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histrionicotoxin (45) 45
chemistry, organic (35) 35
alkaloids (28) 28
-histrionicotoxin (21) 21
animals (20) 20
histrionicotoxins (18) 18
-perhydrohistrionicotoxin (15) 15
chemistry, multidisciplinary (15) 15
perhydrohistrionicotoxin (15) 15
acetylcholine (13) 13
derivatives (11) 11
amphibian venoms - chemical synthesis (10) 10
alkaloids - chemistry (8) 8
amphibian venoms - chemistry (8) 8
formal synthesis (8) 8
indolizidines (8) 8
molecular structure (8) 8
index medicus (7) 7
pharmacology & pharmacy (7) 7
piperidines (7) 7
stereoisomerism (7) 7
1,3-dipolar cycloaddition (6) 6
alkaloids - chemical synthesis (6) 6
asymmetric-synthesis (6) 6
biochemistry & molecular biology (6) 6
chemistry (6) 6
analogs (5) 5
cyclic nitrones (5) 5
histrionicotoxin family (5) 5
ions (5) 5
muscle (5) 5
ring-system (5) 5
spiro compounds (5) 5
stereoselective-synthesis (5) 5
synthesis (5) 5
torpedo (5) 5
2-directional synthesis (4) 4
alcohols (4) 4
amphibian venoms - pharmacology (4) 4
anura (4) 4
chemical synthesis (4) 4
chemistry, medicinal (4) 4
dipolar cycloaddition routes (4) 4
in vitro techniques (4) 4
ion channels - drug effects (4) 4
ketones (4) 4
male (4) 4
nitrones (4) 4
paper (4) 4
phencyclidine (4) 4
receptor (4) 4
receptors, nicotinic - metabolism (4) 4
research (4) 4
route (4) 4
skin alkaloids (4) 4
system (4) 4
acetylcholine-receptor (3) 3
acyclic aldehydes (3) 3
alkaloid (3) 3
alkenyl oximes (3) 3
amphibian skin (3) 3
amphibian venoms - metabolism (3) 3
asymmetric synthesis (3) 3
binding (3) 3
carbonyl-compounds (3) 3
chemical properties (3) 3
classification (3) 3
cycloaddition (3) 3
dendrobatidae (3) 3
desensitization (3) 3
dipolar cycloaddition (3) 3
domino reactions (3) 3
frog (3) 3
ion channel (3) 3
ion channels - metabolism (3) 3
letter (3) 3
membrane potential (3) 3
membrane potentials - drug effects (3) 3
mice (3) 3
nicotinic antagonists (3) 3
nitriles (3) 3
organic compounds (3) 3
organic-synthesis (3) 3
organopalladium route (3) 3
pyrrolizidines (3) 3
ray-analysis (3) 3
rearrangement (3) 3
ring-closing metathesis (3) 3
skin - chemistry (3) 3
total synthesis (3) 3
toxins (3) 3
1,2 chrirality transfer (2) 2
1-azaspiro<5.5>undecanes (2) 2
235a (2) 2
acetals (2) 2
acetylcholine - metabolism (2) 2
acetylcholine receptors (2) 2
acetylcholine-receptor-channel (2) 2
acid (2) 2
alkaloids - pharmacology (2) 2
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RSC ADVANCES, ISSN 2046-2069, 2018, Volume 8, Issue 21, pp. 11296 - 11303
The efficient formal total synthesis of histrionicotoxin alkaloids was achieved. In this process, two key reactions were used to construct a core... 
ALCOHOLS | REDUCTION | 235A | CHEMISTRY, MULTIDISCIPLINARY | (-)-HISTRIONICOTOXIN
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 08/2017, Volume 82, Issue 16, pp. 8725 - 8732
The development of an efficient, high yielding six-step convergent synthesis of the semisynthetic alkaloid (−)-perhydrohistrionicotoxin is described. The key... 
REARRANGEMENT | TANDEM CATALYSIS | RING-CLOSING METATHESIS | HISTRIONICOTOXIN FAMILY | PERHYDROHISTRIONICOTOXIN | CHEMISTRY, ORGANIC | HIGHLY EFFICIENT SYNTHESIS | ASYMMETRIC HYDROGENATION | (-)-HISTRIONICOTOXIN | AMINO-ACID-DERIVATIVES | ALKALOIDS
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 02/2019, Volume 2019, Issue 6, pp. 1215 - 1224
The formal synthesis of (–)‐PHTX is described. Our approach was based on the anodic cyanation of (S)‐1‐(1‐phenylethyl)‐piperidine (–)‐1 to afford... 
Alkaloids | Nitrogen heterocycles | Asymmetric synthesis | Spiro compounds | Alkylation | HISTRIONICOTOXIN ALKALOIDS | ASYMMETRIC-SYNTHESIS | CROSS-COUPLING REACTION | CHEMISTRY, ORGANIC | (-)-HISTRIONICOTOXIN | KETONES | PERHYDROHISTRIONICOTOXIN | STEREOSELECTIVE-SYNTHESIS | Organic chemistry | Chemical Sciences
Journal Article
Tetrahedron, ISSN 0040-4020, 03/2018, Volume 74, Issue 12, pp. 1245 - 1252
Four histrionicotoxin analogues were prepared in an efficient manner utilizing a nitrone dipolar cycloaddition reaction as the key step in forming tricyclic... 
1,3-Dipolar cycloaddition | Antagonist | Histrionicotoxin | Poison arrow frog toxin | Nicotinic acetylcholine receptor
Journal Article
TETRAHEDRON, ISSN 0040-4020, 03/2018, Volume 74, Issue 12, pp. 1245 - 1252
Four histrionicotoxin analogues were prepared in an efficient manner utilizing a nitrone dipolar cycloaddition reaction as the key step in forming tricyclic... 
1,3-Dipolar cycloaddition | PERHYDROHISTRIONICOTOXIN | Histrionicotoxin | Poison arrow frog toxin | Nicotinic acetylcholine receptor | CHEMISTRY, ORGANIC | Antagonist | ION CHANNELS | DERIVATIVES
Journal Article
Tetrahedron, ISSN 0040-4020, 2010, Volume 66, Issue 33, pp. 6445 - 6449
A domino cyclization reaction of the bis-unsaturated ketone with hydroxylamine proceeds with good yield and high stereoselectivity, in a flow reactor system.... 
1,3-Dipolar cycloaddition | Domino reactions | Spiropiperidines | Olefination reactions | Flow chemistry | ORGANIC-SYNTHESIS | REACTORS | CHEMISTRY | CHEMISTRY, ORGANIC | 2-DIRECTIONAL SYNTHESIS | (-)-HISTRIONICOTOXIN | MULTISTEP SYNTHESIS | Alkaloids | Hydroxides
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2004, Volume 45, Issue 22, pp. 4229 - 4231
The asymmetric synthesis of the (+)-Kishi lactam and an intermediate for the preparation of the marine natural product fasicularin is reported. The keystone of... 
Dearomatization | Fasicularin | Histrionicotoxin | Nitrenium ions | Polyvalent iodine | (-)-PERHYDROHISTRIONICOTOXIN | ROUTE | polyvalent iodine | fasicularin | FORMAL SYNTHESIS | nitrenium ions | dearomatization | CHEMISTRY, ORGANIC | histrionicotoxin | (-)-HISTRIONICOTOXIN | (+/-)-FASICULARIN | CYCLOADDITION | 235A | ALKALOIDS
Journal Article
Organic Letters, ISSN 1523-7060, 08/2011, Volume 13, Issue 16, pp. 4446 - 4449
A total synthesis of (−)-histrionicotoxin was achieved. Our synthesis features preparation of a pseudosymmetrical dienyne through chirality transfer from an... 
ANIONIC REARRANGEMENTS | KETONES | ASYMMETRIC TRANSFER HYDROGENATION | HOMOPROPARGYLIC ALCOHOLS | ENYNE METATHESIS | RING-CLOSING METATHESIS | HISTRIONICOTOXIN FAMILY | ALLENYLSILANES | CHEMISTRY, ORGANIC | CARBONYL-COMPOUNDS | ALDEHYDES | Amphibian Venoms - chemical synthesis | Stereoisomerism | Molecular Structure
Journal Article
Synthesis, ISSN 0039-7881, 11/2013, Volume 45, Issue 22, pp. 3118 - 3124
Abstract A concise synthesis of spiropyrrolidines and spiropiperidines has been developed. The approach employs a ruthenium–­alkylidene-catalysed... 
paper | VCAM-1 INDUCTION | ACID | piperidines | CHEMISTRY, ORGANIC | catalysis | spiro compounds | HISTRIONICOTOXIN | TRICYCLIC MARINE ALKALOIDS | metathesis | HALICHLORINE | pyrrolidines | (+/-)-CYLINDRICINES | ring expansion | DIELS-ALDER REACTION | INHIBITOR | ASCIDIAN CLAVELINA-CYLINDRICA | LEPADIFORMINE
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2011, Volume 52, Issue 17, pp. 2181 - 2184
Intramolecular 1,3-dipolar cycloadditions of two -alkenylnitrones are studied by means of density functional theory calculations. Cycloaddition of an acyclic... 
Transition states | 1,3-Dipolar cycloaddition | Density functional calculations | Ring strain | Nitrone | ACID | CHEMISTRY, ORGANIC | INDOLIZIDINES | (-)-HISTRIONICOTOXIN | DENSITY FUNCTIONALS | CYCLIZATIONS | REGIOCHEMISTRY | DISTORTION/INTERACTION | PIPERIDINES | ALKALOIDS | Cycloaddition | Mathematical analysis | Boats | Tetrahedrons | Distortion | Density functional theory | Entropy | Strain
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 01/2017, Volume 56, Issue 4, pp. 1087 - 1091
Stereoselective total syntheses of (−)‐histrionicotoxin and (−)‐histrionicotoxin 235A are described. The 1‐azaspiro[5.5]undecane skeleton was constructed... 
radical cyclization | diastereoselectivity | total synthesis | spiro compounds | alkaloids | (-)-PERHYDROHISTRIONICOTOXIN | REAGENTS | ANALOGS | CHEMISTRY, MULTIDISCIPLINARY | RATE CONSTANTS | HISTRIONICOTOXINS | EFFICIENT | CHLORIDE | Silane | Synthesis | Organic compounds | Translocation | Stereoselectivity | Alkenes | Amides | Chemical reactions | Allyl compounds | Chemical synthesis | Alcohols
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 10/2006, Volume 128, Issue 39, pp. 12656 - 12657
The synthesis of (±)-histrionicotoxin has been achieved in just nine steps using a two-directional synthesis strategy. Key reactions include a two-directional... 
CHANNEL | ANALOGS | NICOTINIC ACETYLCHOLINE-RECEPTOR | MUSCLE | REGULATORY SITE | 2-DIRECTIONAL SYNTHESIS | CLEAVAGE | CHEMISTRY, MULTIDISCIPLINARY | (-)-HISTRIONICOTOXIN | Anura | Amphibian Venoms - chemistry | Alkynes - chemistry | Animals | Amphibian Venoms - chemical synthesis | Stereoisomerism | Chemical synthesis | Toxins | Chemical properties
Journal Article
ORGANIC & BIOMOLECULAR CHEMISTRY, ISSN 1477-0520, 2004, Volume 2, Issue 8, pp. 1258 - 1265
The sequential intramolecular conjugate addition of the oxime 13 followed by intramolecular dipolar cycloaddition of the intermediate nitrone 14 affords a... 
CYCLIC NITRONES | X=Y-ZH SYSTEMS | ALKENYL OXIMES | AMPHIBIAN SKIN | MUSCLE | CHEMISTRY, ORGANIC | RECEPTOR | 2-DIRECTIONAL SYNTHESIS | POTENTIAL 1,3-DIPOLES | (-)-HISTRIONICOTOXIN | HISTRIONICOTOXIN
Journal Article
Journal Article
Heterocycles, ISSN 0385-5414, 12/2011, Volume 84, Issue 1, pp. 597 - 613
Heating alpha-benzenesulfonyl- or alpha-phenylthio-aldehydes that contain a tethered alkyl chloride and alkene originating from the alpha- position of the... 
MYRIONEURON-NUTANS | AZOMETHINE YLIDES | CHEMISTRY, ORGANIC | Myrioxazine A | RING-SYSTEM | HISTRIONICOTOXIN | Stereoselective Reaction | Tandem Reaction | MYRIOXAZINE | Intramolecular Cycloaddition | AMINES | ACYCLIC ALDEHYDES | MANZAMINE-A | ALKALOIDS
Journal Article