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Nature, ISSN 0028-0836, 08/2016, Volume 536, Issue 7617, pp. 469 - 473
Journal Article
Journal Article
Science, ISSN 0036-8075, 10/2015, Volume 350, Issue 6257, pp. 203 - 207
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2010, Volume 107, Issue 13, pp. 6076 - 6081
Spirolide and gymnodimine macrocyclic imine phycotoxins belong to an emerging class of chemical agents associated with marine algal blooms and shelfish... 
Receptors | Imines | Shellfish | Ligands | Agonists | Toxins | Pharmacology | Nicotinic receptors | Nitrogen | Oocytes | Pharmacological and structural analyses | Seafood poisoning | Acetylcholine binding protein | Nicotinic acetylcholine receptor | Marine phycotoxins | PLANKTON | acetylcholine binding protein | seafood poisoning | DINOFLAGELLATE ALEXANDRIUM-OSTENFELDII | SHELLFISH TOXINS | SPIROLIDE-C | PROTEIN | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | marine phycotoxins | AGONISTS | ACETYLCHOLINE-RECEPTOR | GYMNODIMINE | pharmacological and structural analyses | nicotinic acetylcholine receptor | REVEALS | Heterocyclic Compounds, 3-Ring - metabolism | Heterocyclic Compounds, 3-Ring - pharmacology | Nicotinic Antagonists - metabolism | Humans | Aplysia - metabolism | Crystallography, X-Ray | Acetylcholine - metabolism | Nicotinic Antagonists - pharmacology | Hydrocarbons, Cyclic - pharmacology | Imines - chemistry | Oocytes - drug effects | Carrier Proteins - chemistry | Female | Molecular Structure | Spiro Compounds - chemistry | Receptors, Nicotinic - metabolism | Marine Toxins - metabolism | Oocytes - metabolism | Imines - metabolism | Models, Molecular | Electric Organ - metabolism | Marine Toxins - pharmacology | Imines - pharmacology | Macromolecular Substances | Animals | Carrier Proteins - metabolism | Xenopus - metabolism | Marine Toxins - chemistry | Nicotinic Antagonists - chemistry | Heterocyclic Compounds, 3-Ring - chemistry | Torpedo - metabolism | Kinetics | In Vitro Techniques | Hydrocarbons, Cyclic - chemistry | Spiro Compounds - pharmacology | Hydrocarbons, Cyclic - metabolism | Spiro Compounds - metabolism | Marine toxins | Crystals | Physiological aspects | Acetylcholine | Structure | Properties | Protein binding | Index Medicus | Life Sciences | Neurons and Cognition | Biological Sciences
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 06/2012, Volume 32, Issue 26, pp. 8767 - 8777
Alzheimer's disease (AD) is the major cause of dementia. During the development of AD, neurofibrillary tangles progress in a fixed pattern, starting in the... 
PRION PROTEIN | CELLS | TRANSPORT | ALZHEIMERS-DISEASE | MECHANISMS | PRECURSOR PROTEIN | NEUROSCIENCES | BRAIN | OLIGOMERS | PEPTIDE | PARKINSONS-DISEASE | Membrane Glycoproteins - metabolism | Coculture Techniques | Humans | Cell Communication - physiology | Male | Green Fluorescent Proteins - genetics | rab5 GTP-Binding Proteins - metabolism | Neurons - ultrastructure | Time Factors | Amyloid beta-Peptides - metabolism | Synaptic Transmission - drug effects | Neurons - metabolism | Animals, Newborn | Microinjections | Endocytosis - drug effects | Rats | Rats, Sprague-Dawley | Nerve Degeneration - pathology | Patch-Clamp Techniques | Cell Communication - drug effects | Lysosomal-Associated Membrane Protein 2 - metabolism | Heterocyclic Compounds, 3-Ring - metabolism | Synaptic Transmission - physiology | Peptide Fragments - toxicity | Exocytosis - physiology | Exocytosis - drug effects | Nerve Degeneration - chemically induced | Neuroglia - drug effects | Dose-Response Relationship, Drug | Tetrazolium Salts | Transfection | Thiazoles | Female | Neurons - drug effects | Neuroblastoma - pathology | Dendrites - metabolism | Green Fluorescent Proteins - metabolism | Microscopy, Electron, Transmission | Peptide Fragments - metabolism | Amyloid beta-Peptides - toxicity | Cells, Cultured | Hippocampus - cytology | Endocytosis - physiology | Nerve Tissue Proteins - metabolism | Animals | Cell Differentiation - drug effects | Heterocyclic Compounds, 3-Ring - administration & dosage | Neocortex - cytology | Neuroglia - metabolism | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2013, Volume 56, Issue 18, pp. 7458 - 7462
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 02/2013, Volume 41, Issue 2, pp. 353 - 361
Dolutegravir (DTG; S/GSK1349572) is a potent HIV-1 integrase inhibitor with a distinct resistance profile and a once-daily dose regimen that does not require... 
SERUM CREATININE LEVELS | IMMUNODEFICIENCY-VIRUS-INFECTION | HUMAN HEPATOCYTES | HEALTHY-SUBJECTS | CYTOCHROME-P450 ENZYMES | GLOMERULAR-FILTRATION | PHARMACOLOGY & PHARMACY | GASTROINTESTINAL PH | MULTIDRUG-RESISTANCE | BOOSTED PROTEASE INHIBITORS | P-GLYCOPROTEIN | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | HIV Integrase Inhibitors - pharmacology | Heterocyclic Compounds, 3-Ring - metabolism | Cricetulus | Cytochrome P-450 Enzyme Inhibitors | Heterocyclic Compounds, 3-Ring - pharmacology | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Cytochrome P-450 Enzyme System - metabolism | Membrane Transport Proteins - drug effects | Male | Neoplasm Proteins - antagonists & inhibitors | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Neoplasm Proteins - metabolism | Organic Anion Transporters - metabolism | Glucuronosyltransferase - genetics | Drug Interactions | Transfection | Membrane Transport Proteins - genetics | Microsomes, Liver - drug effects | Madin Darby Canine Kidney Cells | ATP-Binding Cassette Transporters - metabolism | Female | Membrane Transport Proteins - metabolism | Microsomes, Liver - enzymology | Hepatocytes - drug effects | CHO Cells | Cricetinae | Organic Anion Transporters - antagonists & inhibitors | Isoenzymes | Enzyme Induction | HIV Integrase Inhibitors - metabolism | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | Animals | Glucuronosyltransferase - metabolism | Dogs | Cytochrome P-450 Enzyme System - genetics | Glucuronosyltransferase - antagonists & inhibitors | ATP Binding Cassette Transporter, Sub-Family B | Multidrug Resistance-Associated Proteins - metabolism | ATP-Binding Cassette Transporters - antagonists & inhibitors | Hepatocytes - enzymology
Journal Article