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International Journal of Cancer, ISSN 0020-7136, 11/2017, Volume 141, Issue 10, pp. 2131 - 2142
The Warburg effect is a predominant metabolic pathway in cancer cells characterized by enhanced glucose uptake and its conversion to l ‐lactate and is... 
pancreatic cancer | lactate | PKM2 | metabolomics | metabolic reprogramming | Warburg effect | l-lactate | STEREOISOMERS | ACTIVATION | FENOTEROL | PROLIFERATION | DISCOVERY | INHIBITION | ONCOLOGY | GLUCOSE-METABOLISM | PROMOTES | EXPRESSION | Metabolomics | Fenoterol - pharmacology | Pancreatic Neoplasms - metabolism | Signal Transduction | Apoptosis - drug effects | Humans | Pancreatic Neoplasms - pathology | Fenoterol - analogs & derivatives | Glycolysis - drug effects | Gene Expression Regulation - drug effects | Pancreatic Neoplasms - drug therapy | Receptors, Cannabinoid - metabolism | Xenograft Model Antitumor Assays | Cell Movement - drug effects | Animals | Mice, Nude | Female | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Tumor Cells, Cultured | Receptors, Cannabinoid - chemistry | Prevention | Lactates | Glucose metabolism | Metabolites | Analysis | Pancreatic cancer | Physiological aspects | Fatty acids | Cancer | Carnitine | Cell proliferation | Energy metabolism | Nuclear magnetic resonance--NMR | Amino acids | AKT protein | Pyruvic acid | Glucose | Kinases | Accumulation | Signal transduction | Hypoxia-inducible factor 1a | Energy | Xenografts | P-Glycoprotein | Catenin | Cell survival | Pyruvate kinase | Epidermal growth factor receptors | Glycoprotein | Extracellular signal-regulated kinase | Data processing | Metabolism | Hexokinase | 1-Phosphatidylinositol 3-kinase | Inhibitors | Glycolysis | Lactic acid | Intracellular | Transporter | Tumors | Index Medicus | L-lactate
Journal Article
BMC Research Notes, ISSN 1756-0500, 03/2012, Volume 5, Issue 1, pp. 146 - 146
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 04/2013, Volume 433, Issue 4, pp. 508 - 512
Journal Article
FEMS Yeast Research, ISSN 1567-1356, 05/2010, Volume 10, Issue 3, pp. 282 - 289
Abstract During stress, many organisms accumulate compatible solutes. These solutes must be eliminated upon return to optimal conditions as they inhibit cell... 
Glycolysis enzyme-association | Yeast | Trehalose | Compatible-solute | Stress | THERMAL-STABILITY | stress | compatible-solute | OSMOTIC-STRESS | MICROBIOLOGY | trehalose | MUSCLE ALDOLASE | KINETIC EVIDENCE | SACCHAROMYCES-CEREVISIAE | yeast | HUMAN ERYTHROCYTE-MEMBRANE | D-GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | glycolysis enzyme-association | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE | 3-PHOSPHOGLYCERATE KINASE | MYCOLOGY | KLUYVEROMYCES-LACTIS | L-Lactate Dehydrogenase - metabolism | Enzyme Inhibitors | Fructose-Bisphosphate Aldolase - antagonists & inhibitors | Hexokinase - antagonists & inhibitors | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | Saccharomyces cerevisiae - metabolism | Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) - metabolism | Trehalose - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Glucosephosphate Dehydrogenase - antagonists & inhibitors | Glucosephosphate Dehydrogenase - metabolism | Glycolysis | Phosphoglycerate Kinase - antagonists & inhibitors | Fructose-Bisphosphate Aldolase - metabolism | Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) - antagonists & inhibitors | Hexokinase - metabolism | L-Lactate Dehydrogenase - antagonists & inhibitors | Saccharomyces cerevisiae - growth & development | Phosphoglycerate Kinase - metabolism | Trehalose - pharmacology | Phosphates | Enzymes | Glucose metabolism | Physiological aspects | Glucose | Sugars | Dextrose | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2009, Volume 417, Issue 3, pp. 717 - 726
Journal Article
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2011, Volume 163, Issue 3, pp. 624 - 637
BACKGROUND AND PURPOSE Although opioids have been reported to affect glucose homeostasis, relatively little is known on the role of δ‐opioid receptors. We have... 
glucose uptake | receptor tyrosine kinases | protein kinase Cζ | phosphatidylinositol 3‐kinase | Src tyrosine kinases | Akt | δ‐Opioid receptor | Chinese hamster ovary cells | δ-Opioid receptor | protein kinase CÎ | phosphatidylinositol 3-kinase | 3T3-L1 ADIPOCYTES | OXIDATIVE-PHOSPHORYLATION | protein kinase C zeta | TYROSINE KINASE | PROTEIN-COUPLED RECEPTORS | CYCLIC-AMP | HAMSTER OVARY CELLS | delta-Opioid receptor | HEXOKINASE-ACTIVITY | PHARMACOLOGY & PHARMACY | KINASE-C-ZETA | TRANSPORTER ISOFORMS | Deoxyglucose - metabolism | Cricetulus | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Male | Transfection | Biological Transport | Cyclic AMP - analogs & derivatives | Receptors, Opioid, delta - genetics | Glucose Transporter Type 1 - physiology | Cell Membrane - metabolism | src-Family Kinases - physiology | CHO Cells | Pertussis Toxin - pharmacology | Cricetinae | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | src-Family Kinases - antagonists & inhibitors | Rats | Protein Kinase C - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - physiology | Rats, Sprague-Dawley | Cyclic AMP - pharmacology | Animals | Receptor, IGF Type 1 - physiology | Glucose - metabolism | Phosphatidylinositol 3-Kinases - physiology | Kinetics | Receptors, Opioid, delta - agonists | Glucose Transporter Type 1 - antagonists & inhibitors | Receptors, Opioid, delta - physiology | Index Medicus | Research Papers
Journal Article
Journal Article
Cell Biochemistry and Function, ISSN 0263-6484, 07/2013, Volume 31, Issue 5, pp. 374 - 379
The flavanone hesperetin is known to decrease basal glucose uptake, although the inhibitory mechanism is largely unknown. Here, we used MDA‐MB‐231 breast... 
GLUT1 | breast cancer cells | glucose uptake | GLUT4 | hesperetin | Glucose uptake | Hesperetin | Breast cancer cells | TRANSPORTER | INSULIN STIMULATION | PHOSPHATIDYLINOSITOL 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ORANGE JUICE | PLASMA-MEMBRANE | CELL BIOLOGY | HEXOKINASE-II | FAT-CELLS | INTRACELLULAR DELIVERY | GLUT1 EXPRESSION | CARCINOMA | Phosphorylation | Glucose Transporter Type 4 - metabolism | Humans | Glucose Transporter Type 1 - metabolism | Antigens, CD - genetics | Proto-Oncogene Proteins c-akt - genetics | Antigens, CD - metabolism | Receptor, Insulin - genetics | Female | Biological Transport - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Flavones - pharmacology | Glucose Transporter Type 4 - antagonists & inhibitors | Glucose Transporter Type 4 - genetics | Signal Transduction | Receptor, Insulin - antagonists & inhibitors | Glucose Transporter Type 1 - genetics | Cell Line, Tumor | Glucose - metabolism | Hesperidin - pharmacology | Receptor, Insulin - metabolism | Cell Proliferation - drug effects | Antineoplastic Agents, Phytogenic - pharmacology | Glucose Transporter Type 1 - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Glucose metabolism | Breast cancer | Glucose | Dextrose | Cancer cells | Index Medicus
Journal Article
Science, ISSN 0036-8075, 03/2017, Volume 355, Issue 6332, pp. 1416 - 1420
The parasitic protists of the Trypanosoma genus infect humans and domestic mammals, causing severe mortality and huge economic losses. The most threatening... 
RECEPTORS PEX5 | GLYCOLYSIS | MAINTENANCE | CRUZI | PEROXISOMES | HEXOKINASE | MULTIDISCIPLINARY SCIENCES | CHAGAS-DISEASE | BRUCEI | DRUG-RESISTANCE | COMPARTMENTATION | Small Molecule Libraries - pharmacology | Trypanosomiasis, African - drug therapy | Protozoan Proteins - antagonists & inhibitors | Humans | Microbodies - metabolism | Trypanocidal Agents - chemistry | Protein Transport - drug effects | Peroxisomes - drug effects | Receptors, Cytoplasmic and Nuclear - chemistry | Drug Design | Nuclear Magnetic Resonance, Biomolecular | Protein Domains | Protozoan Proteins - chemistry | Trypanocidal Agents - therapeutic use | Small Molecule Libraries - therapeutic use | Microbodies - drug effects | Trypanosoma brucei brucei - drug effects | Peroxisomes - metabolism | Small Molecule Libraries - chemistry | Animals | Membrane Proteins - antagonists & inhibitors | Membrane Proteins - chemistry | Trypanocidal Agents - pharmacology | Peroxisome-Targeting Signal 1 Receptor | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Chagas Disease - drug therapy | Receptors, Cytoplasmic and Nuclear - metabolism | Collapse | Vector-borne diseases | Enzymes | High resolution | Nuclear magnetic resonance--NMR | Pex5 protein | Homology | Parasites | Imports | Metabolism | Mimicry | Proteins | Inhibitors | Parasitic diseases | Glycolysis | Glycosomes | Chagas' disease | Economic impact | Protein transport | Protein interaction | African trypanosomiasis | Cytoplasm | Trypanosome | Index Medicus | Therapy | Mice
Journal Article
Nature Communications, ISSN 2041-1723, 2015, Volume 6, Issue 1, pp. 6053 - 6053
Manganese superoxide dismutase (MnSOD/SOD2) is a mitochondria-resident enzyme that governs the types of reactive oxygen species egressing from the organelle to... 
HYPOXIA-INDUCIBLE FACTOR | LIFE-SPAN | OXIDATIVE STRESS | ACTIVATED PROTEIN-KINASE | EPITHELIAL-CELLS | MANGANESE SUPEROXIDE-DISMUTASE | MULTIDISCIPLINARY SCIENCES | INHIBIT APOPTOSIS | C-MYC | CELL-CYCLE PROGRESSION | BREAST | Mitochondria - enzymology | RNA, Small Interfering - genetics | AMP-Activated Protein Kinases - metabolism | Colonic Neoplasms - genetics | Superoxide Dismutase - genetics | Reactive Oxygen Species - metabolism | Humans | Transcriptional Activation | Gene Expression Regulation, Neoplastic | Phosphofructokinase-1 - genetics | Superoxide Dismutase - antagonists & inhibitors | Male | Glycolysis - genetics | Breast Neoplasms - enzymology | Prostatic Neoplasms - genetics | Mitochondria - genetics | Female | Hexokinase - genetics | Superoxide Dismutase - metabolism | Prostatic Neoplasms - pathology | Oxidation-Reduction | Pyruvate Kinase - metabolism | Signal Transduction | AMP-Activated Protein Kinases - antagonists & inhibitors | Hydrogen Peroxide - metabolism | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Colonic Neoplasms - pathology | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Colonic Neoplasms - enzymology | Hexokinase - metabolism | Neoplasm Staging | Phosphofructokinase-1 - metabolism | Pyruvate Kinase - genetics | AMP-Activated Protein Kinases - genetics | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 446 - 14
Hepatocellular carcinoma (HCC) cells are metabolically distinct from normal hepatocytes by expressing the high-affinity hexokinase (HK2) and suppressing... 
C-13-METABOLIC FLUX ANALYSIS | METABOLISM | MULTIDISCIPLINARY SCIENCES | GROWTH | PARALLEL LABELING EXPERIMENTS | MASS ISOTOPOMER DISTRIBUTIONS | REDD1 | EXPRESSION | CANCER-THERAPY | MTOR | DELETION | Niacinamide - analogs & derivatives | Metformin - therapeutic use | Humans | Male | Antineoplastic Agents - therapeutic use | Metabolic Flux Analysis | Molecular Targeted Therapy | Carcinogenesis | Carcinoma, Hepatocellular - drug therapy | Antineoplastic Agents - pharmacology | Liver Neoplasms - enzymology | Hypoglycemic Agents - therapeutic use | Hexokinase - antagonists & inhibitors | Metformin - pharmacology | Liver Neoplasms - drug therapy | Oxidative Phosphorylation | Niacinamide - therapeutic use | Phenylurea Compounds - therapeutic use | Mechanistic Target of Rapamycin Complex 1 - antagonists & inhibitors | Carcinoma, Hepatocellular - enzymology | Mechanistic Target of Rapamycin Complex 1 - metabolism | Hep G2 Cells | Hypoglycemic Agents - pharmacology | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Sorafenib | Glycolysis | Phenylurea Compounds - pharmacology | Niacinamide - pharmacology | Hexokinase - metabolism | Phosphorylation | Secretion | Serine | Pyruvic acid | Hepatocellular carcinoma | Fluxes | Glycine | Hexokinase | Liver cancer | Mitochondria | Depletion | Clonal deletion | Oxidative phosphorylation | Hepatocytes | Cell death | Rodents | Glucokinase | Deletion | Tumorigenesis | Lactic acid | Metformin | Inhibition | Apoptosis | Index Medicus
Journal Article
Journal Article