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FASEB Journal, ISSN 0892-6638, 07/2004, Volume 18, Issue 10, pp. 1080 - 1089
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 02/2018, Volume 115, pp. 202 - 218
KRIT1 (CCM1) is a disease gene responsible for Cerebral Cavernous Malformations (CCM), a major cerebrovascular disease of proven genetic origin affecting... 
Oxidative stress | Heme oxygenase-1 (HO-1) | Argpyrimidine-modified heat-shock proteins | Redox signaling | Cerebral Cavernous Malformations | Antioxidant defense | Glyoxalase 1 (Glo1) | c-Jun | Oxidative DNA damage and apoptosis | Nuclear factor erythroid 2-related factor 2 (Nrf2) | Adaptive redox homeostasis | CCM1/KRIT1 | Cerebrovascular disease | GLYCATION END-PRODUCT | GLYOXALASE I | METHYLGLYOXAL MODIFICATION | ARGPYRIMIDINE-MODIFIED HSP70 | ENDOCRINOLOGY & METABOLISM | NF-KAPPA-B | AORTIC ENDOTHELIAL-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CRYSTALLINE SILICA | DEFENSE PATHWAY | SIGNALING PATHWAY | VASCULAR INTEGRITY | Humans | Homeostasis | Hemangioma, Cavernous, Central Nervous System - genetics | Hemangioma, Cavernous, Central Nervous System - metabolism | Pyruvaldehyde - metabolism | Autophagy - genetics | Endothelial Cells - physiology | Central Nervous System Neoplasms - metabolism | Oxidation-Reduction | Lactoylglutathione Lyase - metabolism | Central Nervous System Neoplasms - genetics | KRIT1 Protein - metabolism | Cells, Cultured | Oxidative Stress - genetics | KRIT1 Protein - genetics | Mutation - genetics | HSP70 Heat-Shock Proteins - metabolism | Mice, Knockout | Animals | NF-E2-Related Factor 2 - metabolism | Brain - pathology | HSP27 Heat-Shock Proteins - metabolism | Mice | Protein Processing, Post-Translational | Apoptosis | Antioxidants | Proteins | Brain | Heme | Heat shock proteins | PTM, post-translational modification | hBMEC, human brain microvascular endothelial cells | Casp-3, Caspase-3 | COX-2, cycloxygenase-2 | BBB, blood-brain barrier | NVU, neurovascular unit | Cyt c, cytochrome c | ICH, intracerebral hemorrhage | MG, methylglyoxal | HO-1, Heme oxygenase-1 | CCM, Cerebral Cavernous Malformation | AP, argpyrimidine (Nẟ-(5-hydroxy-4,6-dimethylpyrimidine-2-yl)-l-ornithine) | Glo1, Glyoxalase 1 | ARE, antioxidant-response element | KRIT1 | ROS, reactive oxygen species | KRIT1, Krev interaction trapped 1 | AGEs, advanced glycation end-products | TUNEL, TdT-mediated dUTP nick-end labeling | EndMT, endothelial-to-mesenchymal transition | Nrf2, nuclear factor erythroid 2-related factor 2 | Keap1, Kelch-like ECH-associated protein 1 | SOD, superoxide dismutase | Hsp, heat-shock protein | CNS, central nervous system | JNK, c-Jun NH2-terminal kinase | MEF, mouse embryonic fibroblast | CCM1
Journal Article
by Chen, ZM and Zhong, H and Wei, JS and Lin, SE and Zong, ZX and Gong, F and Huang, XQ and Sun, JH and Li, P and Lin, H and Wei, B and Chu, JQ
ARTHRITIS RESEARCH & THERAPY, ISSN 1478-6354, 12/2019, Volume 21, Issue 1, pp. 300 - 13
Introduction: Osteoarthritis (OA) is an inflammatory disease of the joints that causes progressive disability in the elderly. Reactive oxygen species (ROS)... 
Synovitis | OXIDATIVE STRESS | MECHANISM | ROS | Nrf2/HO-1 signaling | NLRP3 | DEGRADATION | MEDIATORS | RHEUMATOLOGY | Osteoarthritis | EXPRESSION | Proteins | Medical research | Researchers | Cytokines | Surgery | Arthritis | Joint surgery | Gene expression | Laboratory animals | HO-1 signaling | Nrf2
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2015, Volume 88, Issue Pt B, pp. 417 - 426
In light of the emerging interplay between redox and metabolic signaling pathways we investigated the potential cross talk between nuclear factor E2-related... 
Xanthohumol | Nrf2 | ER stress | AMPK | HO-1 | PERK | LKB1 | MEF | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | MECHANISMS | ENERGY SENSOR | CELL DEFENSE PATHWAY | ENDOTHELIAL-CELLS | ENDOCRINOLOGY & METABOLISM | NRF2-MEDIATED INDUCTION | HEME OXYGENASE-1 | STRESS | AMP-Activated Protein Kinases - metabolism | Heme Oxygenase-1 - metabolism | Reactive Oxygen Species - metabolism | Oxidation-Reduction | Oxidative Stress - physiology | Propiophenones - pharmacology | Mitochondria - metabolism | Mitochondria - drug effects | Receptor Cross-Talk - physiology | Blotting, Western | Animals | Flow Cytometry | Fibroblasts - drug effects | NF-E2-Related Factor 2 - metabolism | Signal Transduction - physiology | Flavonoids - pharmacology | Membrane Proteins - metabolism | Mice | Real-Time Polymerase Chain Reaction | Unfolded Protein Response - physiology | Fibroblasts - metabolism | RNA | Glycogen | Synthesis | ACC, acetyl-CoA carboxylase | CHO, Chinese hamster ovary | GSH, glutathione (reduced) | OCR, oxygen consumption rate | HO-1, heme oxygenase 1 | CaMKK, calcium calmodulin-dependent kinase kinase | Maf, small musculoaponeurotic fibrosarcoma | PERK, protein kinase RNA-like endoplasmic reticulum kinase | Xn, xanthohumol | Hrd1, synoviolin | TAK, transforming growth factor β-activated kinase | UPR, unfolded protein response | Hrd1 (HMG-CoA reductase degradation)-ubiquitin ligase | MEF, mouse embryonic fibroblasts | βTrcP1, β-transducin-repeat containing protein 1 | mTOR, mammalian target of rapamycin | ROS, reactive oxygen species | LKB1, liver kinase B1 | Keap1, Kelch-like ECH-associated protein | GSSG, oxidized glutathione | ARE, antioxidant response element | WT, wild type | GSK3β, glycogen synthase kinase 3β | Nrf2, nuclear factor E2-related factor 2 | AMPK, AMP-activated kinase | DCF, dichlorofluorescein | NADPH, nicotinamide adenine dinucleotide phosphate | DMSO, dimethyl sulfoxide | ER, endoplasmic reticulum | FCS, fetal calf serum
Journal Article
International Journal of Hyperthermia, ISSN 0265-6736, 12/2018, Volume 35, Issue 1, pp. 112 - 121
Purpose: Intestinal epithelial barrier dysfunction is crucial in the pathogenesis of intestinal and systemic diseases. Ferulic acid (FA) possesses promising... 
intestinal epithelial barrier | Nrf2/HO-1 signaling | heat stress | oxidative stress | Ferulic acid | INDUCED INJURY | ACTIVATION | PERMEABILITY | HO-1 | ONCOLOGY | INFLAMMATION | TIGHT JUNCTION PROTEINS | HEME OXYGENASE-1 | UP-REGULATION | PUNICALAGIN | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Journal Article
by Gao, K and Liu, MY and Ding, Y and Yao, MN and Zhu, YR and Zhao, JY and Cheng, LH and Bai, J and Wang, F and Cao, JY and Li, JK and Tang, HF and Jia, YY and Wen, AD
AGING-US, ISSN 1945-4589, 12/2019, Volume 11, Issue 24, pp. 12361 - 12374
Lyciumamide A (LyA), a dimer of phenolic amide isolated from the fruits of Lycium barbarum, has been confirmed to possess potent antioxidant activity. This... 
Lyciumamide A | Nrf2 | PKC epsilon | TARGETS | HO-1 | ischemic stroke | oxidative stress | CELL BIOLOGY | GERIATRICS & GERONTOLOGY
Journal Article
by Shi, Y and Zhang, YZ and Li, Y and Tong, CJ
RSC ADVANCES, ISSN 2046-2069, 06/2019, Volume 9, Issue 30, pp. 17065 - 17071
Diabetic retinopathy (DR) is a common complication of diabetes mellitus and results in acquired blindness among working-age adults. It has been demonstrated... 
PATHOGENESIS | NRF2/HO-1 | PATHWAY | CARCINOMA | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 10/2011, Volume 44, Issue 2, pp. 192 - 201
In recent years, there has been a growing interest, supported by a large number of experimental and epidemiological studies, for the beneficial effects of some... 
Neurosciences | Heterodimers of NF-E2-related factors 2 (Nrf2) | Alzheimer’s disease | (-)- epigallocatechin-3- gallate (EGCG) | Neurobiology | Heme oxygenase 1 (HO-1) | Neurodegenerative disorders | Cell Biology | Neurology | Biomedicine | Polyphenols | Curcumin | Antioxidant responsive element (ARE) | Brain ageing | Alzheimer's disease | OXIDATIVE STRESS | ALZHEIMERS-DISEASE | ACID PHENETHYL ESTER | NEUROSCIENCES | (-)- epigallocatechin-3-gallate (EGCG) | FERULIC ACID | MOUSE MODEL | CARBON-MONOXIDE SUPPRESS | HEME OXYGENASE-1 | NF-KAPPA-B | TRANSCRIPTION FACTOR | GREEN TEA POLYPHENOL | Neurodegenerative Diseases - diet therapy | Neuroprotective Agents - therapeutic use | Heme Oxygenase-1 - metabolism | Antioxidants - chemistry | Curcumin - chemistry | Humans | Polyphenols - pharmacology | Heme Oxygenase-1 - genetics | Neuroprotective Agents - pharmacology | Catechin - therapeutic use | NF-E2-Related Factor 2 - genetics | Molecular Structure | Catechin - pharmacology | Food | Cognition Disorders - physiopathology | Neuroprotective Agents - chemistry | Curcumin - therapeutic use | Response Elements | Curcumin - pharmacology | Antioxidants - pharmacology | Antioxidants - therapeutic use | Animals | Neurodegenerative Diseases - physiopathology | Diet | NF-E2-Related Factor 2 - metabolism | Polyphenols - chemistry | Catechin - analogs & derivatives | Polyphenols - therapeutic use | Catechin - chemistry | Cognition Disorders - diet therapy | Antioxidants | Catechin | Nervous system diseases | Neurons | Cell death | Analysis | Genes | Heme | Genetic research | Green tea | Cognition & reasoning | Nutrition | Neurological disorders | Herbs | Neurodegenerative diseases | Astrocytes | Central nervous system | Cognitive ability | green tea | phenolic compounds | Data processing | Esters | Regulatory sequences | Caffeic acid | Transcription activation | Spices | Cancer
Journal Article
by Kwon, DH and Cha, HJ and Lee, H and Hong, SH and Park, C and Park, SH and Kim, GY and Kim, S and Kim, HS and Hwang, HJ and Choi, YH
ANTIOXIDANTS, ISSN 2076-3921, 04/2019, Volume 8, Issue 4, p. 82
Reactive oxygen species (ROS), products of oxidative stress, contribute to the initiation and progression of the pathogenesis of various diseases. Glutathione... 
CELLS | CHEMISTRY, MEDICINAL | glutathione | DNA damage | HO-1 EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOOD SCIENCE & TECHNOLOGY | apoptosis | HO-1 | MECHANISMS | CANCER | Nrf2 | ROS | RESISTANCE | MITOCHONDRIAL DYSFUNCTION | REDOX | HEME OXYGENASE-1 | oxidative stress | Nrf2/HO-1
Journal Article
Journal Article