K and Bagger, Y and Wilensky, R.L and Reilly, M.P and Morris, A.D and Kimber, C.H and Adeyemo, A and Chen, Y and Zhou, J and So, W.Y and Tong, P.C and Ng, M.C and Hansen, T and Andersen, G and Borch-Johnsen, K and Jorgensen, T and Tres, A and Fuertes, F and Ruiz-Echarri, M and Asin, L and Saez, B and Boven, E. van and Klaver, S and Swinkels, D.W and Aben, K.K.H and Graif, T and Cashy, J and Suarez, B.K and Vierssen Trip, O. van and Frigge, M.L and Ober, C and Hofker, M.H and Wijmenga, C and Christiansen, C and Rader, D.J and Palmer, C.N and Rotimi, C and Chan, J.C and Pedersen, O and Sigurdsson, G and Benediktsson, R and Jonsson, E and Einarsson, G.V and Mayordomo, J.I and Catalona, W.J and Kiemeney, L.A.L.M and Barkardottir, R.B and Gulcher, J.R and Thorsteinsdottir, U and Kong, A and Stefansson, K
Nature Genetics, ISSN 1061-4036, 2007, Volume 39, Issue 8, pp. 977 - 983
We performed a genome-wide association scan to search for sequence variants conferring risk of prostate cancer using 1,501 Icelandic men with prostate cancer... 
GENETICS | FAMILIES | GENES | GENETICS & HEREDITY | UNCOMMON | MUTATIONS | BRCA1 | SCAN | LINKAGE | ASSOCIATION | HEPATOCYTE NUCLEAR FACTOR-1-BETA | Haplotypes | Genetic Predisposition to Disease | Prostatic Neoplasms - genetics | Chromosomes, Human, Pair 17 | Diabetes Mellitus, Type 2 - genetics | Humans | Male | Polymorphism, Single Nucleotide | Case-Control Studies | Hepatocyte Nuclear Factor 1-beta - genetics | Type 2 diabetes | Genetic variation | Physiological aspects | Genetic aspects | Research | Diagnosis | Prostate cancer | Risk factors | Mutation | Population genetics | Genomics
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9. Full Text Genome-wide association study identifies a common variant associated with risk of endometrial cancer
by Spurdle, Amanda B and Thompson, Deborah J and Ahmed, Shahana and Ferguson, Kaltin and Healey, Catherine S and O'Mara, Tracy and Walker, Logan C and Montgomery, Stephen B and Dermitzakis, Emmanouil T and Fahey, Paul and Montgomery, Grant W and Webb, Penelope M and Fasching, Peter A and Beckmann, Matthias W and Ekici, Arif B and Hein, Alexander and Lambrechts, Diether and Coenegrachts, Lieve and Vergote, Ignace and Amant, Frederic and Salvesen, Helga B and Trovik, Jone and Njolstad, Tormund S and Helland, Harald and Scott, Rodney J and Ashton, Katie and Proietto, Tony and Otton, Geoffrey and Tomlinson, Ian and Gorman, Maggie and Howarth, Kimberley and Hodgson, Shirley and Garcia-Closas, Montserrat and Wentzensen, Nicolas and Yang, Hannah and Chanock, Stephen and Hall, Per and Czene, Kamila and Liu, Jianjun and Li, Jingmei and Shu, Xiao-Ou and Zheng, Wei and Long, Jirong and Xiang, Yong-Bing and Shah, Mitul and Morrison, Jonathan and Michailidou, Kyriaki and Pharoah, Paul D and Dunning, Alison M and Easton, Douglas F and Australian Natl Endometrial Canc and Natl Study Endometrial Canc Geneti and Australian National Endometrial Cancer Study Group and National Study of Endometrial Cancer Genetics Group and The Australian National Endometrial Cancer Study Group
Nature Genetics, ISSN 1061-4036, 05/2011, Volume 43, Issue 5, pp. 451 - 455
Endometrial cancer is the most common malignancy of the female genital tract in developed countries. To identify genetic variants associated with endometrial... 
DIABETES-MELLITUS | METAANALYSIS | REPLICATION | PROSTATE-CANCER | GENETICS & HEREDITY | FACTOR-1-BETA | CLEAR-CELL CARCINOMA | EXPRESSION | YOUNGER | FAMILY | AGE | Genetic Predisposition to Disease | Genome-Wide Association Study | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | Risk Factors | Male | Case-Control Studies | Genetic Variation | Young Adult | Prostatic Neoplasms - genetics | Endometrial Neoplasms - genetics | Adolescent | Aged, 80 and over | Adult | Female | Aged | Polymorphism, Single Nucleotide | Odds Ratio | Hepatocyte Nuclear Factor 1-beta - genetics | Disease susceptibility | Genetic aspects | Single nucleotide polymorphisms | Research | Endometrial cancer | Risk factors | Studies | Medical research | Genetics | Breast cancer
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10. Full Text Hepatocyte Nuclear Factor-1 beta Controls Mitochondrial Respiration in Renal Tubular Cells
by Casemayou, A and Fournel, A and Bagattin, A and Schanstra, J and Belliere, J and Decramer, S and Marsal, D and Gillet, M and Chassaing, N and Huart, A and Pontoglio, M and Knauf, C and Bascands, JL and Chauveau, D and Faguer, S
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, ISSN 1046-6673, 11/2017, Volume 28, Issue 11, pp. 3204 - 3216
AKI is a frequent condition that involves renalmicrocirculation impairment, infiltration of inflammatory cells with local production of proinflammatory... 
ACUTE KIDNEY INJURY | GENE | METABOLISM | FANCONI SYNDROME | DISEASE | TRANSCRIPTION | UROLOGY & NEPHROLOGY | HNF1B | DYSFUNCTION | MUTATIONS | SEPSIS | Animals | Hepatocyte Nuclear Factor 1-beta - physiology | Humans | Mice, Inbred C57BL | Hepatocyte Nuclear Factor 1-beta - antagonists & inhibitors | Kidney Tubules, Proximal - metabolism | Adult | Mitochondria - metabolism | Acute Kidney Injury - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - physiology | Acute Kidney Injury - etiology | Hepatocyte Nuclear Factor 1-beta - genetics | acute kidney injury | PPARGC1A | mitochondria | Basic Research
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11. Full Text Diabetes, associated clinical spectrum, long-term prognosis, and genotype/phenotype correlations in 201 adult patients with hepatocyte nuclear factor 1B (HNF1B) molecular defects
by Dubois-Laforgue, Danièle and Cornu, Erika and Saint-Martin, Cécile and Coste, Joël and Bellanné-Chantelot, Christine and Timsit, José and Soc Francophone Diabet and Monogenic Diabetes Study Group of the Société Francophone du Diabète
Diabetes Care, ISSN 0149-5992, 11/2017, Volume 40, Issue 11, pp. 1436 - 1443
OBJECTIVE Molecular defects of hepatocyte nuclear factor 1B (HNF1B) are associated with a multiorgan disease, including diabetes (maturity-onset diabetes of... 
KIDNEY-DISEASE | DIAGNOSIS | RENAL CYSTS | YOUNG | ENDOCRINOLOGY & METABOLISM | FACTOR-1-BETA | PHENOTYPES | MUTATIONS | PREVALENCE | TRANSPLANTATION | DELETION | Prognosis | Follow-Up Studies | Diabetes Mellitus, Type 2 - genetics | Humans | Kidney Diseases - diagnosis | Male | Cardiovascular Diseases - genetics | Kidney Diseases - genetics | Diabetic Retinopathy - complications | Young Adult | Diabetic Retinopathy - diagnosis | Gene Deletion | Kidney Diseases - epidemiology | Cardiovascular Diseases - epidemiology | Adult | Female | Kidney Diseases - complications | Retrospective Studies | Child | Diabetes Mellitus, Type 2 - complications | Hepatocyte Nuclear Factor 1-beta - genetics | Hepatocyte Nuclear Factor 1-beta - metabolism | Body Mass Index | Cardiovascular Diseases - etiology | Genetic Association Studies | Risk Factors | Diabetic Retinopathy - genetics | Diabetes Mellitus, Type 2 - diagnosis | Diabetic Retinopathy - epidemiology | Adolescent | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Insulin - therapeutic use | Kidneys | Diabetes | Diagnosis | Research | Liver cells | Health aspects | Causes and theories of causation | Diseases
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12. Full Text Hepatocyte nuclear factor 1β controls nephron tubular development
by Massa, Filippo and Garbay, Serge and Bouvier, Raymonde and Sugitani, Yoshinobu and Noda, Tetsuo and Gubler, Marie-Claire and Heidet, Laurence and Pontoglio, Marco and Fischer, Evelyne
Development (Cambridge), ISSN 0950-1991, 02/2013, Volume 140, Issue 4, pp. 886 - 896
Nephron morphogenesis is a complex process that generates blood-filtration units (glomeruli) connected to extremely long and patterned tubular structures.... 
CAKUT | Notch pathway | HNF1β | MODY5 | Kidney development | HNF1 beta | POLYCYSTIC KIDNEY-DISEASE | DISTINCT | HNF1-BETA | DEVELOPMENTAL BIOLOGY | MAMMALIAN KIDNEY | MORPHOGENESIS | GENE-EXPRESSION | MOUSE KIDNEY | FACTOR-1-BETA | MUTATIONS | TRANSCRIPTION FACTOR | Immunohistochemistry | Nephrons - embryology | Homeodomain Proteins - metabolism | Gene Expression Regulation, Developmental - genetics | Nephrons - abnormalities | Microscopy, Electron | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Animals | In Situ Hybridization | Chromatin Immunoprecipitation | Nephrons - ultrastructure | Organogenesis - genetics | Mice | Organogenesis - physiology | Real-Time Polymerase Chain Reaction | Hepatocyte Nuclear Factor 1-beta - genetics | Gene Expression Regulation, Developmental - physiology | Hepatocyte Nuclear Factor 1-beta - metabolism | POU Domain Factors - metabolism
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13. Full Text Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12
by Isaacs, William B and Grönberg, Henrik and Zheng, Siqun Lilly and Zhu, Yi and Johansson, Jan-Erik and Kim, Seong-Tae and Sun, Jishan and Partin, Alan W and Wiley, Kathleen E and Adami, Hans-Olov and Gao, Zhengrong and Trock, Bruce J and Sun, Jielin and Dimitrov, Latchezar and Lowey, James and Turner, Aubrey R and Trent, Jeffrey M and Xu, Jianfeng and Adolfsson, Jan and Liu, Wennuan and Hsu, Fang-Chi and Stattin, Pär and Duggan, David and Chang, Bao-Li and Wiklund, Fredrik and Li, Tao and Isaacs, Sarah D and Purcell, Lina D and Walsh, Patrick C and Carpten, John and Adams, Tamara S and Hälsoakademin and Örebro universitet
Nature Genetics, ISSN 1061-4036, 10/2008, Volume 40, Issue 10, pp. 1153 - 1155
We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, ∼26... 
8Q24 | AMERICANS | VARIANTS | GENETICS & HEREDITY | GENOME-WIDE ASSOCIATION | Prostatic Neoplasms - pathology | Genetic Predisposition to Disease - genetics | Humans | Middle Aged | Risk Factors | Male | Chromosome Mapping | Chromosomes, Human, Pair 17 - genetics | Haplotypes - genetics | Prostatic Neoplasms - genetics | Polymorphism, Single Nucleotide - genetics | Aged | Hepatocyte Nuclear Factor 1-beta - genetics | Genetic Linkage | Genetic aspects | DNA binding proteins | Research | Single nucleotide polymorphisms | Health aspects | Prostate cancer | Risk factors | Studies | Genetic markers | Data analysis | Data collection | Regression analysis | Hepatocyte Nuclear Factor 1-beta/genetics | Medical and Health Sciences | Medicin och hälsovetenskap | Prostatic Neoplasms/genetics/pathology | Genetic Predisposition to Disease/genetics | MEDICINE | Chromosomes; Human; Pair 17/genetics | Haplotypes/genetics | Medical Genetics | Medicinsk genetik | Clinical genetics | Dermatologi och venerologi, klinisk genetik, invärtesmedicin | Basic Medicine | Polymorphism; Single Nucleotide/genetics | Klinisk genetik | Dermatology and venerology,clinical genetics, internal medicine | Linkage (Genetics) | MEDICIN | Medicinska och farmaceutiska grundvetenskaper
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14. Full Text Comment on Dubois-Laforgue et al. Diabetes, Associated Clinical Spectrum, Long-term Prognosis, and Genotype/Phenotype Correlations in 201 Adult Patients With Hepatocyte Nuclear Factor 1B (HNF1B) Molecular Defects. Diabetes Care 2017;40:1436-1443
by Clissold, RL and Harries, LW and Ellard, S and Bingham, C and Hattersley, AT
DIABETES CARE, ISSN 0149-5992, 01/2018, Volume 41, Issue 1, pp. E7 - E7
MUTATIONS | DECAY | DISEASE | ENDOCRINOLOGY & METABOLISM | Phenotype | Prognosis | Genetic Association Studies | Humans | Adult | Genotype | Diabetes Mellitus, Type 2 | Mutation | Hepatocyte Nuclear Factor 1-beta - genetics
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