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chromatography, high pressure liquid (45) 45
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hesperidin - isolation & purification (43) 43
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1. Full Text Rikkunshito, an Herbal Medicine, Suppresses Cisplatin-Induced Anorexia in Rats Via 5-HT2 Receptor Antagonism
by Takeda, Hiroshi and Sadakane, Chiharu and Hattori, Tomohisa and Katsurada, Takehiko and Ohkawara, Tatsuya and Nagai, Koichi and Asaka, Masahiro
Gastroenterology, ISSN 0016-5085, 2008, Volume 134, Issue 7, pp. 2004 - 2013
Background & Aims: Chemotherapy with an anticancer agent generally causes gastrointestinal tract disorders such as vomiting and anorexia, but the mechanism... 
Gastroenterology and Hepatology | SEROTONIN RECEPTOR | GHRELIN LEVELS | SYMPTOMS | MICE | EMESIS | GASTROENTEROLOGY & HEPATOLOGY | STOMACH | Receptor, Serotonin, 5-HT2B - metabolism | Receptor, Serotonin, 5-HT2C - metabolism | Body Weight - drug effects | Drugs, Chinese Herbal - pharmacology | Male | Stomach - metabolism | Drugs, Chinese Herbal - metabolism | Anorexia - physiopathology | Quinolines - pharmacology | Serotonin Receptor Agonists - pharmacology | Dose-Response Relationship, Drug | Serotonin 5-HT2 Receptor Antagonists | Chalcones - pharmacology | Dopamine Antagonists - metabolism | Receptors, Ghrelin - metabolism | Indoles - pharmacology | Stomach - innervation | Stomach - drug effects | Drugs, Chinese Herbal - therapeutic use | Flavones - pharmacology | Acylation | Disease Models, Animal | Antineoplastic Agents | Rats | Thiophenes - pharmacology | Anorexia - metabolism | Dopamine Antagonists - therapeutic use | Receptors, Ghrelin - drug effects | Piperazines - pharmacology | Rats, Sprague-Dawley | Vagotomy | Cisplatin | Ghrelin - metabolism | Eating - drug effects | Gastrointestinal Agents - pharmacology | Ghrelin - blood | Animals | Dopamine Antagonists - pharmacology | Aminopyridines - pharmacology | Serotonin - metabolism | Gastrointestinal Agents - therapeutic use | Anorexia - prevention & control | Hesperidin - pharmacology | Protein Binding | Anorexia - chemically induced | Oligopeptides - pharmacology | Gastrointestinal Agents - metabolism | Medicine, Botanic | Medicine, Herbal
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2. Full Text Scrophularia lucida L. as a valuable source of bioactive compounds for pharmaceutical applications: In vitro antioxidant, anti-inflammatory, enzyme inhibitory properties, in silico studies, and HPLC profiles
by Zengin, Gokhan and Stefanucci, Azzurra and Rodrigues, Maria João and Mollica, Adriano and Custodio, Luisa and Aumeeruddy, Muhammad Zakariyyah and Mahomoodally, Mohamad Fawzi
Journal of Pharmaceutical and Biomedical Analysis, ISSN 0731-7085, 01/2019, Volume 162, pp. 225 - 233
The genus has received much interest with regards to its traditional uses against eczema, psoriasis, and mastitis. Yet, the medicinal properties of some... 
S. lucida | Phenolic | Docking | Antioxidant | Anti-inflammatory | Tyrosinase | CHOLINESTERASE | ROSMARINIC ACID | CANINA | CHEMISTRY, ANALYTICAL | PROTEIN | SPECIFICITY | PROLIFERATION | DIFFERENT EXTRACTS | PHENYLPROPANOID GLYCOSIDES | ASSAYS | PHARMACOLOGY & PHARMACY | Depsides - isolation & purification | Plant Extracts - chemistry | Antioxidants - chemistry | Plant Extracts - pharmacology | Scrophularia - classification | Solvents - chemistry | Glycoside Hydrolase Inhibitors - isolation & purification | Acetates - chemistry | Monophenol Monooxygenase - antagonists & inhibitors | Scrophularia - chemistry | Structure-Activity Relationship | Chromatography, High Pressure Liquid | Hesperidin - isolation & purification | Depsides - pharmacology | Monophenol Monooxygenase - metabolism | Amylases - metabolism | Cinnamates - isolation & purification | Computer Simulation | Enzyme Inhibitors - chemistry | Kaempferols - isolation & purification | Anti-Inflammatory Agents - isolation & purification | Cholinesterase Inhibitors - isolation & purification | Molecular Structure | Methanol - chemistry | Anti-Inflammatory Agents - pharmacology | Plant Components, Aerial - chemistry | Enzyme Inhibitors - pharmacology | Plant Extracts - isolation & purification | Antioxidants - pharmacology | Glycoside Hydrolase Inhibitors - pharmacology | Luteolin - pharmacology | Cinnamates - pharmacology | Molecular Dynamics Simulation | Enzyme Inhibitors - isolation & purification | Luteolin - isolation & purification | Macrophages - metabolism | Amylases - antagonists & inhibitors | Animals | Cholinesterase Inhibitors - pharmacology | Antioxidants - isolation & purification | Plant Roots - chemistry | Hesperidin - pharmacology | Macrophages - drug effects | RAW 264.7 Cells | Kaempferols - pharmacology | Mice | Molecular Docking Simulation | Nitric Oxide - metabolism | Antioxidants | Esters | Anti-inflammatory drugs | High performance liquid chromatography
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3. Full Text Flavonoids inhibit high glucose-induced up-regulation of ICAM-1 via the p38 MAPK pathway in human vein endothelial cells
by Kim, Sung-Whan and Kim, Chae Eun and Kim, Moo Hyun
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 2011, Volume 415, Issue 4, pp. 602 - 607
► We examine the effects of high-glucose (HG) and flavonoids on ICAM-1 in HUVECs. ► HG increased the levels of ICAM-1 in HUVECs. ► Pretreatment with flavonoids... 
Mitogen-activated protein kinase | ICAM-1 | Flavonoid | Atherosclerosis | OXIDATIVE STRESS | INTERCELLULAR-ADHESION MOLECULE-1 | ACTIVATED PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SURFACE EXPRESSION | INSULIN SENSITIVITY | DARK CHOCOLATE | BLOOD-PRESSURE | DIABETES-MELLITUS | VCAM-1 | BIOPHYSICS | Up-Regulation | Butadienes - pharmacology | Nitriles - pharmacology | Flavanones - pharmacology | Humans | Cells, Cultured | Enzyme Inhibitors - pharmacology | Endothelium, Vascular - drug effects | Glucose - pharmacology | Imidazoles - pharmacology | Stilbenes - pharmacology | Anthracenes - pharmacology | Hyperglycemia - metabolism | Veins - drug effects | Endothelium, Vascular - metabolism | Veins - metabolism | Intercellular Adhesion Molecule-1 - biosynthesis | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Glucose - metabolism | Hesperidin - pharmacology | Pyridines - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Isoflavones | Endothelium
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4. Full Text Phenolic compounds and biological effects of edible Rumex scutatus and Pseudosempervivum sempervivum: potential sources of natural agents with health benefits
by Savran, Ahmet and Zengin, Gokhan and Aktumsek, Abdurrahman and Mocan, Andrei and Glamo lija, Jasmina and iri, Ana and Sokovi, Marina
Food and Function, ISSN 2042-6496, 7/2016, Volume 7, Issue 7, pp. 3252 - 3262
The present study outlines a chemical characterization and further effects beneficial to health of edible Rumex scutatus and Pseudosempervivum sempervivum , in... 
INHIBITORY-ACTIVITIES | ANTIOXIDANT BENEFITS | PHYTOCHEMISTRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOOD SCIENCE & TECHNOLOGY | CHEMICAL-COMPOSITION | ROOTS | ETHNOBOTANICAL SURVEY | EXTRACTS | IDENTIFICATION | MEDICINAL-PLANTS | alpha-Amylases - antagonists & inhibitors | Fungi - drug effects | Crassulaceae - chemistry | Plant Extracts - pharmacology | Anti-Infective Agents - pharmacology | Benzoic Acid - pharmacology | Rutin - pharmacology | Bacteria - drug effects | Rumex - chemistry | Biological Products - pharmacology | alpha-Amylases - metabolism | Antioxidants - pharmacology | Glycoside Hydrolase Inhibitors - pharmacology | Functional Food | Cholinesterase Inhibitors - pharmacology | Hesperidin - pharmacology | Phenols - pharmacology
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5. Full Text Role of Nitric Oxide in Regulating Aldose Reductase Activation in the Ischemic Heart
by Karin Kaiserova and Xian-Liang Tang and Sanjay Srivastava and Aruni Bhatnagar
Journal of Biological Chemistry, ISSN 0021-9258, 04/2008, Volume 283, Issue 14, pp. 9101 - 9112
Aldose reductase (AR) catalyzes the reduction of several aldehydes ranging from lipid peroxidation products to glucose. The activity of AR is increased in the... 
S-NITROSYLATION | MOUSE HEART | LATE-PHASE | PEROXYNITRITE | BIOCHEMISTRY & MOLECULAR BIOLOGY | REPERFUSION INJURY | MYOCARDIAL-CONTRACTILITY | SMOOTH-MUSCLE-CELLS | RAT-HEART | AKT | PROTEIN-SULFENIC ACIDS | Imidazolidines - pharmacology | Male | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Metalloporphyrins - pharmacology | Myocardial Reperfusion Injury - enzymology | Myocardial Reperfusion Injury - pathology | Nitric Oxide Synthase Type II - antagonists & inhibitors | Nitric Oxide Synthase Type I - antagonists & inhibitors | Lipid Peroxidation - drug effects | Aldehyde Reductase - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Bradykinin - pharmacology | Dithiothreitol - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Insulin - pharmacology | Aldehyde Reductase - antagonists & inhibitors | Vasodilator Agents - pharmacology | Enzyme Inhibitors - pharmacology | Rats | Ferric Compounds - pharmacology | Myocardium - pathology | Enzyme Activation - drug effects | Hypoglycemic Agents - pharmacology | Naphthalenes - pharmacology | Myocardium - enzymology | Animals | Signal Transduction - drug effects | Nitric Oxide Synthase Type I - metabolism | Peroxynitrous Acid - metabolism | Glucose - metabolism | Hesperidin - pharmacology | Nitric Oxide - metabolism | Sorbitol - pharmacology | Nitric Oxide Synthase Type II - metabolism | Index Medicus | Enzyme Catalysis and Regulation
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6. Full Text Chemistry and pharmacology of the citrus bioflavonoid hesperidin
by Garg, A and Garg, S and Zaneveld, L. J. D and Singla, A. K
Phytotherapy Research, ISSN 0951-418X, 12/2001, Volume 15, Issue 8, pp. 655 - 669
Hesperidin, a bioflavonoid, is an abundant and inexpensive by‐product of Citrus cultivation. A deficiency of this substance in the diet has been linked with... 
bioflavonoid | analysis | hesperetin | pharmacology | hesperidin | Pharmacology | Hesperetin | Bioflavonoid | Analysis | Hesperidin | ANTIINFLAMMATORY ACTIVITY | CHEMISTRY, MEDICINAL | STRIPPING VOLTAMMETRY | MICRONIZED FLAVONOID FRACTION | ORANGE JUICE | SPECTROPHOTOMETRIC DETERMINATION | CHRONIC VENOUS INSUFFICIENCY | NEOHESPERIDIN DIHYDROCHALCONE | DAFLON 500 MG | PERFORMANCE LIQUID-CHROMATOGRAPHY | ROTAVIRUS INFECTIVITY | PHARMACOLOGY & PHARMACY | Citrus | Hesperidin - pharmacology | Phytotherapy | Hesperidin - pharmacokinetics | Humans | Hesperidin - chemistry
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7. Full Text Combinatorial Activity of Flavonoids with Antibiotics Against Drug-Resistant Staphylococcus aureus
by Abreu, Ana Cristina and Serra, Sofia C and Borges, Anabela and Saavedra, Maria José and Mcbain, Andrew J and Salgado, António J and Simões, Manuel
Microbial Drug Resistance, ISSN 1076-6294, 12/2015, Volume 21, Issue 6, pp. 6 - 609
The use of resistance-modifying agents is a potential strategy that is used to prolong the effective life of antibiotics in the face of increasing antibiotic... 
Epidemiology | AGAR DILUTION | INFECTIOUS DISEASES | ANTIMICROBIAL AGENTS | MICROBIOLOGY | IN-VITRO SUSCEPTIBILITY | SYNERGISTIC ACTIVITIES | ACINETOBACTER-BAUMANNII | QUERCETIN | MULTIDRUG EFFLUX PUMPS | MICRODILUTION CHECKERBOARD | PSEUDOMONAS-AERUGINOSA | PHARMACOLOGY & PHARMACY | TIME-KILL | Staphylococcal Infections - drug therapy | Drug Resistance, Multiple, Bacterial - physiology | Staphylococcus aureus - isolation & purification | Erythromycin - pharmacology | Humans | Oxacillin - pharmacology | Rutin - pharmacology | Tetracycline - pharmacology | Ciprofloxacin - pharmacology | Microbial Sensitivity Tests | Quercetin - pharmacology | Hesperidin - pharmacology | Ampicillin - pharmacology | Anti-Bacterial Agents - pharmacology | Flavonoids - pharmacology | Staphylococcal Infections - microbiology | Catechin - pharmacology | Drug Therapy, Combination | Staphylococcus aureus - drug effects | Staphylococcus aureus - growth & development | Drug Resistance, Multiple, Bacterial - drug effects | Staphylococcus infections | Flavonoids | Antibiotics | Drug resistance | Combinatorics
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8. Full Text Antioxidant and Anti‐Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An Updated Review of their Molecular Mechanisms and Experimental Models
by Parhiz, Hamideh and Roohbakhsh, Ali and Soltani, Fatemeh and Rezaee, Ramin and Iranshahi, Mehrdad
Phytotherapy Research, ISSN 0951-418X, 03/2015, Volume 29, Issue 3, pp. 323 - 331
Inflammation and oxidative stress are two major causes of various life‐threatening diseases. Hesperidin (Hsd) and its aglycone, hesperetin (Hst), are two... 
allergy | antioxidant | flavonoid | inflammation | hesperetin | Allergy | Inflammation | Hesperetin | Antioxidant | Flavonoid | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | INDUCED TOXICITY | ALPHA | FACTOR-KAPPA-B | LUNG CARCINOGENESIS | DAMAGE | INHIBITION | PHARMACOLOGY | PHARMACOLOGY & PHARMACY | EXPRESSION | Animals | Signal Transduction - drug effects | Anti-Inflammatory Agents - pharmacology | Inflammation - drug therapy | Humans | Citrus - chemistry | Hesperidin - pharmacology | NF-kappa B - metabolism | Antioxidants - pharmacology | Oxidative Stress - drug effects | Disease Models, Animal | Citrus | Citrus fruits | Antioxidants | Anti-inflammatory drugs | Analysis | Models | Isoflavones
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9. Full Text Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases
by Roohbakhsh, Ali and Parhiz, Hamideh and Soltani, Fatemeh and Rezaee, Ramin and Iranshahi, Mehrdad
Life Sciences, ISSN 0024-3205, 03/2015, Volume 124, pp. 64 - 74
Hesperidin (Hsd) and its aglycone, hesperetin (Hst), are two flavonoids from citrus species that have various biological properties, particularly those for the... 
Anticoagulant | Hesperetin | Anti-cancer | Flavonoid | MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE STRESS | GLUCOSYL HESPERIDIN | KAPPA-B | LUNG CARCINOGENESIS | BETA-CRYPTOXANTHIN | CITRUS FLAVONOIDS | ANTIOXIDANT STATUS | GENE-EXPRESSION | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | UP-REGULATION | Free Radical Scavengers - pharmacology | Cardiovascular Diseases - physiopathology | Anti-Inflammatory Agents - pharmacology | Cardiovascular Diseases - prevention & control | Humans | Citrus - chemistry | Neoplasms - prevention & control | Antioxidants - pharmacology | Hesperidin - isolation & purification | Free Radical Scavengers - isolation & purification | Animals | Antioxidants - isolation & purification | Hesperidin - pharmacology | Anti-Inflammatory Agents - isolation & purification | Neoplasms - pathology | Prevention | COX-2 inhibitors | Cellular proteins | Analysis | Lymphomas | Cardiovascular diseases | Cancer
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10. Full Text Opioid receptors are involved in the sedative and antinociceptive effects of hesperidin as well as in its potentiation with benzodiazepines
by Loscalzo, Leonardo M and Wasowski, Cristina and Paladini, Alejandro C and Marder, Mariel
European Journal of Pharmacology, ISSN 0014-2999, 02/2008, Volume 580, Issue 3, pp. 306 - 313
Previous reports from our laboratory described the sedative activity of hesperidin (hesperetin-7-rhamnoglucoside). This property is greatly increased when the... 
Analgesia | Sedation | Opioid receptors | Hesperidin | Benzodiazepines | opioid receptors | benzodiazepines | DIAZEPAM | ANXIETY | BEHAVIOR | analgesia | HOLE-BOARD | FLAVONOIDS | ANALGESIC ACTIVITY | sedation | hesperidin | CHLORDIAZEPOXIDE | NITRIC-OXIDE | ISOFLAVONOIDS | PHARMACOLOGY & PHARMACY | MICE | Naltrexone - analogs & derivatives | Analgesics - pharmacology | Hypnotics and Sedatives - chemistry | Narcotic Antagonists - administration & dosage | Motor Activity - drug effects | Male | Pain - chemically induced | Dose-Response Relationship, Drug | Receptors, Opioid - physiology | Acetic Acid | Naltrexone - pharmacology | Alprazolam - administration & dosage | Behavior, Animal - drug effects | Alprazolam - pharmacology | Naltrexone - administration & dosage | Benzodiazepines - pharmacology | Morphine - pharmacology | Pain - prevention & control | Flunitrazepam - administration & dosage | Injections, Intraperitoneal | Drug Synergism | Pain Measurement - methods | Animals | Analgesics - chemistry | Narcotic Antagonists - pharmacology | Hesperidin - chemistry | Hesperidin - pharmacology | Benzodiazepines - administration & dosage | Hypnotics and Sedatives - pharmacology | Mice | Morphine - administration & dosage | Flunitrazepam - pharmacology | Alprazolam | Physiological aspects | Glycosides | Analysis | Diazepam
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11. Full Text Antioxidant capacities and total phenolic contents increase with gamma irradiation in two types of Malaysian honey
by Hussein, Saba Zuhair and Yusoff, Kamaruddin Mohd and Makpol, Suzana and Yusof, Yasmin Anum Mohd
Molecules, ISSN 1420-3049, 08/2011, Volume 16, Issue 8, pp. 6378 - 6395
Gamma irradiation | Nenas honey | Gelam honey | Phenolics | Antioxidant activity
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12. Full Text Sterically stabilized polymeric nanoparticles with a combinatorial approach for multi drug resistant cancer: In vitro and in vivo investigations
by Zafar, Sobiya and Negi, Lalit Mohan and Verma, Anita Kamra and Kumar, Vijay and Tyagi, Aakriti and Singh, Pratibha and Iqbal, Zeenat and Talegaonkar, Sushama
International Journal of Pharmaceutics, ISSN 0378-5173, 12/2014, Volume 477, Issue 1-2, pp. 454 - 468
The present work describes the preparation of sterically stabilize polymeric nanoparticles of mitoxantrone dihydrochloride (MTO) along with an efflux... 
Nanoparticles | Long circulating | Hyaluronic acid | Multidrug resistance | CD44 | MITOXANTRONE | DELIVERY SYSTEMS | TUMOR | CHITOSAN NANOPARTICLES | ANTITUMOR-ACTIVITY | FORMULATION | PACLITAXEL | BREAST-CANCER | THERAPY | PHARMACOLOGY & PHARMACY | LIPID CARRIERS | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Mitoxantrone - administration & dosage | Nanoparticles - chemistry | Rats, Wistar | Drug Resistance, Multiple - drug effects | Humans | Deoxycholic Acid - chemistry | Hyaluronic Acid - pharmacology | Male | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - administration & dosage | Drug Carriers - chemistry | Tissue Distribution | Flavanones - chemistry | MCF-7 Cells | Surface Properties | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Cell Survival - drug effects | Microscopy, Electron, Transmission | Microscopy, Electron, Scanning | Quercetin - chemistry | Drug Stability | Flavanones - pharmacology | Hyaluronic Acid - chemistry | Drug Carriers - pharmacology | Particle Size | Animals | Deoxycholic Acid - pharmacology | Quercetin - pharmacology | Drug Liberation | Mitoxantrone - pharmacology | Mitoxantrone - pharmacokinetics | Hesperidin | ATP-Binding Cassette Transporters - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | Drug resistance | Investigations
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