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Cell Host & Microbe, ISSN 1931-3128, 04/2013, Volume 13, Issue 4, pp. 395 - 405
Histone posttranslational modifications control eukaryotic gene expression and regulate many biological processes including immunity. Pathogens alter host... 
COMPLEX | METHYLATION | PROTEIN | METHYLTRANSFERASE | VIROLOGY | ACETYLATION | STRATEGY | TARGETS | MICROBIOLOGY | HISTONE MODIFICATIONS | VIRULENCE | PARASITOLOGY | Gene Expression - genetics | Humans | Immunity, Innate - genetics | Molecular Sequence Data | Legionella pneumophila - genetics | Promoter Regions, Genetic - genetics | Chromatin - immunology | Gene Expression - immunology | Bacterial Proteins - immunology | Nuclear Proteins - genetics | Amino Acid Sequence | Cell Line | Legionella pneumophila - immunology | Histones - immunology | Bacterial Proteins - genetics | Nuclear Proteins - immunology | Immunity, Innate - immunology | Sequence Alignment | Histones - genetics | DNA Replication - immunology | DNA Replication - genetics | Transcription, Genetic - immunology | Promoter Regions, Genetic - immunology | Transcription, Genetic - genetics | Methylation | Chromatin - genetics | Chromatin | Analysis | Genes | Transferases | Histones | Legionella pneumophila | Bacterial genetics | Gene expression | Bacterial Proteins/immunology | Nuclear Proteins/immunology | Promoter Regions, Genetic/genetics | DNA Replication/genetics | Cellular Biology | Chromatin/immunology | Legionella pneumophila/genetics | Life Sciences | DNA Replication/immunology | Transcription, Genetic/genetics | Transcription, Genetic/immunology | Nuclear Proteins/genetics | Immunity, Innate/immunology | Promoter Regions, Genetic/immunology | Immunity, Innate/genetics | Histones/immunology | Bacterial Proteins/genetics | Legionella pneumophila/immunology | Chromatin/genetics | Gene Expression/immunology | Histones/genetics | Gene Expression/genetics
Journal Article
Arthritis & Rheumatology, ISSN 2326-5191, 12/2015, Volume 67, Issue 12, pp. 3234 - 3244
Objective. To determine the relationships between systemic sclerosis (SSc)-related autoantibodies, as well as their clinical associations, in a... 
ANTIBODIES | ANTRAL VASCULAR ECTASIA | SUBSETS | CLASSIFICATION | PREVALENCE | RHEUMATOLOGY | JAPANESE PATIENTS | FRENCH | RNA-POLYMERASE-III | CLINICAL-SIGNIFICANCE | FEATURES | Receptors, Platelet-Derived Growth Factor - immunology | Gastric Antral Vascular Ectasia - immunology | Humans | Middle Aged | Centromere Protein B - immunology | Immunoblotting | Male | Raynaud Disease - etiology | DNA Topoisomerases, Type I - immunology | Esophageal Motility Disorders - etiology | Centromere Protein A | Scleroderma, Systemic - complications | Ribonucleoproteins - immunology | Female | Contracture - immunology | Gastric Antral Vascular Ectasia - etiology | Telangiectasis - immunology | Principal Component Analysis | DNA-Binding Proteins - immunology | Exoribonucleases - immunology | RNA-Binding Proteins - immunology | Scleroderma, Systemic - immunology | RNA Polymerase III - immunology | Scleroderma, Systemic - epidemiology | Chromosomal Proteins, Non-Histone - immunology | Autoantibodies - immunology | Ku Autoantigen | Telangiectasis - etiology | Smoking - epidemiology | Autoantigens - immunology | Sex Factors | Aged | Exosome Multienzyme Ribonuclease Complex - immunology | Pol1 Transcription Initiation Complex Proteins - immunology | Raynaud Disease - immunology | Australia | Esophageal Motility Disorders - immunology | Antigens, Nuclear - immunology | Neoplasms - epidemiology | Cohort Studies | Contracture - etiology | Principal components analysis | RNA polymerase | Autoimmune diseases | Patients
Journal Article
Nature Reviews Rheumatology, ISSN 1759-4790, 12/2016, Volume 12, Issue 12, pp. 716 - 730
Journal Article
Arthritis Research and Therapy, ISSN 1478-6354, 06/2014, Volume 16, Issue 3, pp. R122 - R122
Introduction: Neutrophil extracellular traps (NETs) have recently been implicated in a number of autoimmune conditions, including rheumatoid arthritis (RA). We... 
AUTOANTIBODIES | NETOSIS | CITRULLINATION | THROMBOSIS | DEATH | MECHANISMS | INDUCTION | RHEUMATOLOGY | HISTONES | CELL-FREE DNA | INNATE IMMUNITY | Immunohistochemistry | Leukocyte Elastase - metabolism | Hydrolases - genetics | Reactive Oxygen Species - metabolism | Arthritis, Rheumatoid - blood | Extracellular Traps - metabolism | Extracellular Traps - genetics | Humans | Middle Aged | Citrulline - metabolism | Neutrophils - ultrastructure | Male | Signal Transduction - immunology | Extracellular Traps - immunology | Reactive Oxygen Species - immunology | Female | Arthritis, Rheumatoid - diagnosis | Neutrophils - metabolism | Hydrolases - metabolism | Microscopy, Electron, Scanning | Peroxidase - immunology | DNA - immunology | Histones - immunology | Cells, Cultured | Neutrophils - immunology | Nucleosomes - metabolism | Peptides, Cyclic - immunology | DNA - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Synovial Fluid - immunology | Autoantibodies - immunology | Hydrolases - immunology | Histones - metabolism | Arthritis, Rheumatoid - immunology | Leukocyte Elastase - immunology | Nucleosomes - immunology | Microscopy, Fluorescence | Protein-Arginine Deiminases | Peroxidase - metabolism | Photographic industry | Product enhancement | Immunoglobulin G | Enzyme-linked immunosorbent assay
Journal Article
Blood, ISSN 0006-4971, 04/2017, Volume 129, Issue 17, pp. 2420 - 2428
The endoplasmic reticulum kinase inositol-requiring enzyme 1 (IRE1) and its downstream target X-box-binding protein 1 (XBP1) drive B-cell differentiation... 
GERMINAL CENTER FORMATION | MULTIPLE-MYELOMA | B-CELL LYMPHOMA | UNFOLDED-PROTEIN RESPONSE | TRANSCRIPTION FACTOR XBP-1 | CERVICAL-CANCER | ENDOPLASMIC-RETICULUM STRESS | BIVALENT PROMOTERS | DIFFERENTIATION | HEMATOLOGY | METHYLTRANSFERASE EZH2 | Enhancer of Zeste Homolog 2 Protein - antagonists & inhibitors | RNA, Messenger - immunology | Endoribonucleases - genetics | Cell Proliferation | Epigenesis, Genetic | Germinal Center - immunology | Humans | Gene Expression Regulation, Neoplastic | X-Box Binding Protein 1 - antagonists & inhibitors | Endoribonucleases - antagonists & inhibitors | Mice, 129 Strain | Plasma Cells - pathology | Lymphoma, Large B-Cell, Diffuse - therapy | RNA, Messenger - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Lymphoma, Large B-Cell, Diffuse - immunology | Cell Differentiation | B-Lymphocytes - pathology | Promoter Regions, Genetic | Enhancer of Zeste Homolog 2 Protein - genetics | X-Box Binding Protein 1 - immunology | Histones - immunology | Lymphoma, Large B-Cell, Diffuse - pathology | Signal Transduction | RNA, Messenger - genetics | Protein-Serine-Threonine Kinases - genetics | Germinal Center - pathology | Indazoles - pharmacology | Xenograft Model Antitumor Assays | Leupeptins - pharmacology | Animals | B-Lymphocytes - immunology | Histones - genetics | Enhancer of Zeste Homolog 2 Protein - immunology | Cell Line, Tumor | Protein-Serine-Threonine Kinases - immunology | Mice | Lymphoma, Large B-Cell, Diffuse - genetics | X-Box Binding Protein 1 - genetics | Pyridones - pharmacology | Endoribonucleases - immunology | Plasma Cells - immunology
Journal Article
Nature Immunology, ISSN 1529-2908, 06/2017, Volume 18, Issue 7, pp. 800 - 812
An imbalance in the lineages of immunosuppressive regulatory T cells (T cells) and the inflammatory T 17 subset of helper T cells leads to the development of... 
Forkhead Transcription Factors - immunology | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Sjogren's Syndrome - immunology | Immunoblotting | Intracellular Signaling Peptides and Proteins - immunology | Case-Control Studies | T-Lymphocytes, Regulatory - immunology | DNA-Binding Proteins - metabolism | Flow Cytometry | Chromatin Immunoprecipitation | Forkhead Transcription Factors - metabolism | Histone Acetyltransferases - metabolism | Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism | HEK293 Cells | Adaptor Proteins, Signal Transducing - immunology | Acetylation | Colitis - immunology | Lysine Acetyltransferase 5 | Transcription Factors - immunology | Real-Time Polymerase Chain Reaction | STAT3 Transcription Factor - metabolism | Cytokines - immunology | Nuclear Receptor Subfamily 1, Group F, Member 3 - immunology | DNA-Binding Proteins - immunology | Smad Proteins - immunology | Mice, Transgenic | Mice, Knockout | Transcription Factors - metabolism | Cell Differentiation - immunology | Microscopy, Confocal | Animals | Adaptor Proteins, Signal Transducing - genetics | Th17 Cells - immunology | Trans-Activators - metabolism | Mice | HeLa Cells | Proteasome Endopeptidase Complex - metabolism | STAT3 Transcription Factor - immunology | Arthritis, Rheumatoid - immunology | Smad Proteins - metabolism | Microscopy, Fluorescence
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2013, Volume 288, Issue 23, pp. 16225 - 16234
Sepsis-associated immunosuppression (SAIS) is regarded as one of main causes for the death of septic patients at the late stage because of the decreased innate... 
IFN-BETA | CELLS | ACTIVATION | PROTEIN | NEGATIVE REGULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | DEGRADATION | SEPSIS | TRIGGERED INFLAMMATORY RESPONSES | INNATE IMMUNITY | Interferon-beta - immunology | Humans | Tumor Necrosis Factor-alpha - genetics | Intracellular Signaling Peptides and Proteins - immunology | Male | Monocytes - immunology | Lipopolysaccharides - immunology | Gene Knockdown Techniques | Ubiquitin-Protein Ligases - immunology | Sepsis - pathology | Reactive Oxygen Species - immunology | Monocytes - pathology | Tumor Necrosis Factor-alpha - immunology | Interferon-beta - genetics | Female | Tumor Necrosis Factor alpha-Induced Protein 3 | Hydro-Lyases - genetics | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Macrophages - immunology | Immune Tolerance - drug effects | Cysteine Endopeptidases | Sepsis - immunology | DNA-Binding Proteins - immunology | Lipopolysaccharides - toxicity | Histones - immunology | Immunity, Innate - drug effects | Interleukin-6 - genetics | Macrophages - pathology | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | DNA-Binding Proteins - genetics | Nuclear Proteins - immunology | Proteins - immunology | Sepsis - genetics | Gene Expression Regulation - drug effects | Proteins - genetics | Animals | Histones - genetics | Interleukin-6 - immunology | Mice | Ubiquitin-Protein Ligases - genetics | Hydro-Lyases - immunology | Toll-like Receptors (TLR) | Immunology | Reactive Oxygen Species (ROS) | Innate Immunity | Endotoxin Tolerance | ROS | Inflammation | Macrophages | A20 | Immune Responsive Gene 1
Journal Article
Immunity, ISSN 1074-7613, 05/2014, Volume 40, Issue 5, pp. 772 - 784
Journal Article
Nature immunology, ISSN 1529-2908, 05/2016, Volume 17, Issue 5, pp. 505 - 513
The effect of alterations in intestinal microbiota on microbial metabolites and on disease processes such as graft-versus-host disease (GVHD) is not known.... 
Butyrates - metabolism | Epithelial Cells - metabolism | Gas Chromatography-Mass Spectrometry | Butyrates - pharmacology | Histone Acetyltransferases - genetics | Immunoblotting | Gastrointestinal Microbiome - physiology | Histone Deacetylases - immunology | Bone Marrow Transplantation - methods | Graft vs Host Disease - immunology | Graft vs Host Disease - microbiology | Fatty Acids, Volatile - metabolism | Intestines - immunology | Transplantation, Homologous | Fatty Acids, Volatile - immunology | T-Lymphocytes - metabolism | Butyrates - immunology | Histone Acetyltransferases - metabolism | Gene Expression - immunology | Female | Graft vs Host Disease - etiology | Histone Deacetylases - genetics | Histones - immunology | Mice, Inbred C57BL | Cells, Cultured | Histone Deacetylases - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Acetylation - drug effects | Animals | Intestines - microbiology | Epithelial Cells - immunology | Epithelial Cells - microbiology | Bone Marrow Transplantation - adverse effects | Metabolome - immunology | Histone Acetyltransferases - immunology | T-Lymphocytes - immunology | Mice, Inbred BALB C | Gastrointestinal Microbiome - immunology | Histones - metabolism | Intestines - cytology | Microbiota (Symbiotic organisms) | Graft versus host reaction | Development and progression | Genetic aspects | Properties | Health aspects | Fatty acids
Journal Article
Blood, ISSN 0006-4971, 2009, Volume 114, Issue 15, pp. 3244 - 3254
Journal Article