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Journal of medicinal chemistry, ISSN 0022-2623, 09/2016, Volume 59, Issue 17, pp. 7991 - 8007
Anti-HIV Agents - pharmacology | Pyrimidines - chemical synthesis | HIV Reverse Transcriptase - antagonists & inhibitors | Humans | Drug Resistance, Viral | Reverse Transcriptase Inhibitors - pharmacology | Male | Structure-Activity Relationship | Anti-HIV Agents - chemical synthesis | Pyrimidines - chemistry | Reverse Transcriptase Inhibitors - chemistry | Reverse Transcriptase Inhibitors - chemical synthesis | Reverse Transcriptase Inhibitors - pharmacokinetics | Sulfonamides - chemistry | Heterocyclic Compounds, 2-Ring - chemistry | Thiophenes - pharmacology | Heterocyclic Compounds, 2-Ring - pharmacokinetics | Pyrimidines - pharmacology | HIV-1 - genetics | Sulfonamides - pharmacology | Rats, Sprague-Dawley | Sulfonamides - pharmacokinetics | Heterocyclic Compounds, 2-Ring - pharmacology | Sulfonamides - chemical synthesis | Thiophenes - chemical synthesis | Thiophenes - pharmacokinetics | Anti-HIV Agents - chemistry | Animals | Anti-HIV Agents - pharmacokinetics | Cell Line, Tumor | Pyrimidines - pharmacokinetics | HIV-1 - enzymology | Mice | Molecular Docking Simulation | Mutation | Thiophenes - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis | Index Medicus
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 04/2014, Volume 57, Issue 8, pp. 3205 - 3212
Pyrans - chemical synthesis | Hypoglycemic Agents - pharmacokinetics | Dipeptidyl-Peptidase IV Inhibitors - toxicity | Humans | Pyrans - toxicity | Structure-Activity Relationship | Heterocyclic Compounds, 2-Ring - pharmacokinetics | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Heterocyclic Compounds, 2-Ring - pharmacology | Hypoglycemic Agents - pharmacology | Hypoglycemic Agents - toxicity | Dipeptidyl-Peptidase IV Inhibitors - chemical synthesis | Heterocyclic Compounds, 2-Ring - toxicity | Pyrans - pharmacokinetics | Animals | Dipeptidyl-Peptidase IV Inhibitors - pharmacokinetics | Hypoglycemic Agents - chemical synthesis | Diabetes Mellitus, Type 2 - drug therapy | Heterocyclic Compounds, 2-Ring - chemical synthesis | Pyrans - pharmacology | Index Medicus | 60 APPLIED LIFE SCIENCES | INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Journal Article
Organic letters, ISSN 1523-7060, 06/2015, Volume 17, Issue 11, pp. 2852 - 2855
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Journal of medicinal chemistry, ISSN 0022-2623, 07/2011, Volume 54, Issue 14, pp. 5013 - 5030
Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Imidazoles - chemistry | Cercopithecus aethiops | Structure-Activity Relationship | Topoisomerase II Inhibitors - chemistry | S Phase | HEK293 Cells | Antineoplastic Agents - pharmacology | Topoisomerase II Inhibitors - chemical synthesis | Imidazoles - chemical synthesis | Intercalating Agents - chemical synthesis | Binding Sites | Vero Cells | Cell Survival - drug effects | Antigens, Neoplasm | DNA-Binding Proteins - antagonists & inhibitors | Heterocyclic Compounds, 2-Ring - chemistry | Etoposide - pharmacology | Models, Molecular | Imidazoles - pharmacology | Intercalating Agents - pharmacology | Topoisomerase II Inhibitors - pharmacology | Antineoplastic Agents - chemistry | Intercalating Agents - chemistry | Molecular Dynamics Simulation | Heterocyclic Compounds, 2-Ring - pharmacology | Cell Movement - drug effects | G1 Phase | Animals | Cell Line, Tumor | Adenosine Triphosphatases - chemistry | DNA Topoisomerases, Type II | Fluorouracil - pharmacology | Adenosine Triphosphate - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis | Drug Screening Assays, Antitumor | Index Medicus
Journal Article
European journal of medicinal chemistry, ISSN 0223-5234, 06/2020, Volume 195, pp. 112281 - 112281
Estrogen receptor | OBHS-LSD1i conjugates | Breast cancer | Lysine specific demethylase 1 | Selective estrogen receptor modulators | Cell Survival - drug effects | Chemistry Techniques, Synthetic | Estrogen Receptor alpha - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Heterocyclic Compounds, 2-Ring - chemistry | Models, Molecular | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - chemistry | Molecular Targeted Therapy | Heterocyclic Compounds, 2-Ring - pharmacology | Histone Demethylases - metabolism | MCF-7 Cells | Breast Neoplasms - pathology | Heterocyclic Compounds, 2-Ring - therapeutic use | Drug Design | Estrogen Receptor alpha - metabolism | Protein Conformation | Antineoplastic Agents - pharmacology | Heterocyclic Compounds, 2-Ring - chemical synthesis | Index Medicus
Journal Article
Organic letters, ISSN 1523-7060, 09/2012, Volume 14, Issue 17, pp. 4386 - 4389
Oxidation-Reduction | Pyridines - chemistry | Stereoisomerism | Heterocyclic Compounds, 2-Ring - chemistry | Imidazoles - chemistry | Pyridines - chemical synthesis | Ferric Compounds - chemistry | Alkynes - chemistry | Combinatorial Chemistry Techniques | Copper - chemistry | Catalysis | Imidazoles - chemical synthesis | Heterocyclic Compounds, 2-Ring - chemical synthesis | Index Medicus
Journal Article
Organic letters, ISSN 1523-7060, 12/2014, Volume 16, Issue 23, pp. 6232 - 6235
Combinatorial Chemistry Techniques | Copper - chemistry | Amination | Pyridines - chemistry | Heterocyclic Compounds, 2-Ring - chemistry | Imidazoles - chemistry | Ketones - chemistry | Iodides - chemistry | Catalysis | Heterocyclic Compounds, 2-Ring - chemical synthesis | Aldehydes - chemistry | Index Medicus
Journal Article
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 07/2018, Volume 28, Issue 13, pp. 2328 - 2337
Carbohydrazide Schiff’s bases | 3D QSAR | CoMFA and CoMSIA studies | Anti-cancer activity | Pyrido[3′,2′:4,5]furo[3,2-d]pyrimidin-4(3H)-one | Carbohydrazide Schiff's bases | Heterocyclic Compounds, 3-Ring - pharmacology | Pyridines - chemistry | Pyrimidines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Furans - pharmacology | Humans | Heterocyclic Compounds, 3-Ring - chemical synthesis | Pyrimidines - chemistry | Antineoplastic Agents - toxicity | Heterocyclic Compounds, 2-Ring - toxicity | Pyrimidines - toxicity | Furans - chemistry | HEK293 Cells | Heterocyclic Compounds, 3-Ring - toxicity | Antineoplastic Agents - pharmacology | Molecular Structure | Furans - toxicity | Quantitative Structure-Activity Relationship | Heterocyclic Compounds, 2-Ring - chemistry | Pyridines - chemical synthesis | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Heterocyclic Compounds, 2-Ring - pharmacology | Cyclization | Hydrogen Bonding | Pyridines - toxicity | Heterocyclic Compounds, 3-Ring - chemistry | Cell Line, Tumor | Pyridines - pharmacology | Furans - chemical synthesis | Heterocyclic Compounds, 2-Ring - chemical synthesis | Drug Screening Assays, Antitumor | Alkaloids | Amines | Pyridine | Aldehydes | Analysis | Index Medicus
Journal Article
Organic letters, ISSN 1523-7060, 12/2012, Volume 14, Issue 23, pp. 5948 - 5951
Amines - chemistry | Benzene Derivatives - chemical synthesis | Combinatorial Chemistry Techniques | Oxidants - chemistry | Heterocyclic Compounds, 2-Ring - chemistry | Molecular Structure | Sulfur Compounds - chemistry | Benzene Derivatives - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis | Index Medicus | Organic chemistry | Chemical Sciences
Journal Article
European journal of medicinal chemistry, ISSN 0223-5234, 03/2015, Volume 92, pp. 754 - 765
Structure-based drug design | HIV-1 RT | Triazolopyrimidines | Biological activity | Physicochemical properties | Molecular simulations | Anti-HIV Agents - pharmacology | HIV Reverse Transcriptase - antagonists & inhibitors | Humans | Heterocyclic Compounds - pharmacology | Reverse Transcriptase Inhibitors - pharmacology | Heterocyclic Compounds - chemical synthesis | Structure-Activity Relationship | Sulfones - pharmacology | Anti-HIV Agents - chemical synthesis | Reverse Transcriptase Inhibitors - chemistry | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Reverse Transcriptase Inhibitors - chemical synthesis | Heterocyclic Compounds - chemistry | Sulfones - chemistry | Molecular Structure | Sulfones - chemical synthesis | HIV-1 - drug effects | Heterocyclic Compounds, 2-Ring - chemistry | Solubility | Models, Molecular | Heterocyclic Compounds, 2-Ring - pharmacology | HIV Reverse Transcriptase - metabolism | Anti-HIV Agents - chemistry | Nitrogen - chemistry | Cell Line, Tumor | Heterocyclic Compounds, 2-Ring - chemical synthesis | DNA polymerases | Antiviral agents | Pyrimidines | HIV (Viruses) | Analysis | Medical colleges | Index Medicus
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 09/2016, Volume 59, Issue 17, pp. 7801 - 7817
Neoplasm Transplantation | Stereoisomerism | Humans | Crystallography, X-Ray | Piperazines - chemistry | Structure-Activity Relationship | Hepatocytes - metabolism | Heterografts | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Piperazines - pharmacokinetics | Hepatocytes - drug effects | Caco-2 Cells | Heterocyclic Compounds, 2-Ring - chemistry | Rats | Transcription Factors - antagonists & inhibitors | Heterocyclic Compounds, 2-Ring - pharmacokinetics | Antineoplastic Agents - chemistry | Mice, SCID | Piperazines - pharmacology | Heterocyclic Compounds, 2-Ring - pharmacology | Animals | Nuclear Proteins - antagonists & inhibitors | Dogs | Protein Conformation | Index Medicus
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 06/2017, Volume 60, Issue 12, pp. 5146 - 5161
Chemistry Techniques, Synthetic | Rats, Transgenic | Rats, Wistar | Soluble Guanylyl Cyclase - metabolism | Administration, Oral | Pyrimidines - administration & dosage | Humans | Heterocyclic Compounds, 2-Ring - administration & dosage | Heterocyclic Compounds, 2-Ring - chemistry | Male | NG-Nitroarginine Methyl Ester - adverse effects | Structure-Activity Relationship | Pyrimidines - pharmacology | Pyrimidines - chemistry | Heart Failure - drug therapy | Heterocyclic Compounds, 2-Ring - pharmacology | Administration, Intravenous | Animals | Soluble Guanylyl Cyclase - genetics | Dogs | Blood Pressure - drug effects | Hepatocytes - drug effects | Index Medicus
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Full Text
Acylazetine as a Dienophile in Bioorthogonal Inverse Electron-Demand Diels–Alder Ligation
Organic letters, ISSN 1523-7060, 05/2014, Volume 16, Issue 10, pp. 2744 - 2747
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 09/2015, Volume 58, Issue 18, pp. 7195 - 7216
Stereoisomerism | Humans | Microsomes, Liver - metabolism | Rats, Inbred Lew | Male | Structure-Activity Relationship | Graft vs Host Disease - immunology | Janus Kinase 3 - antagonists & inhibitors | Valine - chemistry | Janus Kinase 2 - chemistry | Janus Kinase 3 - chemistry | Mice, Inbred CBA | Female | Autoimmune Diseases - drug therapy | Cell Line | Valine - pharmacokinetics | Valine - analogs & derivatives | Heterocyclic Compounds, 2-Ring - chemistry | Models, Molecular | Rats | Heterocyclic Compounds, 2-Ring - pharmacokinetics | Rats, Sprague-Dawley | Haplorhini | Heterocyclic Compounds, 2-Ring - pharmacology | Animals | Graft vs Host Disease - drug therapy | Databases, Chemical | Dogs | Mice | Mice, Inbred BALB C | Valine - pharmacology | Index Medicus
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 03/2009, Volume 52, Issue 5, pp. 1486 - 1490
Antiviral agents | Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Antibiotics. Antiinfectious agents. Antiparasitic agents | Benzoxazoles - pharmacology | Pyridines - chemistry | Humans | Imidazoles - chemistry | Hepacivirus - genetics | Coumarins - chemistry | Structure-Activity Relationship | Antiviral Agents - chemistry | Imidazoles - chemical synthesis | Hepacivirus - drug effects | Purines - chemical synthesis | Cell Line | Virus Replication - drug effects | Antiviral Agents - pharmacology | Purines - pharmacology | Heterocyclic Compounds, 2-Ring - chemistry | Pyridines - chemical synthesis | Models, Molecular | Imidazoles - pharmacology | Benzoxazoles - chemical synthesis | Heterocyclic Compounds, 2-Ring - pharmacology | Coumarins - pharmacology | Benzoxazoles - chemistry | Purines - chemistry | Coumarins - chemical synthesis | Antiviral Agents - chemical synthesis | Cell Proliferation - drug effects | Pyridines - pharmacology | RNA, Viral - drug effects | Heterocyclic Compounds, 2-Ring - chemical synthesis | Index Medicus
Journal Article
Chemosphere (Oxford), ISSN 0045-6535, 01/2019, Volume 214, pp. 543 - 552
Photodegradation | DFT | Kinetics | Transformation product | Fluazaindolizine | Environmental Sciences & Ecology | Life Sciences & Biomedicine | Science & Technology | Environmental Sciences | Heterocyclic Compounds, 2-Ring - analysis | Heterocyclic Compounds, 2-Ring - radiation effects | Sulfonamides - analysis | Ferric Compounds - chemistry | Water Pollutants, Chemical - analysis | Water Pollutants, Chemical - metabolism | Nitrates - chemistry | Photolysis | Heterocyclic Compounds, 2-Ring - metabolism | Humic Substances - analysis | Sulfonamides - metabolism | Water - chemistry | Sunlight | Water Pollutants, Chemical - radiation effects | Sulfonamides - radiation effects | Specific gravity | Density functionals | Nitrates | Mass spectrometry | Humic acid | High performance liquid chromatography | Index Medicus
Journal Article
Organic letters, ISSN 1523-7060, 12/2014, Volume 16, Issue 23, pp. 6204 - 6207
Propanols - chemistry | Benzene Derivatives - chemical synthesis | Sulfones - chemistry | Heterocyclic Compounds, 2-Ring - chemistry | Nitriles - chemistry | Silver - chemistry | Alkynes - chemistry | Molecular Structure | Catalysis | Benzene Derivatives - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis | Sulfones - chemical synthesis | Index Medicus
Journal Article
Organic letters, ISSN 1523-7060, 04/2013, Volume 15, Issue 8, pp. 2066 - 2069
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 09/2015, Volume 58, Issue 18, pp. 7485 - 7500
Calcium - metabolism | Pyridines - chemistry | Stereoisomerism | Allosteric Regulation | Humans | Microsomes, Liver - metabolism | Pyridines - pharmacokinetics | Receptors, Metabotropic Glutamate - metabolism | Structure-Activity Relationship | Brain - metabolism | Anti-Anxiety Agents - pharmacokinetics | Antidepressive Agents - chemistry | Madin Darby Canine Kidney Cells | Anti-Anxiety Agents - chemistry | Antidepressive Agents - pharmacology | Heterocyclic Compounds, 2-Ring - chemistry | Anti-Anxiety Agents - pharmacology | Rats | Heterocyclic Compounds, 2-Ring - pharmacokinetics | Permeability | Heterocyclic Compounds, 2-Ring - pharmacology | Animals | Dogs | Mice | Pyridines - pharmacology | Antidepressive Agents - pharmacokinetics | Index Medicus
Journal Article
Current medicinal chemistry, ISSN 0929-8673, 01/2019, Volume 26, Issue 10, pp. 1806 - 1832
Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Janus Kinase Inhibitors - pharmacology | Animals | Janus Kinase Inhibitors - therapeutic use | Heterocyclic Compounds, 2-Ring - therapeutic use | Humans | Heterocyclic Compounds, 2-Ring - chemistry | Cell Line, Tumor | Janus Kinase Inhibitors - chemistry | Molecular Structure | Structure-Activity Relationship | Heterocyclic Compounds, 2-Ring - pharmacology | Tyrosine | Medical research | Tyk2 protein | Clinical trials | Selectivity | Derivatives | Kinases | Biological activity | Neoplasms | Organic chemistry | Signal transduction | Inhibitors | Janus kinase 2 | Janus kinase | Mutation | Autoimmune diseases | Scaffolds
Journal Article
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