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1. Full Text Antiviral drug resistance in herpesviruses other than cytomegalovirus
by Piret, Jocelyne and Boivin, Guy
Reviews in Medical Virology, ISSN 1052-9276, 05/2014, Volume 24, Issue 3, pp. 186 - 218
The discovery of acyclovir (ACV), a nucleoside analogue, more than 30 years ago, represents a milestone in the management of HSV and VZV infections. The modest... 
DNA-POLYMERASE GENE | ACQUIRED-IMMUNODEFICIENCY-SYNDROME | HERPES-SIMPLEX-VIRUS | ORGAN TRANSPLANT RECIPIENTS | VIROLOGY | THYMIDINE KINASE GENE | VARICELLA-ZOSTER-VIRUS | AMINO-ACID SUBSTITUTIONS | STEM-CELL TRANSPLANTATION | SITE-DIRECTED MUTAGENESIS | REAL-TIME-PCR | Cytosine - analogs & derivatives | Acyclovir - therapeutic use | Humans | Herpesvirus 2, Human - metabolism | Herpesvirus 2, Human - genetics | Herpesvirus 3, Human - drug effects | Herpesvirus 3, Human - metabolism | Ganciclovir - therapeutic use | Cytosine - therapeutic use | Herpesvirus 2, Human - drug effects | Herpesvirus 6, Human - drug effects | Cytomegalovirus - genetics | Herpesvirus 1, Human - metabolism | Herpesvirus 6, Human - metabolism | Organophosphonates - therapeutic use | Antiviral Agents - therapeutic use | Cytomegalovirus - metabolism | Herpesvirus 6, Human - genetics | Herpesviridae Infections - virology | Herpesviridae Infections - drug therapy | Herpesvirus 3, Human - genetics | Herpesvirus 1, Human - drug effects | Drug Resistance, Viral - genetics | Herpesvirus 1, Human - genetics | Foscarnet - therapeutic use | Immunocompromised Host | Cytomegalovirus - drug effects | Herpesviridae Infections - immunology | Antiviral agents | Herpesviruses | Drug resistance | Drug therapy
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2. Full Text CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses
by Yamamoto, Makoto and Onogi, Hiroshi and Kii, Isao and Yoshida, Suguru and Iida, Kei and Sakai, Hiroyuki and Abe, Minako and Tsubota, Toshiaki and Ito, Nobutoshi and Hosoya, Takamitsu and Hagiwara, Masatoshi
Journal of Clinical Investigation, ISSN 0021-9738, 08/2014, Volume 124, Issue 8, pp. 3479 - 3488
A wide range of antiviral drugs is currently available; however, drug-resistant viruses have begun to emerge and represent a potential public health risk.... 
CYCLIN-DEPENDENT KINASES | MEDICINE, RESEARCH & EXPERIMENTAL | HERPES-SIMPLEX-VIRUS | IN-VITRO | FACTOR P-TEFB | PROTEIN-KINASE | TRANSCRIPTION | ANTIVIRAL ACTIVITY | HOST | HIV-1 REPLICATION | IDENTIFICATION | Transcription, Genetic - drug effects | Rats, Wistar | Antiviral Agents - toxicity | Pyridines - chemistry | Humans | Drug Resistance, Viral | Host-Pathogen Interactions - drug effects | DNA Viruses - genetics | Herpes Simplex - drug therapy | Herpesvirus 1, Human - physiology | Protein Kinase Inhibitors - chemistry | Piperidines - pharmacology | Antiviral Agents - chemistry | HEK293 Cells | Flavonoids - pharmacology | DNA Viruses - physiology | Cytomegalovirus - physiology | Herpesvirus 2, Human - drug effects | Disease Models, Animal | Virus Replication - drug effects | Antiviral Agents - pharmacology | Acyclovir - pharmacology | Adenoviruses, Human - physiology | Rats | Cyclin-Dependent Kinase 9 - antagonists & inhibitors | Transcriptome - drug effects | Mice, Inbred ICR | Herpesvirus 1, Human - drug effects | Herpes Simplex - virology | Animals | Host-Pathogen Interactions - genetics | Pyridines - toxicity | Herpes Simplex - pathology | Adenoviruses, Human - drug effects | Protein Kinase Inhibitors - toxicity | Herpesvirus 2, Human - physiology | Mice | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | HeLa Cells | DNA Viruses - drug effects | Cytomegalovirus - drug effects | Physiological aspects | Research | DNA viruses | Health aspects | Protein kinases | Medical research | Drug resistance | Kinases | Cell cycle
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3. Full Text beta-Amyloid peptides display protective activity against the human Alzheimer's disease-associated herpes simplex virus-1
by Bourgade, K and Garneau, H and Giroux, G and Le Page, AY and Bocti, C and Dupuis, G and Frost, EH and Fulop, T
BIOGERONTOLOGY, ISSN 1389-5729, 02/2015, Volume 16, Issue 1, pp. 85 - 98
Amyloid plaques, the hallmark of Alzheimer's disease (AD), contain fibrillar beta-amyloid (A beta) 1-40 and 1-42 peptides. Herpes simplex virus 1 (HSV-1) has... 
PROTEIN | Human adenovirus type 5 | MECHANISMS | NEUROTOXICITY | OLIGOMERS | GERIATRICS & GERONTOLOGY | ENCEPHALITIS | Antimicrobial peptides | HYPOTHESIS | A-BETA | ANTIMICROBIAL PEPTIDE | ADENOVIRUSES | Viral replication inhibition | Beta-amyloid peptides | Herpes simplex virus-1 | Alzheimer's disease | VIRAL ENTRY | Fibroblasts - virology | Cell Line | Virus Replication - drug effects | Neuroglia - pathology | Amyloid beta-Peptides - pharmacology | Epithelial Cells - drug effects | Humans | Risk Factors | Epithelial Cells - pathology | Peptide Fragments - pharmacology | Fibroblasts - pathology | Herpesvirus 1, Human - drug effects | Neuroglia - drug effects | Alzheimer Disease - virology | Herpesvirus 1, Human - physiology | Amyloid beta-Peptides - therapeutic use | Epithelial Cells - virology | Fibroblasts - drug effects | Cell Line, Tumor | Plaque, Amyloid - virology | Alzheimer Disease - epidemiology | Herpes Simplex - prevention & control | Peptide Fragments - therapeutic use | Neuroglia - virology
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4. Full Text Houttuynia cordata targets the beginning stage of herpes simplex virus infection
by Hung, Pei-Yun and Ho, Bing-Ching and Lee, Szu-Yuan and Chang, Sui-Yuan and Kao, Chuan-Liang and Lee, Shoei-Sheng and Lee, Chun-Nan
PLoS ONE, ISSN 1932-6203, 02/2015, Volume 10, Issue 2, p. e0115475
Herpes simplex virus (HSV), a common latent virus in humans, causes certain severe diseases. Extensive use of acyclovir (ACV) results in the development of... 
IN-VITRO | MULTIDISCIPLINARY SCIENCES | CELL-SURFACE RECEPTORS | PSEUDORABIES VIRUS | HEPARAN-SULFATE | DRUG-RESISTANCE | INFLUENZA-VIRUS | TYPE-1 | NF-KAPPA-B | ANTI-HSV ACTIVITY | GLYCOPROTEIN-D | Gene Expression Regulation, Viral - drug effects | Plant Extracts - pharmacology | Humans | NF-kappa B - metabolism | Herpesvirus 2, Human - metabolism | Virus Internalization - drug effects | Houttuynia - chemistry | Herpesvirus 2, Human - genetics | Herpesvirus 1, Human - physiology | Viral Envelope Proteins - metabolism | Water - chemistry | Herpesvirus 2, Human - drug effects | Cell Line | Virus Replication - drug effects | Antiviral Agents - pharmacology | Herpesvirus 1, Human - metabolism | Virion - physiology | Acyclovir - pharmacology | Plant Extracts - isolation & purification | Hot Temperature | Herpesvirus 1, Human - drug effects | Virion - drug effects | Animals | Drug Resistance, Viral - drug effects | Herpesvirus 1, Human - genetics | Herpesvirus 2, Human - physiology | Antiviral Agents - isolation & purification | Virus diseases | Infection | Herpes simplex | Acyclovir | Gene expression | Health aspects | Herpes simplex virus | Drugs | Cell culture | Biotechnology | Pneumonia | Laboratories | Viruses | Infections | Drug resistance | Drug development | Kinases | Proteins | Chinese medicine | Human immunodeficiency virus--HIV | Meningitis | NF-κB protein | Encephalitis | Free radicals | FDA approval | Molecular chains | Penetration resistance | Herbal medicine | Flavonoids | Molecular modelling | Influenza | Herpes viruses | Quercetin | Viral infections | HIV | Human immunodeficiency virus
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5. Full Text Resistance of Herpes Simplex Viruses to Nucleoside Analogues: Mechanisms, Prevalence, and Management
by Jocelyne Piret and Guy Boivin
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 02/2011, Volume 55, Issue 2, pp. 459 - 472
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
DNA-POLYMERASE GENE | ACQUIRED-IMMUNODEFICIENCY-SYNDROME | REAL-TIME PCR | IMIQUIMOD 5-PERCENT CREAM | THYMIDINE KINASE GENE | BACTERIAL ARTIFICIAL CHROMOSOME | ANTIVIRAL DRUG SUSCEPTIBILITY | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | STEM-CELL TRANSPLANTATION | RECURRENT GENITAL HERPES | HELICASE-PRIMASE INHIBITOR | Antiviral Agents - pharmacology | Nucleosides - chemistry | Prevalence | Acyclovir - analogs & derivatives | Humans | Drug Resistance, Viral | Acyclovir - pharmacology | Viral Plaque Assay | Herpes Simplex - drug therapy | Herpesvirus 1, Human - drug effects | Microbial Sensitivity Tests | Herpes Simplex - virology | Acyclovir - chemistry | Antiviral Agents - chemistry | Nucleosides - pharmacology | Mutation | Herpesvirus 2, Human - drug effects | Minireview
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6. Full Text Inhibitors of nucleotidyltransferase superfamily enzymes suppress herpes simplex virus replication
by Tavis, John E and Wang, Hong and Tollefson, Ann E and Ying, Baoling and Korom, Maria and Cheng, Xiaohong and Cao, Feng and Davis, Katie L and Wold, William S. M and Morrison, Lynda A
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 12/2014, Volume 58, Issue 12, pp. 7451 - 7461
Herpesviruses are large double-stranded DNA viruses that cause serious human diseases. Herpesvirus DNA replication depends on multiple processes typically... 
RNASE-H | ACYCLOVIR | RIBONUCLEASE H ACTIVITY | CRYSTAL-STRUCTURE | GENITAL HERPES | ESCHERICHIA-COLI | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | DNA-POLYMERASE | INFECTED-CELLS | HIV-1 REVERSE-TRANSCRIPTASE | ANTIVIRAL DRUGS | Small Molecule Libraries - pharmacology | DNA Replication - drug effects | Humans | Cercopithecus aethiops | Viral Proteins - metabolism | Dose-Response Relationship, Drug | Herpesvirus 1, Human - growth & development | DNA, Viral - antagonists & inhibitors | Nucleotidyltransferases - antagonists & inhibitors | Nucleotidyltransferases - metabolism | Herpesvirus 2, Human - enzymology | Herpesvirus 2, Human - drug effects | Vero Cells | Fibroblasts - virology | Virus Replication - drug effects | Antiviral Agents - pharmacology | DNA, Viral - metabolism | Enzyme Inhibitors - pharmacology | Acyclovir - pharmacology | Viral Proteins - genetics | Viral Proteins - antagonists & inhibitors | Herpesvirus 1, Human - drug effects | Cytomegalovirus - growth & development | Animals | Herpesvirus 2, Human - growth & development | Herpesvirus 1, Human - enzymology | Fibroblasts - drug effects | Nucleotidyltransferases - genetics | Drug Resistance, Viral - drug effects | Cytomegalovirus - enzymology | Primary Cell Culture | DNA, Viral - genetics | Cytomegalovirus - drug effects | Antiviral Agents
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7. Full Text ASP2151, a novel helicase-primase inhibitor, possesses antiviral activity against varicella-zoster virus and herpes simplex virus types 1 and 2
by Chono, Koji and Katsumata, Kiyomitsu and Kontani, Toru and Kobayashi, Masayuki and Sudo, Kenji and Yokota, Tomoyuki and Konno, Kenji and Shimizu, Yasuaki and Suzuki, Hiroshi
Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, 06/2010, Volume 65, Issue 8, pp. 1733 - 1741
To evaluate and describe the anti-herpesvirus effect of ASP2151, amenamevir, a novel non-nucleoside oxadiazolylphenyl-containing herpesvirus helicase-primase... 
Antiviral agents | Amenamevir | Alphaherpesvirinae viruses | INFECTIOUS DISEASES | COMPLEX | antiviral agents | MICROBIOLOGY | amenamevir | DRUG-RESISTANCE | IDENTIFICATION | ACYCLOVIR | REPLICATION | SEQUENCE | MUTATION | DISEASE | PHARMACOLOGY & PHARMACY | DNA HELICASE | ASSOCIATION | Virus Replication - drug effects | Antiviral Agents - pharmacology | Antiviral Agents - therapeutic use | Drug Resistance, Viral | Enzyme Inhibitors - pharmacology | Viral Plaque Assay | Viral Proteins - antagonists & inhibitors | Enzyme Inhibitors - therapeutic use | Sequence Analysis, DNA | Herpesvirus 1, Human - drug effects | Microbial Sensitivity Tests | Herpes Zoster - drug therapy | Herpesvirus 3, Human - drug effects | Animals | DNA Mutational Analysis | Female | Mice | DNA Helicases - antagonists & inhibitors | Herpesvirus 2, Human - drug effects | Cytomegalovirus - drug effects | Disease Models, Animal
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8. Full Text The Herpes Simplex Virus-1 genome contains multiple clusters of repeated G-quadruplex: Implications for the antiviral activity of a G-quadruplex ligand
by Artusi, Sara and Nadai, Matteo and Perrone, Rosalba and Biasolo, Maria Angela and Palù, Giorgio and Flamand, Louis and Calistri, Arianna and Richter, Sara N
Antiviral Research, ISSN 0166-3542, 06/2015, Volume 118, pp. 123 - 131
Guanine-rich nucleic acids can fold into G-quadruplexes, secondary structures implicated in important regulatory functions at the genomic level in humans,... 
Antiviral compound | DNA secondary structure | Herpes Simplex Virus 1 | G-rich sequence | G-quadruplex | DNA conformation | TELOMERIC G-QUADRUPLEX | MOTIFS | RNA | DOUBLE-STRANDED DNA | POTENT | ACYCLOVIR | REPLICATION | VIROLOGY | SEQUENCE | TARGETS | PHARMACOLOGY & PHARMACY | WIDE | Genome, Viral | Virus Replication - drug effects | DNA, Viral - drug effects | Herpesvirus 1, Human - physiology | G-Quadruplexes - drug effects | Acridines - metabolism | Humans | Herpesvirus 1, Human - genetics | Antiviral Agents - metabolism | DNA, Viral - genetics | Herpesvirus 1, Human - drug effects | Antiviral agents | Genomics
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9. Full Text A mutation in the DNA polymerase accessory factor of herpes simplex virus 1 restores viral DNA replication in the presence of raltegravir
by Zhou, Bin and Yang, Kui and Wills, Elizabeth and Tang, Liang and Baines, Joel D
Journal of Virology, ISSN 0022-538X, 2014, Volume 88, Issue 19, pp. 11121 - 11129
Previous reports showed that raltegravir, a recently approved antiviral compound that targets HIV integrase, can inhibit the nuclease function of human... 
UL15 GENE | IN-VITRO | PROTEIN | VIROLOGY | NUCLEASE DOMAIN | INFECTED-CELLS | STRAND TRANSFER | TYPE-1 | INTEGRASE INHIBITOR | PUTATIVE TERMINASE | MOLECULAR-MECHANISMS | Transcription, Genetic - drug effects | Gene Expression Regulation, Viral - drug effects | DNA Replication - drug effects | Humans | Cercopithecus aethiops | DNA-Directed DNA Polymerase - genetics | Herpesvirus 2, Human - genetics | Pyrrolidinones - pharmacology | Exodeoxyribonucleases - genetics | Raltegravir Potassium | Herpesvirus 2, Human - drug effects | Cell Line | Cytomegalovirus - genetics | Antiviral Agents - pharmacology | Models, Molecular | Viral Proteins - genetics | Muromegalovirus - drug effects | Herpesvirus 1, Human - drug effects | Drug Resistance, Viral - genetics | Animals | Herpesvirus 1, Human - genetics | Mice | Muromegalovirus - genetics | Mutation | DNA, Viral - genetics | Cytomegalovirus - drug effects | Vaccines and Antiviral Agents
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10. Full Text β-Carboline derivatives as novel antivirals for herpes simplex virus
by Gonzalez, M. Micaela and Cabrerizo, Franco M and Baiker, Armin and Erra-Balsells, Rosa and Osterman, Andreas and Nitschko, Hans and Vizoso-Pinto, María G
International Journal of Antimicrobial Agents, ISSN 0924-8579, 10/2018, Volume 52, Issue 4, pp. 459 - 468
Several commercial and novel synthetic β-carbolines (βCs) were evaluated for their antiviral activity against herpes simplex virus type 1 (HSV-1) using an... 
ICP0 | Alkaloids | Antiviral | Carbolines | Antiherpetic | Herpes simplex virus | INFECTIOUS DISEASES | VIRAL GENE-EXPRESSION | PROTEIN | DNA-DAMAGE | MICROBIOLOGY | DRUG-RESISTANCE | REPLICATION | HSV-1 INFECTION | DEGRADATION | PHARMACOLOGY & PHARMACY | ICPO | HARMINE | Carbolines - chemical synthesis | Cell Survival - drug effects | Virus Replication - drug effects | Antiviral Agents - pharmacology | DNA, Viral - biosynthesis | Humans | Cercopithecus aethiops | Structure-Activity Relationship | Herpesvirus 1, Human - drug effects | Dose-Response Relationship, Drug | Herpesvirus 2, Human - genetics | Carbolines - chemistry | Animals | Herpesvirus 2, Human - growth & development | Antiviral Agents - chemistry | Herpesvirus 1, Human - growth & development | DNA, Viral - antagonists & inhibitors | Antiviral Agents - chemical synthesis | Herpesvirus 1, Human - genetics | Molecular Structure | Viral Load - drug effects | Herpesvirus 2, Human - drug effects | Vero Cells | Carbolines - pharmacology
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11. Full Text Inhibitors of dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) exert a strong anti-herpesviral activity
by Hutterer, Corina and Milbradt, Jens and Hamilton, Stuart and Zaja, Mirko and Leban, Johann and Henry, Christophe and Vitt, Daniel and Steingruber, Mirjam and Sonntag, Eric and Zeitträger, Isabel and Bahsi, Hanife and Stamminger, Thomas and Rawlinson, William and Strobl, Stefan and Marschall, Manfred
Antiviral Research, ISSN 0166-3542, 07/2017, Volume 143, pp. 113 - 121
Infection with human cytomegalovirus (HCMV) is a serious medical problem, particularly in immunocompromised individuals and neonates. The success of... 
Virus-induced upregulation of DYRK1A and DYRK1B | Antiviral therapy | Broad anti-herpesviral activity | Antiviral drug target | DYRK inhibitors | Human cytomegalovirus | RNA-POLYMERASE-II | LOCALIZATION | ACTIVATION | DYRK1B | NUCLEAR EGRESS COMPLEX | Virus-induced upregulation of DYRK1A and | GREEN FLUORESCENT PROTEIN | REPLICATION | VIROLOGY | CARBOXYL-TERMINAL DOMAIN | PHARMACOLOGY & PHARMACY | INFECTION | REVEALS | Phosphorylation | Humans | Cercopithecus aethiops | Antiviral Agents - antagonists & inhibitors | Drug Delivery Systems | Gene Knockdown Techniques | Harmine - antagonists & inhibitors | Microbial Sensitivity Tests | Macaca mulatta - virology | Herpesvirus 3, Human - drug effects | Protein-Tyrosine Kinases - genetics | Sensitivity and Specificity | Protein-Tyrosine Kinases - drug effects | Vero Cells | Fibroblasts - virology | Cell Line | Cell Survival - drug effects | Virus Replication - drug effects | Ganciclovir - antagonists & inhibitors | Herpesviridae - drug effects | Protein-Serine-Threonine Kinases - genetics | Drug Discovery | Herpesvirus 1, Human - drug effects | Animals | Signal Transduction - drug effects | Cell Differentiation - drug effects | Protein-Serine-Threonine Kinases - drug effects | Cell Proliferation - drug effects | Cell Cycle - drug effects | Cytomegalovirus - drug effects | Tyrosine | Phenols | Antiviral agents | Gene expression | Health aspects | Analysis | Index Medicus
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