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Nature, ISSN 0028-0836, 04/2011, Volume 472, Issue 7344, pp. 466 - 470
Adult hippocampal neurogenesis is a unique form of neural circuit plasticity that results in the generation of new neurons in the dentate gyrus throughout... 
DEPRESSION | MODELS | MEMORY | MULTIDISCIPLINARY SCIENCES | NEURONS | DISORDER | DENTATE GYRUS | MATURATION | SYNAPTIC PLASTICITY | FLUOXETINE | BRAIN | Apoptosis - drug effects | Learning - drug effects | Neuronal Plasticity - drug effects | Male | Neural Stem Cells - cytology | Anxiety - therapy | Neuronal Plasticity - physiology | Long-Term Potentiation - drug effects | Exploratory Behavior - drug effects | Cognition - physiology | Long-Term Potentiation - physiology | Antidepressive Agents - pharmacology | bcl-2-Associated X Protein - deficiency | Extinction, Psychological - physiology | Cell Survival - drug effects | Synapses - drug effects | Conditioning, Classical - drug effects | Affect - physiology | bcl-2-Associated X Protein - metabolism | Anxiety - physiopathology | Mice, Transgenic | Hippocampus - pathology | Cognition - drug effects | Mice, Knockout | Dentate Gyrus - cytology | Aging - physiology | Dentate Gyrus - physiology | Mice | Dentate Gyrus - pathology | Hippocampus - physiopathology | Memory - physiology | Memory - drug effects | Aging - drug effects | Extinction, Psychological - drug effects | Fear - physiology | Dentate Gyrus - physiopathology | Exploratory Behavior - physiology | Synapses - metabolism | Fear - psychology | Female | Neurogenesis - drug effects | bcl-2-Associated X Protein - genetics | Neural Stem Cells - drug effects | Hippocampus - cytology | Physical Conditioning, Animal - physiology | Conditioning, Classical - physiology | Aging - pathology | Learning - physiology | Animals | Neurogenesis - physiology | Models, Neurological | Hippocampus - physiology | Neural Stem Cells - metabolism | Physiological aspects | Hippocampus (Brain) | Neurogenesis | Health aspects | Proteins | Studies | Young adults | Cognition & reasoning | Neurons | Anxieties | Rodents | Behavior | Index Medicus
Journal Article
Neuron, ISSN 0896-6273, 2009, Volume 62, Issue 4, pp. 479 - 493
Understanding the physiopathology of affective disorders and their treatment relies on the availability of experimental models that accurately mimic aspects of... 
STEMCELL | HUMDISEASE | MOLNEURO | SEROTONIN-1A RECEPTOR FUNCTION | MESSENGER-RNA | BETA-ARRESTINS | PROTEIN-COUPLED RECEPTORS | ANTIDEPRESSANT TREATMENT | CELL-PROLIFERATION | ADULT MICE | MAJOR DEPRESSION | DENTATE GYRUS | HIPPOCAMPAL NEUROGENESIS | NEUROSCIENCES | Depression - pathology | Microtubule-Associated Proteins - metabolism | Radiation | Arrestins - genetics | GTP-Binding Protein alpha Subunit, Gi2 - metabolism | Male | Hippocampus - drug effects | Antidepressive Agents, Second-Generation - therapeutic use | RNA, Messenger - metabolism | Arrestins - metabolism | Hypothalamus - radiation effects | Corticosterone - toxicity | Depression - drug therapy | GTP-Binding Protein alpha Subunit, Gi2 - genetics | Anxiety - diet therapy | Depression - chemically induced | Reaction Time - drug effects | Exploratory Behavior - drug effects | Neurogenesis - radiation effects | Neurogenesis - drug effects | Bromodeoxyuridine - metabolism | Fluoxetine - therapeutic use | Hypothalamus - drug effects | Disease Models, Animal | Cell Survival - drug effects | Drug Administration Schedule | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Neuropeptides - metabolism | Hippocampus - pathology | Cell Survival - radiation effects | Anxiety - pathology | Feeding Behavior - drug effects | Mice, Knockout | Gene Expression Regulation - drug effects | Animals | Hypothalamus - metabolism | Analysis of Variance | beta-Arrestin 2 | beta-Arrestins | Hippocampus - radiation effects | Gene Expression Regulation - radiation effects | Anxiety - chemically induced | Cell Proliferation - drug effects | Mice | Arrestins - deficiency | Cell Proliferation - radiation effects | Neurosciences | Corticosterone | Neurons | Fluoxetine | Analysis | Depression, Mental | Models | Survival analysis | Genotype & phenotype | Brain research | Antidepressants | Anxieties | Rodents | Behavior | Feeds | Neurogenesis | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 02/2013, Volume 33, Issue 9, pp. 3953 - 3966
Down syndrome (DS) is associated with neurological complications, including cognitive deficits that lead to impairment in intellectual functioning. Increased... 
Protein Binding - genetics | Electric Stimulation | Cell Count | Male | GABA Modulators - therapeutic use | Learning Disorders - etiology | Hyperkinesis - drug therapy | Neurogenesis - genetics | Long-Term Potentiation - drug effects | Protein Binding - drug effects | Exploratory Behavior - drug effects | Reflex, Startle - drug effects | Imidazoles - therapeutic use | Excitatory Postsynaptic Potentials - genetics | Disease Models, Animal | Mice, Transgenic | Hippocampus - pathology | Imidazoles - pharmacology | Psychomotor Performance - drug effects | Hyperkinesis - etiology | Vesicular Inhibitory Amino Acid Transport Proteins - metabolism | Analysis of Variance | Seizures - etiology | Glutamate Decarboxylase - metabolism | Mice | Receptors, GABA-A - metabolism | Benzodiazepines - therapeutic use | Tritium - pharmacokinetics | Sensory Gating - drug effects | Reflex - genetics | Reflex - drug effects | Hippocampus - drug effects | Excitatory Postsynaptic Potentials - drug effects | Ki-67 Antigen | Reaction Time - drug effects | GABA Modulators - pharmacology | Neurons - physiology | Down Syndrome - complications | Membrane Proteins - metabolism | Neurogenesis - drug effects | Neurons - drug effects | Cues | Down Syndrome - pathology | Benzodiazepines - pharmacology | Acoustic Stimulation | Mice, Inbred C57BL | Learning Disorders - drug therapy | Long-Term Potentiation - genetics | Biophysics | Maze Learning - drug effects | Rotarod Performance Test | Animals | Carrier Proteins - metabolism | Down Syndrome - drug therapy | Cell Proliferation - drug effects | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 11/2016, Volume 539, Issue 7630, pp. 555 - 559
Cellular activity in the brain depends on the high energetic support provided by mitochondria, the cell organelles which use energy sources to generate... 
OXIDATIVE-PHOSPHORYLATION | CATALYTIC SUBUNIT | SOLUBLE ADENYLYL-CYCLASE | METABOLISM | MULTIDISCIPLINARY SCIENCES | ENDOCANNABINOID SYSTEM | SUBCELLULAR-LOCALIZATION | NEURONS | PROTEINS | RECEPTORS | BRAIN | Memory - drug effects | Electron Transport - drug effects | Memory Disorders - metabolism | Male | Hippocampus - drug effects | Cannabinoids - adverse effects | Mitochondrial Membranes - drug effects | Oxidative Phosphorylation - drug effects | Cell Respiration - drug effects | Female | Synaptic Transmission - drug effects | Mitochondrial Membranes - enzymology | Cannabinoids - metabolism | Memory Disorders - pathology | Cyclic AMP-Dependent Protein Kinases - metabolism | Memory Disorders - enzymology | Hippocampus - pathology | Mitochondria - metabolism | Adenylyl Cyclases - metabolism | Mitochondria - drug effects | NADH Dehydrogenase - metabolism | Mitochondrial Membranes - metabolism | Hippocampus - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Animals | Receptor, Cannabinoid, CB1 - genetics | Signal Transduction - drug effects | Mice | Receptor, Cannabinoid, CB1 - deficiency | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Energy Metabolism - drug effects | Memory - physiology | Memory Disorders - chemically induced | Mitochondria | Cannabinoids | Health aspects | Memory | Proteins | Phosphorylation | Rodents | Respiration | Chemical compounds | Index Medicus
Journal Article
Nature Neuroscience, ISSN 1097-6256, 06/2006, Volume 9, Issue 6, pp. 729 - 731
Environmental enrichment increases adult hippocampal neurogenesis and alters hippocampal-dependent behavior in rodents. To investigate a causal link between... 
NEURONS | MICE | LONG-TERM-MEMORY | DENTATE GYRUS | EXPRESSION | NEUROSCIENCES | Memory Disorders - physiopathology | Maze Learning - radiation effects | Neuronal Plasticity - drug effects | Bromodeoxyuridine | Anxiety - drug therapy | Behavior, Animal - radiation effects | Environment, Controlled | Habituation, Psychophysiologic - drug effects | Neuronal Plasticity - physiology | Dentate Gyrus - drug effects | Neurons - physiology | Behavior, Animal - drug effects | Antidepressive Agents - pharmacology | Habituation, Psychophysiologic - radiation effects | Neurons - drug effects | Neuronal Plasticity - radiation effects | Maze Learning - physiology | Stem Cells - radiation effects | Anxiety - physiopathology | Cell Division - radiation effects | Behavior, Animal - physiology | Dentate Gyrus - radiation effects | Maze Learning - drug effects | Cell Division - drug effects | Feeding Behavior - physiology | Feeding Behavior - drug effects | Cell Division - physiology | Animals | Dentate Gyrus - physiology | Habituation, Psychophysiologic - physiology | X-Rays | Feeding Behavior - radiation effects | Stem Cells - drug effects | Stem Cells - physiology | Mice | Neurons - radiation effects | Cell Proliferation - radiation effects | Neural transmission | Regulation | Behavioral assessment | Research | Hippocampus (Brain) | Neurons | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 09/2012, Volume 489, Issue 7414, pp. 150 - 154
Journal Article
Science, ISSN 0036-8075, 2014, Volume 344, Issue 6184, pp. 630 - 634
Journal Article
Nature, ISSN 0028-0836, 08/2011, Volume 476, Issue 7361, pp. 458 - 462
Glucocorticoids are released in response to stressful experiences and serve many beneficial homeostatic functions. However, dysregulation of glucocorticoids is... 
ANTIDEPRESSANTS | FOREBRAIN | GLUCOCORTICOID-RECEPTOR | MULTIDISCIPLINARY SCIENCES | NEURONS | RATS | ANIMAL-MODEL | ASTROCYTES | LESIONS | BRAIN | TRANSGENIC MICE | Depression - physiopathology | Male | Receptors, Glucocorticoid - metabolism | Hippocampus - drug effects | Receptors, Glucocorticoid - analysis | Depression - drug therapy | Dexamethasone - pharmacology | Dentate Gyrus - drug effects | Glucocorticoids - metabolism | Neurogenesis - radiation effects | Behavior, Animal - drug effects | Neurogenesis - drug effects | Stress, Physiological - drug effects | Swimming | Hypothalamo-Hypophyseal System - physiology | Corticosterone - secretion | Pituitary-Adrenal System - physiology | Glucocorticoids - secretion | Stress, Physiological - physiology | Hypothalamo-Hypophyseal System - drug effects | Restraint, Physical - psychology | Pituitary-Adrenal System - drug effects | Mice, Inbred C57BL | Restraint, Physical - physiology | Behavior, Animal - physiology | Mice, Transgenic | Hippocampus - cytology | Dentate Gyrus - cytology | Animals | Dentate Gyrus - physiology | Neurogenesis - physiology | Glucocorticoids - pharmacology | Corticosterone - metabolism | Mice | Hippocampus - physiology | Corticosterone - analysis | Murders & murder attempts | Antidepressants | Rodents | Histology | Behavior | Kinases | Laboratory animals | Index Medicus
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 08/2013, Volume 38, Issue 9, pp. 1609 - 1616
We have previously demonstrated that lipopolysaccharide (LPS) induces depressive-like behavior by activating indoleamine 2,3 dioxygenase (IDO; O'Connor et al,... 
AMPA receptor | depression | lipopolysaccharide | NMDA receptor | inflammation | ketamine | BACILLUS-CALMETTE-GUERIN | PSYCHIATRY | MACROPHAGES | INDOLEAMINE 2,3-DIOXYGENASE | INDUCTION | NEUROSCIENCES | HIPPOCAMPUS | QUINOLINIC ACID | SICKNESS | IMMUNE ACTIVATION | PHARMACOLOGY & PHARMACY | BRAIN | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Body Weight - drug effects | Motor Activity - drug effects | Male | Ketamine - antagonists & inhibitors | Lipopolysaccharides - antagonists & inhibitors | Brain - metabolism | Quinoxalines - pharmacology | Depression - drug therapy | Drug Interactions | Liver - drug effects | Depression - chemically induced | Immobility Response, Tonic - drug effects | Antidepressive Agents - pharmacology | Brain-Derived Neurotrophic Factor - biosynthesis | Ketamine - therapeutic use | Cytokines - metabolism | Drug Administration Schedule | Food Preferences - drug effects | Liver - metabolism | Mice, Inbred C57BL | Excitatory Amino Acid Antagonists - pharmacology | Antidepressive Agents - therapeutic use | Brain - drug effects | Eating - drug effects | Animals | Signal Transduction - drug effects | Mice | Ketamine - pharmacology | Receptors, AMPA - antagonists & inhibitors | Index Medicus | Antidepressants | biological psychiatry | animal models | behavioral science | bipolar | unipolar | Original
Journal Article