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Lancet, The, ISSN 0140-6736, 2009, Volume 373, Issue 9678, pp. 1905 - 1917
Summary Glucocorticoid resistance or insensitivity is a major barrier to the treatment of several common inflammatory diseases—including chronic obstructive... 
Internal Medicine | RHEUMATOID-ARTHRITIS | MEDICINE, GENERAL & INTERNAL | OBSTRUCTIVE PULMONARY-DISEASE | HISTONE DEACETYLASE ACTIVITY | MIGRATION INHIBITORY FACTOR | ULCERATIVE-COLITIS | REGULATORY T-CELLS | RECEPTOR-BETA | RELATIVE CORTICOSTEROID INSENSITIVITY | BLOOD MONONUCLEAR-CELLS | RESPIRATORY-DISTRESS-SYNDROME | Transcription Factor AP-1 - drug effects | Glucocorticoids - therapeutic use | Transcriptional Activation - genetics | Transcription Factor AP-1 - genetics | Humans | Macrophage Migration-Inhibitory Factors - immunology | Transcriptional Activation - drug effects | Transcription Factor AP-1 - immunology | Histone Deacetylases - immunology | Transcriptional Activation - immunology | ATP-Binding Cassette, Sub-Family B, Member 1 - drug effects | Calcineurin Inhibitors | Macrophage Migration-Inhibitory Factors - genetics | Inflammation - drug therapy | Phosphodiesterase 4 Inhibitors | Anti-Inflammatory Agents - therapeutic use | Mitogen-Activated Protein Kinases - immunology | Genetic Predisposition to Disease - genetics | NF-kappa B - antagonists & inhibitors | Histone Deacetylases - genetics | Macrophage Migration-Inhibitory Factors - drug effects | Repressor Proteins - genetics | Histone Deacetylase 2 | Drug Resistance - drug effects | Inflammation - immunology | Asthma - drug therapy | ATP-Binding Cassette, Sub-Family B, Member 1 - immunology | Drug Resistance - genetics | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Drug Resistance - immunology | Repressor Proteins - immunology | Histone Deacetylases - drug effects | Mitogen-Activated Protein Kinases - genetics | Repressor Proteins - drug effects | Mitogen-Activated Protein Kinases - drug effects | Pulmonary Disease, Chronic Obstructive - drug therapy | Corticosteroids | Dosage and administration | Inflammation | Research | Drug resistance | Drug therapy | Health aspects | Complications and side effects | Risk factors | Inflammatory bowel disease | Proteins | Respiratory distress syndrome | Asthma | Steroids
Journal Article
Circulation, ISSN 0009-7322, 03/2014, Volume 129, Issue 10, pp. 1139 - 1151
Journal Article
Nature Communications, ISSN 2041-1723, 06/2015, Volume 6, Issue 1, p. 7320
Journal Article
Molecular Nutrition & Food Research, ISSN 1613-4125, 07/2011, Volume 55, Issue 7, pp. 999 - 1009
Scope: Sulforaphane (SFN) is an isothiocyanate derived from cruciferous vegetables such as broccoli. The ability of SFN to inhibit histone deacetylase (HDAC)... 
Epigenetics | Isothiocyanate | Prostate cancer | Chemoprevention | Apoptosis | LNCAP | MECHANISM | SUBEROYLANILIDE HYDROXAMIC ACID | ACETYLATION | FOOD SCIENCE & TECHNOLOGY | THERAPY | PATHWAY | GROWTH | INHIBITORS | VEGETABLES | EXPRESSION | Thiocyanates - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - drug effects | Apoptosis - drug effects | Epithelial Cells - drug effects | Humans | Cytosol - drug effects | Male | NAD(P)H Dehydrogenase (Quinone) - genetics | Promoter Regions, Genetic - drug effects | Tubulin - drug effects | Prostate - pathology | Tubulin - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Prostate - drug effects | Thiocyanates - pharmacology | Hyperplasia - drug therapy | Anticarcinogenic Agents - pharmacology | Isothiocyanates | Prostatic Neoplasms - drug therapy | Cell Line | Prostatic Neoplasms - pathology | Histone Deacetylase 6 | Epithelial Cells - pathology | Histone Deacetylases - metabolism | Hyperplasia - pathology | Acetylation - drug effects | NAD(P)H Dehydrogenase (Quinone) - drug effects | Prostate - cytology | Cell Line, Tumor | Cytosol - metabolism | Histone Deacetylase Inhibitors - pharmacology | Histone Deacetylases - drug effects | Histone Deacetylase 2 - metabolism | Histones - metabolism | Cell Cycle - drug effects | apoptosis | isothiocyanate | prostate cancer | chemoprevention | epigenetics
Journal Article
Circulation Research, ISSN 0009-7330, 03/2012, Volume 110, Issue 5, pp. 739 - 748
Journal Article
Journal Article