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1. Full Text Aryl-1,3,5-triazine derivatives as histamine H-4 receptor ligands
by Lazewska, D and Wicek, M and Ner, J and Kamiriska, K and Kottke, T and Schwed, JS and Zygmunt, M and Karcz, T and Olejarz, A and Kuder, K and Latacz, G and Grosicki, M and Sapa, J and Karolak-Wojciechowska, J and Stark, H and Kiee-Kononowicz, K
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0223-5234, 08/2014, Volume 83, pp. 534 - 546
A series of novel 2-amino-4-(4-methylpiperazin-1-yl)-1,3,5-triazine derivatives with different aryl substituents in the 6-position was designed, synthesized... 
Histamine H-4 receptor | CHEMISTRY, MEDICINAL | CYTOCHROMES | METABOLISM | Anti-inflammatory properties | METASITE | 2,4,6-Trisubstituted 1,3,5-triazines | 4-Methylpiperazines | INHIBITOR | BINDING | 2,4-DIAMINO-1,3,5-TRIAZINE DERIVATIVES
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2. Full Text The histamine H-4 receptor: Targeting inflammatory disorders
by Walter, M and Kottke, T and Stark, H
EUROPEAN JOURNAL OF PHARMACOLOGY, ISSN 0014-2999, 10/2011, Volume 668, Issue 1-2, pp. 1 - 5
The discovery of the histamine H-4 receptor has added a new chapter to the century of extensive biogenic amine research. The human histamine H-4 receptor is... 
Allergy | EOSINOPHILS | Autoimmune disease | Inflammation | MODEL | MEDIATES CHEMOTAXIS | MURINE | RESPONSES | Histamine H-4 receptor | Immunology | CELL-MIGRATION | EXPRESS | PHARMACOLOGY & PHARMACY | Antagonist | ANTAGONISTS | BINDING
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3. Full Text The histamine H-4 receptor: from orphan to the clinic
by Thurmond, RL
FRONTIERS IN PHARMACOLOGY, ISSN 1663-9812, 03/2015, Volume 6
The histamine H-4 receptor (H4R) was first noted as a sequence in genomic databases that had features of a class A G-protein coupled receptor. This putative... 
pruritus | ALLERGIC CONTACT-DERMATITIS | COLLAGEN-INDUCED ARTHRITIS | histamine | DENDRITIC CELLS | PHARMACOLOGICAL CHARACTERIZATION | MAST-CELLS | atopic dermatitis | asthma | H4 RECEPTOR | ATOPIC-DERMATITIS | HUMAN EOSINOPHILS | arthritis | PHARMACOLOGY & PHARMACY | MOLECULAR-CLONING | T-CELLS
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4. Full Text The histamine H-4 receptor is functionally expressed on T(H)2 cells
by Gutzmer, R and Mommert, S and Gschwandtner, M and Zwingmann, K and Stark, H and Werfel, T
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ISSN 0091-6749, 03/2009, Volume 123, Issue 3, pp. 619 - 625
Background: Histamine influences T-cell reactions via histamine receptors I and 2. The histamine receptor 4 (H4R) is the most recently identified histamine... 
ACTIVATION | ANTIHISTAMINES | DENDRITIC CELLS | PRURITUS | AIRWAY INFLAMMATION | IMMUNOLOGY | T cells | IL-31 | SCRATCHING BEHAVIOR | Histamine | ATOPIC-DERMATITIS | ALLERGY | MICE | H-4 receptor | T-CELLS
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5. Full Text Histamine H-4 receptor in oral lichen planus
by Salem, A and Al-Samadi, A and Stegajev, V and Stark, H and Hayrinen-Immonen, R and Ainola, M and Hietanen, J and Konttinen, YT
ORAL DISEASES, ISSN 1354-523X, 04/2015, Volume 21, Issue 3, pp. 378 - 385
ObjectivesOral lichen planus (OLP) is an autoimmune disease characterized by a band-like T-cell infiltrate below the apoptotic epithelial cells and degenerated... 
KINASE | NOD1 | oral lichen planus | mast cells | RESPONSES | INHIBITION | EPITHELIAL-CELLS | oral pathology | DENTISTRY, ORAL SURGERY & MEDICINE | TOLL-LIKE RECEPTORS | histamine H-4 receptor | cytokines | EXPRESSION
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6. Full Text Profiling of histamine H-4 receptor agonists in native human monocytes
by Gschwandtner, M and Koether, B and Werfel, T and Stark, H and Gutzmer, R
BRITISH JOURNAL OF PHARMACOLOGY, ISSN 0007-1188, 09/2013, Volume 170, Issue 1, pp. 136 - 143
Background and Purpose Since the identification of the histamine H-4 receptor, several ligands activating this receptor have been described and more compounds... 
histamine | clobenpropit | VUF8430 | PHARMACOLOGY & PHARMACY | histamine H-4 receptor | 4-methylhistamine | ST-1006 | UR-PI376
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7. Full Text The role of histamine H 4 receptor in immune and inflammatory disorders
by Zampeli, E and Tiligada, E
British Journal of Pharmacology, ISSN 0007-1188, 05/2009, Volume 157, Issue 1, pp. 24 - 33
Since its discovery at the beginning of the 20th century, histamine has been established to play a pathophysiological regulatory role in cellular events... 
Allergy; asthma | receptor ligands | Histamine | receptor | Histamine h | Immunomodulation | Rheumatoid arthritis | Inflammation | Pruritus | Immune system | pruritus | immunomodulation | histamine | PHARMACOLOGICAL CHARACTERIZATION | 1ST POTENT | allergy | asthma | T-CELL | rheumatoid arthritis | MAST-CELL | NEUTROPHIL RECRUITMENT | MEDIATES CHEMOTAXIS | H4 RECEPTOR | SYNOVIAL-CELLS | HUMAN EOSINOPHILS | inflammation | immune system | PHARMACOLOGY & PHARMACY | histamine H-4 receptor | MOLECULAR-CLONING | H-4 receptor ligands
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8. Full Text Histamine H-3 and H-4 receptors as novel drug targets
by Tiligada, E and Zampeli, E and Sander, K and Stark, H
EXPERT OPINION ON INVESTIGATIONAL DRUGS, ISSN 1354-3784, 10/2009, Volume 18, Issue 10, pp. 1519 - 1531
The identification of histamine H-3 (H3R) and H-4 (H4R) receptors some years ago revived interest in histamine research and exposed attractive perspectives for... 
epilepsy | RHEUMATOID-ARTHRITIS | histamine | attention deficit hyperactivity disorder | H3R | MAST-CELLS | schizophrenia | INVERSE AGONISTS | inflammation | H-3-RECEPTOR LIGANDS | PHARMACOLOGY & PHARMACY | autoimmune disorders | pain | SYNOVIAL TISSUE | BRAIN HISTAMINE | H4R | H4 RECEPTORS | 1ST POTENT | allergy | sleep/wake | neuronal diseases | NEUROPATHIC PAIN | ANTIINFLAMMATORY PROPERTIES | arthritis | cancer | cognitive impairment | drug target
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9. Full Text Fragment based design of new H-4 receptor-ligands with anti-inflammatory properties in vivo
by Smits, RA and Lim, HD and Hanzer, A and Zuiderveld, OP and Guaita, E and Adami, M and Coruzzi, G and Leurs, R and de Esch, LJP
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 04/2008, Volume 51, Issue 8, pp. 2457 - 2467
Using a previously reported flexible alignment model we have designed, synthesized, and evaluated a series of compounds at the human histamine H-4 receptor... 
CELLS | POTENT | CHEMISTRY, MEDICINAL | INDOLE | CLONING | HUMAN HISTAMINE-RECEPTOR | PHARMACOLOGICAL CHARACTERIZATION | INFLAMMATION | BENZIMIDAZOLE | ANTAGONISTS | EXPRESSION
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10. Full Text Molecular and biochemical pharmacology of the histamine H 4 receptor
by Leurs, Rob and Chazot, Paul L and Shenton, Fiona C and Lim, Herman D and De Esch, Iwan J. P
British Journal of Pharmacology, ISSN 0007-1188, 05/2009, Volume 157, Issue 1, pp. 14 - 23
The elucidation of the human genome has had a major impact on histamine receptor research. The identification of the human H-4 receptor by several groups has... 
Heterogeneity | Signal transduction | receptor | Species difference | Histamine h | Isoforms | Biochemistry | Molecular pharmacology | Selective agonists and antagonists | signal transduction | CRYSTAL-STRUCTURE | molecular pharmacology | isoforms | AGONIST BINDING | N-GLYCOSYLATION | H-4-RECEPTOR AGONIST | SPLICE VARIANTS | heterogeneity | MEDIATES CHEMOTAXIS | species difference | H4 RECEPTOR | HUMAN EOSINOPHILS | PROTEIN-COUPLED RECEPTOR | FUNCTIONAL EXPRESSION | biochemistry | selective agonists and antagonists | PHARMACOLOGY & PHARMACY | histamine H-4 receptor
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11. Full Text Proinflammatory role of the histamine H-4 receptor in dextrane sodium sulfate-induced acute colitis
by Schirmer, B and Rezniczek, T and Seifert, R and Neumann, D
BIOCHEMICAL PHARMACOLOGY, ISSN 0006-2952, 11/2015, Volume 98, Issue 1, pp. 102 - 109
Millions of people worldwide are suffering from inflammatory bowel disease (IBD), which severely affects patients' life qualities and even life expectancies.... 
Inflammatory bowel diseases | ACTIVATION | Cytokines | MAST-CELLS | ULCERATIVE-COLITIS | AIRWAY INFLAMMATION | CD4(+) T-CELLS | KNOCKOUT MICE | H4 RECEPTOR | Experimental colitis | Histamine | Histamine H-4 receptor | INFLAMMATORY-BOWEL-DISEASE | MODELS | PHARMACOLOGY & PHARMACY | SEX-DIFFERENCES
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12. Full Text Cellular analysis of the histamine H-4 receptor in human myeloid cells
by Capelo, R and Lehmann, C and Ahmad, K and Snodgrass, R and Diehl, O and Ringleb, J and Flamand, N and Weigert, A and Stark, H and Steinhilber, D and Kahnt, AS
BIOCHEMICAL PHARMACOLOGY, ISSN 0006-2952, 03/2016, Volume 103, pp. 74 - 84
The human histamine H-4 receptor (H4R) is a G alpha(i/o)-coupled receptor which is mainly expressed on hematopoietic cells. Accordingly, the receptor is... 
HUMAN DENDRITIC CELLS | EOL-1 CELLS | Inflammation | Macrophages | HUMAN MONOCYTES | Monocytes | HUMAN EOSINOPHILS | PHARMACOLOGY & PHARMACY | Histamine receptor | DIFFERENTIATION | HISTONE DEACETYLASE INHIBITORS | UP-REGULATION | T-CELLS | Eosinophils
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13. Full Text The histamine H 4 receptor is functionally expressed on neurons in the mammalian CNS
by Connelly, W.M and Shenton, F.C and Lethbridge, N and Leurs, R and Waldvogel, H.J and Faull, R.L.M and Lees, G and Chazot, P.L
British Journal of Pharmacology, ISSN 0007-1188, 05/2009, Volume 157, Issue 1, pp. 55 - 63
The histamine H-4 receptor is the most recently identified of the G protein-coupled histamine receptor family and binds several neuroactive drugs, including... 
Human | Brain | receptor | Mouse | Histamine h | Neurons | JNJ 10191584 | Hyperpolarization | CORTEX IN-VITRO | CELLS | HUMAN BRAIN | RAT | PHARMACOLOGICAL CHARACTERIZATION | FRONTAL-CORTEX | 1ST POTENT | brain | neurons | SPLICE VARIANTS | mouse | PHARMACOLOGY & PHARMACY | histamine H-4 receptor | hyperpolarization | MOLECULAR-CLONING | ANTAGONISTS | human
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14. Full Text Diaminopyrimidines, diaminopyridines and diaminopyridazines as histamine H-4 receptor modulators
by Savall, BM and Meduna, SP and Tays, K and Cai, H and Thurmond, RL and McGovern, P and Gaul, M and Zhao, BP and Edwards, JP
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 02/2015, Volume 25, Issue 4, pp. 956 - 959
Previously disclosed H-4 receptor modulators, the triamino substituted pyridines and pyrimidines, contain a free primary amino (-NH2) group. In this Letter we... 
CHEMISTRY, MEDICINAL | Pyridine | LIGANDS | Pyridazine | CHEMISTRY, ORGANIC | Antagonists | Histamine H-4 | Pyrimidine
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15. Full Text Histamine H-4 receptor antagonism reduces hapten-induced scratching behaviour but not inflammation
by Rossbach, K and Wendorff, S and Sander, K and Stark, H and Gutzmer, R and Werfel, T and Kietzmann, M and Baumer, W
EXPERIMENTAL DERMATOLOGY, ISSN 0906-6705, 01/2009, Volume 18, Issue 1, pp. 57 - 63
Effects of the histamine H-4 receptor antagonist JNJ 7777120 (1-[(5-chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine) were tested in two models of allergic... 
pruritus | ALLERGIC CONTACT-DERMATITIS | AWD 12-281 | HUMAN SKIN | PHOSPHODIESTERASE-4 INHIBITOR | 1ST POTENT | JNJ 7777120 | MEDIATES CHEMOTAXIS | DERMATOLOGY | DENDRITIC CELL-FUNCTION | allergic dermatitis | ELICITATION PHASE | histamine H-4 receptor | MICE
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16. Full Text Alkyl derivatives of 1,3,5-triazine as histamine H 4 receptor ligands
by Łażewska, Dorota and Mogilski, Szczepan and Hagenow, Stefanie and Kuder, Kamil and Głuch-Lutwin, Monika and Siwek, Agata and Więcek, Małgorzata and Kaleta, Maria and Seibel, Ulla and Buschauer, Armin and Filipek, Barbara and Stark, Holger and Kieć-Kononowicz, Katarzyna
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 04/2019, Volume 27, Issue 7, pp. 1254 - 1262
This study focuses on the design, synthesis, molecular modeling and biological evaluation of a novel group of alkyl-1,3,5-triazinyl-methylpiperazines. New... 
ligands | Docking | Pain | receptors | 1,3,5-Triazine | Histamine H | ACTIVATION | CHEMISTRY, MEDICINAL | Histamine H-4 ligands | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | Histamine H-4 receptors | H-4-RECEPTOR | DISCOVERY | H4 RECEPTOR | NEUROPATHIC PAIN | JNJ7777120 | MODELS
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17. Full Text Histamine H 4 receptor activation alleviates neuropathic pain through differential regulation of ERK, JNK, and P38 MAPK phosphorylation
by Sanna, Maria D and Stark, Holger and Lucarini, Laura and Ghelardini, Carla and Masini, Emanuela and Galeotti, Nicoletta
Pain, ISSN 0304-3959, 2015, Volume 156, Issue 12, pp. 2492 - 2504
Histamine plays a complex role in pain modulation with opposite roles in nociception for histamine receptor subtypes 1, 2, and 3. The histamine H-4 receptor... 
Histamine H 4 receptors | P38 | JNK | Central nervous system | ERK | Neuropathic pain | MECHANICAL ALLODYNIA | PROTEIN-KINASE | MAST-CELLS | Histamine H-4 receptors | RAT MODELS | NEUROSCIENCES | CLINICAL NEUROLOGY | H4 RECEPTOR | INFLAMMATION | SPINAL NERVE LIGATION | TERMINAL KINASE JNK | NEURONS | ANESTHESIOLOGY | MOLECULAR-CLONING
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18. In silico modeling techniques for predicting the tertiary structure of human H-4 receptor
by Zaid, H and Raiyn, J and Osman, M and Falah, M and Srouji, S and Rayan, A
FRONTIERS IN BIOSCIENCE-LANDMARK, ISSN 1093-9946, 01/2016, Volume 21, pp. 597 - 619
First cloned in 2000, the human Histamine H-4 Receptor (hH(4)R) is the last member of the histamine receptors family discovered so far, it belongs to the GPCR... 
3D-structure prediction | RESOLUTION CRYSTAL-STRUCTURE | H4R - H-4 receptor | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-COUPLED RECEPTORS | Review | Drug Discovery | MUSCARINIC ACETYLCHOLINE-RECEPTOR | CELL BIOLOGY | HISTAMINE H4 RECEPTOR | DOPAMINE D2 RECEPTOR | homology modeling | LIGAND-BINDING MODES | G-protein coupled receptors (GPCRs) | MEMBRANE-PROTEINS | HOMOLOGY MODEL | MOLECULAR-MECHANISMS
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19. Full Text (2-Arylethenyl)-1,3,5-triazin-2-amines as a novel histamine H 4 receptor ligands
by Kamińska, Katarzyna and Ziemba, Julia and Ner, Joanna and Schwed, Johannes Stephan and Łazewska, Dorota and Więcek, Małgorzata and Karcz, Tadeusz and Olejarz, Agnieszka and Latacz, Gniewomir and Kuder, Kamil and Kottke, Tim and Zygmunt, Małgorzata and Sapa, Jacek and Karolak-Wojciechowska, Janina and Stark, Holger and Kieć-Kononowicz, Katarzyna
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2015, Volume 103, pp. 238 - 251
Within the constantly growing number of histamine H 4 (H 4 R) receptor ligands there is a large group of azine derivatives. A series of novel compounds in the... 
4-Methylpiperazines | Histamine H4 receptor | 1,3,5-Triazin-2-amines | Anti-inflammatory properties | CHEMISTRY, MEDICINAL | ANTAGONIST | ANTIHISTAMINES | PHARMACOLOGICAL CHARACTERIZATION | NEUROBLASTOMA | INFLAMMATORY DISORDERS | Histamine H-4 receptor | POTENT | ANTIINFLAMMATORY PROPERTIES | CLONING | INHIBITOR | DERIVATIVES
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20. EXPERIMENTAL AUTOIMMUNE MYOCARDITIS IN RATS AND THERAPEUTIC HISTAMINE H-1 - H-4 RECEPTOR INHIBITION
by Stasiak, A and Gola, J and Kraszewska, K and Mussur, M and Kobos, J and Mazurek, U and Stark, H and Fogel, WA
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, ISSN 0867-5910, 12/2018, Volume 69, Issue 6, pp. 889 - 900
Myocarditis, a life threatening disease, is still not adequately treated. Histamine plays an important role in physiology and pathophysiology of cardiovascular... 
STANDARDIZATION | ACTIVATION | PHYSIOLOGY | HEART-FAILURE | experimental autoimmune myocarditis | histamine receptors' antagonists | MEDIATES CHEMOTAXIS | IMMUNE | INFLAMMATION | PHARMACOLOGY | angiotensin converting enzyme inhibitor | QUINAPRIL | EXPRESSION | PROGRESSION | dilated cardiomyopathy
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