X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
heterocyclic compounds, 2-ring - chemistry (411) 411
index medicus (346) 346
heterocyclic compounds, 2-ring - chemical synthesis (265) 265
heterocyclic compounds, 2-ring - pharmacology (252) 252
molecular structure (218) 218
animals (207) 207
humans (198) 198
chemistry, organic (182) 182
chemistry, medicinal (171) 171
structure-activity relationship (125) 125
biochemistry & molecular biology (94) 94
stereoisomerism (94) 94
mice (91) 91
chemistry, multidisciplinary (78) 78
models, molecular (76) 76
pharmacology & pharmacy (73) 73
cell line, tumor (70) 70
catalysis (69) 69
derivatives (69) 69
cyclization (64) 64
analysis (63) 63
rats (63) 63
chemistry (62) 62
heterocyclic compounds (61) 61
crystallography, x-ray (56) 56
organic chemistry (56) 56
male (55) 55
antineoplastic agents - pharmacology (49) 49
dose-response relationship, drug (49) 49
heterocyclic compounds, 2-ring (49) 49
magnetic resonance spectroscopy (46) 46
female (44) 44
molecular conformation (44) 44
article (43) 43
chemical properties (43) 43
heterocyclic compounds, 2-ring - isolation & purification (43) 43
heterocyclic compounds, 2-ring - metabolism (42) 42
ligands (42) 42
research (42) 42
antineoplastic agents - chemistry (40) 40
inhibitors (40) 40
cell proliferation - drug effects (37) 37
heterocyclic compounds, 2-ring - pharmacokinetics (37) 37
cancer (36) 36
drug design (36) 36
potent (34) 34
heterocyclic compounds, 2-ring - administration & dosage (31) 31
metallurgy (31) 31
discovery (30) 30
apoptosis (29) 29
chemistry, applied (29) 29
furans - chemistry (29) 29
microbial sensitivity tests (29) 29
models, chemical (29) 29
protein binding (29) 29
antineoplastic agents - chemical synthesis (28) 28
binding sites (28) 28
enzyme inhibitors - pharmacology (28) 28
alkaloids (27) 27
cell line (27) 27
expression (27) 27
activation (26) 26
design (26) 26
heterocyclic compounds, 2-ring - therapeutic use (26) 26
plant sciences (26) 26
pyridines - chemistry (26) 26
drug screening assays, antitumor (25) 25
heterocyclic compounds, 2-ring - toxicity (25) 25
pyrazoles - chemistry (25) 25
proteins (23) 23
apoptosis - drug effects (22) 22
cell survival - drug effects (22) 22
human necessities (22) 22
hygiene (22) 22
identification (22) 22
kinetics (22) 22
medical or veterinary science (22) 22
preparations for medical, dental, or toilet purposes (22) 22
anti-bacterial agents - pharmacology (21) 21
aza compounds - chemistry (21) 21
inhibitory concentration 50 (21) 21
mass spectrometry (21) 21
oxidation-reduction (21) 21
structure (21) 21
amides - chemistry (20) 20
combinatorial chemistry techniques (20) 20
copper - chemistry (20) 20
enzyme inhibitors - chemistry (20) 20
oncology (20) 20
rats, sprague-dawley (20) 20
cells (19) 19
dogs (19) 19
drug discovery (19) 19
in-vitro (19) 19
protein kinase inhibitors - chemistry (19) 19
pyrazoles - pharmacology (19) 19
specific therapeutic activity of chemical compounds ormedicinal preparations (19) 19
alkynes - chemistry (18) 18
heterocycles (18) 18
protein kinase inhibitors - pharmacology (18) 18
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (677) 677
Chinese (8) 8
French (7) 7
German (4) 4
Russian (4) 4
Spanish (3) 3
Korean (1) 1
Ukrainian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2016, Volume 59, Issue 17, pp. 7991 - 8007
We designed and synthesized a series of human immunodeficiency virus type 1 (HIV-1), non-nucleoside reverse transcriptase,inhibitors (NNRTIs) with a... 
BEARING BRIDGEHEAD NITROGEN | CHEMISTRY, MEDICINAL | ENTRANCE CHANNEL | MUTANT VIRUSES | ENHANCED SOLUBILITY | PRELIMINARY SAR | COLORIMETRIC ASSAY | BIOLOGICAL EVALUATION | NNRTI BINDING POCKET | CRYSTAL-STRUCTURES | ETRAVIRINE TMC125 | Anti-HIV Agents - pharmacology | Pyrimidines - chemical synthesis | HIV Reverse Transcriptase - antagonists & inhibitors | Humans | Drug Resistance, Viral | Reverse Transcriptase Inhibitors - pharmacology | Male | Structure-Activity Relationship | Anti-HIV Agents - chemical synthesis | Pyrimidines - chemistry | Reverse Transcriptase Inhibitors - chemistry | Reverse Transcriptase Inhibitors - chemical synthesis | Reverse Transcriptase Inhibitors - pharmacokinetics | Sulfonamides - chemistry | Heterocyclic Compounds, 2-Ring - chemistry | Thiophenes - pharmacology | Heterocyclic Compounds, 2-Ring - pharmacokinetics | Pyrimidines - pharmacology | HIV-1 - genetics | Sulfonamides - pharmacology | Rats, Sprague-Dawley | Sulfonamides - pharmacokinetics | Heterocyclic Compounds, 2-Ring - pharmacology | Sulfonamides - chemical synthesis | Thiophenes - chemical synthesis | Thiophenes - pharmacokinetics | Anti-HIV Agents - chemistry | Animals | Anti-HIV Agents - pharmacokinetics | Cell Line, Tumor | Pyrimidines - pharmacokinetics | HIV-1 - enzymology | Mice | Molecular Docking Simulation | Mutation | Thiophenes - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2011, Volume 54, Issue 14, pp. 5013 - 5030
On the basis of structures of known topoisomerase H catalytic inhibitors and initial molecular docking studies, bicyclic N-fused aminoimidazoles were predicted... 
DNA TOPOISOMERASE | CELLS | MOLECULAR-DYNAMICS | ETOPOSIDE | DOMAIN | CHEMISTRY, MEDICINAL | MECHANISM | ICRF-187 | ATP-BINDING-SITE | CANCER | FLEXIBLE DOCKING | Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Imidazoles - chemistry | Cercopithecus aethiops | Structure-Activity Relationship | Topoisomerase II Inhibitors - chemistry | S Phase | HEK293 Cells | Antineoplastic Agents - pharmacology | Topoisomerase II Inhibitors - chemical synthesis | Imidazoles - chemical synthesis | Intercalating Agents - chemical synthesis | Binding Sites | Vero Cells | Cell Survival - drug effects | Antigens, Neoplasm | DNA-Binding Proteins - antagonists & inhibitors | Heterocyclic Compounds, 2-Ring - chemistry | Etoposide - pharmacology | Models, Molecular | Imidazoles - pharmacology | Intercalating Agents - pharmacology | Topoisomerase II Inhibitors - pharmacology | Antineoplastic Agents - chemistry | Intercalating Agents - chemistry | Molecular Dynamics Simulation | Heterocyclic Compounds, 2-Ring - pharmacology | Cell Movement - drug effects | G1 Phase | Animals | Cell Line, Tumor | Adenosine Triphosphatases - chemistry | DNA Topoisomerases, Type II | Fluorouracil - pharmacology | Adenosine Triphosphate - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis | Drug Screening Assays, Antitumor | Index Medicus
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 01/2008, Volume 130, Issue 2, pp. 416 - 417
Aromatic aminoaldehydes react with cyclic amines to produce ring-fused aminals under thermal conditions. This process applied to two-step syntheses of the... 
X=Y-ZH COMPOUNDS | CYCLOADDITION REACTIONS | IMINIUM ION ROUTE | MACKINAZOLINONE | AZOMETHINE YLIDES | RUTAECARPINE | POTENTIAL 1,3-DIPOLES | DEOXYVASICINONE | LUOTONIN-A | CHEMISTRY, MULTIDISCIPLINARY | ALKALOIDS | Amination | Nitrogen - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis | Heterocyclic Compounds, 2-Ring - chemistry
Journal Article
Organic Letters, ISSN 1523-7060, 08/2015, Volume 17, Issue 17, pp. 4176 - 4179
A method for the efficient preparation of hydronaphthalene and -cinnoline derivatives by Au(I)-catalyzed cycloisomerzation of 1,6-diyne esters followed by a... 
Gold - chemistry | Naphthalenes - chemistry | Combinatorial Chemistry Techniques | Imides - chemistry | Heterocyclic Compounds, 2-Ring - chemistry | Esters | Molecular Structure | Catalysis
Journal Article
ORGANIC LETTERS, ISSN 1523-7060, 08/2012, Volume 14, Issue 16, pp. 4254 - 4257
Journal Article
Organic Letters, ISSN 1523-7060, 05/2014, Volume 16, Issue 10, pp. 2744 - 2747
A new bioorthogonal N-acylazetine tag, suitable for tetrazine mediated inverse electron-demand Diels-Alder conjugation, is developed. The tag is small and... 
CELLS | POTENT | CYCLOADDITIONS | IN-VIVO | REACTIVITY | CHEMISTRY | CHEMISTRY, ORGANIC | PROTEASOME INHIBITOR | EPOXOMICIN | CYCLOPROPENES | PROBES | Molecular Structure | Heterocyclic Compounds, 1-Ring - chemistry | Azetidines - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis | Heterocyclic Compounds, 2-Ring - chemistry | Electrons
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2018, Volume 61, Issue 8, pp. 3325 - 3349
In the preceding manuscript [Moreau et al. 2018, 10.1021/acs.jmedchem.7b01691] we described a successful fragment-based lead discovery (FBLD) strategy for... 
PHOSPHINOXYDE ALS OLEFINIERUNGSREAGENZIEN | CROSS-COUPLING REACTIONS | CHEMISTRY, MEDICINAL | MULTIDRUG EFFLUX PUMPS | ESCHERICHIA-COLI | ARYL HALIDES | ANTIBIOTIC-RESISTANCE | OUTER-MEMBRANE PERMEABILITY | COENZYME-A | RESISTANCE GENE MCR-1 | MOLECULAR-MECHANISMS | Nucleotidyltransferases - chemistry | Triazoles - chemistry | Escherichia coli - drug effects | Pyrimidinones - metabolism | Benzimidazoles - chemistry | Enzyme Inhibitors - chemical synthesis | Pyrimidinones - chemistry | Microbial Sensitivity Tests | Anti-Bacterial Agents - chemistry | Enzyme Inhibitors - chemistry | Nucleotidyltransferases - antagonists & inhibitors | Pyrimidinones - pharmacology | Triazoles - chemical synthesis | Molecular Structure | Escherichia coli Proteins - antagonists & inhibitors | Nucleotidyltransferases - metabolism | Pyrimidinones - chemical synthesis | Binding Sites | Escherichia coli - enzymology | Enzyme Inhibitors - metabolism | Benzimidazoles - chemical synthesis | Enzyme Inhibitors - pharmacology | Heterocyclic Compounds, 2-Ring - chemistry | Anti-Bacterial Agents - metabolism | Escherichia coli Proteins - metabolism | Drug Discovery | Heterocyclic Compounds, 2-Ring - pharmacology | Anti-Bacterial Agents - chemical synthesis | Triazoles - pharmacology | Triazoles - metabolism | Benzimidazoles - metabolism | Heterocyclic Compounds, 2-Ring - metabolism | Escherichia coli Proteins - genetics | Nucleotidyltransferases - genetics | Protein Binding | Benzimidazoles - pharmacology | Anti-Bacterial Agents - pharmacology | Mutation | Escherichia coli Proteins - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2017, Volume 60, Issue 12, pp. 5146 - 5161
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2009, Volume 52, Issue 5, pp. 1486 - 1490
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2018, Volume 61, Issue 8, pp. 3309 - 3324
The discovery and development of new antibiotics capable of curing infections due to multidrug-resistant and pandrug-resistant Gram-negative bacteria are a... 
COENZYME-A BIOSYNTHESIS | MEDICINAL CHEMISTRY | CHEMISTRY, MEDICINAL | LEAD DISCOVERY | ESCHERICHIA-COLI | ANTIBIOTIC-RESISTANCE | OUTER-MEMBRANE PERMEABILITY | N-PENTYLPANTOTHENAMIDE | ANTIBACTERIAL DISCOVERY | BETA-LACTAMASES | RESISTANCE GENE MCR-1 | Nucleotidyltransferases - chemistry | Triazoles - chemistry | Escherichia coli - drug effects | Pyrimidinones - metabolism | Benzimidazoles - chemistry | Enzyme Inhibitors - chemical synthesis | Pyrimidinones - chemistry | Microbial Sensitivity Tests | Pseudomonas aeruginosa - enzymology | Anti-Bacterial Agents - chemistry | Enzyme Inhibitors - chemistry | Nucleotidyltransferases - antagonists & inhibitors | Pyrimidinones - pharmacology | Triazoles - chemical synthesis | Molecular Structure | Escherichia coli Proteins - antagonists & inhibitors | Nucleotidyltransferases - metabolism | Pyrimidinones - chemical synthesis | Binding Sites | Escherichia coli - enzymology | Enzyme Inhibitors - metabolism | Benzimidazoles - chemical synthesis | Enzyme Inhibitors - pharmacology | Heterocyclic Compounds, 2-Ring - chemistry | Anti-Bacterial Agents - metabolism | Escherichia coli Proteins - metabolism | Pseudomonas aeruginosa - drug effects | Drug Discovery | Heterocyclic Compounds, 2-Ring - pharmacology | Anti-Bacterial Agents - chemical synthesis | Triazoles - pharmacology | Triazoles - metabolism | Benzimidazoles - metabolism | Heterocyclic Compounds, 2-Ring - metabolism | Protein Binding | Benzimidazoles - pharmacology | Anti-Bacterial Agents - pharmacology | Escherichia coli Proteins - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis
Journal Article