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1. Full Text Design, Synthesis, and Evaluation of Thiophene[3,2‑d]pyrimidine Derivatives as HIV‑1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles
by Kang, Dongwei and Fang, Zengjun and Li, Zhenyu and Huang, Boshi and Zhang, Heng and Lu, Xueyi and Xu, Haoran and Zhou, Zhongxia and Ding, Xiao and Daelemans, Dirk and De Clercq, Erik and Pannecouque, Christophe and Zhan, Peng and Liu, Xinyong
Journal of medicinal chemistry, ISSN 0022-2623, 09/2016, Volume 59, Issue 17, pp. 7991 - 8007
Anti-HIV Agents - pharmacology | Pyrimidines - chemical synthesis | HIV Reverse Transcriptase - antagonists & inhibitors | Humans | Drug Resistance, Viral | Reverse Transcriptase Inhibitors - pharmacology | Male | Structure-Activity Relationship | Anti-HIV Agents - chemical synthesis | Pyrimidines - chemistry | Reverse Transcriptase Inhibitors - chemistry | Reverse Transcriptase Inhibitors - chemical synthesis | Reverse Transcriptase Inhibitors - pharmacokinetics | Sulfonamides - chemistry | Heterocyclic Compounds, 2-Ring - chemistry | Thiophenes - pharmacology | Heterocyclic Compounds, 2-Ring - pharmacokinetics | Pyrimidines - pharmacology | HIV-1 - genetics | Sulfonamides - pharmacology | Rats, Sprague-Dawley | Sulfonamides - pharmacokinetics | Heterocyclic Compounds, 2-Ring - pharmacology | Sulfonamides - chemical synthesis | Thiophenes - chemical synthesis | Thiophenes - pharmacokinetics | Anti-HIV Agents - chemistry | Animals | Anti-HIV Agents - pharmacokinetics | Cell Line, Tumor | Pyrimidines - pharmacokinetics | HIV-1 - enzymology | Mice | Molecular Docking Simulation | Mutation | Thiophenes - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis | Index Medicus
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2. Full Text Omarigliptin (MK-3102): A Novel Long-Acting DPP‑4 Inhibitor for Once-Weekly Treatment of Type 2 Diabetes
by Biftu, Tesfaye and Sinha-Roy, Ranabir and Chen, Ping and Qian, Xiaoxia and Feng, Dennis and Kuethe, Jeffrey T and Scapin, Giovanna and Gao, Ying Duo and Yan, Youwei and Krueger, Davida and Bak, Annette and Eiermann, George and He, Jiafang and Cox, Jason and Hicks, Jacqueline and Lyons, Kathy and He, Huaibing and Salituro, Gino and Tong, Sharon and Patel, Sangita and Doss, George and Petrov, Aleksandr and Wu, Joseph and Xu, Shiyao Sherrie and Sewall, Charles and Zhang, Xiaoping and Zhang, Bei and Thornberry, Nancy A and Weber, Ann E and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Journal of medicinal chemistry, ISSN 0022-2623, 04/2014, Volume 57, Issue 8, pp. 3205 - 3212
Pyrans - chemical synthesis | Hypoglycemic Agents - pharmacokinetics | Dipeptidyl-Peptidase IV Inhibitors - toxicity | Humans | Pyrans - toxicity | Structure-Activity Relationship | Heterocyclic Compounds, 2-Ring - pharmacokinetics | Dipeptidyl-Peptidase IV Inhibitors - pharmacology | Heterocyclic Compounds, 2-Ring - pharmacology | Hypoglycemic Agents - pharmacology | Hypoglycemic Agents - toxicity | Dipeptidyl-Peptidase IV Inhibitors - chemical synthesis | Heterocyclic Compounds, 2-Ring - toxicity | Pyrans - pharmacokinetics | Animals | Dipeptidyl-Peptidase IV Inhibitors - pharmacokinetics | Hypoglycemic Agents - chemical synthesis | Diabetes Mellitus, Type 2 - drug therapy | Heterocyclic Compounds, 2-Ring - chemical synthesis | Pyrans - pharmacology | Index Medicus | 60 APPLIED LIFE SCIENCES | INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
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3. Full Text Rh(III)-catalyzed direct coupling of azobenzenes with α-diazo esters: Facile synthesis of cinnolin-3(2 H)-ones
by Sharma, Satyasheel and Han, Sang Hoon and Han, Sangil and Ji, Wontae and Oh, Jongchan and Lee, Seok-Yong and Oh, Joa Sub and Jung, Young Hoon and Kim, In Su
Organic letters, ISSN 1523-7060, 06/2015, Volume 17, Issue 11, pp. 2852 - 2855
Azo Compounds - chemistry | Heterocyclic Compounds, 2-Ring - chemistry | Esters | Molecular Structure | Catalysis | Heterocyclic Compounds, 2-Ring - chemical synthesis | Dioxanes - chemistry | Rhodium - chemistry | Index Medicus
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4. Full Text N-Fused Imidazoles As Novel Anticancer Agents That Inhibit Catalytic Activity of Topoisomerase IIα and Induce Apoptosis in G1/S Phase
by Baviskar, Ashish T and Madaan, Chetna and Preet, Ranjan and Mohapatra, Purusottam and Jain, Vaibhav and Agarwal, Amit and Guchhait, Sankar K and Kundu, Chanakya N and Banerjee, Uttam C and Bharatam, Prasad V
Journal of medicinal chemistry, ISSN 0022-2623, 07/2011, Volume 54, Issue 14, pp. 5013 - 5030
Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Imidazoles - chemistry | Cercopithecus aethiops | Structure-Activity Relationship | Topoisomerase II Inhibitors - chemistry | S Phase | HEK293 Cells | Antineoplastic Agents - pharmacology | Topoisomerase II Inhibitors - chemical synthesis | Imidazoles - chemical synthesis | Intercalating Agents - chemical synthesis | Binding Sites | Vero Cells | Cell Survival - drug effects | Antigens, Neoplasm | DNA-Binding Proteins - antagonists & inhibitors | Heterocyclic Compounds, 2-Ring - chemistry | Etoposide - pharmacology | Models, Molecular | Imidazoles - pharmacology | Intercalating Agents - pharmacology | Topoisomerase II Inhibitors - pharmacology | Antineoplastic Agents - chemistry | Intercalating Agents - chemistry | Molecular Dynamics Simulation | Heterocyclic Compounds, 2-Ring - pharmacology | Cell Movement - drug effects | G1 Phase | Animals | Cell Line, Tumor | Adenosine Triphosphatases - chemistry | DNA Topoisomerases, Type II | Fluorouracil - pharmacology | Adenosine Triphosphate - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis | Drug Screening Assays, Antitumor | Index Medicus
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5. Full Text Design, synthesis and biological evaluation of novel dual-acting modulators targeting both estrogen receptor α (ERα) and lysine-specific demethylase 1 (LSD1) for treatment of breast cancer
by He, Ming and Ning, Wentao and Hu, Zhiye and Huang, Jian and Dong, Chune and Zhou, Hai-Bing
European journal of medicinal chemistry, ISSN 0223-5234, 06/2020, Volume 195, pp. 112281 - 112281
Estrogen receptor | OBHS-LSD1i conjugates | Breast cancer | Lysine specific demethylase 1 | Selective estrogen receptor modulators | Cell Survival - drug effects | Chemistry Techniques, Synthetic | Estrogen Receptor alpha - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Heterocyclic Compounds, 2-Ring - chemistry | Models, Molecular | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - chemistry | Molecular Targeted Therapy | Heterocyclic Compounds, 2-Ring - pharmacology | Histone Demethylases - metabolism | MCF-7 Cells | Breast Neoplasms - pathology | Heterocyclic Compounds, 2-Ring - therapeutic use | Drug Design | Estrogen Receptor alpha - metabolism | Protein Conformation | Antineoplastic Agents - pharmacology | Heterocyclic Compounds, 2-Ring - chemical synthesis | Index Medicus
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6. Full Text Copper(II)/Iron(III) Co-catalyzed Intermolecular Diamination of Alkynes: Facile Synthesis of Imidazopyridines
by Zeng, Jing and Tan, Yu Jia and Leow, Min Li and Liu, Xue-Wei
Organic letters, ISSN 1523-7060, 09/2012, Volume 14, Issue 17, pp. 4386 - 4389
Oxidation-Reduction | Pyridines - chemistry | Stereoisomerism | Heterocyclic Compounds, 2-Ring - chemistry | Imidazoles - chemistry | Pyridines - chemical synthesis | Ferric Compounds - chemistry | Alkynes - chemistry | Combinatorial Chemistry Techniques | Copper - chemistry | Catalysis | Imidazoles - chemical synthesis | Heterocyclic Compounds, 2-Ring - chemical synthesis | Index Medicus
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7. Full Text Cu(I)-Catalyzed Transannulation of N‑Heteroaryl Aldehydes or Ketones with Alkylamines via C(sp3)–H Amination
by Li, Mingyang and Xie, Ying and Ye, Yong and Zou, Yong and Jiang, Huanfeng and Zeng, Wei
Organic letters, ISSN 1523-7060, 12/2014, Volume 16, Issue 23, pp. 6232 - 6235
Combinatorial Chemistry Techniques | Copper - chemistry | Amination | Pyridines - chemistry | Heterocyclic Compounds, 2-Ring - chemistry | Imidazoles - chemistry | Ketones - chemistry | Iodides - chemistry | Catalysis | Heterocyclic Compounds, 2-Ring - chemical synthesis | Aldehydes - chemistry | Index Medicus
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8. Full Text Synthesis of novel hetero ring fused pyridine derivatives; Their anticancer activity, CoMFA and CoMSIA studies
by Santhosh Kumar, G and Poornachandra, Y and Kumar Gunda, Shravan and Ratnakar Reddy, K and Mohmed, Jaheer and Shaik, Kamal and Ganesh Kumar, C and Narsaiah, B
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 07/2018, Volume 28, Issue 13, pp. 2328 - 2337
Carbohydrazide Schiff’s bases | 3D QSAR | CoMFA and CoMSIA studies | Anti-cancer activity | Pyrido[3′,2′:4,5]furo[3,2-d]pyrimidin-4(3H)-one | Carbohydrazide Schiff's bases | Heterocyclic Compounds, 3-Ring - pharmacology | Pyridines - chemistry | Pyrimidines - chemical synthesis | Antineoplastic Agents - chemical synthesis | Furans - pharmacology | Humans | Heterocyclic Compounds, 3-Ring - chemical synthesis | Pyrimidines - chemistry | Antineoplastic Agents - toxicity | Heterocyclic Compounds, 2-Ring - toxicity | Pyrimidines - toxicity | Furans - chemistry | HEK293 Cells | Heterocyclic Compounds, 3-Ring - toxicity | Antineoplastic Agents - pharmacology | Molecular Structure | Furans - toxicity | Quantitative Structure-Activity Relationship | Heterocyclic Compounds, 2-Ring - chemistry | Pyridines - chemical synthesis | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Heterocyclic Compounds, 2-Ring - pharmacology | Cyclization | Hydrogen Bonding | Pyridines - toxicity | Heterocyclic Compounds, 3-Ring - chemistry | Cell Line, Tumor | Pyridines - pharmacology | Furans - chemical synthesis | Heterocyclic Compounds, 2-Ring - chemical synthesis | Drug Screening Assays, Antitumor | Alkaloids | Amines | Pyridine | Aldehydes | Analysis | Index Medicus
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9. Full Text Benzazoles from Aliphatic Amines and o‑Amino/Mercaptan/Hydroxyanilines: Elemental Sulfur as a Highly Efficient and Traceless Oxidizing Agent
by Nguyen, Thanh Binh and Ermolenko, Ludmila and Dean, William A and Al-Mourabit, Ali
Organic letters, ISSN 1523-7060, 12/2012, Volume 14, Issue 23, pp. 5948 - 5951
Amines - chemistry | Benzene Derivatives - chemical synthesis | Combinatorial Chemistry Techniques | Oxidants - chemistry | Heterocyclic Compounds, 2-Ring - chemistry | Molecular Structure | Sulfur Compounds - chemistry | Benzene Derivatives - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis | Index Medicus | Organic chemistry | Chemical Sciences
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10. Full Text Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 3: Optimization of [1,2,4]triazolo[1,5-a]pyrimidine core via structure-based and physicochemical property-driven approaches
by Huang, Boshi and Li, Cuicui and Chen, Wenmin and Liu, Tao and Yu, Mingyan and Fu, Lu and Sun, Yueyue and Liu, Huiqing and De Clercq, Erik and Pannecouque, Christophe and Balzarini, Jan and Zhan, Peng and Liu, Xinyong
European journal of medicinal chemistry, ISSN 0223-5234, 03/2015, Volume 92, pp. 754 - 765
Structure-based drug design | HIV-1 RT | Triazolopyrimidines | Biological activity | Physicochemical properties | Molecular simulations | Anti-HIV Agents - pharmacology | HIV Reverse Transcriptase - antagonists & inhibitors | Humans | Heterocyclic Compounds - pharmacology | Reverse Transcriptase Inhibitors - pharmacology | Heterocyclic Compounds - chemical synthesis | Structure-Activity Relationship | Sulfones - pharmacology | Anti-HIV Agents - chemical synthesis | Reverse Transcriptase Inhibitors - chemistry | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Reverse Transcriptase Inhibitors - chemical synthesis | Heterocyclic Compounds - chemistry | Sulfones - chemistry | Molecular Structure | Sulfones - chemical synthesis | HIV-1 - drug effects | Heterocyclic Compounds, 2-Ring - chemistry | Solubility | Models, Molecular | Heterocyclic Compounds, 2-Ring - pharmacology | HIV Reverse Transcriptase - metabolism | Anti-HIV Agents - chemistry | Nitrogen - chemistry | Cell Line, Tumor | Heterocyclic Compounds, 2-Ring - chemical synthesis | DNA polymerases | Antiviral agents | Pyrimidines | HIV (Viruses) | Analysis | Medical colleges | Index Medicus
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11. Full Text Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3R)‑4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3‑b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153)
by Bradbury, Robert H and Callis, Rowena and Carr, Gregory R and Chen, Huawei and Clark, Edwin and Feron, Lyman and Glossop, Steve and Graham, Mark A and Hattersley, Maureen and Jones, Chris and Lamont, Scott G and Ouvry, Gilles and Patel, Anil and Patel, Joe and Rabow, Alfred A and Roberts, Craig A and Stokes, Stephen and Stratton, Natalie and Walker, Graeme E and Ward, Lara and Whalley, David and Whittaker, David and Wrigley, Gail and Waring, Michael J
Journal of medicinal chemistry, ISSN 0022-2623, 09/2016, Volume 59, Issue 17, pp. 7801 - 7817
Neoplasm Transplantation | Stereoisomerism | Humans | Crystallography, X-Ray | Piperazines - chemistry | Structure-Activity Relationship | Hepatocytes - metabolism | Heterografts | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Piperazines - pharmacokinetics | Hepatocytes - drug effects | Caco-2 Cells | Heterocyclic Compounds, 2-Ring - chemistry | Rats | Transcription Factors - antagonists & inhibitors | Heterocyclic Compounds, 2-Ring - pharmacokinetics | Antineoplastic Agents - chemistry | Mice, SCID | Piperazines - pharmacology | Heterocyclic Compounds, 2-Ring - pharmacology | Animals | Nuclear Proteins - antagonists & inhibitors | Dogs | Protein Conformation | Index Medicus
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12. Full Text Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure
by Follmann, Markus and Ackerstaff, Jens and Redlich, Gorden and Wunder, Frank and Lang, Dieter and Kern, Armin and Fey, Peter and Griebenow, Nils and Kroh, Walter and Becker-Pelster, Eva-Maria and Kretschmer, Axel and Geiss, Volker and Li, Volkhart and Straub, Alexander and Mittendorf, Joachim and Jautelat, Rolf and Schirok, Hartmut and Schlemmer, Karl-Heinz and Lustig, Klemens and Gerisch, Michael and Knorr, Andreas and Tinel, Hanna and Mondritzki, Thomas and Trübel, Hubert and Sandner, Peter and Stasch, Johannes-Peter
Journal of medicinal chemistry, ISSN 0022-2623, 06/2017, Volume 60, Issue 12, pp. 5146 - 5161
Chemistry Techniques, Synthetic | Rats, Transgenic | Rats, Wistar | Soluble Guanylyl Cyclase - metabolism | Administration, Oral | Pyrimidines - administration & dosage | Humans | Heterocyclic Compounds, 2-Ring - administration & dosage | Heterocyclic Compounds, 2-Ring - chemistry | Male | NG-Nitroarginine Methyl Ester - adverse effects | Structure-Activity Relationship | Pyrimidines - pharmacology | Pyrimidines - chemistry | Heart Failure - drug therapy | Heterocyclic Compounds, 2-Ring - pharmacology | Administration, Intravenous | Animals | Soluble Guanylyl Cyclase - genetics | Dogs | Blood Pressure - drug effects | Hepatocytes - drug effects | Index Medicus
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13. Full Text Acylazetine as a Dienophile in Bioorthogonal Inverse Electron-Demand Diels–Alder Ligation
by Engelsma, Sander B and Willems, Lianne I and van Paaschen, Claudia E and van Kasteren, Sander I and van der Marel, Gijsbert A and Overkleeft, Herman S and Filippov, Dmitri V
Organic letters, ISSN 1523-7060, 05/2014, Volume 16, Issue 10, pp. 2744 - 2747
Molecular Structure | Heterocyclic Compounds, 1-Ring - chemistry | Azetidines - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis | Heterocyclic Compounds, 2-Ring - chemistry | Electrons | Index Medicus
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14. Full Text Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases
by Farmer, Luc J and Ledeboer, Mark W and Hoock, Thomas and Arnost, Michael J and Bethiel, Randy S and Bennani, Youssef L and Black, James J and Brummel, Christopher L and Chakilam, Ananthsrinivas and Dorsch, Warren A and Fan, Bin and Cochran, John E and Halas, Summer and Harrington, Edmund M and Hogan, James K and Howe, David and Huang, Hui and Jacobs, Dylan H and Laitinen, Leena M and Liao, Shengkai and Mahajan, Sudipta and Marone, Valerie and Martinez-Botella, Gabriel and McCarthy, Pamela and Messersmith, David and Namchuk, Mark and Oh, Luke and Penney, Marina S and Pierce, Albert C and Raybuck, Scott A and Rugg, Arthur and Salituro, Francesco G and Saxena, Kumkum and Shannon, Dean and Shlyakter, Dina and Swenson, Lora and Tian, Shi-Kai and Town, Christopher and Wang, Jian and Wang, Tiansheng and Wannamaker, M. Woods and Winquist, Raymond J and Zuccola, Harmon J
Journal of medicinal chemistry, ISSN 0022-2623, 09/2015, Volume 58, Issue 18, pp. 7195 - 7216
Stereoisomerism | Humans | Microsomes, Liver - metabolism | Rats, Inbred Lew | Male | Structure-Activity Relationship | Graft vs Host Disease - immunology | Janus Kinase 3 - antagonists & inhibitors | Valine - chemistry | Janus Kinase 2 - chemistry | Janus Kinase 3 - chemistry | Mice, Inbred CBA | Female | Autoimmune Diseases - drug therapy | Cell Line | Valine - pharmacokinetics | Valine - analogs & derivatives | Heterocyclic Compounds, 2-Ring - chemistry | Models, Molecular | Rats | Heterocyclic Compounds, 2-Ring - pharmacokinetics | Rats, Sprague-Dawley | Haplorhini | Heterocyclic Compounds, 2-Ring - pharmacology | Animals | Graft vs Host Disease - drug therapy | Databases, Chemical | Dogs | Mice | Mice, Inbred BALB C | Valine - pharmacology | Index Medicus
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15. Full Text Structure−Activity Relationship of New Anti-Hepatitis C Virus Agents: Heterobicycle−Coumarin Conjugates
by Neyts, Johan and Clercq, Erik De and Singha, Raghunath and Chang, Yung Hsiung and Das, Asish R and Chakraborty, Subhasish K and Hong, Shih Ching and Tsay, Shwu-Chen and Hsu, Ming-Hua and Hwu, Jih Ru
Journal of medicinal chemistry, ISSN 0022-2623, 03/2009, Volume 52, Issue 5, pp. 1486 - 1490
Antiviral agents | Biological and medical sciences | Medical sciences | Pharmacology. Drug treatments | Antibiotics. Antiinfectious agents. Antiparasitic agents | Benzoxazoles - pharmacology | Pyridines - chemistry | Humans | Imidazoles - chemistry | Hepacivirus - genetics | Coumarins - chemistry | Structure-Activity Relationship | Antiviral Agents - chemistry | Imidazoles - chemical synthesis | Hepacivirus - drug effects | Purines - chemical synthesis | Cell Line | Virus Replication - drug effects | Antiviral Agents - pharmacology | Purines - pharmacology | Heterocyclic Compounds, 2-Ring - chemistry | Pyridines - chemical synthesis | Models, Molecular | Imidazoles - pharmacology | Benzoxazoles - chemical synthesis | Heterocyclic Compounds, 2-Ring - pharmacology | Coumarins - pharmacology | Benzoxazoles - chemistry | Purines - chemistry | Coumarins - chemical synthesis | Antiviral Agents - chemical synthesis | Cell Proliferation - drug effects | Pyridines - pharmacology | RNA, Viral - drug effects | Heterocyclic Compounds, 2-Ring - chemical synthesis | Index Medicus
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16. Full Text Photodegradation of fluazaindolizine in water under simulated sunlight irradiation: Identification of transformation products and elucidation of transformation mechanism
by Lin, Hongfang and Pang, Kyongjin and Ma, Yecheng and Hu, Jiye
Chemosphere (Oxford), ISSN 0045-6535, 01/2019, Volume 214, pp. 543 - 552
Photodegradation | DFT | Kinetics | Transformation product | Fluazaindolizine | Environmental Sciences & Ecology | Life Sciences & Biomedicine | Science & Technology | Environmental Sciences | Heterocyclic Compounds, 2-Ring - analysis | Heterocyclic Compounds, 2-Ring - radiation effects | Sulfonamides - analysis | Ferric Compounds - chemistry | Water Pollutants, Chemical - analysis | Water Pollutants, Chemical - metabolism | Nitrates - chemistry | Photolysis | Heterocyclic Compounds, 2-Ring - metabolism | Humic Substances - analysis | Sulfonamides - metabolism | Water - chemistry | Sunlight | Water Pollutants, Chemical - radiation effects | Sulfonamides - radiation effects | Specific gravity | Density functionals | Nitrates | Mass spectrometry | Humic acid | High performance liquid chromatography | Index Medicus
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17. Full Text Modular synthesis of sulfonyl benzoheteroles by silver-catalyzed heteroaromatization of propargylic alcohols with p -toluenesulfonylmethyl isocyanide (TosMIC): Dual roles of TosMIC
by Liu, Jianquan and Liu, Zhenhua and Liao, Peiqiu and Bi, Xihe
Organic letters, ISSN 1523-7060, 12/2014, Volume 16, Issue 23, pp. 6204 - 6207
Propanols - chemistry | Benzene Derivatives - chemical synthesis | Sulfones - chemistry | Heterocyclic Compounds, 2-Ring - chemistry | Nitriles - chemistry | Silver - chemistry | Alkynes - chemistry | Molecular Structure | Catalysis | Benzene Derivatives - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis | Sulfones - chemical synthesis | Index Medicus
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18. Full Text [Ir(P−OP)]-Catalyzed Asymmetric Hydrogenation of Diversely Substituted CN-Containing Heterocycles
by Núñez-Rico, José Luis and Vidal-Ferran, Anton
Organic letters, ISSN 1523-7060, 04/2013, Volume 15, Issue 8, pp. 2066 - 2069
Stereoisomerism | Heterocyclic Compounds, 2-Ring - chemistry | Molecular Structure | Catalysis | Heterocyclic Compounds, 2-Ring - chemical synthesis | Hydrogenation | Iridium - chemistry | Index Medicus
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19. Full Text Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents
by Engers, Julie L and Rodriguez, Alice L and Konkol, Leah C and Morrison, Ryan D and Thompson, Analisa D and Byers, Frank W and Blobaum, Anna L and Chang, Sichen and Venable, Daryl F and Loch, Matthew T and Niswender, Colleen M and Daniels, J. Scott and Jones, Carrie K and Conn, P. Jeffrey and Lindsley, Craig W and Emmitte, Kyle A
Journal of medicinal chemistry, ISSN 0022-2623, 09/2015, Volume 58, Issue 18, pp. 7485 - 7500
Calcium - metabolism | Pyridines - chemistry | Stereoisomerism | Allosteric Regulation | Humans | Microsomes, Liver - metabolism | Pyridines - pharmacokinetics | Receptors, Metabotropic Glutamate - metabolism | Structure-Activity Relationship | Brain - metabolism | Anti-Anxiety Agents - pharmacokinetics | Antidepressive Agents - chemistry | Madin Darby Canine Kidney Cells | Anti-Anxiety Agents - chemistry | Antidepressive Agents - pharmacology | Heterocyclic Compounds, 2-Ring - chemistry | Anti-Anxiety Agents - pharmacology | Rats | Heterocyclic Compounds, 2-Ring - pharmacokinetics | Permeability | Heterocyclic Compounds, 2-Ring - pharmacology | Animals | Dogs | Mice | Pyridines - pharmacology | Antidepressive Agents - pharmacokinetics | Index Medicus
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20. An Update on JAK Inhibitors
by Musumeci, Francesca and Greco, Chiara and Giacchello, Ilaria and Fallacara, Anna Lucia and Ibrahim, Munjed M and Grossi, Giancarlo and Brullo, Chiara and Schenone, Silvia
Current medicinal chemistry, ISSN 0929-8673, 01/2019, Volume 26, Issue 10, pp. 1806 - 1832
Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Janus Kinase Inhibitors - pharmacology | Animals | Janus Kinase Inhibitors - therapeutic use | Heterocyclic Compounds, 2-Ring - therapeutic use | Humans | Heterocyclic Compounds, 2-Ring - chemistry | Cell Line, Tumor | Janus Kinase Inhibitors - chemistry | Molecular Structure | Structure-Activity Relationship | Heterocyclic Compounds, 2-Ring - pharmacology | Tyrosine | Medical research | Tyk2 protein | Clinical trials | Selectivity | Derivatives | Kinases | Biological activity | Neoplasms | Organic chemistry | Signal transduction | Inhibitors | Janus kinase 2 | Janus kinase | Mutation | Autoimmune diseases | Scaffolds
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