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1. Full Text Fluorescent substrates for ADAM15 useful for assaying and high throughput screening
by Moss, Marcia L and Miller, Miles A and Vujanovic, Nikola and Yoneyama, Toshie and Rasmussen, Fred H
Analytical biochemistry, ISSN 0003-2697, 12/2016, Volume 514, pp. 42 - 47
FRET | Metalloproteinase | Disintegrin | ADAM15 | Fluorescent substrate | TIMP | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Biochemical Research Methods | Chemistry, Analytical | Science & Technology | ADAM Proteins - antagonists & inhibitors | Peptides - chemistry | Dipeptides - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Fluorescent Dyes - metabolism | ADAM Proteins - metabolism | Peptides - metabolism | Membrane Proteins - antagonists & inhibitors | Fluorescence Resonance Energy Transfer | Membrane Proteins - metabolism | Kinetics | Hydroxamic Acids - pharmacology | High-Throughput Screening Assays - methods | Physiological aspects | Immunoglobulin E | Neovascularization | Glycine | Glutamine | Index Medicus
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2. Full Text Impact of high-throughput screening in biomedical research
by Garyantes, Tina and Hertzberg, Robert P and Burns, David J and Janzen, William P and Sittampalam, G. Sitta and Green, Darren V. S and Paslay, Jeff W and Macarron, Ricardo and Banks, Martyn N and Schopfer, Ulrich and Bojanic, Dejan and Cirovic, Dragan A
Nature reviews. Drug discovery, ISSN 1474-1776, 03/2011, Volume 10, Issue 3, pp. 188 - 195
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Animals | Drug Evaluation, Preclinical - standards | Small Molecule Libraries | Humans | Drug Design | Drug Evaluation, Preclinical - statistics & numerical data | Biomedical Research | Usage | Product development | Management | High-throughput screening (Biochemical assaying) | Pharmaceutical industry | Index Medicus
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3. Full Text Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis
by Mei, Feng and Mei, Feng and Fancy, Stephen P.J and Shen, Yun-An A and Niu, Jianqin and Zhao, Chao and Presley, Bryan and Miao, Edna and Lee, Seonok and Mayoral, Sonia R and Mayoral, Sonia R and Redmond, Stephanie A and Etxeberria, Ainhoa and Xiao, Lan and Franklin, Robin J.M and Green, Ari and Hauser, Stephen L and Chan, Jonah R
Nature medicine, ISSN 1078-8956, 2014, Volume 20, Issue 8, pp. 954 - 960
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Drug Evaluation, Preclinical - methods | Muscarinic Antagonists - isolation & purification | Mice, Inbred C57BL | Nerve Fibers, Myelinated - drug effects | Cells, Cultured | Rats | Mice, Transgenic | Nanostructures | Rats, Sprague-Dawley | Regeneration - drug effects | Animals | Oligodendroglia - drug effects | Oligodendroglia - physiology | Cell Differentiation - drug effects | Histamine H1 Antagonists - pharmacology | Muscarinic Antagonists - pharmacology | Female | Mice | Oligodendroglia - cytology | Clemastine - pharmacology | High-Throughput Screening Assays - methods | Multiple Sclerosis - drug therapy | Multiple sclerosis | Care and treatment | Diagnosis | High-throughput screening (Biochemical assaying) | Analysis | Models | Medical screening | Arrays | Rodents | Index Medicus
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4. Full Text CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes
by Evers, Bastiaan and Jastrzebski, Katarzyna and Heijmans, Jeroen P. M and Grernrum, Wipawadee and Beijersbergen, Roderick L and Bernards, Rene
Nature biotechnology, ISSN 1087-0156, 06/2016, Volume 34, Issue 6, pp. 631 - 633
Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | RNA, Small Interfering - genetics | Gene Expression Profiling - methods | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Genetic Testing - methods | Genetic Markers - genetics | Gene Knockout Techniques - methods | Comparative analysis | Genetic screening | High-throughput screening (Biochemical assaying) | Oncology | Genetic testing | Ribonucleic acid--RNA | Research & development--R&D | Index Medicus
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5. Full Text Using in vitro high throughput screening assays to identify potential endocrine-disrupting chemicals
by Rotroff, Daniel M and Dix, David J and Houck, Keith A and Knudsen, Thomas B and Martin, Matthew T and McLaurin, Keith W and Reif, David M and Crofton, Kevin M and Singh, Amar V and Xia, Menghang and Huang, Ruili and Judson, Richard S
Environmental health perspectives, ISSN 0091-6765, 01/2013, Volume 121, Issue 1, pp. 7 - 14
High throughput | Endocrine | Toxcast | Androgen | In vitro | Estrogen | Public, Environmental & Occupational Health | Environmental Sciences & Ecology | Toxicology | Life Sciences & Biomedicine | Science & Technology | Environmental Sciences | Endocrine Disruptors - analysis | United States Environmental Protection Agency | Androgens - analysis | United States | Estrogens - analysis | High-Throughput Screening Assays - methods | Endocrine disruptors | Usage | High-throughput screening (Biochemical assaying) | Research | Identification and classification | Studies | Enzymes | Estrogens | Homeostasis | Hormones | Metabolism | Chemicals | Index Medicus | Screening | Receptors | Accuracy | Balancing | Mathematical models | In vitro testing | Environment protection | Assaying | androgen | estrogen | in vitro | Review | ToxCast | high throughput | endocrine
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6. Full Text High-throughput assay for determining enantiomeric excess of chiral diols, amino alcohols, and amines and for direct asymmetric reaction screening
by Shcherbakova, Elena G and James, Tony D and Anzenbacher, Pavel
Nature protocols, ISSN 1754-2189, 07/2020, Volume 15, Issue 7, pp. 2203 - 2229
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Biochemical Research Methods | Science & Technology | High-throughput screening (Biochemical assaying) | Enantiomers | Chirality | Analysis | Methods | Self assembly | Additives | Amines | Catalysts | Fluorescence | Esters | Amino acids | Alcohol | Drug development | Assaying | Alcohols | Combinatorial libraries | Reaction products | Robustness | Chemical synthesis | Diols | Substrates | Screening | Self-assembly | Impurities | Asymmetry | Reagents | Acetonitrile | Ligands | Combinatorial analysis | Index Medicus
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7. Full Text High-throughput screening with transcriptomics
by Singh, Arunima
Nature methods, ISSN 1548-7091, 03/2020, Volume 17, Issue 3, pp. 251 - 251
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Biochemical Research Methods | Science & Technology | Transcription factors | High-throughput screening (Biochemical assaying) | Identification and classification | Methods | High-throughput screening | Index Medicus
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8. Full Text Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets
by Knudsen, Thomas B and Houck, Keith A and Sipes, Nisha S and Singh, Amar V and Judson, Richard S and Martin, Matthew T and Weissman, Arthur and Kleinstreuer, Nicole C and Mortensen, Holly M and Reif, David M and Rabinowitz, James R and Setzer, R. Woodrow and Richard, Ann M and Dix, David J and Kavlock, Robert J
Toxicology (Amsterdam), ISSN 0300-483X, 2011, Volume 282, Issue 1, pp. 1 - 15
Emergency | High-throughput screening, Computational toxicology, ToxCast, Environmental chemicals | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Biological and medical sciences | Medical sciences | Data Interpretation, Statistical | Reproducibility of Results | United States | Humans | Rats | Automation, Laboratory | Animals | High-Throughput Screening Assays | Osmolar Concentration | Cell-Free System | Models, Biological | Animal Use Alternatives | Enzyme Inhibitors - toxicity | Ligands | Environmental Pollutants - toxicity | Environmental Pollutants - classification | Pesticide Residues - toxicity | United States Environmental Protection Agency | Toxicity Tests | Databases, Factual | Index Medicus | Enzymes | Receptors | Toxicity | Biocompatibility | Biochemistry | Kinases | Assaying | Arrays | Screens
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9. Full Text Engineering and assaying of cytochrome P450 biocatalysts
by Rabe, Kersten S and Gandubert, Valérie J and Spengler, Mark and Erkelenz, Michael and Niemeyer, Christof M
Analytical and bioanalytical chemistry, ISSN 1618-2642, 11/2008, Volume 392, Issue 6, pp. 1059 - 1073
Analytical methods | Chemistry | Analytical Chemistry | Food Science | Ecotoxicology | Physical Chemistry | Enzyme engineering | Cytochrome P450 | High-throughput screening | Inorganic Chemistry | P450 substrates | Biochemistry & Molecular Biology | Physical Sciences | Life Sciences & Biomedicine | Biochemical Research Methods | Chemistry, Analytical | Science & Technology | Cytochrome P-450 Enzyme System - analysis | Reactive Oxygen Species - metabolism | Oxidation-Reduction | Protein Engineering - methods | Humans | Oxygen Consumption | Peroxides - chemistry | Cytochrome P-450 Enzyme System - metabolism | Substrate Specificity | Biological Assay - methods | Cytochrome P-450 Enzyme System - chemistry | Animals | Peroxides - metabolism | Catalysis | NADP - metabolism | Binding Sites | Screening | Enzymes | Biotechnology | Searching | Mathematical analysis | Assaying | Metabolism | Cytochromes P450 | Index Medicus
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