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JAIDS Journal of Acquired Immune Deficiency Syndromes, ISSN 1525-4135, 02/2017, Volume 75, Issue 1, pp. 61 - 66
Journal Article
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 12/2014, Volume 111, Issue 50, pp. E5455 - E5462
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2017, Volume 60, Issue 1, pp. 290 - 306
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2009, Volume 52, Issue 14, pp. 4288 - 4305
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2014, Volume 57, Issue 21, pp. 9078 - 9095
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2012, Volume 55, Issue 2, pp. 661 - 669
A family of huprine-tacrine heterodimers has been developed to simultaneously block the active and peripheral sites of acetylcholinesterase (AChE). Their dual... 
PERIPHERAL SITE | CHEMISTRY, MEDICINAL | ACTIVE-SITE GORGE | INHIBITORY-ACTIVITY | MOUSE MODEL | BETA-PEPTIDE | HIGHLY POTENT | TORPEDO-CALIFORNICA ACETYLCHOLINESTERASE | AGGREGATION | APOLIPOPROTEIN-E | TRANSGENIC MICE | Cholinesterase Inhibitors - pharmacokinetics | Aminoquinolines - chemical synthesis | Stereoisomerism | Humans | Cholinesterase Inhibitors - chemical synthesis | Heterocyclic Compounds, 4 or More Rings - chemical synthesis | Structure-Activity Relationship | Heterocyclic Compounds, 4 or More Rings - pharmacology | Brain - metabolism | Tacrine - pharmacology | Butyrylcholinesterase - chemistry | Tacrine - pharmacokinetics | Tacrine - analogs & derivatives | Aminoquinolines - pharmacology | Prion Diseases - drug therapy | Alzheimer Disease - drug therapy | Membranes, Artificial | Models, Molecular | Recombinant Proteins - chemistry | Acetylcholinesterase - chemistry | Permeability | Prions - chemistry | Prions - antagonists & inhibitors | Tacrine - chemical synthesis | Amyloid beta-Peptides - antagonists & inhibitors | Peptide Fragments - chemistry | Animals | Cholinesterase Inhibitors - pharmacology | Heterocyclic Compounds, 4 or More Rings - pharmacokinetics | Peptide Fragments - antagonists & inhibitors | Mice | Aminoquinolines - pharmacokinetics | Amyloid beta-Peptides - chemistry | Acetylcholinesterase - metabolism
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 12/2014, Volume 74, Issue 6, pp. 1125 - 1137
The aim of the study was to demonstrate the activity of etirinotecan pegol, a polymer conjugate of irinotecan, in multiple human tumor models and to establish... 
Medicine & Public Health | SN38 | Anticancer activity | Etirinotecan pegol | Oncology | Cancer Research | Pharmacology/Toxicology | Pharmacokinetics | Topoisomerase 1 inhibition | XENOGRAFT MODELS | IRINOTECAN CPT-11 | SOLID TUMORS | MULTICENTER PHASE-II | ANTICANCER AGENTS | OVARIAN-CANCER | METASTATIC COLORECTAL-CANCER | CELL LUNG-CANCER | BREAST-CANCER | 2 SCHEDULES | ONCOLOGY | PHARMACOLOGY & PHARMACY | Species Specificity | Humans | Male | Antineoplastic Agents - administration & dosage | Heterocyclic Compounds, 4 or More Rings - pharmacology | Neoplasms, Experimental - pathology | Topoisomerase I Inhibitors - pharmacology | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Camptothecin - analogs & derivatives | Polyethylene Glycols - pharmacology | Heterocyclic Compounds, 4 or More Rings - administration & dosage | Topoisomerase I Inhibitors - pharmacokinetics | Topoisomerase I Inhibitors - administration & dosage | Polyethylene Glycols - pharmacokinetics | Rats | Treatment Outcome | Mice, SCID | Rats, Sprague-Dawley | Polyethylene Glycols - administration & dosage | Xenograft Model Antitumor Assays | Animals | Heterocyclic Compounds, 4 or More Rings - pharmacokinetics | Mice, Nude | Dogs | Mice | Camptothecin - pharmacology | Neoplasms, Experimental - drug therapy | Plasma physics | Polymers | Analysis | Lung cancer | Cancer | Original
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 01/2013, Volume 19, Issue 1, pp. 268 - 278
Journal Article
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2013, Volume 14, Issue 12, pp. 1216 - 1225
Journal Article
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 05/2018, Volume 81, Issue 5, pp. 897 - 909
Etirinotecan pegol (EP), a long-acting topoisomerase-1 inhibitor, is a polyethylene glycol conjugate of irinotecan, with an intended indication for treatment... 
Etirinotecan pegol | Irinotecan | Population pharmacokinetics | Breast cancer | SN38 | PARA-AMINOSALICYLIC ACID | CPT-11 | TUBERCULOSIS | DOSE-DEPENDENT ASSOCIATION | POLYMORPHISM | CLINICAL PHARMACOKINETICS | RESISTANT | ONCOLOGY | TOLERABILITY | IRINOTECAN-INDUCED NEUTROPENIA | PHARMACOLOGY & PHARMACY | UGT1A1-ASTERISK-28 GENOTYPE | Humans | Middle Aged | Male | Antineoplastic Agents - administration & dosage | Antineoplastic Agents - metabolism | Glucuronosyltransferase - genetics | Aged, 80 and over | Adult | Female | Antineoplastic Agents - pharmacokinetics | Camptothecin - analogs & derivatives | Camptothecin - pharmacokinetics | Heterocyclic Compounds, 4 or More Rings - administration & dosage | Polyethylene Glycols - metabolism | Camptothecin - metabolism | Polyethylene Glycols - pharmacokinetics | Clinical Trials as Topic | Irinotecan - metabolism | Irinotecan - pharmacokinetics | Polyethylene Glycols - administration & dosage | Neoplasms - drug therapy | Glucuronosyltransferase - metabolism | Heterocyclic Compounds, 4 or More Rings - pharmacokinetics | Models, Biological | Heterocyclic Compounds, 4 or More Rings - metabolism | Aged | Medical research | Cancer patients | Care and treatment | Metabolites | Polyethylene glycol | Analysis | Physiological aspects | Medicine, Experimental | Metastasis | Polyols | Brain | Demography | Metastases | Demographics | Genotypes | Polyethylene | Parameters | Computer simulation | Data processing | Pharmacology | Metabolism | Population statistics | Patients | Glomerular filtration rate | Adenomatous polyposis coli | Approximation method | Solid tumors | Pharmacokinetics | Surface area | Cancer | Tumors | Original
Journal Article
Drugs, ISSN 0012-6667, 4/2018, Volume 78, Issue 5, pp. 601 - 606
Journal Article