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Journal of the American Chemical Society, ISSN 0002-7863, 09/2008, Volume 130, Issue 38, pp. 12570 - 12571
A family of lipophilic, cationic Au(I) complexes of N-heterocyclic carbenes (NHCs) have been designed as new mitochondria-targeted antitumor agents that... 
SYSTEM | APOPTOSIS | INHIBITION | ANTICANCER | LIGANDS | AURANOFIN | THIOREDOXIN REDUCTASE | TUMOR-CELLS | SELENOCYSTEINE | INDUCTION | CHEMISTRY, MULTIDISCIPLINARY | Mitochondria - enzymology | Selenocysteine - metabolism | Methane - pharmacokinetics | Apoptosis - drug effects | Methane - analogs & derivatives | Antineoplastic Agents - chemical synthesis | Humans | Heterocyclic Compounds - pharmacology | Heterocyclic Compounds - chemical synthesis | Breast Neoplasms - metabolism | Heterocyclic Compounds - chemistry | Mitochondrial Proteins - metabolism | Drug Design | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Cysteine - metabolism | Gold - chemistry | Methane - pharmacology | Organometallic Compounds - pharmacokinetics | Mitochondria - metabolism | Gold - pharmacology | Mitochondria - drug effects | Antineoplastic Agents - chemistry | Breast Neoplasms - drug therapy | Gold - pharmacokinetics | Organometallic Compounds - chemical synthesis | Cell Line, Tumor | Heterocyclic Compounds - pharmacokinetics | Methane - chemistry | Organometallic Compounds - chemistry | Thioredoxin-Disulfide Reductase - antagonists & inhibitors | Methane - chemical synthesis | Organometallic Compounds - pharmacology | Drug Screening Assays, Antitumor | Mitochondria | Gold compounds | Chemical properties | Analysis | Electric properties | Apoptosis | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2013, Volume 56, Issue 6, pp. 2547 - 2555
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 08/2010, Volume 9, Issue 8, pp. 2344 - 2353
Journal Article
Nature Medicine, ISSN 1078-8956, 02/2013, Volume 19, Issue 2, pp. 202 - 208
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 03/2015, Volume 125, Issue 3, pp. 1269 - 1285
Cholangiocarcinoma (CC) is typically diagnosed at an advanced stage and is refractory to surgical intervention and chemotherapy. Despite a global increase in... 
BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | INTRAHEPATIC CHOLANGIOCARCINOMA | THIOACETAMIDE | PORCUPINE | LIVER | BILIARY | BETA-CATENIN | RAT CHOLANGIOCARCINOMA | PROGRESSION | CANCER STEM-CELLS | Anisoles - pharmacology | Humans | Male | Cholangiocarcinoma - metabolism | Bile Ducts, Intrahepatic - metabolism | Keratins - metabolism | Pyrimidinones - pharmacology | Antineoplastic Agents - pharmacology | Benzeneacetamides - pharmacology | Wnt Signaling Pathway | Bile Duct Neoplasms - drug therapy | Cell Survival - drug effects | Aniline Compounds - pharmacology | Bile Duct Neoplasms - metabolism | Pyrimidines - pharmacology | Rats, Sprague-Dawley | beta Catenin - metabolism | Heterocyclic Compounds, 2-Ring - pharmacology | Xenograft Model Antitumor Assays | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Macrophages - metabolism | Animals | Cholangiocarcinoma - drug therapy | Mice, Nude | Tamoxifen - pharmacology | Cell Line, Tumor | Macrophages - drug effects | Cell Proliferation - drug effects | Clodronic Acid - administration & dosage | Pyridines - pharmacology | Liposomes | Physiological aspects | Research | Tumor proteins | Wnt proteins | Oncology, Experimental | Cancer | Heparan sulfate | Medical research | Liver | Gene expression | Cancer therapies | Studies | Councils | Medical prognosis | Cell cycle | Ligands | Mutation | Tumors | Index Medicus | Abridged Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2015, Volume 90, pp. 82 - 92
A series of benzimidazole-based N-heterocyclic carbene (NHC) proligands {1-benzyl-3-(2-methylbenzyl)-benzimidazolium bromide/hexafluorophosphate ( / ),... 
Carbene complex | HT29 | Anticancer agent | Ag–NHC complex | HCT 116 | Antibacterial agent | CHEMISTRY, MEDICINAL | TRANSITION-METAL-COMPLEXES | STABILITY | GOLD COMPOUNDS | LIPOXYGENASE | AG(I) | DNA | AGENTS | Ag-NHC complex | PALLADIUM(II) | MERCURY(II) | CYTOTOXICITY | Antineoplastic Agents - chemical synthesis | Escherichia coli - drug effects | Humans | Heterocyclic Compounds - pharmacology | Heterocyclic Compounds - chemical synthesis | Structure-Activity Relationship | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Carbolines - chemistry | Heterocyclic Compounds - chemistry | Anti-Bacterial Agents - chemistry | Antineoplastic Agents - pharmacology | Molecular Structure | Carbolines - chemical synthesis | Silver - pharmacology | Silver - chemistry | Antineoplastic Agents - chemistry | Anti-Bacterial Agents - chemical synthesis | Organometallic Compounds - chemical synthesis | Ligands | Organometallic Compounds - chemistry | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | Organometallic Compounds - pharmacology | Bacillus subtilis - drug effects | Carbolines - pharmacology | Drug Screening Assays, Antitumor | Heterocyclic compounds | Analysis | Colorectal cancer | Crystals | Nuclear magnetic resonance spectroscopy | Fluorides | Structure | Antibacterial agents | Index Medicus
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 06/2015, Volume 97, pp. 164 - 172
Journal Article
Journal Article
Cancer Discovery, ISSN 2159-8274, 2014, Volume 4, Issue 3, pp. 362 - 675
Journal Article
Scientific Reports, ISSN 2045-2322, 04/2014, Volume 4, Issue 1, pp. 1 - 11
Journal Article