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BBA - Proteins and Proteomics, ISSN 1570-9639, 05/2017, Volume 1865, Issue 5, pp. 531 - 538
The repressive Nucleosome Remodeling and histone Deacetylation (NuRD) complex remodels the chromatin structure by coupling ATP-dependent remodeling activity... 
Negative stain electron microscopy | Transient HEK293F cell expression | NuRD complex | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BAH DOMAIN | ELECTRON-MICROSCOPY | CANCER | NUCLEOSOME | ANGSTROM RESOLUTION | CHROMATIN REMODELING COMPLEX | BIOPHYSICS | STRUCTURAL BASIS | NURD | HISTONE DEACETYLASE | Histone Deacetylase 1 - chemistry | Histone Deacetylase 2 - chemistry | Retinoblastoma-Binding Protein 7 - chemistry | Humans | Histone Chaperones - metabolism | Chromatin Assembly and Disassembly - genetics | Mi-2 Nucleosome Remodeling and Deacetylase Complex - genetics | Mi-2 Nucleosome Remodeling and Deacetylase Complex - metabolism | Amino Acid Sequence - genetics | Histone Chaperones - chemistry | HEK293 Cells | Repressor Proteins - isolation & purification | Histone Deacetylases - isolation & purification | Histone Chaperones - isolation & purification | Histone Deacetylase 1 - genetics | Histone Deacetylase 2 - genetics | Repressor Proteins - chemistry | Histone Deacetylases - genetics | Gene Expression Regulation | Histone Deacetylases - chemistry | Repressor Proteins - genetics | Retinoblastoma-Binding Protein 7 - genetics | Retinoblastoma-Binding Protein 7 - isolation & purification | Mi-2 Nucleosome Remodeling and Deacetylase Complex - chemistry | Histone Deacetylase 2 - metabolism | Histone Deacetylase 1 - metabolism | Proteins | Protein binding | Chromatin | Genetic transcription | Metastasis | Electron microscopy | Index Medicus
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 04/2015, Volume 94, pp. 87 - 101
A series of novel quinazolinone hybrids were synthesized by employing click chemistry and evaluated for anti-proliferative activities against MCF-7, HeLa and... 
Docking studies | Quinazolinone hybrids | Senescence | HDACs | Click chemistry | CHOLINE KINASE | CHEMISTRY, MEDICINAL | PROLIFERATION | ONCOGENE-INDUCED SENESCENCE | CELLULAR SENESCENCE | CANCER | P53 | IN-VITRO | HISTONE DEACETYLASE INHIBITORS | DERIVATIVES | CYTOTOXICITY | Histone Deacetylase 1 - chemistry | Histone Deacetylase 2 - chemistry | Apoptosis - drug effects | Humans | Cellular Senescence - drug effects | HeLa Cells - metabolism | K562 Cells - drug effects | Tumor Suppressor Protein p53 - genetics | Inhibitory Concentration 50 | Quinazolinones - pharmacology | Tumor Suppressor Proteins - metabolism | Quinones - chemistry | Histone Deacetylases - genetics | Click Chemistry | Histone Deacetylases - chemistry | Tumor Suppressor Protein p53 - metabolism | Histone Deacetylases - metabolism | Histone Deacetylase Inhibitors - chemistry | MCF-7 Cells - drug effects | Polycomb Repressive Complex 2 - chemistry | Enhancer of Zeste Homolog 2 Protein | HeLa Cells - drug effects | Quinazolinones - chemical synthesis | Pyrroles - chemistry | Histone Deacetylase Inhibitors - pharmacology | Molecular Docking Simulation | Quinazolinones - chemistry | Histone Deacetylase 2 - metabolism | Cell Cycle - drug effects | Polycomb Repressive Complex 2 - metabolism | Histone Deacetylase 1 - metabolism | Zinc compounds | Histidine | RNA | Analysis | Tumor proteins | Tumors | Apoptosis
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2014, Volume 461, Issue 3, pp. 477 - 486
HLCS (holocarboxylase synthetase) is a nuclear protein that catalyses the binding of biotin to distinct lysine residues in chromatin proteins. HLCS-dependent... 
Histone deacetylase 1 (HDAC1) | Epigenetics | Chromatin | Gene repression | Holocarboxylase synthetase (HLCS) | Nuclear receptor co-repressor (N-CoR) | gene repression | BIOTINYLATION | CELLS | METHYLATION | DROSOPHILA-MELANOGASTER | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-COR | PATTERNS | chromatin | epigenetics | ELEMENTS | nuclear receptor co-repressor (N-CoR) | holocarboxylase synthetase (HLCS) | REGIONS | BIOTIN | EXPRESSION | histone deacetylase 1 (HDAC1) | Histone Deacetylase 1 - chemistry | Immunoprecipitation | Alternative Splicing | Epigenetic Repression | Humans | Nuclear Receptor Co-Repressor 1 - genetics | Genetic Complementation Test | Carbon-Nitrogen Ligases - genetics | Proteolysis | HEK293 Cells | Protein Interaction Domains and Motifs | Acetylation | Carbon-Nitrogen Ligases - chemistry | Histone Deacetylase 1 - genetics | Peptide Fragments - genetics | Biomarkers - metabolism | Recombinant Proteins - metabolism | Peptide Fragments - metabolism | Carbon-Nitrogen Ligases - metabolism | Nuclear Receptor Co-Repressor 1 - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Mutant Proteins - metabolism | Peptide Fragments - chemistry | Mutant Proteins - chemistry | Nuclear Receptor Co-Repressor 1 - metabolism | Protein Processing, Post-Translational | Histones - metabolism | Amino Acid Substitution | Histone Deacetylase 1 - metabolism
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 01/2017, Volume 482, Issue 4, pp. 1327 - 1333
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2016, Volume 113, Issue 50, pp. E8051 - E8058
Protein–protein interactions play a central role in cellular function. Improving the understanding of complex formation has many practical applications,... 
Druggable surface | Direct coupling analysis | Drug design | Protein-protein interface | Hot spots | drug design | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | DIMERIZATION | protein-protein interface | INHIBITION | CONSERVATION | hot spots | CDK1 | HOT-SPOTS | direct coupling analysis | HIV-1 PROTEASE | BINDING-SITES | WEB SERVER | druggable surface | COMPUTATIONAL PREDICTION | Histone Deacetylase 1 - chemistry | Molecular Probes | HIV Protease - drug effects | Humans | Proto-Oncogene Proteins c-mdm2 - chemistry | CDC2-CDC28 Kinases - antagonists & inhibitors | Repressor Proteins - antagonists & inhibitors | HIV Protease Inhibitors - pharmacology | Proto-Oncogene Proteins c-mdm2 - drug effects | CDC2 Protein Kinase - drug effects | Drug Design | Histone Deacetylase 1 - drug effects | CDC2 Protein Kinase - chemistry | Histone Deacetylase 1 - antagonists & inhibitors | Binding Sites | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Molecular Docking Simulation - methods | Repressor Proteins - chemistry | Protein Interaction Domains and Motifs - drug effects | CDC2 Protein Kinase - antagonists & inhibitors | HIV-1 - drug effects | CDC2-CDC28 Kinases - chemistry | CDC2-CDC28 Kinases - drug effects | Histone Deacetylases - chemistry | HIV Protease Inhibitors - chemistry | Tumor Necrosis Factor-alpha - chemistry | Tumor Necrosis Factor-alpha - drug effects | HIV-1 - enzymology | Histone Deacetylases - drug effects | Repressor Proteins - drug effects | HIV Protease - chemistry | Protein Multimerization - drug effects | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Evolution, Molecular | Observations | Protein-protein interactions | Biological Sciences | PNAS Plus | protein−protein interface
Journal Article
Journal Article