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Proceedings of the National Academy of Sciences, ISSN 0027-8424, 11/2014, Volume 111, Issue 45, pp. E4878 - E4886
Inflammation is accompanied by the release of highly reactive oxygen and nitrogen species (RONS) that damage DNA, among other cellular molecules. Base excision... 
Aag/Mpg DNA glycosylase | DNA repair | Ischemia reperfusion | Liver | Base excision | GLYCOSYLASE | liver | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | ischemia reperfusion | MECHANISMS | HMGB1 | CELL-DEATH | PROTECTS | PATHWAY | base excision | INFLAMMATION | POLY(ADP-RIBOSE) POLYMERASE-1 | STRESS | Inflammation - pathology | Liver - pathology | Liver - enzymology | Reactive Oxygen Species - metabolism | Kidney - pathology | Kidney - enzymology | Brain - enzymology | Brain Infarction - pathology | Hepatocytes - pathology | Acute Kidney Injury - genetics | HMGB1 Protein - genetics | HMGB1 Protein - metabolism | Cell Death | Reperfusion Injury - genetics | DNA Glycosylases - metabolism | Brain Infarction - enzymology | Reperfusion Injury - pathology | Acute Kidney Injury - pathology | Reactive Nitrogen Species - metabolism | Reperfusion Injury - enzymology | DNA Glycosylases - genetics | Acute Kidney Injury - enzymology | Mice, Knockout | Enzyme Induction - genetics | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | DNA Repair | Brain - pathology | Inflammation - genetics | Mice | DNA Damage | Brain Infarction - genetics | Inflammation - enzymology | Hepatocytes - enzymology | Brain | Kidneys | DNA polymerase | Rodents | DNA damage | Index Medicus | Biological Sciences | PNAS Plus | Aag | Mpg DNA glycosylase
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2013, Volume 123, Issue 4, pp. 1821 - 1832
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 02/2013, Volume 41, Issue 2, pp. 256 - 262
There is increasing evidence that pregnancy alters the function of drug-metabolizing enzymes and drug transporters in a gestational-stage and tissue-specific... 
WOMEN | METFORMIN | CLEARANCE | IN-VITRO | PHARMACOKINETICS | PLASMA-CONCENTRATIONS | 3RD TRIMESTER | ZIDOVUDINE | PHARMACOLOGY & PHARMACY | HUMAN-IMMUNODEFICIENCY-VIRUS | EXPRESSION | Smoking - adverse effects | Estrogens - pharmacology | Liver - enzymology | Cholestasis - metabolism | Minor Histocompatibility Antigens | Taurocholic Acid - metabolism | Humans | Kidney - enzymology | Cytochrome P-450 Enzyme System - metabolism | Male | Hepatocytes - metabolism | Organic Anion Transporters - metabolism | Intestine, Small - enzymology | Lung - enzymology | Glucuronosyltransferase - genetics | RNA, Messenger - biosynthesis | Kidney - metabolism | Estrogen Receptor alpha - agonists | Liver - drug effects | Cotinine - metabolism | Maternal Behavior | ATP-Binding Cassette Transporters - metabolism | Female | Membrane Transport Proteins - metabolism | Pesticides - metabolism | Adrenal Glands - enzymology | Progesterone - pharmacology | Estradiol - pharmacology | Hepatocytes - drug effects | Retinoic Acid 4-Hydroxylase | Multidrug Resistance-Associated Proteins - drug effects | Gene Expression Regulation, Developmental - drug effects | Placenta - enzymology | Ethinyl Estradiol - pharmacology | Aryldialkylphosphatase - metabolism | Carboxylesterase - metabolism | Fetus - drug effects | Placenta - drug effects | Pregnancy | Animals | Glucuronosyltransferase - metabolism | Cytochrome P-450 Enzyme System - biosynthesis | Cytochrome P-450 Enzyme System - genetics | Hydroxyprogesterones - metabolism | Index Medicus | Special Section on Drug Metabolizing Enzymes and Transporters in Pregnancy
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2012, Volume 7, Issue 9, pp. e45285 - e45285
A role for the NADPH oxidases NOX1 and NOX2 in liver fibrosis has been proposed, but the implication of NOX4 is poorly understood yet. The aim of this work was... 
GROWTH-FACTOR-BETA | OXIDATIVE STRESS | TGF-BETA | INDUCED APOPTOSIS | ADENINE-DINUCLEOTIDE PHOSPHATE | MULTIDISCIPLINARY SCIENCES | FIBROGENESIS | DIFFERENTIATION | MESENCHYMAL TRANSITION | UP-REGULATION | Liver - virology | Hepatitis C, Chronic - pathology | Liver - enzymology | Gene Expression - drug effects | Apoptosis - drug effects | ATP Binding Cassette Transporter, Sub-Family B - deficiency | Carbon Tetrachloride | Humans | NADPH Oxidases - metabolism | Hepatitis C, Chronic - virology | Myofibroblasts - enzymology | Liver Cirrhosis - enzymology | Liver Cirrhosis - chemically induced | Liver - drug effects | Cell Transdifferentiation - drug effects | Hepatitis C, Chronic - enzymology | STAT3 Transcription Factor - deficiency | NADPH Oxidases - genetics | Hepacivirus - physiology | Hepatic Stellate Cells - virology | Myofibroblasts - virology | Hepatocytes - drug effects | STAT3 Transcription Factor - genetics | Hepatic Stellate Cells - drug effects | Cyclin-Dependent Kinase Inhibitor p16 - deficiency | Hepatic Stellate Cells - enzymology | Cyclin-Dependent Kinase Inhibitor p16 - genetics | NADPH Oxidase 4 | Myofibroblasts - drug effects | Mice, Knockout | Transforming Growth Factor beta - pharmacology | Animals | Liver Cirrhosis - virology | Signal Transduction - drug effects | Biopsy | Hepatocytes - virology | Liver Cirrhosis - pathology | Mice | ATP Binding Cassette Transporter, Sub-Family B - genetics | Hepatocytes - enzymology | Oxidases | Care and treatment | Liver diseases | Research | Gene expression | Liver cells | Animal models | Biomedical research | Mesenchyme | Liver | Carbon tetrachloride | Viruses | Activation | Metastasis | Experiments | NAD(P)H oxidase | Hepatitis | Genotype & phenotype | Cell activation | NOX4 protein | Rodents | Hepatology | Gastroenterology | CYBB protein | Fibroblasts | Growth factors | Medical research | Stellate cells | Patients | Pulmonary fibrosis | Hepatocytes | Cell death | Fibrosis | Hepatitis C virus | Hepatitis C | Cancer | Apoptosis | Bile | Index Medicus | Malalties del fetge | Cèl·lules hepàtiques
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 513, Issue 7516, pp. 110 - 114
Mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 are among the most common genetic alterations in intrahepatic cholangiocarcinoma (IHCC), a deadly liver... 
PROGENITORS | INTRAHEPATIC CHOLANGIOCARCINOMA | HOMEOSTASIS | LIVER-REGENERATION | MULTIDISCIPLINARY SCIENCES | MUTATION | GROWTH | MICE | PROLIFERATION | EXPRESSION | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Hepatocyte Nuclear Factor 4 - antagonists & inhibitors | Humans | ras Proteins - metabolism | Hepatocytes - pathology | Male | Hepatocytes - metabolism | Bile Duct Neoplasms - enzymology | Cell Differentiation - genetics | Neoplasm Metastasis | Hepatocyte Nuclear Factor 4 - biosynthesis | Female | Bile Duct Neoplasms - genetics | Cell Lineage - genetics | Cholangiocarcinoma - enzymology | Disease Models, Animal | Cell Division - genetics | Proto-Oncogene Proteins - metabolism | Hepatocyte Nuclear Factor 4 - metabolism | Bile Ducts, Intrahepatic - pathology | Mutant Proteins - genetics | Isocitrate Dehydrogenase - genetics | Mice, Transgenic | Mutant Proteins - metabolism | Proto-Oncogene Proteins - genetics | Hepatocyte Nuclear Factor 4 - genetics | Mutation - genetics | Bile Ducts, Intrahepatic - enzymology | Cholangiocarcinoma - pathology | Animals | Cholangiocarcinoma - genetics | Stem Cells - pathology | Isocitrate Dehydrogenase - metabolism | Glutarates - metabolism | Mice | Bile Duct Neoplasms - pathology | Hepatocytes - enzymology | Index Medicus | Càncer | Diferenciació cel·lular | Gallbladder diseases | Metabolisme | Cell diferentiation | Metabolism | Malalties de la vesícula biliar | Cancer
Journal Article
FASEB JOURNAL, ISSN 0892-6638, 07/2004, Volume 18, Issue 10, pp. 1080 - 1089
Journal Article
Sleep, ISSN 0161-8105, 10/2015, Volume 38, Issue 10, pp. 1583 - 1591B
Journal Article
Oncogene, ISSN 0950-9232, 08/2012, Volume 31, Issue 32, pp. 3679 - 3695
Colitis-associated colorectal cancers are an etiologically distinct subgroup of colon cancers that occur in individuals suffering from inflammatory bowel... 
intestinal barrier | inflammatory bowel disease | colon carcinogenesis | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEPATOCYTE GROWTH-FACTOR | ULCERATIVE-COLITIS | BARRIER FUNCTION | INTESTINAL HOMEOSTASIS | PLASMINOGEN ACTIVATION | CELL BIOLOGY | MATRIX METALLOPROTEINASES | INFLAMMATORY-BOWEL-DISEASE | ONCOLOGY | COLORECTAL-CANCER | MOUSE MODEL | GENETICS & HEREDITY | SERINE-PROTEASE MATRIPTASE | Adenocarcinoma - pathology | Cell Proliferation | Epithelium - enzymology | Humans | Gene Expression Regulation, Neoplastic | Colitis - pathology | Mice, 129 Strain | Intestinal Absorption | Adenoma - enzymology | Inflammatory Bowel Diseases - enzymology | Inflammatory Bowel Diseases - pathology | Serine Endopeptidases - genetics | Basement Membrane - enzymology | Genes, Tumor Suppressor | Metagenome - drug effects | Epithelium - metabolism | Signal Transduction | Colon - pathology | Neoplasm Invasiveness | Mice, Inbred C57BL | Adenocarcinoma - enzymology | Basement Membrane - metabolism | Cell Transformation, Neoplastic - metabolism | beta Catenin - metabolism | Mice, Knockout | Gene Expression Regulation, Enzymologic | Membrane Proteins | Animals | Colitis - enzymology | Colitis - microbiology | Colonic Neoplasms - pathology | Inflammatory Bowel Diseases - microbiology | Anti-Bacterial Agents - pharmacology | Colonic Neoplasms - enzymology | Mice | Serine Endopeptidases - metabolism | Precancerous Conditions | Colon cancer | Immune response | Research | Carcinogenesis | Analysis | Stem cells | Inflammatory bowel disease | Proteins | Gene expression | Pathogenesis | Colorectal cancer | Index Medicus
Journal Article
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, ISSN 0892-6638, 2004, Volume 18, Issue 7, pp. 854 - 856
Carbon monoxide (CO) has recently emerged as having potent cytoprotective properties; the mechanisms underlying these effects, however, are just beginning to... 
heme oxygenase | nitric oxide | KINASE PATHWAY | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INJURY | INDUCTION | CELL BIOLOGY | iNOS/NOS2 | HEMORRHAGIC-SHOCK | ALPHA-INDUCED APOPTOSIS | INHIBITION | inflammation | BIOLOGY | GENE-EXPRESSION | HEME OXYGENASE-1 PROTECTS | PROVIDES PROTECTION | oxidative stress | Bronchoalveolar Lavage Fluid | Liver - enzymology | Apoptosis - drug effects | Nitric Oxide Synthase - physiology | Male | Shock, Septic - prevention & control | Nitric Oxide Synthase Type II | Lung - enzymology | Hepatocytes - cytology | Carbon Monoxide - pharmacology | Chemotaxis, Leukocyte - drug effects | Heme Oxygenase (Decyclizing) - biosynthesis | Enzyme Induction - drug effects | Heme Oxygenase-1 | Nitric Oxide Synthase - biosynthesis | Hepatocytes - drug effects | Cytokines - blood | Cells, Cultured - drug effects | Lipopolysaccharides - toxicity | Cytokines - secretion | Rats | Shock, Septic - complications | Nitric Oxide - physiology | Macrophages, Alveolar - secretion | Organ Specificity | Rats, Sprague-Dawley | Cells, Cultured - enzymology | Macrophages, Alveolar - enzymology | Tumor Necrosis Factor-alpha - pharmacology | Animals | Multiple Organ Failure - prevention & control | Macrophages, Alveolar - drug effects | Multiple Organ Failure - etiology | Lipopolysaccharides - pharmacology | Multiple Organ Failure - enzymology | NF-kappa B - physiology | Shock, Septic - enzymology | Macrophage Activation - drug effects | Hepatocytes - enzymology | Index Medicus
Journal Article
Clinical Science, ISSN 0143-5221, 06/2017, Volume 131, Issue 12, pp. 1301 - 1315
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2012, Volume 287, Issue 25, pp. 21492 - 21500
Journal Article
Modern Pathology, ISSN 0893-3952, 03/2006, Volume 19, Issue 3, pp. 447 - 452
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2017, Volume 112, pp. 141 - 148
Steatosis intensifies hepatic ischemia/reperfusion (I/R) injury increasing hepatocyte damage and hepatic inflammation. This study evaluates if this process is... 
Ischemia reperfusion damage | Hepatocyte death | Hepatoprotection | Hepatic damage | Oxidative damage | Steatosis | RAT-LIVER | STIMULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | MECHANISMS | TRANSPLANTATION | ISCHEMIA-REPERFUSION INJURY | UNFOLDED PROTEIN RESPONSE | INFLAMMATION | ENDOCRINOLOGY & METABOLISM | NONALCOHOLIC STEATOHEPATITIS NASH | RESISTANCE | Kupffer Cells - pathology | Liver - pathology | Palmitic Acid - pharmacology | Liver - enzymology | Oxidative Stress | Fatty Liver - pathology | Diet, High-Fat - adverse effects | Hepatocytes - pathology | Male | Endoplasmic Reticulum Stress - genetics | MAP Kinase Kinase 4 - metabolism | Fatty Liver - enzymology | p38 Mitogen-Activated Protein Kinases - metabolism | Liver - surgery | MAP Kinase Kinase Kinase 5 - metabolism | Reperfusion Injury - genetics | Hepatocytes - drug effects | Fatty Liver - genetics | MAP Kinase Kinase Kinase 5 - genetics | Reperfusion Injury - pathology | Signal Transduction | Reperfusion Injury - enzymology | Mice, Inbred C57BL | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | Kupffer Cells - enzymology | Kupffer Cells - drug effects | Animals | MAP Kinase Kinase 4 - genetics | Mice | Primary Cell Culture | Fatty Liver - etiology | Hepatocytes - enzymology | Stress (Physiology) | Liver diseases | Fatty acids | Liver | Fatty liver | Analysis | Index Medicus
Journal Article
World Journal of Gastroenterology, ISSN 1007-9327, 06/2015, Volume 21, Issue 21, pp. 6591 - 6603
AIM: To investigate the continuous hepatic histopathological processes which occur in response to the loss of Dicer1. METHODS: We generated a... 
Dicer1 | Hepatocellular carcinoma | Liver fibrosis | MicroRNAs | Liver inflammation | microRNAs | STEM-CELLS | MICRORNA BIOGENESIS | REGENERATION | PROLIFERATION | HEPATOCARCINOGENESIS | LIVER-CANCER | MIR-122 | DIFFERENTIATION | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | TUMORIGENESIS | Liver - pathology | Cell Proliferation | Liver - enzymology |