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Cellular and molecular life sciences : CMLS, ISSN 1420-9071, 2008, Volume 66, Issue 1, pp. 27 - 42
The glucokinase (GCK) gene was one of the first candidate genes to be identified as a human “diabetes gene". Subsequently, important advances were made in... 
Biochemistry, general | hepatocyte | insulin | Biomedicine general | Cell Biology | Life Sciences | islet of Langerhans | MODY | Life Sciences, general | Glucokinase | diabetes | glucose metabolism | hexokinase | Glucose metabolism | Hepatocyte | Islet of Langerhans | Diabetes | Insulin | Hexokinase | INSULIN-DEPENDENT INDUCTION | HEPATIC GLYCOGEN-SYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ELEMENT-BINDING PROTEIN-1C | YOUNG TYPE-2 MODY-2 | BETA-CELL GLUCOKINASE | CELL BIOLOGY | PERSISTENT HYPERINSULINEMIC HYPOGLYCEMIA | GENE-EXPRESSION | REGULATORY PROTEIN | LIVER-X-RECEPTOR | GROWTH-FACTOR-I | Hexokinase - physiology | Liver - enzymology | Insulin - physiology | Islets of Langerhans - enzymology | Diabetes Mellitus, Type 2 - genetics | Humans | Diabetes Mellitus, Type 2 - enzymology | Gene Expression Regulation | Brain - enzymology | Congenital Hyperinsulinism - enzymology | Congenital Hyperinsulinism - genetics | Homeostasis - physiology | Glucose - metabolism | Mitochondrial Membranes - enzymology | Adaptor Proteins, Signal Transducing - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Hexokinase - genetics | Hexokinase - chemistry | Homeostasis - genetics | Anopheles | Isoenzymes | Analysis | Physiological aspects | Glucose | Gene expression | Dextrose | Proteins | Enzymes | Biochemistry | Molecular biology | Review
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2014, Volume 111, Issue 45, pp. E4878 - E4886
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2013, Volume 123, Issue 4, pp. 1821 - 1832
Journal Article
Drug metabolism and disposition, ISSN 0090-9556, 02/2013, Volume 41, Issue 2, pp. 256 - 262
There is increasing evidence that pregnancy alters the function of drug-metabolizing enzymes and drug transporters in a gestational-stage and tissue-specific... 
WOMEN | METFORMIN | CLEARANCE | IN-VITRO | PHARMACOKINETICS | PLASMA-CONCENTRATIONS | 3RD TRIMESTER | ZIDOVUDINE | PHARMACOLOGY & PHARMACY | HUMAN-IMMUNODEFICIENCY-VIRUS | EXPRESSION | Smoking - adverse effects | Estrogens - pharmacology | Liver - enzymology | Cholestasis - metabolism | Minor Histocompatibility Antigens | Taurocholic Acid - metabolism | Humans | Kidney - enzymology | Cytochrome P-450 Enzyme System - metabolism | Male | Hepatocytes - metabolism | Organic Anion Transporters - metabolism | Intestine, Small - enzymology | Lung - enzymology | Glucuronosyltransferase - genetics | RNA, Messenger - biosynthesis | Kidney - metabolism | Estrogen Receptor alpha - agonists | Liver - drug effects | Cotinine - metabolism | Maternal Behavior | ATP-Binding Cassette Transporters - metabolism | Female | Membrane Transport Proteins - metabolism | Pesticides - metabolism | Adrenal Glands - enzymology | Progesterone - pharmacology | Estradiol - pharmacology | Hepatocytes - drug effects | Retinoic Acid 4-Hydroxylase | Multidrug Resistance-Associated Proteins - drug effects | Gene Expression Regulation, Developmental - drug effects | Placenta - enzymology | Ethinyl Estradiol - pharmacology | Aryldialkylphosphatase - metabolism | Carboxylesterase - metabolism | Fetus - drug effects | Placenta - drug effects | Pregnancy | Animals | Glucuronosyltransferase - metabolism | Cytochrome P-450 Enzyme System - biosynthesis | Cytochrome P-450 Enzyme System - genetics | Hydroxyprogesterones - metabolism | Special Section on Drug Metabolizing Enzymes and Transporters in Pregnancy
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2019, Volume 156, Issue 1, pp. 187 - 202.e14
Upon liver injury in which hepatocyte proliferation is compromised, liver progenitor cells (LPCs), derived from biliary epithelial cells (BECs), differentiate... 
Development | CDE Diet | Hepatic | Signal Transduction | STEM-CELLS | HEPATOCYTES | ZEBRAFISH | DOWN-REGULATION | DRIVEN | FATE | IDENTIFICATION | HISTONE DEACETYLASE INHIBITORS | WNT | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Liver - pathology | Cell Proliferation | Liver - enzymology | Acute-On-Chronic Liver Failure - enzymology | Humans | Hepatocytes - pathology | Liver Cirrhosis - enzymology | F-Box-WD Repeat-Containing Protein 7 - genetics | Stem Cells - enzymology | Gene Expression Regulation, Developmental | Choline Deficiency - metabolism | Cyclin-Dependent Kinase 8 - genetics | Choline Deficiency - genetics | Receptor, Notch3 - genetics | Cell Differentiation | Histone Deacetylase 1 - genetics | Disease Models, Animal | SOX9 Transcription Factor - metabolism | Liver Regeneration | Receptor, Notch3 - metabolism | Zebrafish Proteins - metabolism | Acute-On-Chronic Liver Failure - pathology | Choline Deficiency - pathology | Bile Ducts - enzymology | beta Catenin - metabolism | Zebrafish - genetics | beta Catenin - genetics | Mice, Knockout | Gene Expression Regulation, Enzymologic | Animals | Zebrafish - metabolism | Cyclin-Dependent Kinase 8 - metabolism | Liver Cirrhosis - pathology | Stem Cells - pathology | Mutation | Zebrafish Proteins - genetics | F-Box-WD Repeat-Containing Protein 7 - metabolism | SOX9 Transcription Factor - genetics | Bile Ducts - pathology | Hepatocytes - enzymology | Histone Deacetylase 1 - metabolism | hepatic | development | signal transduction | CDE diet
Journal Article
Nature (London), ISSN 1476-4687, 2014, Volume 513, Issue 7516, pp. 110 - 114
Mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 are among the most common genetic alterations in intrahepatic cholangiocarcinoma (IHCC), a deadly liver... 
PROGENITORS | INTRAHEPATIC CHOLANGIOCARCINOMA | HOMEOSTASIS | LIVER-REGENERATION | MULTIDISCIPLINARY SCIENCES | MUTATION | GROWTH | MICE | PROLIFERATION | EXPRESSION | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Hepatocyte Nuclear Factor 4 - antagonists & inhibitors | Humans | ras Proteins - metabolism | Hepatocytes - pathology | Male | Hepatocytes - metabolism | Bile Duct Neoplasms - enzymology | Cell Differentiation - genetics | Neoplasm Metastasis | Hepatocyte Nuclear Factor 4 - biosynthesis | Female | Bile Duct Neoplasms - genetics | Cell Lineage - genetics | Cholangiocarcinoma - enzymology | Disease Models, Animal | Cell Division - genetics | Proto-Oncogene Proteins - metabolism | Hepatocyte Nuclear Factor 4 - metabolism | Bile Ducts, Intrahepatic - pathology | Mutant Proteins - genetics | Isocitrate Dehydrogenase - genetics | Mice, Transgenic | Mutant Proteins - metabolism | Proto-Oncogene Proteins - genetics | Hepatocyte Nuclear Factor 4 - genetics | Mutation - genetics | Bile Ducts, Intrahepatic - enzymology | Cholangiocarcinoma - pathology | Animals | Cholangiocarcinoma - genetics | Stem Cells - pathology | Isocitrate Dehydrogenase - metabolism | Glutarates - metabolism | Mice | Bile Duct Neoplasms - pathology | Hepatocytes - enzymology | Index Medicus | Càncer | Diferenciació cel·lular | Gallbladder diseases | Metabolisme | Cell diferentiation | Metabolism | Malalties de la vesícula biliar | Cancer
Journal Article
Sleep (New York, N.Y.), ISSN 1550-9109, 2015, Volume 38, Issue 10, pp. 1583 - 1591
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 9, p. e45285
A role for the NADPH oxidases NOX1 and NOX2 in liver fibrosis has been proposed, but the implication of NOX4 is poorly understood yet. The aim of this work was... 
GROWTH-FACTOR-BETA | OXIDATIVE STRESS | TGF-BETA | INDUCED APOPTOSIS | ADENINE-DINUCLEOTIDE PHOSPHATE | MULTIDISCIPLINARY SCIENCES | FIBROGENESIS | DIFFERENTIATION | MESENCHYMAL TRANSITION | UP-REGULATION | Liver - virology | Hepatitis C, Chronic - pathology | Liver - enzymology | Gene Expression - drug effects | Apoptosis - drug effects | ATP Binding Cassette Transporter, Sub-Family B - deficiency | Carbon Tetrachloride | Humans | NADPH Oxidases - metabolism | Hepatitis C, Chronic - virology | Myofibroblasts - enzymology | Liver Cirrhosis - enzymology | Liver Cirrhosis - chemically induced | Liver - drug effects | Cell Transdifferentiation - drug effects | Hepatitis C, Chronic - enzymology | STAT3 Transcription Factor - deficiency | NADPH Oxidases - genetics | Hepacivirus - physiology | Hepatic Stellate Cells - virology | Myofibroblasts - virology | Hepatocytes - drug effects | STAT3 Transcription Factor - genetics | Hepatic Stellate Cells - drug effects | Cyclin-Dependent Kinase Inhibitor p16 - deficiency | Hepatic Stellate Cells - enzymology | Cyclin-Dependent Kinase Inhibitor p16 - genetics | NADPH Oxidase 4 | Myofibroblasts - drug effects | Mice, Knockout | Transforming Growth Factor beta - pharmacology | Animals | Liver Cirrhosis - virology | Signal Transduction - drug effects | Biopsy | Hepatocytes - virology | Liver Cirrhosis - pathology | Mice | ATP Binding Cassette Transporter, Sub-Family B - genetics | Hepatocytes - enzymology | Oxidases | Care and treatment | Liver diseases | Research | Gene expression | Liver cells | Animal models | Biomedical research | Mesenchyme | Liver | Carbon tetrachloride | Viruses | Activation | Metastasis | Experiments | NAD(P)H oxidase | Hepatitis | Genotype & phenotype | Cell activation | NOX4 protein | Rodents | Hepatology | Gastroenterology | CYBB protein | Fibroblasts | Growth factors | Medical research | Stellate cells | Patients | Pulmonary fibrosis | Hepatocytes | Cell death | Fibrosis | Hepatitis C virus | Hepatitis C | Cancer | Apoptosis | Bile | Malalties del fetge | Cèl·lules hepàtiques
Journal Article
Clinical science (1979), ISSN 1470-8736, 2017, Volume 131, Issue 12, pp. 1301 - 1315
Journal Article
Oncogene, ISSN 1476-5594, 2011, Volume 31, Issue 32, pp. 3679 - 3695
Colitis-associated colorectal cancers are an etiologically distinct subgroup of colon cancers that occur in individuals suffering from inflammatory bowel... 
intestinal barrier | inflammatory bowel disease | colon carcinogenesis | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEPATOCYTE GROWTH-FACTOR | ULCERATIVE-COLITIS | BARRIER FUNCTION | INTESTINAL HOMEOSTASIS | PLASMINOGEN ACTIVATION | CELL BIOLOGY | MATRIX METALLOPROTEINASES | INFLAMMATORY-BOWEL-DISEASE | ONCOLOGY | COLORECTAL-CANCER | MOUSE MODEL | GENETICS & HEREDITY | SERINE-PROTEASE MATRIPTASE | Adenocarcinoma - pathology | Cell Proliferation | Epithelium - enzymology | Humans | Gene Expression Regulation, Neoplastic | Colitis - pathology | Mice, 129 Strain | Intestinal Absorption | Adenoma - enzymology | Inflammatory Bowel Diseases - enzymology | Inflammatory Bowel Diseases - pathology | Serine Endopeptidases - genetics | Basement Membrane - enzymology | Genes, Tumor Suppressor | Metagenome - drug effects | Epithelium - metabolism | Signal Transduction | Colon - pathology | Neoplasm Invasiveness | Mice, Inbred C57BL | Adenocarcinoma - enzymology | Basement Membrane - metabolism | Cell Transformation, Neoplastic - metabolism | beta Catenin - metabolism | Mice, Knockout | Gene Expression Regulation, Enzymologic | Membrane Proteins | Animals | Colitis - enzymology | Colitis - microbiology | Colonic Neoplasms - pathology | Inflammatory Bowel Diseases - microbiology | Anti-Bacterial Agents - pharmacology | Colonic Neoplasms - enzymology | Mice | Serine Endopeptidases - metabolism | Precancerous Conditions | Colon cancer | Immune response | Research | Carcinogenesis | Analysis | Stem cells | Inflammatory bowel disease | Proteins | Gene expression | Pathogenesis | Colorectal cancer | Index Medicus
Journal Article