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Molecular Pharmacology, ISSN 0026-895X, 10/2014, Volume 86, Issue 4, pp. 417 - 429
The dopamine D-1 receptor-D-3 receptor (D1R-D3R) heteromer is being considered as a potential therapeutic target for neuropsychiatric disorders. Previous... 
FORMS | INTERFACE | ADENYLYL-CYCLASE | RELEVANCE | TARGETS | D-1 | PHARMACOLOGY & PHARMACY | BRAIN | HETEROMERIZATION
Journal Article
Progress in Retinal and Eye Research, ISSN 1350-9462, 09/2019, p. 100798
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 10/2010, Volume 107, Issue 43, pp. 18676 - 18681
It is well known that cocaine blocks the dopamine transporter. This mechanism should lead to a general increase in dopaminergic neurotransmission, and yet... 
SYSTEM | TRANSPORTER | MULTIDISCIPLINARY SCIENCES | receptor heteromer | drug addiction | MICE | PROTEINS | REWARD | ADDICTION | HETEROMERIZATION
Journal Article
European Neuropsychopharmacology, ISSN 0924-977X, 09/2015, Volume 25, Issue 9, pp. 1470 - 1479
The brain's complexity derives not only from the way the intricate network of neurons is wired, but also by protein complexes that recognize and decode... 
Antiparkinson | Heteromerization | Antipsychotic | G-protein | Aripiprazole | PHNO
Journal Article
Journal Article
NATURE CHEMICAL BIOLOGY, ISSN 1552-4450, 04/2015, Volume 11, Issue 4, pp. 271 - U56
Hypersecretion of norepinephrine (NE) and angiotensin II (AngII) is a hallmark of major prevalent cardiovascular diseases that contribute to cardiac... 
COUPLED-RECEPTOR DIMERS | ACTIVATION | NORADRENALINE RELEASE | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | SYMPATHETIC-NERVE ACTIVITY | GPCR | ANGIOTENSIN-II | REVEALS | HETEROMERIZATION
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 06/2015, Volume 96, Issue 2, pp. 131 - 142
Identification of G protein-coupled receptors and their specific function in a given neuron becomes essential to better understand the variety of signal... 
BRET | Basal ganglia | Calcium release | cAMP | GPCR heteromerization | CELLS | ACTIVATION | D-1 | AT | RELEVANCE | PHARMACOLOGY & PHARMACY | PROTEINS | EXPRESSION | BRAIN | PROGRESSION
Journal Article
BMB Reports, ISSN 1976-6696, 2015, Volume 48, Issue 1, p. 1
Transient Receptor Potential, Melastatin-related, member 4(TRPM4) channels are Ca2+-activated Ca2+-impermeable cationchannels. These channels are expressed in... 
Phosphorylation | Heteromerization | Trafficking | Glycosylation | SUMOylation | 14-3-3γ | TRPM4
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 12/2018, Volume 158, pp. 232 - 242
The type 1 angiotensin II (AngII) receptor (AT R) transactivates the epidermal growth factor receptor (EGFR), which leads to pathological remodeling of heart,... 
G protein-coupled receptor | Receptor heteromerization | Angiotensin II | EGFR transactivation | Epidermal growth factor receptor | Bioluminescence resonance energy transfer
Journal Article
by Cai, X and Bai, B and Zhang, RM and Wang, CM and Chen, J
SCIENTIFIC REPORTS, ISSN 2045-2322, 01/2017, Volume 7
The apelin receptor (APJ) belongs to family A of the G protein-coupled receptors (GPCRs) and is a potential pharmacotherapeutic target for heart failure,... 
PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | REFLECTION FLUORESCENCE MICROSCOPY | CARDIAC-HYPERTROPHY | TRANSDUCTION | HETERODIMERIZATION | IDENTIFICATION | DIMERS | HETEROTETRAMER | LIVING CELLS | HETEROMERIZATION
Journal Article
FASEB JOURNAL, ISSN 0892-6638, 04/2019, Volume 33, Issue 4, pp. 5389 - 5398
With an increasing body of evidence regarding GPCR oligomerization and its clinical implications over the last decade, the modulation and dynamics of GPCR... 
ACTIVATION | secretin receptor | BIOCHEMISTRY & MOLECULAR BIOLOGY | vasopressin | DIMERIZATION | HETERODIMERIZATION | IDENTIFICATION | ANGIOTENSIN | CELL BIOLOGY | ELEMENT | SIGNALING PATHWAY | GPCR heteromerization | BIOLOGY | GENE-EXPRESSION | transmembrane peptides | SECRETIN
Journal Article
JOURNAL OF NEUROCHEMISTRY, ISSN 0022-3042, 05/2016, Volume 137, Issue 4, pp. 549 - 560
The serotonin 5-HT1A receptor (5-HT1AR) and dopamine D-2 receptor (D2R) have been implicated as important sites of action in antipsychotics. Several lines of... 
ADENOSINE A(2A) | HETERO-DIMERIZATION | ACTIVATION | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | HETERODIMERIZATION | MECHANISMS | heteromerization | schizophrenia | MICROSCOPY | NEUROSCIENCES | GPCRs | RELEVANCE | cell signaling | antipsychotics | OLIGOMERIZATION
Journal Article
MOLECULAR NEUROBIOLOGY, ISSN 0893-7648, 06/2018, Volume 55, Issue 6, pp. 4952 - 4958
Dopamine D-2 receptor (D2R) activation triggers both G protein- and beta-arrestin-dependent signaling. Biased D2R ligands activating beta-arrestin pathway have... 
BRET | RECRUITMENT | ACTIVATION | Oligomerization | ANTAGONIST | Functional selectivity, biased ligand, dopamine D-2 receptor | beta-arrestin | SCHIZOPHRENIA | NEUROSCIENCES | HETEROMERIZATION | BETA-ARRESTIN2 | D2 RECEPTOR | AdenosineA2A receptor | PHARMACOLOGY | FUNCTIONAL SELECTIVITY | MODULATION
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2016, Volume 113, Issue 15, pp. 4200 - 4205
Journal Article
HYPERTENSION, ISSN 0194-911X, 10/2016, Volume 68, Issue 4, pp. 1039 - 1048
Bradykinin B-2 receptor (B2R) and angiotensin-(1-7) Mas receptor (MasR)-mediated effects are physiologically interconnected. The molecular basis for such cross... 
B-2 receptor | SYSTEM | ANTAGONIST | ACE | SPONTANEOUSLY HYPERTENSIVE-RATS | DOWN-REGULATION | HETERODIMERIZATION | heteromerization | Mas receptor | INTERNALIZATION | POTENTIATION | NITRIC-OXIDE | PERIPHERAL VASCULAR DISEASE | OLIGOMERIZATION
Journal Article
JOURNAL OF MOLECULAR BIOLOGY, ISSN 0022-2836, 03/2011, Volume 406, Issue 5, pp. 687 - 699
Given that coactivation of adenosine A(2A) (A(2A)R) and dopamine D-2 (D2R) receptors results in the coaggregation, cointernalization, and codesensitization of... 
receptor-protein interaction | ADENOSINE A(2A) | BASAL GANGLIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | internalization | heteromerization | DOPAMINE-D-2 RECEPTORS | BINDING | G-protein-coupled receptors | allosteric modulation
Journal Article
NEUROPSYCHOPHARMACOLOGY, ISSN 0893-133X, 11/2007, Volume 32, Issue 11, pp. 2249 - 2259
The mechanism of action responsible for the motor depressant effects of cannabinoids, which operate through centrally expressed cannabinoid CB1 receptors, is... 
RAT STRIATUM | PSYCHIATRY | BASAL GANGLIA | ULTRASTRUCTURAL-LOCALIZATION | INVOLVEMENT | NEUROSCIENCES | motor activity | cannabinoid CB1 receptor | striatum | PHARMACOLOGY | NEURONS | cyclic AMP | PHARMACOLOGY & PHARMACY | adenosine A(2A) receptor | receptor heteromerization | DOPAMINE-D-2 RECEPTORS | OLIGOMERIZATION | ANTAGONISTS | DERIVATIVES
Journal Article
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