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1. Full Text Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors
by Sekiya, Sayaka and Suzuki, Atsushi
Nature, ISSN 0028-0836, 07/2011, Volume 475, Issue 7356, pp. 390 - 395
The location and timing of cellular differentiation must be stringently controlled for proper organ formation. Normally, hepatocytes differentiate from hepatic... 
CLONAL IDENTIFICATION | FUSION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | LIVER | HEPATIC PROGENITOR CELLS | PANCREATIC-CELLS | DIFFERENTIATION | CARDIOMYOCYTES | NORMALIZATION | MESENCHYMAL STEM-CELLS | Hepatocyte Nuclear Factor 3-beta - metabolism | Hepatocyte Nuclear Factor 4 - metabolism | Liver - enzymology | Hepatocyte Nuclear Factor 3-beta - genetics | Mice, Inbred C57BL | Cells, Cultured | Hepatocyte Nuclear Factor 3-alpha - genetics | Hepatocyte Nuclear Factor 3-gamma - genetics | Hepatocyte Nuclear Factor 4 - genetics | Hydrolases - deficiency | Hepatocytes - metabolism | Hepatocyte Nuclear Factor 3-alpha - metabolism | Cell Differentiation - genetics | Hepatocytes - cytology | Animals | Hepatocyte Nuclear Factor 3-gamma - metabolism | Embryo, Mammalian - cytology | Liver - physiology | Fibroblasts - cytology | Liver - cytology | Mice | Mice, Inbred BALB C | Hepatocytes - transplantation | Polymerase chain reaction | Fibroblasts | Physiological aspects | Usage | Research | Liver cells | Infections | Gene expression | Rodents | Liver | Viral infections | Index Medicus
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2. Full Text Suppression of hepatocyte proliferation by hepatocyte nuclear factor 4α in adult mice
by Bonzo, Jessica A and Ferry, Christina H and Matsubara, Tsutomu and Kim, Jung-Hwan and Gonzalez, Frank J
Journal of Biological Chemistry, ISSN 0021-9258, 03/2012, Volume 287, Issue 10, pp. 7345 - 7356
Hepatocyte nuclear factor 4 alpha (HNF4 alpha) regulates genes involved in lipid and bile acid synthesis, gluconeogenesis, amino acid metabolism, and blood... 
FIBROSIS | HORMONE RECEPTOR SUPERFAMILY | HEPATOCELLULAR-CARCINOMA | LIVER-REGENERATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROSTATE-CANCER | MOUSE | BONE MORPHOGENETIC PROTEIN-7 | GENE-EXPRESSION | HNF4-ALPHA | TRANSCRIPTION FACTOR | Hepatomegaly - pathology | Fatty Liver - pathology | Bone Morphogenetic Protein 7 - genetics | Hepatocytes - pathology | Hepatocytes - metabolism | Phosphoproteins - metabolism | Tumor Suppressor Protein p53 - genetics | Organ Specificity - genetics | Carcinoma, Hepatocellular - genetics | Trans-Activators - genetics | Liver Neoplasms - pathology | Cell Differentiation | Disease Models, Animal | Fatty Liver - genetics | Hepatocyte Nuclear Factor 4 - metabolism | Fatty Liver - metabolism | Liver Neoplasms - genetics | Membrane Proteins - genetics | Tumor Suppressor Protein p53 - metabolism | Hepatocyte Nuclear Factor 4 - genetics | Hepatomegaly - genetics | Phosphoproteins - genetics | Mice, Knockout | Membrane Proteins - biosynthesis | Animals | Cell Cycle | Bone Morphogenetic Protein 7 - metabolism | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Trans-Activators - metabolism | Hepatomegaly - metabolism | Mice | Carcinoma, Hepatocellular - metabolism | Index Medicus | Gene Regulation | Cell Proliferation | General Transcription Factors | Gene Knockout | Hepatocyte | HNF4α
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3. Full Text Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer
by Saha, Supriya K and Saha, Supriya K and Parachoniak, Christine A and Parachoniak, Christine A and Ghanta, Krishna S and Ghanta, Krishna S and Fitamant, Julien and Fitamant, Julien and Ross, Kenneth N and Ross, Kenneth N and Najem, Mortada S and Najem, Mortada S and Gurumurthy, Sushma and Gurumurthy, Sushma and Akbay, Esra A and Akbay, Esra A and Sia, Daniela and Sia, Daniela and Cornella, Helena and Cornella, Helena and Miltiadous, Oriana and Miltiadous, Oriana and Walesky, Chad and Walesky, Chad and Deshpande, Vikram and Deshpande, Vikram and Zhu, Andrew X and Zhu, Andrew X and Hezel, Aram F and Heze, Aram F and Yen, Katharine E and Yen, Katharine E and Straley, Kimberly S and Straley, Kimberly S and Travins, Jeremy and Travins, Jeremy and Popovici-Muller, Janeta and Popovici-Muller, Janeta and Gliser, Camelia and Gliser, Camelia and Ferrone, Cristina R and Ferrone, Cristina R and Apte, Udayan and Apte, Udayan and Llovet, Josep M and Llovet, Josep M and Wong, Kwok-Kin and Wong, Kwok-Kin and Ramaswamy, Sridhar and Ramaswamy, Sridhar and Bardeesy, Nabeel and Bardeesy, Nabeel
Nature, ISSN 0028-0836, 2014, Volume 513, Issue 7516, pp. 110 - 114
Mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 are among the most common genetic alterations in intrahepatic cholangiocarcinoma (IHCC), a deadly liver... 
PROGENITORS | INTRAHEPATIC CHOLANGIOCARCINOMA | HOMEOSTASIS | LIVER-REGENERATION | MULTIDISCIPLINARY SCIENCES | MUTATION | GROWTH | MICE | PROLIFERATION | EXPRESSION | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Hepatocyte Nuclear Factor 4 - antagonists & inhibitors | Humans | ras Proteins - metabolism | Hepatocytes - pathology | Male | Hepatocytes - metabolism | Bile Duct Neoplasms - enzymology | Cell Differentiation - genetics | Neoplasm Metastasis | Hepatocyte Nuclear Factor 4 - biosynthesis | Female | Bile Duct Neoplasms - genetics | Cell Lineage - genetics | Cholangiocarcinoma - enzymology | Disease Models, Animal | Cell Division - genetics | Proto-Oncogene Proteins - metabolism | Hepatocyte Nuclear Factor 4 - metabolism | Bile Ducts, Intrahepatic - pathology | Mutant Proteins - genetics | Isocitrate Dehydrogenase - genetics | Mice, Transgenic | Mutant Proteins - metabolism | Proto-Oncogene Proteins - genetics | Hepatocyte Nuclear Factor 4 - genetics | Mutation - genetics | Bile Ducts, Intrahepatic - enzymology | Cholangiocarcinoma - pathology | Animals | Cholangiocarcinoma - genetics | Stem Cells - pathology | Isocitrate Dehydrogenase - metabolism | Glutarates - metabolism | Mice | Bile Duct Neoplasms - pathology | Hepatocytes - enzymology | Index Medicus
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4. Full Text Proteogenomic characterization of human colon and rectal cancer
by Zhang, Bing and Zhang, Bing and Wang, Jing and Wang, Jing and Wang, Xiaojing and Wang, Xiaojing and Zhu, Jing and Zhu, Jing and Liu, Q and Liu, Qi and Shi, Zhiao and Shi, Zhiao and Chambers, Matthew C and Chambers, Matthew C and Zimmerman, Lisa J and Zimmerman, Lisa J and Shaddox, Kent F and Shaddox, Kent F and Kim, Sangtae and Kim, Sangtae and Davies, Sherri R and Davies, Sherri R and Wang, Sean and Wang, Sean and Wang, Pei and Wang, Pei and Kinsinger, Christopher R and Kinsinger, Christopher R and Rivers, Robert C and Rivers, Robert C and Rodriguez, Henry and Rodriguez, Henry and Townsend, R. Reid and Townsend, R Reid and Ellis, Matthew J. C and Ellis, Matthew J C and Carr, Steven A and Carr, Steven A and Tabb, David L and Tabb, David L and Coffey, Robert J and Coffey, Robert J and Slebos, Robbert J C and Slebos, Robbert J. C and Liebler, Daniel C and Liebler, Daniel C and NCI CPTAC, CPTAC and Gillette, Michael A and Klauser, Karl R and Kuhn, Eric and Mani, D.R and Mertins, Philipp and Ketchum, Karen A and Paulovich, Amanda G and Whiteaker, Jeffrey R and Edwards, Nathan J and McGarvey, Peter B and Madhavan, Subha and Chan, Daniel and Pandey, Akhilesh and Shih, Ie-Ming and Zhang, Hui and Zhang, Zhen and Zhu, Heng and Whiteley, Gordon A and Skates, Steven J and White, Forest M and Levine, Douglas A and Boja, Emily S and Hiltke, Tara and Mesri, Mehdi and Shaw, Kenna M and Stein, Stephen E and Fenyo, David and Liu, Tao and McDermott, Jason E and Payne, Samuel H and Rodland, Karin D and Smith, Richard D and Rudnick, Paul and Snyder, Michael and Zhao, Yingming and Chen, Xian and Ransohoff, David F and Hoofnagle, Andrew N and Sanders, Melinda E and Wang, Yue and Ding, Li and NCI CPTAC and the NCI CPTAC
Nature, ISSN 0028-0836, 2014, Volume 513, Issue 7518, pp. 382 - 387
Extensive genomic characterization of human cancers presents the problem of inference from genomic abnormalities to cancer phenotypes. To address this problem,... 
ANALYSIS REVEALS | GENE | PEPTIDE IDENTIFICATION | COLORECTAL-CANCER | MULTIDISCIPLINARY SCIENCES | PROTEIN EXPRESSION | PROTEOMIC ANALYSIS | HNF4-ALPHA | RNA-SEQ DATA | MASS-SPECTROMETRY | ABUNDANCE | Colonic Neoplasms - genetics | Proteome - genetics | Genomics | Humans | RNA, Messenger - analysis | Neoplasm Proteins - metabolism | RNA, Messenger - metabolism | RNA, Neoplasm - metabolism | Colonic Neoplasms - metabolism | Mutation, Missense - genetics | Mitochondrial Membrane Transport Proteins - genetics | Point Mutation - genetics | DNA Methylation | RNA, Neoplasm - analysis | Rectal Neoplasms - genetics | Neoplasm Proteins - genetics | RNA, Messenger - genetics | DNA Copy Number Variations - genetics | Hepatocyte Nuclear Factor 4 - genetics | Transcriptome - genetics | Proteome - analysis | Microsatellite Repeats - genetics | Proto-Oncogene Proteins pp60(c-src) - genetics | Proteomics | CpG Islands - genetics | RNA, Neoplasm - genetics | Neoplasm Proteins - analysis | Rectal Neoplasms - metabolism | Proteome - metabolism | Chromosomes, Human, Pair 20 - genetics | Care and treatment | Colon cancer | RNA | Analysis | Colorectal cancer | Genetic aspects | Methylation | Proteins | Peptides | Genes | Colon | Mass spectrometry | Tumors | Cancer | Index Medicus
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5. Full Text Mutations in the Genes Encoding the Transcription Factors Hepatocyte Nuclear Factor 1 Alpha and 4 Alpha in Maturity‐Onset Diabetes of the Young and Hyperinsulinemic Hypoglycemia
by Colclough, Kevin and Bellanne‐Chantelot, Christine and Saint‐Martin, Cecile and Flanagan, Sarah E and Ellard, Sian
Human Mutation, ISSN 1059-7794, 05/2013, Volume 34, Issue 5, pp. 669 - 685
Maturity‐onset diabetes of the young ( MODY ) is a monogenic disorder characterized by autosomal dominant inheritance of young‐onset (typically <25 years),... 
HNF | MODY | diabetes | hypoglycemia | Diabetes | HNF1A | Hypoglycemia | HNF4A | C-REACTIVE PROTEIN | INSULIN SECRETORY RESPONSES | FACTOR-4-ALPHA GENE | CLINICAL CHARACTERISTICS | SCALE ASSOCIATION ANALYSIS | HNF4A GENE | AMINO-ACID POLYMORPHISM | GENETICS & HEREDITY | PANCREATIC BETA-CELLS | P2 PROMOTER | CANADIAN OJI-CREE | Hypoglycemia - genetics | Hepatocyte Nuclear Factor 1-alpha - genetics | Diabetes Mellitus, Type 2 - genetics | Humans | Hepatocyte Nuclear Factor 4 - genetics | DNA Primers | Polymorphism, Genetic | Animals | Base Sequence | Chromosome Aberrations | CpG Islands | Hyperinsulinism - genetics | Mutation | Disease Models, Animal | Genes | Index Medicus
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6. Full Text Yes‐associated protein/TEA domain family member and hepatocyte nuclear factor 4‐alpha (HNF4α) repress reciprocally to regulate hepatocarcinogenesis in rats and mice
by Cai, Wang‐Yu and Lin, Ling‐Yun and Hao, Han and Zhang, Sai‐Man and Ma, Fei and Hong, Xin‐Xin and Zhang, Hui and Liu, Qing‐Feng and Ye, Guo‐Dong and Sun, Guang‐Bin and Liu, Yun‐Jia and Li, Sheng‐Nan and Xie, Yuan‐Yuan and Cai, Jian‐Chun and Li, Bo‐An
Hepatology, ISSN 0270-9139, 04/2017, Volume 65, Issue 4, pp. 1206 - 1221
Great progress has been achieved in the study of Hippo signaling in regulating tumorigenesis; however, the downstream molecular events that mediate this... 
CELL CONTACT INHIBITION | TRANSCRIPTION FACTORS | HEPATOCELLULAR-CARCINOMA | CANCER DEVELOPMENT | ORGAN SIZE CONTROL | HIPPO SIGNALING PATHWAY | GENE-EXPRESSION | EPITHELIAL TUMORS | TUMOR-SUPPRESSOR | GASTROENTEROLOGY & HEPATOLOGY | TEAD/TEF FAMILY | Immunohistochemistry | Rats, Wistar | Gene Expression Regulation, Neoplastic | Male | Carcinoma, Hepatocellular - genetics | Sensitivity and Specificity | Liver Neoplasms - pathology | Disease Models, Animal | Cell Proliferation - genetics | Liver Neoplasms - genetics | Signal Transduction | Down-Regulation | Mice, Inbred C57BL | Carcinogenesis - genetics | Rats | Hepatocyte Nuclear Factor 4 - genetics | Phosphoproteins - genetics | Random Allocation | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Animals | Adaptor Proteins, Signal Transducing - genetics | Carcinoma, Hepatocellular - pathology | Cell Line, Tumor | Mice | Biopsy, Needle | Tumorigenesis | Kinases | Rodents | Stem cells | Index Medicus
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7. Full Text Tissue-specific transcriptional regulation has diverged significantly between human and mouse
by Jacobsen, Elizabeth S and MacIsaac, Kenzie D and Rolfe, P Alexander and Gifford, David K and Fraenkel, Ernest and Conboy, Caitlin M and Gordon, William and Odom, Duncan T and Danford, Timothy W and Dowell, Robin D
Nature Genetics, ISSN 1061-4036, 06/2007, Volume 39, Issue 6, pp. 730 - 732
We demonstrate that the binding sites for highly conserved transcription factors vary extensively between human and mouse. We mapped the binding of four... 
EVOLUTION | GENOME | EMBRYONIC STEM-CELLS | LIVER | GENETICS & HEREDITY | Conserved Sequence - genetics | Hepatocyte Nuclear Factor 1-alpha - genetics | Hepatocyte Nuclear Factor 3-beta - genetics | Humans | Regulatory Sequences, Nucleic Acid | Gene Expression Regulation | Hepatocyte Nuclear Factor 4 - genetics | Transcription Factors - genetics | Genetic Variation | Sequence Homology | Animals | Hepatocyte Nuclear Factor 6 - genetics | Transcription, Genetic | Mice | Genetic aspects | DNA binding proteins | Research | Comparative analysis | Gene expression | Identification and classification | Proteins | Comparative studies | Genetics | Rodents | Liver | Binding sites | Index Medicus
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8. Full Text Decreased expression of hepatocyte nuclear factor 4α (Hnf4α)/Microrna-122 (miR-122) axis in hepatitis B virus-associated hepatocellular carcinoma enhances potential oncogenic GALNT10 protein activity
by Wu, Qian and Liu, Hai-Ou and Liu, Yi-Dong and Liu, Wei-Si and Pan, Deng and Zhang, Wei-Juan and Yang, Liu and Fu, Qiang and Xu, Jie-Jie and Gu, Jian-Xin
Journal of Biological Chemistry, ISSN 0021-9258, 01/2015, Volume 290, Issue 2, pp. 1170 - 1185
MicroRNA-122 (miR-122), a mammalian liver-specific miRNA, has been reported to play crucial roles in the control of diverse aspects of hepatic function and... 
HUMAN GLYCOME | LIVER-CANCER | GROWTH-FACTOR RECEPTOR | GALNAC-TRANSFERASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | O-GLYCOSYLATION | TRANSFERASE GENE FAMILY | SURFACE-PROTEINS | N-ACETYLGLUCOSAMINYLTRANSFERASE | P53 ACTIVITY | CELL | Liver Neoplasms - virology | N-Acetylgalactosaminyltransferases - biosynthesis | Promoter Regions, Genetic | Receptor, Epidermal Growth Factor - genetics | Cell Proliferation - genetics | Liver Neoplasms - genetics | Hepatitis B virus - pathogenicity | Humans | Carcinogenesis - genetics | Gene Expression Regulation, Neoplastic | MicroRNAs - biosynthesis | Carcinoma, Hepatocellular - virology | Hepatocyte Nuclear Factor 4 - genetics | Hep G2 Cells | Receptor, Epidermal Growth Factor - metabolism | Hepatocyte Nuclear Factor 4 - biosynthesis | Carcinoma, Hepatocellular - genetics | N-Acetylgalactosaminyltransferases - genetics | Carcinoma, Hepatocellular - pathology | Hepatitis B virus - genetics | Liver Neoplasms - pathology | MicroRNAs - genetics | Index Medicus | Glycobiology | Hepatitis Virus | Hepatitis B Virus | Glycosyltransferase | miR-122 | Hnf4α | Glycobiology and Extracellular Matrices | Glycosylation | Liver Cancer | GALNT10
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