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Cancer cell, ISSN 1535-6108, 01/2011, Volume 19, Issue 1, pp. 17 - 30
...). Hence, tumor-derived IDH1 and IDH2 mutations reduce α-KG and accumulate an α-KG antagonist, 2-HG, leading to genome-wide histone... 
Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Dioxygenases - metabolism | Histone Demethylases - antagonists & inhibitors | Gene Expression - genetics | Caenorhabditis elegans Proteins - chemistry | Humans | Ketoglutaric Acids - chemistry | Glioma - genetics | F-Box Proteins | Oxidoreductases, N-Demethylating - antagonists & inhibitors | Ketoglutaric Acids - pharmacology | Cytosine - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Glutarates - chemistry | Oxidoreductases, N-Demethylating - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Glioma - enzymology | Endostatins - metabolism | Models, Molecular | Isocitrate Dehydrogenase - genetics | Histone Demethylases - metabolism | Dioxygenases - antagonists & inhibitors | Amino Acid Substitution - physiology | Procollagen-Proline Dioxygenase - genetics | Cell Line, Tumor | Isocitrate Dehydrogenase - metabolism | Glutarates - pharmacology | Histones - metabolism | Jumonji Domain-Containing Histone Demethylases - metabolism | Caenorhabditis elegans - enzymology | Cytosine - analogs & derivatives | Gene Expression - drug effects | Caenorhabditis elegans Proteins - metabolism | Isocitrate Dehydrogenase - antagonists & inhibitors | Glioma - metabolism | Procollagen-Proline Dioxygenase - metabolism | DNA-Binding Proteins - metabolism | Mixed Function Oxygenases | Biocatalysis - drug effects | Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors | Jumonji Domain-Containing Histone Demethylases - chemistry | Procollagen-Proline Dioxygenase - antagonists & inhibitors | Ketoglutaric Acids - metabolism | Oxalates - pharmacology | Binding, Competitive | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Catalytic Domain | Proto-Oncogene Proteins - genetics | Hypoxia-Inducible Factor-Proline Dioxygenases | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Animals | 5-Methylcytosine - metabolism | Caenorhabditis elegans Proteins - antagonists & inhibitors | Glutarates - metabolism | Index Medicus
Journal Article
Journal of cell science, ISSN 0021-9533, 2013, Volume 126, Issue 17, pp. 3990 - 3999
.... Here, we use MCF10A cells, which fail to form tight junctions and express very little endogenous Crumbs3, to show that inducing expression of the polarity protein Scribble is sufficient to promote... 
Scribble | Polarity | Tight junctions | Mammary epithelium | EMT | ERK | Life Sciences & Biomedicine | Science & Technology | Cell Biology | MAP Kinase Signaling System - physiology | Phosphorylation | Epithelial-Mesenchymal Transition - physiology | Homeodomain Proteins - metabolism | Humans | Membrane Glycoproteins - biosynthesis | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Transcriptional Activation | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | RNA Interference | Mitogen-Activated Protein Kinase 1 - genetics | HEK293 Cells | Transcription, Genetic | Flavonoids - pharmacology | Membrane Proteins - metabolism | Chromones - pharmacology | Tight Junctions - metabolism | MAP Kinase Kinase 1 - antagonists & inhibitors | Tumor Suppressor Proteins - metabolism | Homeodomain Proteins - biosynthesis | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - genetics | Down-Regulation | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Morpholines - pharmacology | Transcription Factors - antagonists & inhibitors | Transcription Factors - biosynthesis | Anthracenes - pharmacology | Transcription Factors - metabolism | Membrane Proteins - biosynthesis | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Homeodomain Proteins - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Tumor Suppressor Proteins - biosynthesis | Mitogen-Activated Protein Kinase 1 - metabolism | Zinc Finger E-box-Binding Homeobox 1 | Index Medicus
Journal Article
Biochemical journal, ISSN 0264-6021, 02/2014, Volume 457, Issue 3, pp. 451 - 461
PKD (protein kinase D) is a serine/threonine kinase implicated in multiple cardiac roles, including the phosphorylation of the class II HDAC5... 
Histone deacetylase | Signal transduction | Four-and-a-half LIM (FHL) | Cardiac myocyte | Neurohormonal stimulation | Protein kinase | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Protein Kinase C - genetics | Heart Ventricles - cytology | Phosphorylation | Transcription Factors - chemistry | LIM-Homeodomain Proteins - metabolism | Humans | Intracellular Signaling Peptides and Proteins - metabolism | LIM-Homeodomain Proteins - antagonists & inhibitors | LIM Domain Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Isoenzymes - metabolism | Protein Kinase C - metabolism | Muscle Proteins - metabolism | Muscle Proteins - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - genetics | Peptide Fragments - genetics | LIM Domain Proteins - chemistry | Animals, Newborn | Peptide Fragments - metabolism | Myocytes, Cardiac - cytology | Endothelin-1 - metabolism | Isoenzymes - genetics | LIM-Homeodomain Proteins - chemistry | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | LIM Domain Proteins - antagonists & inhibitors | Cells, Cultured | Rats | Histone Deacetylases - metabolism | Transcription Factors - antagonists & inhibitors | Recombinant Fusion Proteins - chemistry | Transcription Factors - genetics | Muscle Proteins - genetics | Transcription Factors - metabolism | LIM-Homeodomain Proteins - genetics | Peptide Fragments - chemistry | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Peptide Fragments - antagonists & inhibitors | MEF2 Transcription Factors - metabolism | Myocytes, Cardiac - metabolism | LIM Domain Proteins - genetics | Heart Ventricles - metabolism | Mice | Muscle Proteins - chemistry | Protein Processing, Post-Translational | Enzyme Activation | Index Medicus | neurohormonal stimulation | FHL, four-and-a-half LIM domains | PKD, protein kinase D | MEF2, myocyte enhancer factor 2 | MuRF, muscle RING finger | protein kinase | ARVM, adult rat ventricular myocyte | ERK, extracellular-signal-regulated kinase | caPKD, constitutively active catalytic domain of PKD | BPKDi, bipyridyl PKD inhibitor | CaMK, Ca2 | PE, phenylephrine | HDAC, histone deacetylase | four-and-a-half LIM (FHL) | calmodulin-dependent protein kinase | signal transduction | PKC, protein kinase C | cMyBP-C, cardiac myosin-binding protein C | IVK, in vitro kinase | TAC, transverse aortic constriction | histone deacetylase | CRM1, chromosome region maintenance 1 | cardiac myocyte | pfu, plaque-forming unit | ET1, endothelin 1 | cTnI, inhibitory subunit of cardiac troponin | MOI, multiplicity of infection | NRVM, neonatal rat ventricular myocyte
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 01/2014, Volume 124, Issue 1, pp. 222 - 236
Acute myelogenous leukemia (AML) subtypes that result from oncogenic activation of homeobox (HOX) transcription factors are associated with poor prognosis. The... 
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Phosphorothioate Oligonucleotides - genetics | Homeodomain Proteins - metabolism | Humans | Leukemia, Myeloid, Acute - metabolism | Regulatory Sequences, Nucleic Acid | Transcriptome | Induction Chemotherapy | MicroRNAs - metabolism | Neoplasm Proteins - metabolism | DNA-Binding Proteins - metabolism | Cell Transformation, Neoplastic - genetics | Base Sequence | Pre-B-Cell Leukemia Transcription Factor 1 | Binding Sites | Leukemia, Myeloid, Acute - therapy | Neoplastic Stem Cells - physiology | Doxorubicin - administration & dosage | Proto-Oncogene Proteins - metabolism | Leukemia, Myeloid, Acute - pathology | Mice, Inbred C57BL | Combined Modality Therapy | Gene Expression Regulation, Leukemic | Mice, SCID | Cell Transformation, Neoplastic - metabolism | Cytarabine - administration & dosage | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Protein Binding | Mice, Inbred NOD | Mice | MicroRNAs - genetics | Myeloid Ecotropic Viral Integration Site 1 Protein | MicroRNA | Genetic transcription | Research | Flow cytometry | Insects | Leukemia | Cloning | MicroRNAs | Cell cycle | Software | Signatures | Gene expression | Deoxyribonucleic acid--DNA | Children & youth | Index Medicus | Abridged Index Medicus
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 03/2004, Volume 199, Issue 6, pp. 805 - 814
Journal Article
Cell reports (Cambridge), ISSN 2211-1247, 09/2015, Volume 12, Issue 12, pp. 1968 - 1977
Breast cancers (BCs) typically express estrogen receptors (ERs) but frequently exhibit de novo or acquired resistance to hormonal therapies. Here, we show that... 
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Estradiol - analogs & derivatives | Receptors, Estrogen - metabolism | Neoplastic Stem Cells - drug effects | Receptors, Notch - metabolism | Homeodomain Proteins - metabolism | Humans | Retinal Dehydrogenase - metabolism | p-Aminoazobenzene - analogs & derivatives | Receptors, Notch - genetics | Fulvestrant | Receptors, Notch - antagonists & inhibitors | Basic Helix-Loop-Helix Transcription Factors - metabolism | Neoplastic Stem Cells - metabolism | Serrate-Jagged Proteins | p-Aminoazobenzene - pharmacology | Neoplastic Stem Cells - pathology | Estradiol - pharmacology | Jagged-1 Protein | Basic Helix-Loop-Helix Transcription Factors - genetics | Signal Transduction | Isoenzymes - genetics | Membrane Proteins - genetics | Cell Cycle Proteins - metabolism | Benzazepines - pharmacology | Retinal Dehydrogenase - genetics | Breast Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | Breast Neoplasms - genetics | Survival Analysis | Cell Line, Tumor | Retinal Dehydrogenase - antagonists & inhibitors | Mice | Calcium-Binding Proteins - genetics | Transcription Factor HES-1 | Gene Expression Regulation, Neoplastic | Cell Cycle Proteins - antagonists & inhibitors | Estrogen Receptor Antagonists - pharmacology | Intercellular Signaling Peptides and Proteins - metabolism | Isoenzymes - metabolism | Cell Cycle Proteins - genetics | Female | Membrane Proteins - metabolism | Calcium-Binding Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Receptors, Estrogen - genetics | Antineoplastic Agents, Hormonal - pharmacology | Intercellular Signaling Peptides and Proteins - genetics | Proto-Oncogene Proteins - genetics | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | Aldehyde Dehydrogenase 1 | Homeodomain Proteins - genetics | Xenograft Model Antitumor Assays | Animals | Breast Neoplasms - pathology | Homeodomain Proteins - antagonists & inhibitors | Tamoxifen - pharmacology | Breast Neoplasms - mortality | Cell Proliferation - drug effects | Isoenzymes - antagonists & inhibitors | Receptor, Notch4 | Drug Resistance, Neoplasm - drug effects | Index Medicus | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Cancer and Oncology | Medicin och hälsovetenskap | Cancer och onkologi
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2008, Volume 283, Issue 8, pp. 4490 - 4500
.... Here, we have addressed this apparent paradox by demonstrating that Cripto forms analogous receptor complexes with Nodal and activin and functions as a noncompetitive activin antagonist... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Activin Receptors, Type II - metabolism | Membrane Glycoproteins - metabolism | Xenopus Proteins - genetics | Homeodomain Proteins - metabolism | Humans | Activins - antagonists & inhibitors | GPI-Linked Proteins | Activins - metabolism | Multiprotein Complexes - genetics | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Activin Receptors - genetics | Multiprotein Complexes - metabolism | Membrane Glycoproteins - antagonists & inhibitors | Binding Sites - physiology | Neoplasm Proteins - genetics | Epidermal Growth Factor - genetics | Intercellular Signaling Peptides and Proteins | Xenopus laevis | Activin Receptors, Type I - metabolism | Epidermal Growth Factor - metabolism | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Activin Receptors, Type I - genetics | Homeodomain Proteins - genetics | Membrane Glycoproteins - genetics | Xenopus Proteins - antagonists & inhibitors | Transcription Factors - metabolism | Activin Receptors - metabolism | Animals | Transforming Growth Factor beta - genetics | Homeodomain Proteins - antagonists & inhibitors | Activin Receptors, Type II - genetics | Epidermal Growth Factor - antagonists & inhibitors | Ligands | Signal Transduction - physiology | Xenopus Proteins - metabolism | Activins - genetics | Mice | Transforming Growth Factor beta - metabolism | Nodal Protein | Index Medicus
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 12/2009, Volume 137, Issue 6, pp. 2136 - 2145.e7
Journal Article
Development, ISSN 0950-1991, 12/1999, Volume 126, Issue 23, pp. 5515 - 5522
Journal Article