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2006, 1st ed., ISBN 9781405125093, xii, 372
Plant secondary metabolites have been a fertile area of chemical investigation for many years, driving the development of both analytical chemistry and of new... 
Metabolism, Secondary | Plantes | Botanical chemistry | Métabolisme secondaire | Chimie végétale | Plants | Metabolism | Métabolisme | TECHNOLOGY & ENGINEERING | General | Food Science | Nutrition | Plant metabolites | Food
Book
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2013, Volume 56, Issue 6, pp. 2547 - 2555
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2004, Volume 47, Issue 6, pp. 1465 - 1474
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2010, Volume 107, Issue 13, pp. 6076 - 6081
Spirolide and gymnodimine macrocyclic imine phycotoxins belong to an emerging class of chemical agents associated with marine algal blooms and shelfish... 
Receptors | Imines | Shellfish | Ligands | Agonists | Toxins | Pharmacology | Nicotinic receptors | Nitrogen | Oocytes | Pharmacological and structural analyses | Seafood poisoning | Acetylcholine binding protein | Nicotinic acetylcholine receptor | Marine phycotoxins | PLANKTON | acetylcholine binding protein | seafood poisoning | DINOFLAGELLATE ALEXANDRIUM-OSTENFELDII | SHELLFISH TOXINS | SPIROLIDE-C | PROTEIN | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | marine phycotoxins | AGONISTS | ACETYLCHOLINE-RECEPTOR | GYMNODIMINE | pharmacological and structural analyses | nicotinic acetylcholine receptor | REVEALS | Heterocyclic Compounds, 3-Ring - metabolism | Heterocyclic Compounds, 3-Ring - pharmacology | Nicotinic Antagonists - metabolism | Humans | Aplysia - metabolism | Crystallography, X-Ray | Acetylcholine - metabolism | Nicotinic Antagonists - pharmacology | Hydrocarbons, Cyclic - pharmacology | Imines - chemistry | Oocytes - drug effects | Carrier Proteins - chemistry | Female | Molecular Structure | Spiro Compounds - chemistry | Receptors, Nicotinic - metabolism | Marine Toxins - metabolism | Oocytes - metabolism | Imines - metabolism | Models, Molecular | Electric Organ - metabolism | Marine Toxins - pharmacology | Imines - pharmacology | Macromolecular Substances | Animals | Carrier Proteins - metabolism | Xenopus - metabolism | Marine Toxins - chemistry | Nicotinic Antagonists - chemistry | Heterocyclic Compounds, 3-Ring - chemistry | Torpedo - metabolism | Kinetics | In Vitro Techniques | Hydrocarbons, Cyclic - chemistry | Spiro Compounds - pharmacology | Hydrocarbons, Cyclic - metabolism | Spiro Compounds - metabolism | Marine toxins | Crystals | Physiological aspects | Acetylcholine | Structure | Properties | Protein binding | Index Medicus | Life Sciences | Neurons and Cognition | Biological Sciences
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2005, Volume 206, Issue 1, pp. 73 - 93
Polycyclic aromatic hydrocarbons (PAHs) and heterocyclic aromatic compounds (HACs) constitute a major class of chemical carcinogens present in the environment.... 
Metabolic activation | Chemical carcinogens | DNA damages | DNA adducts | Polycyclic aromatic hydrocarbons | Heterocyclic aromatic compounds | heterocyclic aromatic compounds | MUTAGENIC 7,8-DIOL 9,10-EPOXIDES | SULFURIC-ACID ESTER | REGION 3,4-DIOL 1,2-EPOXIDES | polycyclic aromatic hydrocarbons | RAT-LIVER MICROSOMES | POTENT CARCINOGEN DIBENZOPYRENE | COVALENT NUCLEOSIDE ADDUCTS | TUMOR-INITIATING ACTIVITY | chemical carcinogens | metabolic activation | MAMMALIAN-CELL MUTAGENICITY | ONE-ELECTRON OXIDATION | PHARMACOLOGY & PHARMACY | TOXICOLOGY | HUMAN CYTOCHROMES P450 | Epoxy Compounds - metabolism | Polycyclic Aromatic Hydrocarbons - pharmacokinetics | Stereoisomerism | Heterocyclic Compounds - metabolism | Structure-Activity Relationship | Carcinogens - metabolism | Epoxy Compounds - pharmacokinetics | Animals | Polycyclic Aromatic Hydrocarbons - metabolism | Epoxy Compounds - chemical synthesis | Biotransformation | Heterocyclic Compounds - pharmacokinetics | Carcinogens - pharmacokinetics | DNA Adducts - biosynthesis | Enzymes | Micropollutants | Metabolites | DNA | Hydrocarbons | Persistent organic pollutants | OXIDATION | REVIEWS | METABOLITES | CARCINOGENS | METABOLIC ACTIVATION | BENZOQUINONES | 60 APPLIED LIFE SCIENCES | CATIONS | DNA ADDUCTS | DNA DAMAGES | EPOXIDES | ENZYMES | SULFONATION | HYDROXIDES | POLYCYCLIC AROMATIC HYDROCARBONS
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 12/2013, Volume 206, Issue 3, pp. 545 - 554
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 09/2017, Volume 106, Issue 9, pp. 2632 - 2641
Regorafenib is a multikinase inhibitor orally administered to colorectal cancer patients, and is known to often exhibit dermal toxicity. The purpose of this... 
P-glycoprotein | skin | tissue partition | ABC transporters | transporters | BCRP | MULTICENTER | CHEMISTRY, MEDICINAL | TRANSDERMAL ABSORPTION | CHEMISTRY, MULTIDISCIPLINARY | IN-VITRO | POLYMORPHISMS | COLORECTAL-CANCER | PHASE-3 TRIAL | PHARMACOLOGY & PHARMACY | FOOT SKIN REACTION | EXPRESSION | BRAIN | Diketopiperazines - chemistry | Pyridines - chemistry | Skin - metabolism | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Male | Phenylurea Compounds - toxicity | Heterocyclic Compounds, 4 or More Rings - pharmacology | Breast Neoplasms - metabolism | Antineoplastic Agents - metabolism | Tissue Distribution | Protein Kinase Inhibitors - chemistry | Biological Transport | Tetrahydroisoquinolines - chemistry | Phenylurea Compounds - chemistry | Antineoplastic Agents - pharmacology | Phenylurea Compounds - metabolism | Acridines - chemistry | Tetrahydroisoquinolines - pharmacology | Acridines - metabolism | Heterocyclic Compounds, 4 or More Rings - chemistry | Diketopiperazines - pharmacology | Antineoplastic Agents - chemistry | Breast Neoplasms - drug therapy | Animals | Pyridines - metabolism | Pyridines - toxicity | Tetrahydroisoquinolines - metabolism | Acridines - pharmacology | Heterocyclic Compounds, 4 or More Rings - metabolism | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Diketopiperazines - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | Index Medicus
Journal Article