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Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 06/2014, Volume 95, Issue 6, pp. 653 - 662
Journal Article
Antimicrobial agents and chemotherapy, ISSN 1098-6596, 2017, Volume 61, Issue 3
As new pathogenic viruses continue to emerge, it is paramount to have intervention strategies that target a common denominator in these pathogens. The fusion... 
Envelope protein | Antiviral | Zika virus | Virus entry | Chikungunya virus | Resistant mutant | LYSOSOMAL FUNCTION | envelope protein | MICROBIOLOGY | SEMLIKI-FOREST-VIRUS | chikungunya virus | CHLOROQUINE | FULL-LENGTH CDNA | IN-VITRO | antiviral | virus entry | PHARMACOLOGY & PHARMACY | INFECTION | resistant mutant | MUTATIONS | CELL ENTRY | ANTIVIRALS | Zika Virus - genetics | Chikungunya virus - genetics | Membrane Glycoproteins - metabolism | Epithelial Cells - drug effects | Humans | Yellow fever virus - growth & development | Semliki forest virus - growth & development | Virus Internalization - drug effects | Endosomes - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Lysosomes - metabolism | West Nile virus - genetics | Hydrogen-Ion Concentration - drug effects | Endosomes - drug effects | Viral Envelope Proteins - metabolism | Cell Membrane - drug effects | Hepatocytes - drug effects | Membrane Fusion - drug effects | Lysosomes - drug effects | Cell Line | Virus Replication - drug effects | Antiviral Agents - pharmacology | Cricetinae | Gene Expression | Viral Envelope Proteins - genetics | Zika Virus - growth & development | West Nile virus - growth & development | Zika Virus - drug effects | West Nile virus - drug effects | Chikungunya virus - growth & development | Membrane Glycoproteins - genetics | Chikungunya virus - drug effects | Drug Resistance, Viral - genetics | Pyrroles - pharmacology | Yellow fever virus - drug effects | Animals | Semliki forest virus - genetics | Neutral Red - metabolism | Epithelial Cells - virology | Semliki forest virus - drug effects | Hepatocytes - virology | Cell Membrane - virology | Mutation | Proto-Oncogene Proteins c-bcl-2 - genetics | Yellow fever virus - genetics
Journal Article
Circulation Research, ISSN 0009-7330, 02/2007, Volume 100, Issue 3, pp. 328 - 341
The AMP-activated protein kinase (AMPK) system acts as a sensor of cellular energy status that is conserved in all eukaryotic cells. It is activated by... 
Calcium signaling | Signaling pathways | Diabetes | Metabolism | Insulin | RAT-LIVER | CARDIAC & CARDIOVASCULAR SYSTEMS | insulin | 5-AMINOIMIDAZOLE-4-CARBOXAMIDE RIBONUCLEOSIDE | STIMULATED GLUCOSE-TRANSPORT | calcium signaling | ACETYL-COA CARBOXYLASE | COENZYME-A CARBOXYLASE | SKELETAL-MUSCLE | signaling pathways | FATTY-ACID OXIDATION | ENDOTHELIAL-CELLS | CELL-PERMEABLE ACTIVATOR | PANCREATIC BETA-CELLS | PERIPHERAL VASCULAR DISEASE | metabolism | HEMATOLOGY | diabetes | Consensus Sequence | Protein Subunits | Protein-Serine-Threonine Kinases - deficiency | Insulin - physiology | Obesity - drug therapy | Humans | Muscle Cells - drug effects | Adipocytes - drug effects | AMP-Activated Protein Kinases | Aminoimidazole Carboxamide - pharmacology | Multienzyme Complexes - deficiency | Calcium - physiology | Adenosine Triphosphate - metabolism | Energy Metabolism - physiology | Binding Sites | Peptide Hormones - physiology | Hypoglycemic Agents - therapeutic use | Amino Acid Sequence | Diabetes Mellitus - drug therapy | Models, Molecular | Rats | Hypoglycemic Agents - pharmacology | Mice, Knockout | Calcium-Calmodulin-Dependent Protein Kinase Kinase | Carbohydrate Metabolism - physiology | Aminoimidazole Carboxamide - analogs & derivatives | Diabetes Mellitus - therapy | Protein-Serine-Threonine Kinases - drug effects | Mice | Protein-Serine-Threonine Kinases - chemistry | Cell Cycle - drug effects | Energy Metabolism - drug effects | Lipid Metabolism - physiology | Multienzyme Complexes - drug effects | Carbohydrate Metabolism - drug effects | Phosphorylation | Metformin - therapeutic use | Molecular Sequence Data | Hepatocytes - metabolism | Ribonucleotides - pharmacology | Hepatocytes - drug effects | Adenosine Monophosphate - metabolism | Protein-Serine-Threonine Kinases - physiology | Metformin - pharmacology | Muscle Cells - metabolism | Protein-Serine-Threonine Kinases - genetics | Diabetes Mellitus - metabolism | Neoplasms - enzymology | Multienzyme Complexes - genetics | Enzyme Activation - drug effects | Protein Processing, Post-Translational - physiology | Multienzyme Complexes - chemistry | Obesity - metabolism | Sequence Homology, Amino Acid | Sequence Alignment | Animals | Oxygen Consumption - drug effects | Adipocytes - metabolism | Multienzyme Complexes - physiology | Lipid Metabolism - drug effects | Cell Cycle - physiology | Neoplasms - pathology
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 2011, Volume 473, Issue 7348, pp. 478 - 483
.... Surprisingly, it also showed similar effects in the fruitfly (Drosophila melanogaster). Mechanistic studies revealed that royalactin activated p70 S6 kinase... 
CULTURED RAT HEPATOCYTES | APIS-MELLIFERA | CASTE DIFFERENTIATION | BODY-SIZE | PROTHORACIC GLAND | MULTIDISCIPLINARY SCIENCES | ENHANCES PROLIFERATION | PROTEINS | DROSOPHILA | REGULATES GROWTH | FAMILY | Temperature | Drosophila melanogaster - physiology | Longevity - drug effects | Glycoproteins - metabolism | Body Weight - drug effects | Receptor, Epidermal Growth Factor - deficiency | Bees - growth & development | Glycoproteins - pharmacology | Ovary - growth & development | Receptor, Epidermal Growth Factor - metabolism | RNA Interference | Time Factors | Larva - drug effects | Larva - growth & development | Fertility - drug effects | Female | Glycoproteins - deficiency | Ovary - drug effects | Protein Stability | Fat Body - metabolism | Fatty Acids - metabolism | Insect Proteins - metabolism | Glycoproteins - genetics | Body Size - drug effects | Fatty Acids - chemistry | Insect Proteins - pharmacology | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Juvenile Hormones - metabolism | Cell Size - drug effects | Drosophila melanogaster - cytology | Insect Proteins - genetics | Social Dominance | Drosophila melanogaster - drug effects | Bees - physiology | Phenotype | Animals | Signal Transduction - drug effects | Body Size - physiology | Bees - drug effects | Drosophila melanogaster - enzymology | Bees - genetics | Fat Body - drug effects | Caseins - pharmacology | Fatty Acids - pharmacology | Mitogen-Activated Protein Kinases - metabolism | Mass spectrometry | Bees
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 04/2016, Volume 60, Issue 4, pp. 2532 - 2536
...), the most active of these compounds, showed in vitro inhibition in the single-unit nanomolar range, similar to the activity in the reference drug pentamidine, and presented low toxicity and adequate metabolic stability... 
LEISHMANIA-INFANTUM | CELLS | DNA-BINDING | NIMESULIDE | ASSAY | POLYAMINES | HUMAN AFRICAN TRYPANOSOMIASIS | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | CYTOTOXICITY | Trypanosomiasis, African - drug therapy | Mitochondria, Liver - metabolism | Humans | Microsomes, Liver - metabolism | Neurons - cytology | Structure-Activity Relationship | Hepatocytes - metabolism | Hepatocytes - cytology | Naphthalimides - chemical synthesis | Liver - drug effects | Microsomes, Liver - drug effects | Trypanosomiasis, African - mortality | Inhibitory Concentration 50 | Female | Trypanosomiasis, African - pathology | Neurons - metabolism | Neurons - drug effects | Trypanosoma brucei brucei - growth & development | Hepatocytes - drug effects | Pentamidine - pharmacology | Cell Line | Trypanosoma brucei brucei - metabolism | Drug Stability | Liver - metabolism | Parasite Load | Macrophages - cytology | Trypanosoma brucei brucei - drug effects | Mitochondria, Liver - drug effects | Trypanosomiasis, African - parasitology | Macrophages - metabolism | Animals | Naphthalimides - pharmacology | Trypanocidal Agents - pharmacology | Survival Analysis | Trypanocidal Agents - chemical synthesis | Macrophages - drug effects | Mice | Mice, Inbred BALB C | Primary Cell Culture | Index Medicus
Journal Article
Journal Article
Cell metabolism, ISSN 1550-4131, 2016, Volume 23, Issue 6, pp. 1154 - 1166
During insulin-resistant states such as type II diabetes mellitus (T2DM), insulin fails to suppress hepatic glucose production (HGP) yet promotes lipid... 
HEPATIC GLUCOKINASE | LIPID-METABOLISM | TRANSCRIPTION FACTOR FOXO1 | IN-VIVO | FATTY-ACID | LIVER | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | RESISTANCE | METABOLOMIC ANALYSIS | GLUCOKINASE EXPRESSION | CELL BIOLOGY | TOR Serine-Threonine Kinases - metabolism | Gluconeogenesis - drug effects | Vagus Nerve - drug effects | Male | Glucose - biosynthesis | Hepatocytes - metabolism | Mechanistic Target of Rapamycin Complex 1 | Liver - innervation | Adipose Tissue - metabolism | Efferent Pathways - drug effects | Fatty Acids, Nonesterified - metabolism | Multiprotein Complexes - metabolism | Lipogenesis - genetics | Liver - drug effects | Gene Deletion | Postprandial Period - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Heparin - pharmacology | Hepatocytes - drug effects | Forkhead Box Protein O1 - metabolism | Insulin - pharmacology | Glucose Tolerance Test | Liver - metabolism | Insulin Resistance | Signal Transduction - genetics | Glucokinase - metabolism | Efferent Pathways - metabolism | Mice, Knockout | Gene Expression Regulation - drug effects | Vagus Nerve - physiology | Insulin - metabolism | Animals | Gluconeogenesis - genetics | Diet | Signal Transduction - drug effects | Lipogenesis - drug effects | Glucagon - metabolism | Adipose Tissue - drug effects | Medical colleges | Glucagon | Analysis | Liver | Insulin resistance | Diabetes | Glucose | Insulin | Dextrose
Journal Article
PloS one, ISSN 1932-6203, 2015, Volume 10, Issue 4, pp. e0124595 - e0124595
.... Repurposing Food and Drug Administration (FDA) approved drugs for antimicrobial therapy involves lower risks and costs compared to de novo development of novel antimicrobial agents... 
INTRINSIC RESISTANCE | EFFLUX PUMP(S) | CAENORHABDITIS-ELEGANS | EVOLUTION | VIRULENCE FACTORS | PSEUDOMONAS-AERUGINOSA | MULTIDISCIPLINARY SCIENCES | MODEL HOST | MRSA | INHIBITORS | IDENTIFICATION | Oxyclozanide - pharmacology | Cell Survival - drug effects | Enterococcus faecium - drug effects | Microbial Viability - drug effects | Humans | Methicillin-Resistant Staphylococcus aureus - drug effects | Drug Repositioning | Erythrocytes - drug effects | Hep G2 Cells | Microbial Sensitivity Tests | Gram-Negative Bacteria - drug effects | Methicillin-Resistant Staphylococcus aureus - growth & development | Animals | Anthelmintics - pharmacology | Niclosamide - pharmacology | Gram-Negative Bacteria - growth & development | Erythrocytes - cytology | Sheep | Anti-Bacterial Agents - pharmacology | Enterococcus faecium - growth & development | Drug Resistance, Multiple, Bacterial - drug effects | Drugs | Veterinary supplies industry | Staphylococcus aureus infections | Cross infection | Nosocomial infections | Drug resistance | Comparative analysis | Health aspects | Antibacterial agents | Drug approval | Staphylococcus aureus | Klebsiella | Linezolid | Regulatory agencies | Antimicrobial activity | Low concentrations | Laboratories | Toxicity | Liver | Erythrocytes | Daptomycin | Niclosamide | Gram-positive bacteria | Clinical isolates | Genomes | Infections | Vancomycin | Drug development | Kinases | Veterinary medicine | Antiinfectives and antibacterials | Medical schools | Risk factors | Methicillin | Cell growth | Red blood cells | Pseudomonas aeruginosa | Bacteria | Biocompatibility | Pharmaceutical industry | Aerogenes | Staphylococcus infections | Antimicrobial agents | Bacteriology | Studies | Chemotherapy | Hospitals | Infectious diseases | Biofilms | Antibiotics | Hepatocytes | Minimum inhibitory concentration | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 8, p. e23899
The Wnt/beta-catenin signalling pathway shares a key component, beta-catenin, with the cadherin-based adhesion system. The signalling function of beta-catenin... 
TYROSINE PHOSPHORYLATION | WNT PATHWAY | DEPENDENT TRANSCRIPTION | FACTOR SCATTER FACTOR | BIOLOGY | TUMOR-SUPPRESSOR PROTEIN | ADHERENS JUNCTIONS | BETA-CATENIN | CELL-CELL ADHESION | NUCLEAR TRANSLOCATION | N-CADHERIN | Embryo, Mammalian - drug effects | Transcription, Genetic - drug effects | Epithelial Cells - metabolism | Cadherins - metabolism | Epithelial Cells - drug effects | Humans | Transcriptional Activation - drug effects | Mesoderm - drug effects | Cytoplasm - metabolism | Epithelial-Mesenchymal Transition - drug effects | Protein Transport - drug effects | Mesoderm - cytology | Epithelial-Mesenchymal Transition - genetics | Hepatocyte Growth Factor - pharmacology | Embryo, Mammalian - metabolism | Protein Binding - drug effects | HEK293 Cells | Cell Membrane - metabolism | Epithelial Cells - cytology | Cell Membrane - drug effects | Endocytosis - drug effects | beta Catenin - metabolism | Animals | Wnt Signaling Pathway - drug effects | Wnt Signaling Pathway - genetics | Dogs | Mesoderm - metabolism | Mice | Cytoplasm - drug effects | Regulators | Phosphorylation | Wnt protein | Transcription | Mesenchyme | Colorectal cancer | Activation | Biology | Cell adhesion & migration | Signal transduction | β-catenin | Embryogenesis | Endocytosis | Cell growth | Tumorigenesis | Trends | Growth factors | Chromosomes | Medical research | Gastrulation | Hepatocyte growth factor | Gene expression | Cadherin | Adhesion | Embryonic growth stage | Signaling | Insects | Morphology | Stem cells | Ligands | Mutation | Endoplasmic reticulum | Cytoplasm
Journal Article