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1. Full Text Suppression of hepatocyte proliferation by hepatocyte nuclear factor 4α in adult mice
by Bonzo, Jessica A and Ferry, Christina H and Matsubara, Tsutomu and Kim, Jung-Hwan and Gonzalez, Frank J
The Journal of biological chemistry, ISSN 0021-9258, 03/2012, Volume 287, Issue 10, pp. 7345 - 7356
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Hepatomegaly - pathology | Fatty Liver - pathology | Bone Morphogenetic Protein 7 - genetics | Hepatocytes - pathology | Hepatocytes - metabolism | Phosphoproteins - metabolism | Tumor Suppressor Protein p53 - genetics | Organ Specificity - genetics | Carcinoma, Hepatocellular - genetics | Trans-Activators - genetics | Liver Neoplasms - pathology | Cell Differentiation | Disease Models, Animal | Fatty Liver - genetics | Hepatocyte Nuclear Factor 4 - metabolism | Fatty Liver - metabolism | Liver Neoplasms - genetics | Membrane Proteins - genetics | Tumor Suppressor Protein p53 - metabolism | Hepatocyte Nuclear Factor 4 - genetics | Hepatomegaly - genetics | Phosphoproteins - genetics | Mice, Knockout | Membrane Proteins - biosynthesis | Animals | Cell Cycle | Bone Morphogenetic Protein 7 - metabolism | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Trans-Activators - metabolism | Hepatomegaly - metabolism | Mice | Carcinoma, Hepatocellular - metabolism | Index Medicus | Gene Regulation | Cell Proliferation | General Transcription Factors | Gene Knockout | Hepatocyte | HNF4α
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2. Full Text Role of hepatocyte nuclear factor 4α (HNF4α) in cell proliferation and cancer
by Walesky, Chad and Apte, Udayan
Gene expression, ISSN 1052-2166, 2015, Volume 16, Issue 3, pp. 101 - 108
C-Myc | Proliferating cell nuclear antigen (PCNA) | Hepatocytes | Diethylnitrosamine | Hepatocellular carcinoma (HCC) | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Hepatocyte Nuclear Factor 4 - metabolism | Cell Proliferation - genetics | Humans | Hepatocyte Nuclear Factor 4 - genetics | Hepatocytes - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Cell Differentiation - genetics | Animals | Proliferating Cell Nuclear Antigen - genetics | Neoplasms - genetics | Mice | Proto-Oncogene Proteins c-myc - genetics | Neoplasms - pathology | Index Medicus
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3. Full Text Decreased expression of hepatocyte nuclear factor 4α (Hnf4α)/Microrna-122 (miR-122) axis in hepatitis B virus-associated hepatocellular carcinoma enhances potential oncogenic GALNT10 protein activity
by Wu, Qian and Liu, Hai-Ou and Liu, Yi-Dong and Liu, Wei-Si and Pan, Deng and Zhang, Wei-Juan and Yang, Liu and Fu, Qiang and Xu, Jie-Jie and Gu, Jian-Xin
The Journal of biological chemistry, ISSN 0021-9258, 01/2015, Volume 290, Issue 2, pp. 1170 - 1185
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Liver Neoplasms - virology | N-Acetylgalactosaminyltransferases - biosynthesis | Promoter Regions, Genetic | Cell Proliferation - genetics | ErbB Receptors - metabolism | Liver Neoplasms - genetics | Hepatitis B virus - pathogenicity | Humans | Carcinogenesis - genetics | ErbB Receptors - genetics | Gene Expression Regulation, Neoplastic | MicroRNAs - biosynthesis | Carcinoma, Hepatocellular - virology | Hepatocyte Nuclear Factor 4 - genetics | Hep G2 Cells | Hepatocyte Nuclear Factor 4 - biosynthesis | Carcinoma, Hepatocellular - genetics | N-Acetylgalactosaminyltransferases - genetics | Carcinoma, Hepatocellular - pathology | Hepatitis B virus - genetics | Liver Neoplasms - pathology | MicroRNAs - genetics | Index Medicus | Glycobiology | Hepatitis Virus | Hepatitis B Virus | Glycosyltransferase | miR-122 | Hnf4α | Glycobiology and Extracellular Matrices | Glycosylation | Liver Cancer | GALNT10
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4. Full Text Hepatocyte nuclear factor 4α negatively regulates connective tissue growth factor during liver regeneration
by Zhou, Junmei and Sun, Xiaowei and Yang, Lu and Wang, Liqun and Ran, Gai and Wang, Jinhui and Cao, Qi and Wu, Lizi and Bryant, Andrew and Ling, Chen and Pi, Liya
The FASEB journal, ISSN 0892-6638, 04/2020, Volume 34, Issue 4, pp. 4970 - 4983
hepatocyte nuclear factor 4α (Hnf4α) | liver injury | connective tissue growth factor (Ctgf) | liver regeneration | Biochemistry & Molecular Biology | Biology | Life Sciences & Biomedicine - Other Topics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Hepatocyte Nuclear Factor 4 - metabolism | Up-Regulation | Liver Regeneration | Cell Proliferation | Humans | Cell Cycle Proteins - metabolism | Hepatocyte Nuclear Factor 4 - genetics | Hepatocytes - metabolism | Hep G2 Cells | Collagen - metabolism | Animals | Transforming Growth Factor beta - genetics | Adaptor Proteins, Signal Transducing - genetics | HEK293 Cells | Cell Cycle Proteins - genetics | Protein Binding | Collagen - genetics | Connective Tissue Growth Factor - genetics | Mice | Adaptor Proteins, Signal Transducing - metabolism | Transforming Growth Factor beta - metabolism | Connective Tissue Growth Factor - metabolism | Hepatocytes - physiology | Index Medicus
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5. Full Text Mutations in the Genes Encoding the Transcription Factors Hepatocyte Nuclear Factor 1 Alpha and 4 Alpha in Maturity‐Onset Diabetes of the Young and Hyperinsulinemic Hypoglycemia
by Colclough, Kevin and Bellanne‐Chantelot, Christine and Saint‐Martin, Cecile and Flanagan, Sarah E and Ellard, Sian
Human mutation, ISSN 1059-7794, 05/2013, Volume 34, Issue 5, pp. 669 - 685
MODY | HNF1A | diabetes | HNF4A | hypoglycemia | Diabetes | Hypoglycemia | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Hypoglycemia - genetics | Hepatocyte Nuclear Factor 1-alpha - genetics | Diabetes Mellitus, Type 2 - genetics | Humans | Hepatocyte Nuclear Factor 4 - genetics | DNA Primers | Polymorphism, Genetic | Animals | Base Sequence | Chromosome Aberrations | CpG Islands | Hyperinsulinism - genetics | Mutation | Disease Models, Animal | Genes | Index Medicus
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6. Full Text Yes‐associated protein/TEA domain family member and hepatocyte nuclear factor 4‐alpha (HNF4α) repress reciprocally to regulate hepatocarcinogenesis in rats and mice
by Cai, Wang‐Yu and Lin, Ling‐Yun and Hao, Han and Zhang, Sai‐Man and Ma, Fei and Hong, Xin‐Xin and Zhang, Hui and Liu, Qing‐Feng and Ye, Guo‐Dong and Sun, Guang‐Bin and Liu, Yun‐Jia and Li, Sheng‐Nan and Xie, Yuan‐Yuan and Cai, Jian‐Chun and Li, Bo‐An
Hepatology (Baltimore, Md.), ISSN 0270-9139, 04/2017, Volume 65, Issue 4, pp. 1206 - 1221
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Immunohistochemistry | Rats, Wistar | Gene Expression Regulation, Neoplastic | Male | Carcinoma, Hepatocellular - genetics | Sensitivity and Specificity | Liver Neoplasms - pathology | Disease Models, Animal | Cell Proliferation - genetics | Liver Neoplasms - genetics | Signal Transduction | Down-Regulation | Mice, Inbred C57BL | Carcinogenesis - genetics | Rats | Hepatocyte Nuclear Factor 4 - genetics | Phosphoproteins - genetics | Random Allocation | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Animals | Adaptor Proteins, Signal Transducing - genetics | Carcinoma, Hepatocellular - pathology | Cell Line, Tumor | Mice | Biopsy, Needle | Cell Cycle Proteins | Tumorigenesis | Kinases | Rodents | Stem cells | Index Medicus
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7. Full Text Novel mechanisms of regulation of the expression and transcriptional activity of hepatocyte nuclear factor 4α
by Guo, Shangdong and Lu, Hong
Journal of cellular biochemistry, ISSN 0730-2312, 01/2019, Volume 120, Issue 1, pp. 519 - 532
hepatocyte nuclear factor 4α | D69A | HNF4A | maturity onset diabetes of the young 1 | paired box 6 | Q268X | liver cancer | diabetes | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Hepatocyte Nuclear Factor 4 - metabolism | Promoter Regions, Genetic | PAX6 Transcription Factor - metabolism | Transcriptional Activation - genetics | Introns - genetics | Hepatocyte Nuclear Factor 1-alpha - genetics | Liver Neoplasms - genetics | Diabetes Mellitus, Type 2 - genetics | Humans | Exons - genetics | 5' Untranslated Regions - genetics | Hepatocyte Nuclear Factor 4 - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Hepatocyte Nuclear Factor 1-alpha - metabolism | PAX6 Transcription Factor - genetics | Hep G2 Cells | Transfection | HEK293 Cells | Liver Neoplasms - metabolism | Transcription, Genetic | Mutation | RNA, Long Noncoding - metabolism | Transcription | Liver | Gene regulation | Colorectal cancer | Tissues | Carcinogenesis | Synergism | Liver cancer | Carcinogens | Colon cancer | Intestine | Hepatocyte nuclear factor 4 | Colon | Pancreas | Deoxyribonucleic acid--DNA | Secretion | Fetuses | Diabetes mellitus | Ribonucleic acid--RNA | Insulin | Promoters | Mutants | Pax6 protein | Pancreatic cancer | Cancer | Index Medicus
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