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Cell, ISSN 0092-8674, 06/2018, Volume 174, Issue 1, pp. 231 - 244.e12
The acetyltransferases CBP and p300 are multifunctional transcriptional co-activators. Here, we combined quantitative proteomics with CBP/p300-specific... 
acetylation | CBP | p300 | bromodomain | enhancer | gene transcription | proteomics | acetylation kinetics | mass spectrometry | A-485 | NUCLEOSOMES | METABOLISM | P300 | ANNOTATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TARGETS | LYSINE ACETYLATION | PROTEIN ACETYLATION | INHIBITOR | HISTONE ACETYLATION | BROMODOMAIN | CELL BIOLOGY | Small Molecule Libraries - pharmacology | Acetyltransferases - metabolism | p300-CBP Transcription Factors - antagonists & inhibitors | Humans | Half-Life | Small Molecule Libraries - metabolism | Recombinant Proteins - biosynthesis | Heterocyclic Compounds, 4 or More Rings - pharmacology | Recombinant Proteins - isolation & purification | p300-CBP Transcription Factors - genetics | Mass Spectrometry | Isotope Labeling | Receptors, Aryl Hydrocarbon - metabolism | Acetyltransferases - antagonists & inhibitors | Cell Line | Signal Transduction | Heterocyclic Compounds, 4 or More Rings - chemistry | Receptors, Aryl Hydrocarbon - genetics | Recombinant Proteins - chemistry | Transcriptome - drug effects | Gene Knockout Techniques | Small Molecule Libraries - chemistry | p300-CBP Transcription Factors - metabolism | Acetylation - drug effects | Animals | Heterocyclic Compounds, 4 or More Rings - metabolism | Mice | Histones - metabolism | Kinetics | Peptides - analysis | Genetic transcription | RNA | Mass spectrometry | Analysis | Genes | Cells
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2018, Volume 61, Issue 2, pp. 535 - 542
Journal Article
Current medicinal chemistry, ISSN 0929-8673, 2018, Volume 25, Issue 34, pp. 4432 - 4456
SIRT1 is a nicotinamide adenosine dinucleotide (NAD(+))-dependent deacetylase, which removes acetyl groups from many target proteins, such as histone proteins,... 
NAD | cardioprotection | STACs | activators | SIRT1 | deacetylation | PROGENITOR CELLS | IMPROVES HEALTH | CHEMISTRY, MEDICINAL | MITOCHONDRIAL BIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCED PREMATURE SENESCENCE | ISCHEMIA-REPERFUSION INJURY | SIRT1 ACTIVATOR | INDUCED OXIDATIVE STRESS | PHARMACOLOGY & PHARMACY | VASCULAR ENDOTHELIAL DYSFUNCTION | HYDROGEN-PEROXIDE | SMALL-MOLECULE ACTIVATORS | Sirtuin 1 - metabolism | Cardiotonic Agents - metabolism | Cardiovascular Diseases - drug therapy | Humans | Resveratrol - metabolism | Ginsenosides - metabolism | Resveratrol - therapeutic use | Benzimidazoles - chemistry | Cardiovascular Diseases - pathology | Ginsenosides - therapeutic use | Lignans - therapeutic use | Cardiotonic Agents - therapeutic use | Resveratrol - chemistry | Heterocyclic Compounds, 4 or More Rings - therapeutic use | Sirtuin 1 - chemistry | Polycyclic Compounds - metabolism | Benzimidazoles - therapeutic use | Polycyclic Compounds - chemistry | Lignans - chemistry | Heterocyclic Compounds, 4 or More Rings - chemistry | Cyclooctanes - metabolism | Cardiotonic Agents - chemistry | Lignans - metabolism | Cyclooctanes - therapeutic use | Benzimidazoles - metabolism | Heterocyclic Compounds, 4 or More Rings - metabolism | Cyclooctanes - chemistry | Polycyclic Compounds - therapeutic use | Ginsenosides - chemistry | NADPH | Cardiovascular system | Adenosine | Transcription factors | Nutrient deficiency | Therapeutic applications | Metabolism | SIRT1 protein | Cofactors | Biological activity | Proteins | Life span | Deacetylation | Nicotinamide | Cardiovascular diseases | Heart diseases
Journal Article
Nature, ISSN 0028-0836, 11/2010, Volume 468, Issue 7322, pp. 461 - 467
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 09/2017, Volume 106, Issue 9, pp. 2632 - 2641
Regorafenib is a multikinase inhibitor orally administered to colorectal cancer patients, and is known to often exhibit dermal toxicity. The purpose of this... 
P-glycoprotein | skin | tissue partition | ABC transporters | transporters | BCRP | MULTICENTER | CHEMISTRY, MEDICINAL | TRANSDERMAL ABSORPTION | CHEMISTRY, MULTIDISCIPLINARY | IN-VITRO | POLYMORPHISMS | COLORECTAL-CANCER | PHASE-3 TRIAL | PHARMACOLOGY & PHARMACY | FOOT SKIN REACTION | EXPRESSION | BRAIN | Diketopiperazines - chemistry | Pyridines - chemistry | Skin - metabolism | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Male | Phenylurea Compounds - toxicity | Heterocyclic Compounds, 4 or More Rings - pharmacology | Breast Neoplasms - metabolism | Antineoplastic Agents - metabolism | Tissue Distribution | Protein Kinase Inhibitors - chemistry | Biological Transport | Tetrahydroisoquinolines - chemistry | Phenylurea Compounds - chemistry | Antineoplastic Agents - pharmacology | Phenylurea Compounds - metabolism | Acridines - chemistry | Tetrahydroisoquinolines - pharmacology | Acridines - metabolism | Heterocyclic Compounds, 4 or More Rings - chemistry | Diketopiperazines - pharmacology | Antineoplastic Agents - chemistry | Breast Neoplasms - drug therapy | Animals | Pyridines - metabolism | Pyridines - toxicity | Tetrahydroisoquinolines - metabolism | Acridines - pharmacology | Heterocyclic Compounds, 4 or More Rings - metabolism | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Diketopiperazines - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | Index Medicus
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 09/2009, Volume 20, Issue 17, pp. 3930 - 3940
Journal Article
Journal Article
Angewandte Chemie - International Edition, ISSN 1433-7851, 07/2012, Volume 51, Issue 31, pp. 7786 - 7789
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2017, Volume 25, Issue 22, pp. 6137 - 6148
A D-ring contracted analogue of the strongly cytotoxic marine pyrrole alkaloid lamellarin D was synthesized and investigated for its antiproliferative action... 
Antitumor activity | Transition metal catalysis | Alkaloid synthesis | Natural product mimetics | Molecular docking | CHEMISTRY, MEDICINAL | TRANSPORTER