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Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2003, Volume 100, Issue 15, pp. 8856 - 8861
... (Src homology 2 domain containing tyrosine phosphatase 1). Although these ILTs have been shown to recognize a broad range of classical and nonclassical human MHC class I molecules (MHCIs... 
T lymphocytes | Molecules | Biological Sciences | Receptors | Epithelial cells | Protein refolding | Alleles | Cell lines | Natural killer cells | Leukocytes | T cell antigen receptors | Leukocyte Ig-like receptors | Natural killer cell | Surface plasmon resonance | Major histocompatibility complex | Coreceptor | CRYSTALLIZATION | CELLS | G ANTIGEN | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | LIR-1 | coreceptor | major histocompatibility complex | CYTOMEGALOVIRUS | CUTTING EDGE | MOLECULES | G EXPRESSION | leukocyte Ig-like receptors | surface plasmon resonance | COMPLEX CLASS-I | natural killer cell | Surface Plasmon Resonance | Receptors, Immunologic - chemistry | Humans | DNA, Complementary - genetics | Molecular Sequence Data | HLA Antigens - genetics | Antigens, CD - genetics | Antigens, CD - metabolism | Histocompatibility Antigens Class I - metabolism | Base Sequence | Killer Cells, Natural - immunology | Antigens, CD - chemistry | Membrane Glycoproteins | Binding Sites | Binding, Competitive | Recombinant Proteins - metabolism | Amino Acid Sequence | Leukocyte Immunoglobulin-like Receptor B1 | Models, Molecular | Recombinant Proteins - chemistry | Histocompatibility Antigens Class I - genetics | Recombinant Proteins - genetics | HLA-G Antigens | HLA Antigens - chemistry | HLA Antigens - metabolism | Histocompatibility Antigens Class I - chemistry | Sequence Homology, Amino Acid | CD8 Antigens - metabolism | Protein Conformation | Kinetics | CD8-Positive T-Lymphocytes - immunology | In Vitro Techniques | Receptors, Immunologic - genetics | Receptors, Immunologic - metabolism | Physiological aspects | Killer cells | Research | Antigens, CD8 | Killer Cells, Natural | Histocompatibility Antigens Class I | Recombinant Proteins | CD8-Positive T-Lymphocytes | Life Sciences | Immunology | Receptors, Immunologic | HLA Antigens | Antigens, CD | DNA, Complementary
Journal Article
Stem cells (Dayton, Ohio), ISSN 1066-5099, 01/2008, Volume 26, Issue 1, pp. 212 - 222
... T‐cell response. Here, we report that the nonclassic human leukocyte antigen (HLA) class I molecule HLA... 
Immunosuppression | Regulatory T cells | Human leukocyte antigen‐G | Mesenchymal stem cells | Interleukin‐10 | Interleukin-10 | Human leukocyte antigen-G | T-Lymphocyte Subsets - immunology | T-Lymphocytes, Regulatory - metabolism | Humans | Adult Stem Cells - immunology | Lymphocyte Culture Test, Mixed | Mesenchymal Stromal Cells - immunology | T-Lymphocytes, Regulatory - immunology | Histocompatibility Antigens Class I - metabolism | Mesenchymal Stromal Cells - cytology | Flow Cytometry | Forkhead Transcription Factors - metabolism | Bone Marrow Cells - immunology | Killer Cells, Natural - immunology | T-Lymphocytes, Cytotoxic - immunology | Interferon-gamma | Adult Stem Cells - cytology | Enzyme-Linked Immunosorbent Assay | Bone Marrow Cells - cytology | Cell Communication | Mesenchymal Stromal Cells - metabolism | HLA-G Antigens | HLA Antigens - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Microscopy, Confocal | Adult Stem Cells - metabolism | Interleukin-2 Receptor alpha Subunit - metabolism | T-Lymphocytes, Cytotoxic - metabolism | T-Lymphocyte Subsets - metabolism | Killer Cells, Natural - metabolism | Bone Marrow Cells - metabolism | CD4 Antigens - metabolism | T-Lymphocyte Subsets | Adult Stem Cells | Interleukin-2 Receptor alpha Subunit | Killer Cells, Natural | Antigens, CD4 | Histocompatibility Antigens Class I | T-Lymphocytes, Cytotoxic | Mesenchymal Stem Cells | Life Sciences | Bone Marrow Cells | Immunology | T-Lymphocytes, Regulatory | HLA Antigens | Forkhead Transcription Factors
Journal Article
Brain (London, England : 1878), ISSN 1460-2156, 2012, Volume 135, Issue 4, pp. 1042 - 1054
Peptides presented at the cell surface reflect the protein content of the cell; those on HLA class I molecules comprise the critical peptidome elements interacting with CD8 T lymphocytes... 
peptidome | glioblastoma | tumour-infiltrating lymphocytes | tumour antigen | immunotherapy | AVIDITY | IDENTIFICATION | NEUROSCIENCES | CLINICAL NEUROLOGY | GLIOMA-CELL | GROWTH | CHONDROITIN SULFATE PROTEOGLYCAN | SELECTION | EXPRESSION | T-CELLS | PROGRESSION | TENASCIN-C | Oligonucleotide Array Sequence Analysis | Humans | Brain Neoplasms - pathology | Gene Expression Profiling | Glial Fibrillary Acidic Protein - metabolism | RNA, Messenger - metabolism | Antigens, Neoplasm - chemistry | HLA-A Antigens - analysis | Antigens, CD - metabolism | Sequence Analysis, Protein | Brain Neoplasms - immunology | Flow Cytometry | Antigens, Neoplasm - therapeutic use | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Mass Spectrometry | Chromatography, Liquid | Cytokines - metabolism | Antigens, Neoplasm - immunology | Peptides - immunology | Glioblastoma - therapy | HLA-A Antigens - immunology | Glioblastoma - immunology | Glioblastoma - pathology | Brain Neoplasms - therapy | HLA-A Antigens - chemistry | CD8-Positive T-Lymphocytes - immunology | Antigen Presentation - physiology | Peptides - analysis | Receptor-Like Protein Tyrosine Phosphatases, Class 5 - metabolism | Immunogenicity | CD8 antigen | Immunotherapy | Glioblastoma | Data processing | Histocompatibility antigen HLA | Lymphocytes T | Vaccines | Cell surface | Immunological tolerance
Journal Article
Journal of neuroimmunology, ISSN 0165-5728, 2010, Volume 225, Issue 1, pp. 22 - 33
... antigen-specific cytotoxicity a... 
Neurology | Allergy and Immunology | IDO | Immunomodulation | Immunotherapy | Glioblastoma | TGF-β | PDL-1 | T cells | GLIOMA-CELLS | FAS LIGAND | HLA-G EXPRESSION | RECURRENT GLIOMA | IMMUNE PRIVILEGE | lmmunotherapy | IMMUNOLOGY | POTENTIAL MECHANISM | NEUROSCIENCES | ADJUVANT TEMOZOLOMIDE | TGF-beta | GROWTH-FACTOR-BETA | TRANSFORMING GROWTH-FACTOR-BETA-1 | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Fas Ligand Protein - metabolism | Flow Cytometry - methods | Transforming Growth Factor beta2 - metabolism | Humans | HLA Antigens - genetics | Interferon-gamma - metabolism | Indoleamine-Pyrrole 2,3,-Dioxygenase - pharmacology | Neoplasm Proteins - metabolism | RNA, Messenger - metabolism | Antigens, CD - metabolism | Histocompatibility Antigens Class I - metabolism | T-Lymphocytes - drug effects | Antigens, Neoplasm - metabolism | Cytotoxicity, Immunologic - drug effects | B7-H1 Antigen | Oligonucleotide Array Sequence Analysis - methods | Gene Expression Profiling - methods | Lectins - pharmacology | Histocompatibility Antigens Class I - genetics | HLA-G Antigens | HLA Antigens - metabolism | Gene Expression Regulation - drug effects | Glioblastoma - immunology | Glioblastoma - pathology | Cell Line, Tumor | Antigens, CD - pharmacology | MART-1 Antigen | T-Lymphocytes - immunology | Cell Proliferation - drug effects | HLA-A2 Antigen - metabolism | Cytotoxicity, Immunologic - immunology | Fas Ligand Protein - genetics | Interferon-gamma - pharmacology | Cell research | Histocompatibility antigens | Messenger RNA | HLA histocompatibility antigens | Lectins | Biochemistry | Transforming growth factors | Glioblastoma multiforme | Apoptosis | Cell Proliferation | Oligonucleotide Array Sequence Analysis | Histocompatibility Antigens Class I | Gene Expression Profiling | Life Sciences | Flow Cytometry | Immunology | Neoplasm Proteins | Transforming Growth Factor beta2 | Interferon-gamma | Antigens, Neoplasm | T-Lymphocytes | Gene Expression Regulation | Fas Ligand Protein | HLA-A2 Antigen | Indoleamine-Pyrrole 2,3,-Dioxygenase | HLA Antigens | RNA, Messenger | Antigens, CD | Cytotoxicity, Immunologic | Cancer
Journal Article
The Journal of Immunology, ISSN 0022-1767, 06/1999, Volume 162, Issue 11, pp. 6410 - 6419
.... We show in this study that two types of NKT cells can be defined on the basis of their reactivity to the monomorphic MHC class I-like molecule CD1d, One type of NKT cell is positively selected... 
IMMUNOGLOBULIN-E PRODUCTION | RECEPTOR-ALPHA/BETA(+) CELLS | NK1.1 EXPRESSION | BONE-MARROW | MOUSE CD1 | IN-VIVO | MARROW GRAFT-REJECTION | RECEPTOR-ALPHA-CHAIN | MICE | IMMUNOLOGY | MOLECULES | T-Lymphocyte Subsets - immunology | Protein Biosynthesis | Antigens, Ly | Organ Specificity - immunology | Proteins | Lymphocyte Activation - immunology | Antigens, CD1d | Receptors, Antigen, T-Cell, alpha-beta - biosynthesis | Killer Cells, Natural - immunology | Female | Thymus Gland - metabolism | Antigens, Differentiation, B-Lymphocyte - genetics | Lectins, C-Type | Mice, Inbred C57BL | CD8 Antigens - biosynthesis | Antigens, CD1 - physiology | Animals | Mice, Nude | T-Lymphocyte Subsets - metabolism | Biomarkers | Genes, T-Cell Receptor alpha - immunology | Antigens - biosynthesis | Thymus Gland - immunology | Antigens, Surface | Mice | Mice, Inbred BALB C | Antigens, Differentiation, T-Lymphocyte - biosynthesis | CD4 Antigens - biosynthesis | Histocompatibility Antigens Class II - genetics | NK Cell Lectin-Like Receptor Subfamily B | Thymus Gland | Killer Cells, Natural | Antigens, Differentiation, T-Lymphocyte | Life Sciences | Immunology | Receptors, Antigen, T-Cell, alpha-beta | Histocompatibility Antigens Class II | Antigens | T-Lymphocyte Subsets | Antigens, CD8 | Lymphocyte Activation | Antigens, CD4 | Antigens, CD1 | Organ Specificity | Antigens, Differentiation, B-Lymphocyte | Genes, T-Cell Receptor alpha
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 6/2011, Volume 108, Issue 24, pp. 9927 - 9932
.... Consequently, in the absence of FcRn, Fcγ receptor (FcγR)-mediated antigen uptake fails to initiate cross-presentation... 
T lymphocytes | Antigens | Fc receptors | Cross priming | Dendritic cells | Internalization | Phagosomes | Inflammation | Oxidation | MHC CLASS-I | GAMMA-RECEPTOR | CD8(+) | VIVO | MULTIDISCIPLINARY SCIENCES | DISEASE | MONOCYTES | ANTIGEN PRESENTATION | MYASTHENIA-GRAVIS | T-CELLS | CUTTING EDGE | Dextran Sulfate | Membrane Glycoproteins - metabolism | Cytosol - immunology | Dendritic Cells - immunology | Receptors, Fc - metabolism | NADPH Oxidases - metabolism | NADPH Oxidases - immunology | Vacuolar Proton-Translocating ATPases - metabolism | Receptors, IgG - metabolism | Histocompatibility Antigens Class I - metabolism | Vacuolar Proton-Translocating ATPases - immunology | Phagosomes - immunology | Flow Cytometry | Immunoglobulin G - immunology | Colitis - chemically induced | Membrane Glycoproteins - immunology | Colitis - immunology | Dendritic Cells - metabolism | rab GTP-Binding Proteins - metabolism | CD11b Antigen - immunology | Mice, Inbred C57BL | Phagosomes - metabolism | Histocompatibility Antigens Class I - immunology | Mice, Transgenic | Histocompatibility Antigens Class I - genetics | Receptors, IgG - immunology | NADPH Oxidase 2 | Blotting, Western | CD8 Antigens - immunology | Mice, Knockout | CD8 Antigens - metabolism | Animals | Immunoglobulin G - genetics | Receptors, Fc - immunology | Cross-Priming - immunology | rab GTP-Binding Proteins - immunology | Colitis - metabolism | Protein Binding | rab27 GTP-Binding Proteins | Antigens - immunology | Cytosol - metabolism | Receptors, Fc - genetics | Mice | CD11b Antigen - metabolism | Mutation | Hydrogen-Ion Concentration | Immunoglobulin G - metabolism | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2010, Volume 107, Issue 43, pp. 18599 - 18604
Most antigenic peptides presented by MHC class I molecules result from the degradation of intracellular proteins by the proteasome... 
T lymphocytes | Antigens | Dendritic cells | HEK293 cells | Liver | Melanoma | Cell lines | Antibodies | Cellular immunity | Tumors | MAGE | Antigenic peptide | Tumor antigen | Immunoproteasome | Antigen processing | immunoproteasome | DENDRITIC CELLS | MULTIDISCIPLINARY SCIENCES | CYTOLYTIC T-LYMPHOCYTES | antigenic peptide | SUBUNIT COMPOSITION | CLEAVAGE | 20S PROTEASOME | tumor antigen | ANGSTROM RESOLUTION | GENERATION | antigen processing | STANDARD PROTEASOME | TUMOR-ASSOCIATED ANTIGEN | Recombinant Proteins - metabolism | Amino Acid Sequence | Antigens, Neoplasm - genetics | Protein Subunits | Humans | Molecular Sequence Data | Proteasome Endopeptidase Complex - chemistry | Recombinant Proteins - genetics | Neoplasm Proteins - metabolism | Mice, Knockout | Histocompatibility Antigens Class I - metabolism | Proteasome Endopeptidase Complex - genetics | Sequence Homology, Amino Acid | Animals | Antigen Presentation | Recombinant Proteins - immunology | Antigens, Neoplasm - metabolism | Cell Line, Tumor | Mice | Proteasome Endopeptidase Complex - metabolism | Neoplasm Proteins - genetics | Proteasome Endopeptidase Complex - classification | Research | Ubiquitin-proteasome system | Properties | Tumor antigens | Methods | Immunological research | CD8 antigen | Tumor cells | proteasomes | Lymphocytes T | Lymphoid tissue | Small intestine | Kidney | Major histocompatibility complex | Antigen (tumor-associated) | Histocompatibility antigen HLA | Colon | Catalytic subunits | Biological Sciences
Journal Article
PloS one, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, p. e56738
...(+) T cell responses to self and foreign antigens. It has long been suspected that the dedicated class II chaperone designated HLA-DM in humans or H-2M in mice also makes an important contribution, but due to tight linkage within the MHC, a possible... 
MUTANT MICE | HLA-DM | MULTIDISCIPLINARY SCIENCES | CELL MATURATION | ANTIGEN PRESENTATION | MAJOR HISTOCOMPATIBILITY COMPLEX | INVARIANT CHAIN | PEPTIDE BINDING | SELF-ANTIGENS | H2-M | T-CELLS | Forkhead Transcription Factors - immunology | Embryonic Stem Cells - metabolism | T-Lymphocytes, Regulatory - metabolism | Humans | Diabetes Mellitus, Type 1 - metabolism | Male | T-Lymphocytes, Regulatory - immunology | Forkhead Transcription Factors - metabolism | Antigens, Differentiation, B-Lymphocyte - immunology | Female | Histocompatibility Antigens Class II - metabolism | Diabetes Mellitus, Type 1 - immunology | Embryonic Stem Cells - immunology | Thymus Gland - metabolism | Antigens, Differentiation, B-Lymphocyte - genetics | Genetic Predisposition to Disease - genetics | Mice, Inbred C57BL | Diabetes Mellitus, Type 1 - genetics | Mice, SCID | Blotting, Western | Mice, Knockout | Microscopy, Confocal | Animals | Histocompatibility Antigens Class II - immunology | Mice, Inbred NOD | Thymus Gland - immunology | Mice | Mice, Inbred BALB C | Antigens, Differentiation, B-Lymphocyte - metabolism | Histocompatibility Antigens Class II - genetics | Antigens | Obesity | Pancreatic beta cells | Peptides | Type 1 diabetes | Analysis | Disease susceptibility | T cells | Diabetes therapy | Haplotypes | Lymphocytes T | Histocompatibility antigen H-2 | Defects | Lymphocytes | Foxp3 protein | Pancreas | Immunoregulation | Diabetes mellitus | Autoantigens | Insulin | Disease control | CD4 antigen | Beta cells | Pathology | Major histocompatibility complex | Stem cells | Ligands | Histocompatibility antigen HLA | Diabetes | Mutation | Autoimmune diseases
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 2002, Volume 196, Issue 12, pp. 1627 - 1638
Journal Article
Nature reviews. Immunology, ISSN 1474-1741, 2009, Volume 9, Issue 7, pp. 503 - 513
.... However, in turn, viruses have evolved elegant strategies to inhibit various stages of the MHC class I antigen presentation pathway and prevent the display of viral peptides... 
CYTOMEGALOVIRUS US6 GLYCOPROTEIN | RETICULUM-ASSOCIATED DEGRADATION | CELL-SURFACE EXPRESSION | PEPTIDE-LOADING COMPLEX | ER-ASSOCIATED DEGRADATION | ENDOPLASMIC-RETICULUM | MAJOR HISTOCOMPATIBILITY COMPLEX | HIV-1 NEF PROTEIN | IMMUNOLOGY | EPSTEIN-BARR-VIRUS | E3 UBIQUITIN LIGASE | Humans | Ubiquitin - metabolism | Viral Proteins - immunology | Viral Proteins - metabolism | T-Lymphocytes - virology | Histocompatibility Antigens Class I - metabolism | Ubiquitin-Protein Ligases - immunology | Antigen Presentation | T-Lymphocytes - metabolism | ATP-Binding Cassette Transporters - metabolism | B-Lymphocytes - virology | Membrane Transport Proteins - metabolism | Proteasome Endopeptidase Complex - immunology | B-Lymphocytes - metabolism | Enzyme Inhibitors - metabolism | Histocompatibility Antigens Class I - immunology | Ubiquitin-Protein Ligases - metabolism | Enzyme Inhibitors - immunology | Viruses - immunology | Animals | B-Lymphocytes - immunology | T-Lymphocytes - immunology | Proteasome Endopeptidase Complex - metabolism | Membrane Transport Proteins - immunology | ATP-Binding Cassette Transporters - immunology | Ubiquitin - immunology | Physiological aspects | Antigen presenting cells | Major histocompatibility complex | Research | Viral proteins | Learning | Antigen presentation | Pathogens | Lymphocytes | Cell surface
Journal Article