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Journal Article
Journal Article
Nature Cell Biology, ISSN 1465-7392, 2014, Volume 16, Issue 4, pp. 357 - 366
The YAP and TAZ mediators of the Hippo pathway ( hereafter called YAP/TAZ) promote tissue proliferation and organ growth. However, how their biological... 
ORGAN GROWTH | CHOLESTEROL | YAP/TAZ | TRANSCRIPTION | HIPPO PATHWAY | STATINS | CELL BIOLOGY | Phosphorylation - physiology | Cell Proliferation | Active Transport, Cell Nucleus - physiology | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Phosphoproteins - metabolism | Sterol Regulatory Element Binding Proteins - genetics | Breast Neoplasms - metabolism | Drosophila melanogaster - metabolism | RNA Interference | Tumor Suppressor Proteins - genetics | HEK293 Cells | Trans-Activators - genetics | Female | Transcription, Genetic | Hydroxymethylglutaryl-CoA Reductases, NAD-Dependent - metabolism | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | HCT116 Cells | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Sterol Regulatory Element Binding Proteins - metabolism | Transcription Factors - genetics | Mevalonic Acid - metabolism | Polyisoprenyl Phosphates - metabolism | Transcription Factors - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | rho GTP-Binding Proteins - metabolism | Trans-Activators - metabolism | Mice | Polyisoprenyl Phosphates - biosynthesis | Pyridines - pharmacology | RNA, Small Interfering | Drosophila Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Cell metabolism | Genetic research | Genetic aspects | Research | Cellular control mechanisms | Index Medicus
Journal Article
The EMBO Journal, ISSN 0261-4189, 06/2011, Volume 30, Issue 12, pp. 2325 - 2335
The Hippo tumour suppressor pathway is a conserved signalling pathway that controls organ size. The core of the Hpo pathway is a kinase cascade, which in... 
hippo signalling | F‐actin | growth regulation | F-actin | TISSUE-GROWTH | BIOCHEMISTRY & MOLECULAR BIOLOGY | YORKIE PHOSPHORYLATION | TEAD/TEF FAMILY | CELL BIOLOGY | REGULATE CELL-PROLIFERATION | SIGNALING PATHWAY | GENE-EXPRESSION | CONTACT INHIBITION | SIZE-CONTROL | TUMOR-SUPPRESSOR PATHWAY | PROMOTES APOPTOSIS | Wings, Animal - cytology | Cell Proliferation | Humans | Drosophila melanogaster - genetics | Actins - genetics | Drosophila Proteins - biosynthesis | Organ Specificity - genetics | Wings, Animal - growth & development | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Actins - chemistry | RNA Caps - antagonists & inhibitors | RNA Caps - chemistry | Intracellular Signaling Peptides and Proteins - genetics | Cytoskeleton - chemistry | RNA Caps - genetics | Actins - biosynthesis | Carrier Proteins - biosynthesis | Cells, Cultured | Cytoskeleton - genetics | Drosophila melanogaster - cytology | Protein-Serine-Threonine Kinases - genetics | Signal Transduction - genetics | Drosophila Proteins - chemistry | Carrier Proteins - genetics | Phenotype | Animals | Drosophila melanogaster - chemistry | Intracellular Signaling Peptides and Proteins - chemistry | Wings, Animal - chemistry | Protein-Serine-Threonine Kinases - chemistry | Drosophila Proteins - genetics | HeLa Cells | Proteins | Signal transduction | Tumors | Index Medicus
Journal Article
Journal Article
Genes and Development, ISSN 0890-9369, 06/2015, Volume 29, Issue 12, pp. 1271 - 1284
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2011, Volume 286, Issue 9, pp. 7018 - 7026
The Hippo pathway restricts the activity of transcriptional co-activators TAZ and YAP by phosphorylating them for cytoplasmic sequestration or degradation. In... 
YES-ASSOCIATED PROTEIN | EPITHELIAL-MESENCHYMAL TRANSITION | CELL CONTACT INHIBITION | WW DOMAIN | GROWTH-CONTROL | ORGAN SIZE CONTROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | ONCOGENIC TRANSFORMATION | BINDING | CANCER | Adaptor Proteins, Signal Transducing - chemistry | Protein Interaction Domains and Motifs - physiology | Humans | Intercellular Signaling Peptides and Proteins - chemistry | Cytoplasm - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Phosphoproteins - metabolism | Phosphoproteins - chemistry | Intercellular Signaling Peptides and Proteins - metabolism | HEK293 Cells | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Protein Structure, Tertiary | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Phosphoproteins - genetics | Cell Division - physiology | Transcription, Genetic - physiology | Membrane Proteins - chemistry | Intracellular Signaling Peptides and Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | Signal Transduction - physiology | Connective Tissue Growth Factor - genetics | Adaptor Proteins, Signal Transducing - metabolism | Connective Tissue Growth Factor - metabolism | Index Medicus | Gene Transcription | Transcription Coactivators | Signal Transduction | AmotL1 | YAP | Transcription Factors | Serine Threonine Protein Kinase | Hippo Pathway | TAZ | Amot
Journal Article
Circulation research, ISSN 0009-7330, 6/2018, Volume 123, Issue 1, pp. 30 - 32
Increasing interest in the HIPPO signaling pathway has stemmed largely from its ability to modulate cardioprotection and heart regeneration following injury,... 
cardiovascular disease | fibroblasts | Hippo pathway | inflammation | myocardial infarction
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2010, Volume 285, Issue 48, pp. 37159 - 37169
The TAZ transcription co-activator promotes cell proliferation and epithelial-mesenchymal transition. TAZ is inhibited by the Hippo tumor suppressor pathway,... 
EPITHELIAL-MESENCHYMAL TRANSITION | SUPPRESSOR | APOPTOSIS | SIGNALING PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | GROWTH | TRANSCRIPTION | PROLIFERATION | DROSOPHILA | STEM-CELL DIFFERENTIATION | Transcription Coactivators | E3 Ubiquitin Ligase | Signal Transduction | Protein Phosphorylation | Protein Degradation | Hippo Pathway | TAZ | Breast Cancer
Journal Article