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1. Full Text Transition metal-mediated synthesis of monocyclic aromatic heterocycles
by Gulevich, Anton V and Dudnik, Alexander S and Chernyak, Natalia and Gevorgyan, Vladimir
Chemical Reviews, ISSN 0009-2665, 05/2013, Volume 113, Issue 5, pp. 3084 - 3213
KETONE O-PENTAFLUOROBENZOYLOXIMES | SECONDARY PROPARGYLIC ALCOHOLS | ALPHA-DIAZOCARBONYL COMPOUNDS | RING-CLOSING METATHESIS | ONE-STEP SYNTHESIS | ONE-POT SYNTHESIS | PALLADIUM-CATALYZED CYCLIZATION | N BOND FORMATION | CHEMISTRY, MULTIDISCIPLINARY | HIGHLY SUBSTITUTED FURANS | H INSERTION REACTIONS | Transition Elements - chemistry | Transition Elements - chemical synthesis | Heterocyclic Compounds, 1-Ring - chemistry | Heterocyclic Compounds, 2-Ring - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis | Chemistry Techniques, Synthetic - methods | Heterocyclic Compounds, 1-Ring - chemical synthesis | Furans | Chemical properties | Research | Chemical synthesis | Pyrrole
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2. Full Text Copper(II)/iron(III) co-catalyzed intermolecular diamination of alkynes: Facile synthesis of imidazopyridines
by Zeng, Jing and Tan, Yu Jia and Leow, Min Li and Liu, Xue-Wei
Organic Letters, ISSN 1523-7060, 09/2012, Volume 14, Issue 17, pp. 4386 - 4389
A facile synthesis of imidazo[1,2-alpha]pyridines has been achieved by copper(II) and iron(III) co-catalyzed C-N bond formation. This reaction involves an... 
INTRAMOLECULAR DIAMINATION | ALKENES | MECHANISTIC PATHWAYS | CONJUGATED DIENES | CHEMISTRY, ORGANIC | REGIOSELECTIVE DIAMINATION | BOND FORMATION | METAL-FREE DIAMINATION | BETA-KETO-ESTERS | UNACTIVATED OLEFINS | N-HETEROCYCLES | Oxidation-Reduction | Pyridines - chemistry | Stereoisomerism | Heterocyclic Compounds, 2-Ring - chemistry | Imidazoles - chemistry | Pyridines - chemical synthesis | Ferric Compounds - chemistry | Alkynes - chemistry | Combinatorial Chemistry Techniques | Copper - chemistry | Catalysis | Imidazoles - chemical synthesis | Heterocyclic Compounds, 2-Ring - chemical synthesis
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3. Full Text Rh(III)-catalyzed direct coupling of azobenzenes with α-diazo esters: Facile synthesis of cinnolin-3(2 H)-ones
by Sharma, Satyasheel and Han, Sang Hoon and Han, Sangil and Ji, Wontae and Oh, Jongchan and Lee, Seok-Yong and Oh, Joa Sub and Jung, Young Hoon and Kim, In Su
Organic Letters, ISSN 1523-7060, 06/2015, Volume 17, Issue 11, pp. 2852 - 2855
The rhodium(III)-catalyzed direct CH functionalization of azobenzenes with alpha-diazo compounds is described. These transformations provide the facile and... 
FUNCTIONALIZATION | SULFONYL AZIDES | AROMATIC AZO-COMPOUNDS | BIOLOGICAL EVALUATION | CHEMISTRY, ORGANIC | BOND FORMATION | OXOCARBOXYLIC ACIDS | DECARBOXYLATIVE ORTHO-ACYLATION | DIRECT ACCESS | N-OXIDES | C-H ACTIVATION | Azo Compounds - chemistry | Heterocyclic Compounds, 2-Ring - chemistry | Esters | Molecular Structure | Catalysis | Heterocyclic Compounds, 2-Ring - chemical synthesis | Dioxanes - chemistry | Rhodium - chemistry
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4. Full Text Design, Synthesis, and Evaluation of Thiophene[3,2-d]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles
by Kang, Dongwei and Fang, Zengjun and Li, Zhenyu and Huang, Boshi and Zhang, Heng and Lu, Xueyi and Xu, Haoran and Zhou, Zhongxia and Ding, Xiao and Daelemans, Dirk and De Clercq, Erik and Pannecouque, Christophe and Zhan, Peng and Liu, Xinyong
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2016, Volume 59, Issue 17, pp. 7991 - 8007
We designed and synthesized a series of human immunodeficiency virus type 1 (HIV-1), non-nucleoside reverse transcriptase,inhibitors (NNRTIs) with a... 
BEARING BRIDGEHEAD NITROGEN | CHEMISTRY, MEDICINAL | ENTRANCE CHANNEL | MUTANT VIRUSES | ENHANCED SOLUBILITY | PRELIMINARY SAR | COLORIMETRIC ASSAY | BIOLOGICAL EVALUATION | NNRTI BINDING POCKET | CRYSTAL-STRUCTURES | ETRAVIRINE TMC125 | Anti-HIV Agents - pharmacology | Pyrimidines - chemical synthesis | HIV Reverse Transcriptase - antagonists & inhibitors | Humans | Drug Resistance, Viral | Reverse Transcriptase Inhibitors - pharmacology | Male | Structure-Activity Relationship | Anti-HIV Agents - chemical synthesis | Pyrimidines - chemistry | Reverse Transcriptase Inhibitors - chemistry | Reverse Transcriptase Inhibitors - chemical synthesis | Reverse Transcriptase Inhibitors - pharmacokinetics | Sulfonamides - chemistry | Heterocyclic Compounds, 2-Ring - chemistry | Thiophenes - pharmacology | Heterocyclic Compounds, 2-Ring - pharmacokinetics | Pyrimidines - pharmacology | HIV-1 - genetics | Sulfonamides - pharmacology | Rats, Sprague-Dawley | Sulfonamides - pharmacokinetics | Heterocyclic Compounds, 2-Ring - pharmacology | Sulfonamides - chemical synthesis | Thiophenes - chemical synthesis | Thiophenes - pharmacokinetics | Anti-HIV Agents - chemistry | Animals | Anti-HIV Agents - pharmacokinetics | Cell Line, Tumor | Pyrimidines - pharmacokinetics | HIV-1 - enzymology | Mice | Molecular Docking Simulation | Mutation | Thiophenes - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis
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5. Full Text N-fused imidazoles as novel anticancer agents that inhibit catalytic activity of topoisomerase IIα and induce apoptosis in G1/S phase
by Baviskar, Ashish T and Madaan, Chetna and Preet, Ranjan and Mohapatra, Purusottam and Jain, Vaibhav and Agarwal, Amit and Guchhait, Sankar K and Kundu, Chanakya N and Banerjee, Uttam C and Bharatam, Prasad V
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2011, Volume 54, Issue 14, pp. 5013 - 5030
On the basis of structures of known topoisomerase H catalytic inhibitors and initial molecular docking studies, bicyclic N-fused aminoimidazoles were predicted... 
DNA TOPOISOMERASE | CELLS | MOLECULAR-DYNAMICS | ETOPOSIDE | DOMAIN | CHEMISTRY, MEDICINAL | MECHANISM | ICRF-187 | ATP-BINDING-SITE | CANCER | FLEXIBLE DOCKING | Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Imidazoles - chemistry | Cercopithecus aethiops | Structure-Activity Relationship | Topoisomerase II Inhibitors - chemistry | S Phase | HEK293 Cells | Antineoplastic Agents - pharmacology | Topoisomerase II Inhibitors - chemical synthesis | Imidazoles - chemical synthesis | Intercalating Agents - chemical synthesis | Binding Sites | Vero Cells | Cell Survival - drug effects | Antigens, Neoplasm | DNA-Binding Proteins - antagonists & inhibitors | Heterocyclic Compounds, 2-Ring - chemistry | Etoposide - pharmacology | Models, Molecular | Imidazoles - pharmacology | Intercalating Agents - pharmacology | Topoisomerase II Inhibitors - pharmacology | Antineoplastic Agents - chemistry | Intercalating Agents - chemistry | Molecular Dynamics Simulation | Heterocyclic Compounds, 2-Ring - pharmacology | Cell Movement - drug effects | G1 Phase | Animals | Cell Line, Tumor | Adenosine Triphosphatases - chemistry | DNA Topoisomerases, Type II | Fluorouracil - pharmacology | Adenosine Triphosphate - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis | Drug Screening Assays, Antitumor | Index Medicus
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6. Full Text Benzazoles from aliphatic amines and o -amino/mercaptan/hydroxyanilines: Elemental sulfur as a highly efficient and traceless oxidizing agent
by Nguyen, Thanh Binh and Ermolenko, Ludmila and Dean, William A and Al-Mourabit, Ali
Organic Letters, ISSN 1523-7060, 12/2012, Volume 14, Issue 23, pp. 5948 - 5951
A novel remarkably simple solvent-free and catalyst-free synthesis of benzazoles from alkylamines and o-hydroxy/amino/mercaptan anilines using elemental sulfur... 
BENZOTHIAZOLE | CHEMISTRY, ORGANIC | THIOAMIDES | Amines - chemistry | Benzene Derivatives - chemical synthesis | Combinatorial Chemistry Techniques | Oxidants - chemistry | Heterocyclic Compounds, 2-Ring - chemistry | Molecular Structure | Sulfur Compounds - chemistry | Benzene Derivatives - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis | Organic chemistry | Chemical Sciences
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7. Full Text α-amination of nitrogen heterocycles: Ring-fused aminals
by Zhang, Chen and De, Chandra Kanta and Mal, Rudrajit and Seidel, Daniel
Journal of the American Chemical Society, ISSN 0002-7863, 01/2008, Volume 130, Issue 2, pp. 416 - 417
Aromatic aminoaldehydes react with cyclic amines to produce ring-fused aminals under thermal conditions. This process applied to two-step syntheses of the... 
X=Y-ZH COMPOUNDS | CYCLOADDITION REACTIONS | IMINIUM ION ROUTE | MACKINAZOLINONE | AZOMETHINE YLIDES | RUTAECARPINE | POTENTIAL 1,3-DIPOLES | DEOXYVASICINONE | LUOTONIN-A | CHEMISTRY, MULTIDISCIPLINARY | ALKALOIDS | Amination | Nitrogen - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis | Heterocyclic Compounds, 2-Ring - chemistry
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8. Full Text Gold-Catalyzed Cycloisomerization and Diels-Alder Reaction of 1,6-Diyne Esters with Alkenes and Diazenes to Hydronaphthalenes and -cinnolines
by Yan, Jianming and Tay, Guan Liang and Neo, Cuien and Lee, Bo Ra and Chan, Philip Wai Hong
Organic Letters, ISSN 1523-7060, 08/2015, Volume 17, Issue 17, pp. 4176 - 4179
A method for the efficient preparation of hydronaphthalene and -cinnoline derivatives by Au(I)-catalyzed cycloisomerzation of 1,6-diyne esters followed by a... 
Gold - chemistry | Naphthalenes - chemistry | Combinatorial Chemistry Techniques | Imides - chemistry | Heterocyclic Compounds, 2-Ring - chemistry | Esters | Molecular Structure | Catalysis
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9. Full Text Cu(I)-catalyzed transannulation of N -heteroaryl aldehydes or ketones with alkylamines via C(sp3)-H amination
by Li, Mingyang and Xie, Ying and Ye, Yong and Zou, Yong and Jiang, Huanfeng and Zeng, Wei
Organic Letters, ISSN 1523-7060, 12/2014, Volume 16, Issue 23, pp. 6232 - 6235
A copper(I)-catalyzed direct transannulation of N-heteroaryl aldehydes or ketones with alkylamines via C-sp(3)-H amination has been achieved using molecular... 
FUNCTIONALIZATION | ACTIVATION | HETEROCYCLES | AMINES | COMPLEXES | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | BOND-CLEAVAGE | C-H AMINATION | CYCLIZATION | CATALYZED INTRAMOLECULAR AMINATION | Combinatorial Chemistry Techniques | Copper - chemistry | Amination | Pyridines - chemistry | Heterocyclic Compounds, 2-Ring - chemistry | Imidazoles - chemistry | Ketones - chemistry | Iodides - chemistry | Catalysis | Heterocyclic Compounds, 2-Ring - chemical synthesis | Aldehydes - chemistry
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10. Full Text Organocatalytic One-Pot Asymmetric Synthesis of 4H,5H-Pyrano[2,3-c]pyrazoles
by Enders, D and Grossmann, A and Gieraths, B and Duzdemir, M and Merkens, C
ORGANIC LETTERS, ISSN 1523-7060, 08/2012, Volume 14, Issue 16, pp. 4254 - 4257
An efficient one pot asymmetric synthesis of tetrahydropyrano[2,3-c]pyrazoles has been developed. This class of biologically active heterocycles can be... 
CHEMISTRY, ORGANIC | DERIVATIVES | PYRAZOLIN-5-ONES | MICHAEL ADDITION | Pyrans - chemical synthesis | Pyrazoles - chemistry | Pyrans - chemistry | Pyrazoles - chemical synthesis | Stereoisomerism | Heterocyclic Compounds, 2-Ring - chemistry | Molecular Structure | Catalysis | Heterocyclic Compounds, 2-Ring - chemical synthesis
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11. Full Text A General Method to Diverse Cinnolines and Cinnolinium Salts
by Zhao, Dongbing and Wu, Qian and Huang, Xiaolei and Song, Feijie and Lv, Taiyong and You, Jingsong
Chemistry – A European Journal, ISSN 0947-6539, 05/2013, Volume 19, Issue 20, pp. 6239 - 6244
Rhodium catalysis : A highly efficient and general method has been established to prepare cinnolines, cinnolinium salts, and polycyclic cinnolinium salts... 
cinnolinium salts | catalysis | cinnolines | heterocycles | rhodium | 3,4-DISUBSTITUTED CINNOLINES | OXIDATIVE ANNULATION | INTERNAL ALKYNES | O CYCLIZATION | C-H ACTIVATION | CHEMISTRY, MULTIDISCIPLINARY | CATION-ANION | N BOND FORMATION | IONIC LIQUIDS | DERIVATIVES | EFFICIENT | Azo Compounds - chemistry | Salts | Cyclization | Oxidation-Reduction | Heterocyclic Compounds, 2-Ring - chemistry | Alkynes - chemistry | Molecular Structure | Catalysis | Heterocyclic Compounds, 2-Ring - chemical synthesis | Rhodium - chemistry | Green chemistry | Methods | Green technology | Azo compounds | Activation | Rhodium | Methodology | Alkynes
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12. Full Text Modular synthesis of sulfonyl benzoheteroles by silver-catalyzed heteroaromatization of propargylic alcohols with p -toluenesulfonylmethyl isocyanide (TosMIC): Dual roles of TosMIC
by Liu, Jianquan and Liu, Zhenhua and Liao, Peiqiu and Bi, Xihe
Organic Letters, ISSN 1523-7060, 12/2014, Volume 16, Issue 23, pp. 6204 - 6207
A new silver-catalyzed heteroaromatization of propargylic alcohols with p-toluenesulfonylmethyl isocyanide (TosMIC) has been developed that provides an... 
CYCLOADDITION | BENZOTHIOPHENES | CHEMISTRY, ORGANIC | N BOND | CARBOALKOXYLATION | IODINE | INDOLE SYNTHESIS | PYRROLES | BENZOFURANS | ALKYNES | CYCLIZATION | Propanols - chemistry | Benzene Derivatives - chemical synthesis | Sulfones - chemistry | Heterocyclic Compounds, 2-Ring - chemistry | Nitriles - chemistry | Silver - chemistry | Alkynes - chemistry | Molecular Structure | Catalysis | Benzene Derivatives - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis | Sulfones - chemical synthesis
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13. Full Text Acylazetine as a dienophile in bioorthogonal inverse electron-demand Diels-Alder ligation
by Engelsma, Sander B and Willems, Lianne I and Van Paaschen, Claudia E and Van Kasteren, Sander I and Van Der Marel, Gijsbert A and Overkleeft, Herman S and Filippov, Dmitri V
Organic Letters, ISSN 1523-7060, 05/2014, Volume 16, Issue 10, pp. 2744 - 2747
A new bioorthogonal N-acylazetine tag, suitable for tetrazine mediated inverse electron-demand Diels-Alder conjugation, is developed. The tag is small and... 
CELLS | POTENT | CYCLOADDITIONS | IN-VIVO | REACTIVITY | CHEMISTRY | CHEMISTRY, ORGANIC | PROTEASOME INHIBITOR | EPOXOMICIN | CYCLOPROPENES | PROBES | Molecular Structure | Heterocyclic Compounds, 1-Ring - chemistry | Azetidines - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis | Heterocyclic Compounds, 2-Ring - chemistry | Electrons
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14. Full Text Carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani chagasi are inhibited by benzoxaboroles
by Nocentini, Alessio and Cadoni, Roberta and Dumy, Pascal and Supuran, Claudiu T and Winum, Jean-Yves
Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 01/2018, Volume 33, Issue 1, pp. 286 - 289
A series of 6-substituted ureido- and thioureido-benzoxaboroles were investigated as inhibitors of carbonic anhydrases from Trypanosoma cruzi (TcCA), and... 
Benzoxaborole | protozoan carbonic anhydrases | inhibition | Leishmania donovani chagasi | Trypanosoma cruzi | CHEMISTRY, MEDICINAL | MANAGEMENT | EFFICIENT INHIBITORS | CAUSATIVE AGENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | SULFONAMIDES | BACTERIAL | CLONING | FUNGAL | Boron Compounds - chemistry | Boron Compounds - pharmacology | Carbonic Anhydrase Inhibitors - chemistry | Leishmania donovani - drug effects | Heterocyclic Compounds, 2-Ring - chemistry | Leishmania donovani - enzymology | Antiprotozoal Agents - chemistry | Carbonic Anhydrase Inhibitors - chemical synthesis | Structure-Activity Relationship | Carbonic Anhydrase Inhibitors - pharmacology | Antiprotozoal Agents - pharmacology | Trypanosoma cruzi - enzymology | Carbonic Anhydrases - metabolism | Heterocyclic Compounds, 2-Ring - pharmacology | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Boron Compounds - chemical synthesis | Trypanosoma cruzi - drug effects | Antiprotozoal Agents - chemical synthesis | Molecular Structure | Heterocyclic Compounds, 2-Ring - chemical synthesis | Index Medicus
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15. Full Text Discovery and Optimization of Phosphopantetheine Adenylyltransferase Inhibitors with Gram-Negative Antibacterial Activity
by Skepper, Colin K and Moreau, Robert J and Appleton, Brent A and Benton, Bret M and Drumm, Joseph E and Feng, Brian Y and Geng, Mei and Hu, Cheng and Li, Cindy and Lingel, Andreas and Lu, Yipin and Mamo, Mulugeta and Mergo, Wosenu and Mostafavi, Mina and Rath, Christopher M and Steffek, Micah and Takeoka, Kenneth T and Uehara, Kyoko and Wang, Lisha and Wei, Jun-Rong and Xie, Lili and Xu, Wenjian and Zhang, Qiong and De Vicente, Javier
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2018, Volume 61, Issue 8, pp. 3325 - 3349
In the preceding manuscript [Moreau et al. 2018, 10.1021/acs.jmedchem.7b01691] we described a successful fragment-based lead discovery (FBLD) strategy for... 
PHOSPHINOXYDE ALS OLEFINIERUNGSREAGENZIEN | CROSS-COUPLING REACTIONS | CHEMISTRY, MEDICINAL | MULTIDRUG EFFLUX PUMPS | ESCHERICHIA-COLI | ARYL HALIDES | ANTIBIOTIC-RESISTANCE | OUTER-MEMBRANE PERMEABILITY | COENZYME-A | RESISTANCE GENE MCR-1 | MOLECULAR-MECHANISMS | Nucleotidyltransferases - chemistry | Triazoles - chemistry | Escherichia coli - drug effects | Pyrimidinones - metabolism | Benzimidazoles - chemistry | Enzyme Inhibitors - chemical synthesis | Pyrimidinones - chemistry | Microbial Sensitivity Tests | Anti-Bacterial Agents - chemistry | Enzyme Inhibitors - chemistry | Nucleotidyltransferases - antagonists & inhibitors | Pyrimidinones - pharmacology | Triazoles - chemical synthesis | Molecular Structure | Escherichia coli Proteins - antagonists & inhibitors | Nucleotidyltransferases - metabolism | Pyrimidinones - chemical synthesis | Binding Sites | Escherichia coli - enzymology | Enzyme Inhibitors - metabolism | Benzimidazoles - chemical synthesis | Enzyme Inhibitors - pharmacology | Heterocyclic Compounds, 2-Ring - chemistry | Anti-Bacterial Agents - metabolism | Escherichia coli Proteins - metabolism | Drug Discovery | Heterocyclic Compounds, 2-Ring - pharmacology | Anti-Bacterial Agents - chemical synthesis | Triazoles - pharmacology | Triazoles - metabolism | Benzimidazoles - metabolism | Heterocyclic Compounds, 2-Ring - metabolism | Escherichia coli Proteins - genetics | Nucleotidyltransferases - genetics | Protein Binding | Benzimidazoles - pharmacology | Anti-Bacterial Agents - pharmacology | Mutation | Escherichia coli Proteins - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis
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16. Full Text Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure
by Follmann, Markus and Ackerstaff, Jens and Redlich, Gorden and Wunder, Frank and Lang, Dieter and Kern, Armin and Fey, Peter and Griebenow, Nils and Kroh, Walter and Becker-Pelster, Eva-Maria and Kretschmer, Axel and Geiss, Volker and Li, Volkhart and Straub, Alexander and Mittendorf, Joachim and Jautelat, Rolf and Schirok, Hartmut and Schlemmer, Karl-Heinz and Lustig, Klemens and Gerisch, Michael and Knorr, Andreas and Tinel, Hanna and Mondritzki, Thomas and Trübel, Hubert and Sandner, Peter and Stasch, Johannes-Peter
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2017, Volume 60, Issue 12, pp. 5146 - 5161
The first-in-class soluble guanylate cyclase (sGC) stimulator riociguat was recently introduced as a novel treatment option for pulmonary hypertension. Despite... 
NO | CHEMISTRY, MEDICINAL | PHARMACOKINETICS | PULMONARY ARTERIAL-HYPERTENSION | MODULATORS | DRUG DISCOVERY | RIOCIGUAT | NITRIC-OXIDE | ACTIVATORS | DYSFUNCTION | EXPRESSION | Chemistry Techniques, Synthetic | Rats, Transgenic | Rats, Wistar | Soluble Guanylyl Cyclase - metabolism | Administration, Oral | Pyrimidines - administration & dosage | Humans | Heterocyclic Compounds, 2-Ring - administration & dosage | Heterocyclic Compounds, 2-Ring - chemistry | Male | NG-Nitroarginine Methyl Ester - adverse effects | Structure-Activity Relationship | Pyrimidines - pharmacology | Pyrimidines - chemistry | Heart Failure - drug therapy | Heterocyclic Compounds, 2-Ring - pharmacology | Administration, Intravenous | Animals | Soluble Guanylyl Cyclase - genetics | Dogs | Blood Pressure - drug effects | Hepatocytes - drug effects
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17. Full Text Structure-activity relationship of new anti-hepatitis C virus agents: Heterobicycle-coumarin conjugates
by Neyts, Johan and De Clercq, Erik and Singha, Raghunath and Chang, Yung Hsiung and Das, Asish R and Chakraborty, Subhasish K and Hong, Shih Ching and Tsay, Shwu-Chen and Hsu, Ming-Hua and Hwu, Jih Ru
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2009, Volume 52, Issue 5, pp. 1486 - 1490
For establishment of the structure-activity relationship, 19 heterobicycle-coumarin conjugated compounds with the -SCH2- linker were synthesized and found to... 
NS5B POLYMERASE | IN-VITRO | CHEMISTRY, MEDICINAL | BENZIMIDAZOLE DERIVATIVES | ANTICANCER | BIOLOGICAL-ACTIVITY | INFECTION | INHIBITORS | ANTITUMOR-ACTIVITY | IDENTIFICATION | CELL-LINE | Benzoxazoles - pharmacology | Pyridines - chemistry | Humans | Imidazoles - chemistry | Hepacivirus - genetics | Coumarins - chemistry | Structure-Activity Relationship | Antiviral Agents - chemistry | Imidazoles - chemical synthesis | Hepacivirus - drug effects | Purines - chemical synthesis | Cell Line | Virus Replication - drug effects | Antiviral Agents - pharmacology | Purines - pharmacology | Heterocyclic Compounds, 2-Ring - chemistry | Pyridines - chemical synthesis | Models, Molecular | Imidazoles - pharmacology | Benzoxazoles - chemical synthesis | Heterocyclic Compounds, 2-Ring - pharmacology | Coumarins - pharmacology | Benzoxazoles - chemistry | Purines - chemistry | Coumarins - chemical synthesis | Antiviral Agents - chemical synthesis | Cell Proliferation - drug effects | Pyridines - pharmacology | RNA, Viral - drug effects | Heterocyclic Compounds, 2-Ring - chemical synthesis
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18. Full Text Rhodium(III)‐Catalyzed Synthesis of Cinnolinium Salts from Azobenzenes and Alkynes: Application to the Synthesis of Indoles and Cinnolines
by Muralirajan, Krishnamoorthy and Cheng, Chien‐Hong
Chemistry – A European Journal, ISSN 0947-6539, 05/2013, Volume 19, Issue 20, pp. 6198 - 6202
Versatile salts : A new rhodium‐catalyzed synthesis of cinnolinium salts from various azobenzenes and alkynes under air is described. These salts readily... 
cinnolinium salts | CH activation | air | azobenzenes | alkynes | rhodium | C-H activation | TRANSITION-METAL-COMPLEXES | AROMATIC KETONES | ONE-POT SYNTHESIS | NICKEL-CATALYZED ANNULATION | INTERNAL ALKYNES | C-H ACTIVATION | CHEMISTRY, MULTIDISCIPLINARY | DEHYDROGENATIVE CYCLIZATION | CH activation | REGIOSELECTIVE SYNTHESIS | N BOND FORMATION | ISOQUINOLINIUM SALTS | Azo Compounds - chemistry | Salts - chemistry | Heterocyclic Compounds, 2-Ring - chemistry | Salts - chemical synthesis | Indoles - chemical synthesis | Alkynes - chemistry | Molecular Structure | Catalysis | Heterocyclic Compounds, 2-Ring - chemical synthesis | Indoles - chemistry | Rhodium - chemistry | Rhodium | Synthesis | Indoles | Transforms | Alkynes
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19. Full Text Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria
by Moreau, Robert J and Skepper, Colin K and Appleton, Brent A and Blechschmidt, Anke and Balibar, Carl J and Benton, Bret M and Drumm, Joseph E and Feng, Brian Y and Geng, Mei and Li, Cindy and Lindvall, Mika K and Lingel, Andreas and Lu, Yipin and Mamo, Mulugeta and Mergo, Wosenu and Polyakov, Valery and Smith, Thomas M and Takeoka, Kenneth and Uehara, Kyoko and Wang, Lisha and Wei, Jun-Rong and Weiss, Andrew H and Xie, Lili and Xu, Wenjian and Zhang, Qiong and De Vicente, Javier
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2018, Volume 61, Issue 8, pp. 3309 - 3324
The discovery and development of new antibiotics capable of curing infections due to multidrug-resistant and pandrug-resistant Gram-negative bacteria are a... 
COENZYME-A BIOSYNTHESIS | MEDICINAL CHEMISTRY | CHEMISTRY, MEDICINAL | LEAD DISCOVERY | ESCHERICHIA-COLI | ANTIBIOTIC-RESISTANCE | OUTER-MEMBRANE PERMEABILITY | N-PENTYLPANTOTHENAMIDE | ANTIBACTERIAL DISCOVERY | BETA-LACTAMASES | RESISTANCE GENE MCR-1 | Nucleotidyltransferases - chemistry | Triazoles - chemistry | Escherichia coli - drug effects | Pyrimidinones - metabolism | Benzimidazoles - chemistry | Enzyme Inhibitors - chemical synthesis | Pyrimidinones - chemistry | Microbial Sensitivity Tests | Pseudomonas aeruginosa - enzymology | Anti-Bacterial Agents - chemistry | Enzyme Inhibitors - chemistry | Nucleotidyltransferases - antagonists & inhibitors | Pyrimidinones - pharmacology | Triazoles - chemical synthesis | Molecular Structure | Escherichia coli Proteins - antagonists & inhibitors | Nucleotidyltransferases - metabolism | Pyrimidinones - chemical synthesis | Binding Sites | Escherichia coli - enzymology | Enzyme Inhibitors - metabolism | Benzimidazoles - chemical synthesis | Enzyme Inhibitors - pharmacology | Heterocyclic Compounds, 2-Ring - chemistry | Anti-Bacterial Agents - metabolism | Escherichia coli Proteins - metabolism | Pseudomonas aeruginosa - drug effects | Drug Discovery | Heterocyclic Compounds, 2-Ring - pharmacology | Anti-Bacterial Agents - chemical synthesis | Triazoles - pharmacology | Triazoles - metabolism | Benzimidazoles - metabolism | Heterocyclic Compounds, 2-Ring - metabolism | Protein Binding | Benzimidazoles - pharmacology | Anti-Bacterial Agents - pharmacology | Escherichia coli Proteins - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis
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