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Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2013, Volume 8, Issue 8, p. e71323
Psychiatric diseases, including schizophrenia, bipolar disorder and major depression, are projected to lead global disease burden within the next decade.... 
HIPPOCAMPUS | MESSENGER-RNA | ACETYLATION | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | STRAIN DIFFERENCES | VALPROIC ACID | MICE | HISTONE DEACETYLASE INHIBITORS | LITHIUM | NUCLEUS-ACCUMBENS | Transcription, Genetic - drug effects | Male | Neurons - cytology | Promoter Regions, Genetic - drug effects | Promoter Regions, Genetic - genetics | Brain - metabolism | Mi-2 Nucleosome Remodeling and Deacetylase Complex - antagonists & inhibitors | Time Factors | Behavior, Animal - drug effects | Histone Deacetylase 1 - antagonists & inhibitors | Benzamides - pharmacology | Neurons - drug effects | Chromatin - drug effects | Benzamides - chemistry | Affect - drug effects | Brain - cytology | Reproducibility of Results | Histone Deacetylase 2 - antagonists & inhibitors | Lithium - pharmacology | Mice, Inbred C57BL | Histone Deacetylase Inhibitors - chemistry | Brain - drug effects | Gene Expression Regulation - drug effects | Acetylation - drug effects | Animals | Histone Deacetylase Inhibitors - pharmacology | Mice | Histones - metabolism | Chromatin - genetics | Epigenetic inheritance | Brain | Chromatin | Antidepressants | Genes | Depression, Mental | Schizophrenia | Gene expression | Drugs | Drug abuse | Histone deacetylase | Immunoprecipitation | Transcription | Mental disorders | Medical services | Disorders | Lithium | Bipolar disorder | Genomes | Mental depression | Compounds | Kinases | Benzamide | Psychotropic drugs | Plasticity (behavioral) | Rodents | Inhibition | Acetylation | HDAC2 protein | Locomotor activity | Binding | Cortex (prefrontal) | Hydroxamic acid | Pharmacology | Nucleus accumbens | Amphetamine | Mood | Inhibitors | Acids | In vivo methods and tests
Journal Article
Journal Article
Journal Article
Oncogene, ISSN 0950-9232, 02/2012, Volume 31, Issue 5, pp. 537 - 551
The class-I histone deacetylases (HDACs) HDAC1 and HDAC2 belong to a family of 11 zinc-dependent human HDACs and are overexpressed in many cancers. Inhibitors... 
apoptosis | cancer | sphingosine-1-phosphate | histone deacetylase | histone deacetylase inhibitor | MULTIPLE-MYELOMA | HDAC INHIBITORS | DIFFERENTIAL EXPRESSION | HUMAN LEUKEMIA-CELLS | SUBEROYLANILIDE HYDROXAMIC ACID | REVERSIBLE ACETYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | SYNERGISTICALLY INDUCES APOPTOSIS | MEDIATED PHOSPHORYLATION | CELL BIOLOGY | ONCOLOGY | GENETICS & HEREDITY | NF-KAPPA-B | Neoplasms - metabolism | Lysophospholipids - metabolism | Histone Deacetylase 2 - antagonists & inhibitors | Humans | Neoplasms - enzymology | Depsipeptides - pharmacology | Neoplasms - drug therapy | Sphingosine - analogs & derivatives | Models, Biological | Histone Deacetylase 1 - antagonists & inhibitors | Histone Deacetylase Inhibitors - pharmacology | Hydroxamic Acids - therapeutic use | Depsipeptides - therapeutic use | Histone Deacetylase Inhibitors - therapeutic use | Sphingosine - metabolism | Histone Deacetylase 2 - metabolism | Hydroxamic Acids - pharmacology | Histone Deacetylase 1 - metabolism | Antimitotic agents | Care and treatment | Sphingosine | Histones | Physiological aspects | Development and progression | Drug targeting | Antineoplastic agents | Health aspects | Cancer | Clinical trials | Molecules | Pharmacology | Gene expression | Cancer therapies | Enzymes | Histone deacetylase | Sphingolipids | Nuclei | epigenetics | Chromatin remodeling | Antitumor agents | Molecular modelling | Reviews | Lipid metabolism | HDAC2 protein
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2016, Volume 291, Issue 9, pp. 4523 - 4536
Inhibiting class I histone deacetylases (HDACs) increases energy expenditure, reduces adiposity, and improves insulin sensitivity in obese mice. However, the... 
WHITE FAT | PROTEIN | GENE | BEIGE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | EPIGENETIC REGULATION | UPSTREAM ENHANCER | INSULIN SENSITIVITY | EXPRESSION | ADIPOSE-TISSUE | Polycomb Repressive Complex 2 - antagonists & inhibitors | Polycomb Repressive Complex 2 - agonists | Polycomb Repressive Complex 2 - genetics | Adipocytes, Brown - metabolism | Polycomb Repressive Complex 1 - metabolism | Humans | Ion Channels - genetics | Ubiquitin-Protein Ligases - antagonists & inhibitors | Mitochondrial Proteins - genetics | Mitochondrial Proteins - agonists | Adrenergic beta-3 Receptor Agonists - pharmacology | Promoter Regions, Genetic - drug effects | Polycomb Repressive Complex 1 - genetics | Adipocytes, Brown - enzymology | Protein Processing, Post-Translational - drug effects | RNA Interference | Mitochondrial Proteins - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Polycomb Repressive Complex 1 - antagonists & inhibitors | Histone Deacetylase 1 - antagonists & inhibitors | Lysine - metabolism | Histone Deacetylase 1 - genetics | Recombinant Proteins - metabolism | Adipocytes, Brown - drug effects | Mitochondrial Proteins - antagonists & inhibitors | Ubiquitin-Protein Ligases - metabolism | Recombinant Proteins - chemistry | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Mice, Inbred Strains | Enhancer of Zeste Homolog 2 Protein | Ion Channels - antagonists & inhibitors | Gene Expression Regulation - drug effects | Polycomb Repressive Complex 1 - agonists | Transcription Factors - metabolism | Acetylation - drug effects | Animals | Ion Channels - metabolism | Methylation - drug effects | Ion Channels - agonists | Histones - metabolism | Thermogenesis - drug effects | Transcription Factors - agonists | Uncoupling Protein 1 | Polycomb Repressive Complex 2 - metabolism | Ubiquitin-Protein Ligases - genetics | Cell Line, Transformed | Histone Deacetylase 1 - metabolism | histone methylation | thermogenesis | brown adipocytes | UCP1 | histone deacetylation | H3K27 | Metabolism | epigenetics | obesity | histone deacetylase 1 (HDAC1) | uncoupling protein
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2014, Volume 72, pp. 138 - 145
Abstract While inhibition of class I/IIb histone deacetylases (HDACs) protects the mammalian heart from ischemia reperfusion (IR) injury, class selective... 
Cardiovascular | Histone deacetylase | FOXO | Superoxide dismutase | Isolated heart | Catalase | Ischemia reperfusion | HDAC INHIBITORS | CARDIAC & CARDIOVASCULAR SYSTEMS | ACETYLATION | INJURY | FOXO TRANSCRIPTION FACTORS | HYPOXIA | CELL BIOLOGY | SUPEROXIDE-DISMUTASE | Superoxide Dismutase - genetics | Myocardial Contraction - drug effects | Male | Myocardial Reperfusion Injury - enzymology | Forkhead Transcription Factors - metabolism | Histone Deacetylase 1 - antagonists & inhibitors | Indoles - pharmacology | Benzamides - pharmacology | Histone Deacetylase 1 - genetics | Hydroxamic Acids - pharmacology | Myocardial Reperfusion Injury - genetics | Organ Culture Techniques | Superoxide Dismutase - metabolism | Heart - physiopathology | Histone Deacetylase 2 - genetics | Histone Deacetylases - genetics | Catalase - genetics | Histone Deacetylase 2 - antagonists & inhibitors | Histone Deacetylase 6 | Gene Expression Regulation | Rats | Histone Deacetylases - metabolism | Forkhead Transcription Factors - genetics | Rats, Sprague-Dawley | Myocardial Reperfusion Injury - physiopathology | Catalase - metabolism | Animals | Heart - drug effects | Histone Deacetylase Inhibitors - pharmacology | Pyridines - pharmacology | Histone Deacetylase 2 - metabolism | Forkhead Box Protein O3 | Myocardial Reperfusion Injury - prevention & control | Histone Deacetylase 1 - metabolism | Antioxidants | Ischemia | Superoxide | ischemia reperfusion | isolated heart | histone deacetylase | superoxide dismutase | catalase
Journal Article
Blood, ISSN 0006-4971, 04/2013, Volume 121, Issue 17, pp. 3459 - 3468
Journal Article
Journal Article
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 2012, Volume 46, Issue 2, pp. 351 - 361
Journal Article