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Gastroenterology, ISSN 0016-5085, 2017, Volume 153, Issue 1, pp. 113 - 122
Background & Aims Patients with chronic hepatitis C virus (HCV) infection have high rates of sustained virologic response (SVR) after 12 weeks of treatment... 
Gastroenterology and Hepatology | Direct-Acting Antiviral Agent | Shortened Duration Therapy | Clinical Trial | Comparison | PROTEASE INHIBITOR GS-9857 | SIMEPREVIR PLUS SOFOSBUVIR | COMBINATION | CHALLENGES | GENOTYPE 1 | TREATMENT-NAIVE | THERAPY | HEPATITIS-C VIRUS | CIRRHOSIS | DIRECT-ACTING ANTIVIRALS | GASTROENTEROLOGY & HEPATOLOGY | Humans | Middle Aged | Male | Carbamates - administration & dosage | Young Adult | Heterocyclic Compounds, 4 or More Rings - therapeutic use | Aged, 80 and over | Adult | Female | Sofosbuvir - adverse effects | Drug Therapy, Combination | Heterocyclic Compounds, 4 or More Rings - administration & dosage | Sofosbuvir - therapeutic use | Antiviral Agents - therapeutic use | Heterocyclic Compounds, 4 or More Rings - adverse effects | Macrocyclic Compounds - adverse effects | Hepatitis C, Chronic - drug therapy | Antiviral Agents - administration & dosage | Macrocyclic Compounds - therapeutic use | Sofosbuvir - administration & dosage | Sulfonamides - therapeutic use | Antiviral Agents - adverse effects | Adolescent | Sulfonamides - adverse effects | Carbamates - adverse effects | Aged | Macrocyclic Compounds - administration & dosage | Sustained Virologic Response | Carbamates - therapeutic use | Sulfonamides - administration & dosage | Medical colleges | Care and treatment | Protease inhibitors | Proteases | Transplantation of organs, tissues, etc | Product development | Hepatitis C virus | Hepatitis C | Health aspects | Analysis
Journal Article
Investigative Radiology, ISSN 0020-9996, 03/2017, Volume 52, Issue 6, pp. 324 - 333
OBJECTIVESRetrospective studies in patients with primary brain tumors or other central nervous system pathologies as well as postmortem studies have suggested... 
Gadodiamide | Gadobutrol | Gadolinium retention | MRI | Contrast agent | Gadoteridol | Globus pallidus | Histology | Dentate nucleus | Gadopentetate dimeglumine | HEALTHY RATS DIFFERENCE | HIGH-SIGNAL INTENSITY | GLOBUS-PALLIDUS | RENAL-FUNCTION | gadoteridol | contrast agent | dentate nucleus | DEEP CEREBELLAR NUCLEI | gadodiamide | gadolinium retention | T1-WEIGHTED MR-IMAGES | histology | gadopentetate dimeglumine | gadobutrol | ENHANCED MRI | globus pallidus | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | NEPHROGENIC SYSTEMIC FIBROSIS | Gadolinium - administration & dosage | Injections, Intravenous | Rats, Wistar | Gadolinium - pharmacokinetics | Contrast Media - pharmacokinetics | Male | Muscle, Skeletal - metabolism | Bone and Bones - drug effects | Brain - metabolism | Dose-Response Relationship, Drug | Contrast Media - adverse effects | Bone and Bones - metabolism | Contrast Media - administration & dosage | Mass Spectrometry | Muscle, Skeletal - drug effects | Brain - ultrastructure | Gadolinium DTPA - pharmacokinetics | Models, Animal | Gadolinium DTPA - administration & dosage | Retrospective Studies | Gadolinium DTPA - adverse effects | Heterocyclic Compounds - administration & dosage | Organometallic Compounds - adverse effects | Rodentia | Organometallic Compounds - pharmacokinetics | Rats | Gadolinium - adverse effects | Brain - drug effects | Animals | Heterocyclic Compounds - adverse effects | Skin - ultrastructure | Heterocyclic Compounds - pharmacokinetics | Skin - drug effects | Organometallic Compounds - administration & dosage | Original
Journal Article
Journal Article
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 08/2015, Volume 21, Issue 16, pp. 3705 - 3715
Purpose: Bruton's tyrosine kinase (BTK) is a critical enzyme in the B-cell receptor pathway and is inhibited by ibrutinib due to covalent binding to the kinase... 
B-CELL RECEPTOR | TUMOR PROLIFERATION | BRUTONS TYROSINE KINASE | CLL | ONCOLOGY | BCL-2 INHIBITOR | INITIAL THERAPY | IN-VIVO | PCI-32765 | KINASE INHIBITOR IBRUTINIB | SINGLE-ARM | Piperazines - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Apoptosis - drug effects | Humans | Neoplastic Cells, Circulating - metabolism | Male | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Purines - administration & dosage | Bendamustine Hydrochloride - administration & dosage | Protein-Tyrosine Kinases - genetics | Female | bcl-X Protein - biosynthesis | Protein-Tyrosine Kinases - biosynthesis | B-Cell Activating Factor - biosynthesis | Neoplastic Cells, Circulating - drug effects | Pyrimidines - administration & dosage | Gene Expression Regulation, Leukemic - drug effects | Nitrophenols - administration & dosage | Bridged Bicyclo Compounds, Heterocyclic - administration & dosage | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Pyrazoles - administration & dosage | B-Cell Activating Factor - genetics | Biphenyl Compounds - administration & dosage | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Aged | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Isoquinolines - administration & dosage | Proto-Oncogene Proteins c-bcl-2 - genetics | Sulfonamides - administration & dosage
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2011, Volume 108, Issue 11, pp. 4400 - 4405
Ozonide OZ439 is a synthetic peroxide antimalarial drug candidate designed to provide a single-dose oral cure in humans. OZ439 has successfully completed Phase... 
Artemisinins | Malaria | Half lives | Antimalarials | Peroxides | Parasites | Dosage | Ozonides | Blood | Blood plasma | 1,2,4-trioxolane | Antimalarial drug discovery | OZ277 | PHARMACODYNAMIC PROPERTIES | MULTIDISCIPLINARY SCIENCES | ARTEROLANE | TRIOXOLANE | 1-AMINOBENZOTRIAZOLE | antimalarial drug discovery | PEROXIDES | IN-VITRO ASSESSMENT | PLASMODIUM-FALCIPARUM | ANTIMALARIAL ACTIVITY | ARTEMISININ | Peroxides - administration & dosage | Plasmodium berghei - physiology | Male | Peroxides - therapeutic use | Peroxides - pharmacokinetics | Dose-Response Relationship, Drug | Artemisinins - pharmacology | Heterocyclic Compounds - chemistry | Time Factors | Adamantane - therapeutic use | Adamantane - administration & dosage | Adamantane - pharmacokinetics | Artemisinins - chemistry | Adamantane - analogs & derivatives | Antimalarials - pharmacokinetics | Heterocyclic Compounds - administration & dosage | Drug Stability | Peroxides - chemistry | Rats | Treatment Outcome | Antimalarials - therapeutic use | Iron - metabolism | Rats, Sprague-Dawley | Animals | Artemisinins - therapeutic use | Antimalarials - administration & dosage | Antimalarials - chemistry | Malaria - parasitology | Heterocyclic Compounds - pharmacokinetics | Mice | Adamantane - chemistry | Heterocyclic Compounds - therapeutic use | Malaria - drug therapy | Care and treatment | Composition | Health aspects | Malaria vaccine | Biological Sciences
Journal Article
Journal of Magnetic Resonance Imaging, ISSN 1053-1807, 03/2018, Volume 47, Issue 3, pp. 746 - 752
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2013, Volume 56, Issue 24, pp. 10045 - 10065
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 2010, Volume 143, Issue 1, pp. 120 - 127
Journal Article