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Gastroenterology, ISSN 0016-5085, 2008, Volume 134, Issue 7, pp. 2004 - 2013
Background & Aims: Chemotherapy with an anticancer agent generally causes gastrointestinal tract disorders such as vomiting and anorexia, but the mechanism... 
Gastroenterology and Hepatology | SEROTONIN RECEPTOR | GHRELIN LEVELS | SYMPTOMS | MICE | EMESIS | GASTROENTEROLOGY & HEPATOLOGY | STOMACH | Receptor, Serotonin, 5-HT2B - metabolism | Receptor, Serotonin, 5-HT2C - metabolism | Body Weight - drug effects | Drugs, Chinese Herbal - pharmacology | Male | Stomach - metabolism | Drugs, Chinese Herbal - metabolism | Anorexia - physiopathology | Quinolines - pharmacology | Serotonin Receptor Agonists - pharmacology | Dose-Response Relationship, Drug | Serotonin 5-HT2 Receptor Antagonists | Chalcones - pharmacology | Dopamine Antagonists - metabolism | Receptors, Ghrelin - metabolism | Indoles - pharmacology | Stomach - innervation | Stomach - drug effects | Drugs, Chinese Herbal - therapeutic use | Flavones - pharmacology | Acylation | Disease Models, Animal | Antineoplastic Agents | Rats | Thiophenes - pharmacology | Anorexia - metabolism | Dopamine Antagonists - therapeutic use | Receptors, Ghrelin - drug effects | Piperazines - pharmacology | Rats, Sprague-Dawley | Vagotomy | Cisplatin | Ghrelin - metabolism | Eating - drug effects | Gastrointestinal Agents - pharmacology | Ghrelin - blood | Animals | Dopamine Antagonists - pharmacology | Aminopyridines - pharmacology | Serotonin - metabolism | Gastrointestinal Agents - therapeutic use | Anorexia - prevention & control | Hesperidin - pharmacology | Protein Binding | Anorexia - chemically induced | Oligopeptides - pharmacology | Gastrointestinal Agents - metabolism | Medicine, Botanic | Medicine, Herbal
Journal Article
Journal of Pharmaceutical and Biomedical Analysis, ISSN 0731-7085, 01/2019, Volume 162, pp. 225 - 233
The genus has received much interest with regards to its traditional uses against eczema, psoriasis, and mastitis. Yet, the medicinal properties of some... 
S. lucida | Phenolic | Docking | Antioxidant | Anti-inflammatory | Tyrosinase | CHOLINESTERASE | ROSMARINIC ACID | CANINA | CHEMISTRY, ANALYTICAL | PROTEIN | SPECIFICITY | PROLIFERATION | DIFFERENT EXTRACTS | PHENYLPROPANOID GLYCOSIDES | ASSAYS | PHARMACOLOGY & PHARMACY | Depsides - isolation & purification | Plant Extracts - chemistry | Antioxidants - chemistry | Plant Extracts - pharmacology | Scrophularia - classification | Solvents - chemistry | Glycoside Hydrolase Inhibitors - isolation & purification | Acetates - chemistry | Monophenol Monooxygenase - antagonists & inhibitors | Scrophularia - chemistry | Structure-Activity Relationship | Chromatography, High Pressure Liquid | Hesperidin - isolation & purification | Depsides - pharmacology | Monophenol Monooxygenase - metabolism | Amylases - metabolism | Cinnamates - isolation & purification | Computer Simulation | Enzyme Inhibitors - chemistry | Kaempferols - isolation & purification | Anti-Inflammatory Agents - isolation & purification | Cholinesterase Inhibitors - isolation & purification | Molecular Structure | Methanol - chemistry | Anti-Inflammatory Agents - pharmacology | Plant Components, Aerial - chemistry | Enzyme Inhibitors - pharmacology | Plant Extracts - isolation & purification | Antioxidants - pharmacology | Glycoside Hydrolase Inhibitors - pharmacology | Luteolin - pharmacology | Cinnamates - pharmacology | Molecular Dynamics Simulation | Enzyme Inhibitors - isolation & purification | Luteolin - isolation & purification | Macrophages - metabolism | Amylases - antagonists & inhibitors | Animals | Cholinesterase Inhibitors - pharmacology | Antioxidants - isolation & purification | Plant Roots - chemistry | Hesperidin - pharmacology | Macrophages - drug effects | RAW 264.7 Cells | Kaempferols - pharmacology | Mice | Molecular Docking Simulation | Nitric Oxide - metabolism | Antioxidants | Esters | Anti-inflammatory drugs | High performance liquid chromatography
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2008, Volume 283, Issue 14, pp. 9101 - 9112
Aldose reductase (AR) catalyzes the reduction of several aldehydes ranging from lipid peroxidation products to glucose. The activity of AR is increased in the... 
S-NITROSYLATION | MOUSE HEART | LATE-PHASE | PEROXYNITRITE | BIOCHEMISTRY & MOLECULAR BIOLOGY | REPERFUSION INJURY | MYOCARDIAL-CONTRACTILITY | SMOOTH-MUSCLE-CELLS | RAT-HEART | AKT | PROTEIN-SULFENIC ACIDS | Imidazolidines - pharmacology | Male | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Metalloporphyrins - pharmacology | Myocardial Reperfusion Injury - enzymology | Myocardial Reperfusion Injury - pathology | Nitric Oxide Synthase Type II - antagonists & inhibitors | Nitric Oxide Synthase Type I - antagonists & inhibitors | Lipid Peroxidation - drug effects | Aldehyde Reductase - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Bradykinin - pharmacology | Dithiothreitol - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Insulin - pharmacology | Aldehyde Reductase - antagonists & inhibitors | Vasodilator Agents - pharmacology | Enzyme Inhibitors - pharmacology | Rats | Ferric Compounds - pharmacology | Myocardium - pathology | Enzyme Activation - drug effects | Hypoglycemic Agents - pharmacology | Naphthalenes - pharmacology | Myocardium - enzymology | Animals | Signal Transduction - drug effects | Nitric Oxide Synthase Type I - metabolism | Peroxynitrous Acid - metabolism | Glucose - metabolism | Hesperidin - pharmacology | Nitric Oxide - metabolism | Sorbitol - pharmacology | Nitric Oxide Synthase Type II - metabolism | Index Medicus | Enzyme Catalysis and Regulation
Journal Article
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 02/2008, Volume 580, Issue 3, pp. 306 - 313
Previous reports from our laboratory described the sedative activity of hesperidin (hesperetin-7-rhamnoglucoside). This property is greatly increased when the... 
Analgesia | Sedation | Opioid receptors | Hesperidin | Benzodiazepines | opioid receptors | benzodiazepines | DIAZEPAM | ANXIETY | BEHAVIOR | analgesia | HOLE-BOARD | FLAVONOIDS | ANALGESIC ACTIVITY | sedation | hesperidin | CHLORDIAZEPOXIDE | NITRIC-OXIDE | ISOFLAVONOIDS | PHARMACOLOGY & PHARMACY | MICE | Naltrexone - analogs & derivatives | Analgesics - pharmacology | Hypnotics and Sedatives - chemistry | Narcotic Antagonists - administration & dosage | Motor Activity - drug effects | Male | Pain - chemically induced | Dose-Response Relationship, Drug | Receptors, Opioid - physiology | Acetic Acid | Naltrexone - pharmacology | Alprazolam - administration & dosage | Behavior, Animal - drug effects | Alprazolam - pharmacology | Naltrexone - administration & dosage | Benzodiazepines - pharmacology | Morphine - pharmacology | Pain - prevention & control | Flunitrazepam - administration & dosage | Injections, Intraperitoneal | Drug Synergism | Pain Measurement - methods | Animals | Analgesics - chemistry | Narcotic Antagonists - pharmacology | Hesperidin - chemistry | Hesperidin - pharmacology | Benzodiazepines - administration & dosage | Hypnotics and Sedatives - pharmacology | Mice | Morphine - administration & dosage | Flunitrazepam - pharmacology | Alprazolam | Physiological aspects | Glycosides | Analysis | Diazepam
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 12/2014, Volume 477, Issue 1-2, pp. 454 - 468
The present work describes the preparation of sterically stabilize polymeric nanoparticles of mitoxantrone dihydrochloride (MTO) along with an efflux... 
Nanoparticles | Long circulating | Hyaluronic acid | Multidrug resistance | CD44 | MITOXANTRONE | DELIVERY SYSTEMS | TUMOR | CHITOSAN NANOPARTICLES | ANTITUMOR-ACTIVITY | FORMULATION | PACLITAXEL | BREAST-CANCER | THERAPY | PHARMACOLOGY & PHARMACY | LIPID CARRIERS | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Mitoxantrone - administration & dosage | Nanoparticles - chemistry | Rats, Wistar | Drug Resistance, Multiple - drug effects | Humans | Deoxycholic Acid - chemistry | Hyaluronic Acid - pharmacology | Male | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - administration & dosage | Drug Carriers - chemistry | Tissue Distribution | Flavanones - chemistry | MCF-7 Cells | Surface Properties | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Cell Survival - drug effects | Microscopy, Electron, Transmission | Microscopy, Electron, Scanning | Quercetin - chemistry | Drug Stability | Flavanones - pharmacology | Hyaluronic Acid - chemistry | Drug Carriers - pharmacology | Particle Size | Animals | Deoxycholic Acid - pharmacology | Quercetin - pharmacology | Drug Liberation | Mitoxantrone - pharmacology | Mitoxantrone - pharmacokinetics | Hesperidin | ATP-Binding Cassette Transporters - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | Drug resistance | Investigations
Journal Article