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heterocyclic compounds, 2-ring - chemical synthesis (271) 271
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protein kinase inhibitors - chemistry (14) 14
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Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2014, Volume 57, Issue 8, pp. 3205 - 3212
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2016, Volume 59, Issue 17, pp. 7991 - 8007
We designed and synthesized a series of human immunodeficiency virus type 1 (HIV-1), non-nucleoside reverse transcriptase,inhibitors (NNRTIs) with a... 
BEARING BRIDGEHEAD NITROGEN | CHEMISTRY, MEDICINAL | ENTRANCE CHANNEL | MUTANT VIRUSES | ENHANCED SOLUBILITY | PRELIMINARY SAR | COLORIMETRIC ASSAY | BIOLOGICAL EVALUATION | NNRTI BINDING POCKET | CRYSTAL-STRUCTURES | ETRAVIRINE TMC125 | Anti-HIV Agents - pharmacology | Pyrimidines - chemical synthesis | HIV Reverse Transcriptase - antagonists & inhibitors | Humans | Drug Resistance, Viral | Reverse Transcriptase Inhibitors - pharmacology | Male | Structure-Activity Relationship | Anti-HIV Agents - chemical synthesis | Pyrimidines - chemistry | Reverse Transcriptase Inhibitors - chemistry | Reverse Transcriptase Inhibitors - chemical synthesis | Reverse Transcriptase Inhibitors - pharmacokinetics | Sulfonamides - chemistry | Heterocyclic Compounds, 2-Ring - chemistry | Thiophenes - pharmacology | Heterocyclic Compounds, 2-Ring - pharmacokinetics | Pyrimidines - pharmacology | HIV-1 - genetics | Sulfonamides - pharmacology | Rats, Sprague-Dawley | Sulfonamides - pharmacokinetics | Heterocyclic Compounds, 2-Ring - pharmacology | Sulfonamides - chemical synthesis | Thiophenes - chemical synthesis | Thiophenes - pharmacokinetics | Anti-HIV Agents - chemistry | Animals | Anti-HIV Agents - pharmacokinetics | Cell Line, Tumor | Pyrimidines - pharmacokinetics | HIV-1 - enzymology | Mice | Molecular Docking Simulation | Mutation | Thiophenes - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2011, Volume 54, Issue 14, pp. 5013 - 5030
On the basis of structures of known topoisomerase H catalytic inhibitors and initial molecular docking studies, bicyclic N-fused aminoimidazoles were predicted... 
DNA TOPOISOMERASE | CELLS | MOLECULAR-DYNAMICS | ETOPOSIDE | DOMAIN | CHEMISTRY, MEDICINAL | MECHANISM | ICRF-187 | ATP-BINDING-SITE | CANCER | FLEXIBLE DOCKING | Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Imidazoles - chemistry | Cercopithecus aethiops | Structure-Activity Relationship | Topoisomerase II Inhibitors - chemistry | S Phase | HEK293 Cells | Antineoplastic Agents - pharmacology | Topoisomerase II Inhibitors - chemical synthesis | Imidazoles - chemical synthesis | Intercalating Agents - chemical synthesis | Binding Sites | Vero Cells | Cell Survival - drug effects | Antigens, Neoplasm | DNA-Binding Proteins - antagonists & inhibitors | Heterocyclic Compounds, 2-Ring - chemistry | Etoposide - pharmacology | Models, Molecular | Imidazoles - pharmacology | Intercalating Agents - pharmacology | Topoisomerase II Inhibitors - pharmacology | Antineoplastic Agents - chemistry | Intercalating Agents - chemistry | Molecular Dynamics Simulation | Heterocyclic Compounds, 2-Ring - pharmacology | Cell Movement - drug effects | G1 Phase | Animals | Cell Line, Tumor | Adenosine Triphosphatases - chemistry | DNA Topoisomerases, Type II | Fluorouracil - pharmacology | Adenosine Triphosphate - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis | Drug Screening Assays, Antitumor | Index Medicus
Journal Article
ORGANIC LETTERS, ISSN 1523-7060, 08/2012, Volume 14, Issue 16, pp. 4254 - 4257
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 01/2008, Volume 130, Issue 2, pp. 416 - 417
Aromatic aminoaldehydes react with cyclic amines to produce ring-fused aminals under thermal conditions. This process applied to two-step syntheses of the... 
X=Y-ZH COMPOUNDS | CYCLOADDITION REACTIONS | IMINIUM ION ROUTE | MACKINAZOLINONE | AZOMETHINE YLIDES | RUTAECARPINE | POTENTIAL 1,3-DIPOLES | DEOXYVASICINONE | LUOTONIN-A | CHEMISTRY, MULTIDISCIPLINARY | ALKALOIDS | Amination | Nitrogen - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis | Heterocyclic Compounds, 2-Ring - chemistry
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2009, Volume 52, Issue 5, pp. 1486 - 1490
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2018, Volume 61, Issue 8, pp. 3325 - 3349
In the preceding manuscript [Moreau et al. 2018, 10.1021/acs.jmedchem.7b01691] we described a successful fragment-based lead discovery (FBLD) strategy for... 
PHOSPHINOXYDE ALS OLEFINIERUNGSREAGENZIEN | CROSS-COUPLING REACTIONS | CHEMISTRY, MEDICINAL | MULTIDRUG EFFLUX PUMPS | ESCHERICHIA-COLI | ARYL HALIDES | ANTIBIOTIC-RESISTANCE | OUTER-MEMBRANE PERMEABILITY | COENZYME-A | RESISTANCE GENE MCR-1 | MOLECULAR-MECHANISMS | Nucleotidyltransferases - chemistry | Triazoles - chemistry | Escherichia coli - drug effects | Pyrimidinones - metabolism | Benzimidazoles - chemistry | Enzyme Inhibitors - chemical synthesis | Pyrimidinones - chemistry | Microbial Sensitivity Tests | Anti-Bacterial Agents - chemistry | Enzyme Inhibitors - chemistry | Nucleotidyltransferases - antagonists & inhibitors | Pyrimidinones - pharmacology | Triazoles - chemical synthesis | Molecular Structure | Escherichia coli Proteins - antagonists & inhibitors | Nucleotidyltransferases - metabolism | Pyrimidinones - chemical synthesis | Binding Sites | Escherichia coli - enzymology | Enzyme Inhibitors - metabolism | Benzimidazoles - chemical synthesis | Enzyme Inhibitors - pharmacology | Heterocyclic Compounds, 2-Ring - chemistry | Anti-Bacterial Agents - metabolism | Escherichia coli Proteins - metabolism | Drug Discovery | Heterocyclic Compounds, 2-Ring - pharmacology | Anti-Bacterial Agents - chemical synthesis | Triazoles - pharmacology | Triazoles - metabolism | Benzimidazoles - metabolism | Heterocyclic Compounds, 2-Ring - metabolism | Escherichia coli Proteins - genetics | Nucleotidyltransferases - genetics | Protein Binding | Benzimidazoles - pharmacology | Anti-Bacterial Agents - pharmacology | Mutation | Escherichia coli Proteins - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 07/2018, Volume 28, Issue 13, pp. 2328 - 2337
A series of novel furo[2,3- ]pyridine-2-carboxamide – /pyrido[3′,2′:4,5]furo[3,2- ] pyrimidin-4(3 )-one – , furo [2,3- ] pyridine-2-carbohydrazide Schiff’s... 
Carbohydrazide Schiff’s bases | 3D QSAR | CoMFA and CoMSIA studies | Anti-cancer activity | Pyrido[3′,2′:4,5]furo[3,2-d]pyrimidin-4(3H)-one | Carbohydrazide Schiff's bases | POTENT | CHEMISTRY, MEDICINAL | PRACTICAL SYNTHESIS | KEY INTERMEDIATE | Pyrido[3 ',2 ':4,5]furo[3,2-d]pyrimidin-4(3H)-one | CHEMISTRY, ORGANIC | HIV PROTEASE INHIBITOR | Heterocyclic Compounds, 3-Ring - pharmacology | Pyridines - chemistry | Pyrimidines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Furans - pharmacology | Humans | Heterocyclic Compounds, 3-Ring - chemical synthesis | Pyrimidines - chemistry | Antineoplastic Agents - toxicity | Heterocyclic Compounds, 2-Ring - toxicity | Pyrimidines - toxicity | Furans - chemistry | HEK293 Cells | Heterocyclic Compounds, 3-Ring - toxicity | Antineoplastic Agents - pharmacology | Molecular Structure | Furans - toxicity | Quantitative Structure-Activity Relationship | Heterocyclic Compounds, 2-Ring - chemistry | Pyridines - chemical synthesis | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Heterocyclic Compounds, 2-Ring - pharmacology | Cyclization | Hydrogen Bonding | Pyridines - toxicity | Heterocyclic Compounds, 3-Ring - chemistry | Cell Line, Tumor | Pyridines - pharmacology | Furans - chemical synthesis | Heterocyclic Compounds, 2-Ring - chemical synthesis | Drug Screening Assays, Antitumor | Alkaloids | Analysis | Pyridine | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2018, Volume 61, Issue 8, pp. 3309 - 3324
The discovery and development of new antibiotics capable of curing infections due to multidrug-resistant and pandrug-resistant Gram-negative bacteria are a... 
COENZYME-A BIOSYNTHESIS | MEDICINAL CHEMISTRY | CHEMISTRY, MEDICINAL | LEAD DISCOVERY | ESCHERICHIA-COLI | ANTIBIOTIC-RESISTANCE | OUTER-MEMBRANE PERMEABILITY | N-PENTYLPANTOTHENAMIDE | ANTIBACTERIAL DISCOVERY | BETA-LACTAMASES | RESISTANCE GENE MCR-1 | Nucleotidyltransferases - chemistry | Triazoles - chemistry | Escherichia coli - drug effects | Pyrimidinones - metabolism | Benzimidazoles - chemistry | Enzyme Inhibitors - chemical synthesis | Pyrimidinones - chemistry | Microbial Sensitivity Tests | Pseudomonas aeruginosa - enzymology | Anti-Bacterial Agents - chemistry | Enzyme Inhibitors - chemistry | Nucleotidyltransferases - antagonists & inhibitors | Pyrimidinones - pharmacology | Triazoles - chemical synthesis | Molecular Structure | Escherichia coli Proteins - antagonists & inhibitors | Nucleotidyltransferases - metabolism | Pyrimidinones - chemical synthesis | Binding Sites | Escherichia coli - enzymology | Enzyme Inhibitors - metabolism | Benzimidazoles - chemical synthesis | Enzyme Inhibitors - pharmacology | Heterocyclic Compounds, 2-Ring - chemistry | Anti-Bacterial Agents - metabolism | Escherichia coli Proteins - metabolism | Pseudomonas aeruginosa - drug effects | Drug Discovery | Heterocyclic Compounds, 2-Ring - pharmacology | Anti-Bacterial Agents - chemical synthesis | Triazoles - pharmacology | Triazoles - metabolism | Benzimidazoles - metabolism | Heterocyclic Compounds, 2-Ring - metabolism | Protein Binding | Benzimidazoles - pharmacology | Anti-Bacterial Agents - pharmacology | Escherichia coli Proteins - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2017, Volume 60, Issue 2, pp. 767 - 786
By use of a structure-based computational method for identification of structurally novel Janus kinase (JAK) inhibitors predicted to bind beyond the ATP... 
PLACEBO | CHEMISTRY, MEDICINAL | CHRONIC PLAQUE PSORIASIS | EFFICACY | ACTIVE RHEUMATOID-ARTHRITIS | PHASE-III | METHOTREXATE | OPEN-LABEL | COMBINATION | TOFACITINIB CP-690,550 | DISCOVERY | Phosphorylation | Indazoles - chemical synthesis | Humans | Microsomes, Liver - metabolism | Crystallography, X-Ray | Administration, Cutaneous | Hepatocytes - metabolism | Indazoles - administration & dosage | Lung Diseases - drug therapy | Janus Kinase 3 - antagonists & inhibitors | Heterocyclic Compounds, 2-Ring - toxicity | Drug Design | Anti-Inflammatory Agents - administration & dosage | Binding Sites | Janus Kinase 2 - antagonists & inhibitors | Protein Kinase Inhibitors - chemical synthesis | Anti-Inflammatory Agents - pharmacology | Anti-Inflammatory Agents - toxicity | Heterocyclic Compounds, 2-Ring - administration & dosage | Solubility | Administration, Inhalation | Rats | Skin Diseases - drug therapy | Janus Kinase 1 - antagonists & inhibitors | Heterocyclic Compounds, 2-Ring - pharmacology | Indazoles - pharmacology | Janus Kinases - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Animals | Indazoles - toxicity | Dogs | Protein Kinase Inhibitors - toxicity | Anti-Inflammatory Agents - chemical synthesis | Mice, Inbred BALB C | Protein Kinase Inhibitors - pharmacology | Heterocyclic Compounds, 2-Ring - chemical synthesis | Index Medicus
Journal Article