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Aging Cell, ISSN 1474-9718, 12/2012, Volume 11, Issue 6, pp. 1065 - 1073
We explored molecular events associated with aging‐induced matrix changes in the kidney. C 57 BL 6 mice were studied in youth, middle age, and old age.... 
albuminuria | TGF | RNA | micro | collagen | fibrosis | SMAD | beta | SMAD3 | Albuminuria | TGF beta | Collagen | MicroRNAs | Fibrosis | microRNAs | GLOMERULOSCLEROSIS | MESSENGER-RNA TRANSLATION | KINASE | RENAL-FUNCTION | DIABETIC-NEPHROPATHY | MICRORNA-21 | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | HIGH GLUCOSE | MIR-21 | GENE-TRANSFER | EXPRESSION | Cystatin C - blood | Kidney Cortex - metabolism | Homeodomain Proteins - metabolism | Humans | Collagen Type III - metabolism | Extracellular Matrix - metabolism | Smad3 Protein - metabolism | Phosphoproteins - metabolism | Zinc Finger E-box Binding Homeobox 2 | RNA, Messenger - biosynthesis | Smad3 Protein - genetics | Collagen Type I - genetics | Aging - genetics | Gene Expression Regulation, Developmental | Glomerular Mesangium - metabolism | Kruppel-Like Transcription Factors - metabolism | Proteolysis | Female | Membrane Proteins - metabolism | Repressor Proteins - metabolism | Promoter Regions, Genetic | Collagen Type I - metabolism | Glomerular Filtration Rate | Membrane Proteins - genetics | Mice, Inbred C57BL | Repressor Proteins - genetics | Kidney Cortex - pathology | Collagen Type III - genetics | Phosphoproteins - genetics | Homeodomain Proteins - genetics | Aging - pathology | Adaptor Proteins, Signal Transducing | Glomerular Mesangium - pathology | Animals | Transforming Growth Factor beta - genetics | Protein Binding | Mice | MicroRNAs - genetics | Extracellular Matrix - pathology | Kruppel-Like Transcription Factors - genetics | Transforming Growth Factor beta - metabolism | Aging - metabolism | Serum Albumin - metabolism | Zinc Finger E-box-Binding Homeobox 1 | Fibronectins | Messenger RNA | MicroRNA | Physiological aspects | Protein biosynthesis | Transforming growth factors | Proteins | Aging | Age | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 1, pp. 17 - 30
and mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate... 
BREAST-CANCER | TRANSCRIPTIONAL ACTIVITY | IDH2 MUTATIONS | ONCOLOGY | PROLYL HYDROXYLATION | INTEGRATED GENOMIC ANALYSIS | 2-OXOGLUTARATE OXYGENASES | ACUTE MYELOID-LEUKEMIA | HIF-ALPHA | HISTONE DEMETHYLATION | FAMILY | CELL BIOLOGY | Dioxygenases - metabolism | Histone Demethylases - antagonists & inhibitors | Gene Expression - genetics | Caenorhabditis elegans Proteins - chemistry | Humans | Ketoglutaric Acids - chemistry | Glioma - genetics | F-Box Proteins | Oxidoreductases, N-Demethylating - antagonists & inhibitors | Ketoglutaric Acids - pharmacology | Cytosine - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Glutarates - chemistry | Oxidoreductases, N-Demethylating - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Glioma - enzymology | Endostatins - metabolism | Models, Molecular | Isocitrate Dehydrogenase - genetics | Histone Demethylases - metabolism | Dioxygenases - antagonists & inhibitors | Amino Acid Substitution - physiology | Procollagen-Proline Dioxygenase - genetics | Cell Line, Tumor | Isocitrate Dehydrogenase - metabolism | Glutarates - pharmacology | Histones - metabolism | Jumonji Domain-Containing Histone Demethylases - metabolism | Caenorhabditis elegans - enzymology | Cytosine - analogs & derivatives | Gene Expression - drug effects | Caenorhabditis elegans Proteins - metabolism | Isocitrate Dehydrogenase - antagonists & inhibitors | Glioma - metabolism | Procollagen-Proline Dioxygenase - metabolism | DNA-Binding Proteins - metabolism | Mixed Function Oxygenases | Biocatalysis - drug effects | Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors | Jumonji Domain-Containing Histone Demethylases - chemistry | Procollagen-Proline Dioxygenase - antagonists & inhibitors | Ketoglutaric Acids - metabolism | Oxalates - pharmacology | Binding, Competitive | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Catalytic Domain | Proto-Oncogene Proteins - genetics | Hypoxia-Inducible Factor-Proline Dioxygenases | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Animals | 5-Methylcytosine - metabolism | Caenorhabditis elegans Proteins - antagonists & inhibitors | Glutarates - metabolism | Index Medicus
Journal Article
Science, ISSN 0036-8075, 1/2011, Volume 331, Issue 6013, pp. 76 - 79
Vernalization is an environmentally-induced epigenetic switch in which winter cold triggers epigenetic silencing of floral repressors and thus provides... 
Chromatin | Cold regions | RNA | Reverse transcriptase polymerase chain reaction | Vernalization | REPORTS | Epigenetics | Genetic loci | Promoter regions | Repression | Plants | ARABIDOPSIS-THALIANA | COMPLEX | X-CHROMOSOME | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | GENES | REQUIRES | FLC | POLYCOMB | Chromatin - metabolism | Arabidopsis - physiology | RNA, Untranslated - metabolism | Arabidopsis - growth & development | Genes, Plant | Epigenesis, Genetic | Homeodomain Proteins - metabolism | RNA Polymerase II - metabolism | RNA, Plant - metabolism | RNA, Untranslated - genetics | Arabidopsis Proteins - metabolism | DNA-Binding Proteins - metabolism | RNA Interference | Plants, Genetically Modified | Gene Expression Regulation, Plant | Transcription, Genetic | Repressor Proteins - metabolism | Recombinant Proteins - metabolism | Promoter Regions, Genetic | Arabidopsis Proteins - genetics | Cold Temperature | Response Elements | Introns | MADS Domain Proteins - genetics | Gene Silencing | Nuclear Proteins - metabolism | Polycomb-Group Proteins | RNA, Plant - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Flowers - growth & development | Arabidopsis - genetics | MADS Domain Proteins - metabolism | Transcription Factors - metabolism | Carrier Proteins - metabolism | RNA, Antisense - metabolism | Histones - metabolism | RNA, Antisense - genetics | Epigenetic inheritance | Genetic aspects | Research | Plant biology | Plant reproduction | Flowers & plants | Gene expression | Index Medicus
Journal Article
Neuron, ISSN 0896-6273, 2005, Volume 47, Issue 6, pp. 817 - 831
The molecular mechanisms controlling the differentiation of neural progenitors into distinct subtypes of neurons during neocortical development are unknown.... 
AREA IDENTITY | NEOCORTICAL NEURONS | CELL FATE SPECIFICATION | CEREBRAL CORTICAL DEVELOPMENT | LAYER NEURONS | CENTRAL-NERVOUS-SYSTEM | SUBCORTICAL TARGETS | ZINC-FINGER GENE | SUBVENTRICULAR ZONE | NEUROSCIENCES | ZEBRAFISH FOREBRAIN | Membrane Glycoproteins - metabolism | Embryo, Mammalian | Homeodomain Proteins - metabolism | Nerve Tissue Proteins - deficiency | S100 Proteins - genetics | POU Domain Factors - genetics | Forkhead Transcription Factors - metabolism | In Situ Hybridization - methods | Repressor Proteins - metabolism | Gene Expression Regulation, Developmental - physiology | POU Domain Factors - metabolism | Animals, Newborn | DNA-Binding Proteins - physiology | Motor Neurons - physiology | Tumor Suppressor Proteins - metabolism | Membrane Proteins - genetics | Cell Cycle Proteins - metabolism | S100 Proteins - metabolism | In Situ Nick-End Labeling - methods | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Immunohistochemistry - methods | Annexin A2 - genetics | Cell Death - physiology | Green Fluorescent Proteins - biosynthesis | Mice | Annexin A2 - metabolism | Age Factors | Phosphopyruvate Hydratase - metabolism | Cell Movement - physiology | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | Amino Acids - metabolism | Motor Neurons - cytology | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Membrane Proteins - metabolism | Bromodeoxyuridine - metabolism | Cell Differentiation - physiology | Pyramidal Tracts - physiology | Nerve Tissue Proteins - physiology | Neocortex - growth & development | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Dopamine and cAMP-Regulated Phosphoprotein 32 - metabolism | Nerve Tissue Proteins - genetics | Homeodomain Proteins - genetics | Membrane Glycoproteins - genetics | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Cell Count - methods | Neocortex - cytology | Receptors, Antigen, T-Cell, alpha-beta - metabolism | Neurosciences | Neurons | Developmental biology | Stem cells | Studies | Brain | Ultrasonic imaging | Transcription factors | Hybridization | Neurogenesis | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 03/2012, Volume 483, Issue 7391, pp. 598 - 602
Generation of induced pluripotent stem cells (iPSCs) by somatic cell reprogramming involves global epigenetic remodelling(1). Whereas several proteins are... 
CELLS | LEUKEMIA | PRC2 | HISTONE METHYLATION | MULTIDISCIPLINARY SCIENCES | PLURIPOTENT | Chromatin - metabolism | Homeodomain Proteins - metabolism | Humans | Methyltransferases - metabolism | Methyltransferases - genetics | Methyltransferases - biosynthesis | YY1 Transcription Factor - metabolism | Repressor Proteins - antagonists & inhibitors | DNA-Binding Proteins - metabolism | Kruppel-Like Transcription Factors - metabolism | YY1 Transcription Factor - antagonists & inhibitors | Induced Pluripotent Stem Cells - cytology | Cellular Reprogramming - genetics | Repressor Proteins - metabolism | Fibroblasts - metabolism | Induced Pluripotent Stem Cells - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Nanog Homeobox Protein | Transcription Factors - antagonists & inhibitors | DNA Methylation - genetics | Polycomb-Group Proteins | Proto-Oncogene Proteins c-myc - metabolism | Enhancer of Zeste Homolog 2 Protein | Transcription Factors - metabolism | Polycomb Repressive Complex 2 | Methyltransferases - antagonists & inhibitors | Fibroblasts - cytology | RNA, Small Interfering | Histones - metabolism | Methylation | Chromatin - genetics | RNA-Binding Proteins - metabolism | Physiological aspects | Chromatin | Genetic aspects | Research | Methyltransferases | Embryonic stem cells | Enzymes | Efficiency | Stem cells | Epigenetics | Kinases | Gene expression | Apoptosis | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 2006, Volume 21, Issue 1, pp. 51 - 64
Members of the ING family of tumor suppressors regulate cell cycle progression, apoptosis, and DNA repair as important cofactors of p53. ING1 and ING3 are... 
MYST FAMILY | YEAST | TRANSCRIPTIONAL ACTIVATION | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | REPLICATION ORIGIN | HISTONE ACETYLTRANSFERASE COMPLEX | DEACETYLASE COMPLEX | PHD-FINGER | CANCER METASTASIS SUPPRESSOR-1 | CELL BIOLOGY | Chromatin - metabolism | Trans-Activators - classification | Acetyltransferases - metabolism | Homeodomain Proteins - metabolism | Humans | Multiprotein Complexes | Histone Acetyltransferases - genetics | Molecular Sequence Data | Cell Cycle Proteins - classification | Intracellular Signaling Peptides and Proteins - metabolism | Acetyltransferases - genetics | Receptors, Cytoplasmic and Nuclear - classification | Protein Subunits - metabolism | RNA Interference | Histone Acetyltransferases - metabolism | Tumor Suppressor Proteins - genetics | Trans-Activators - genetics | Cell Cycle Proteins - genetics | Nuclear Proteins - classification | Acetylation | Lysine Acetyltransferase 5 | Nuclear Proteins - genetics | Genes, Tumor Suppressor | Intracellular Signaling Peptides and Proteins - genetics | Repressor Proteins - metabolism | Protein Subunits - genetics | Amino Acid Sequence | Gene Expression | Tumor Suppressor Proteins - classification | Tumor Suppressor Proteins - metabolism | Cell Cycle Proteins - metabolism | Homeodomain Proteins - classification | Repressor Proteins - genetics | DNA Replication | Nuclear Proteins - metabolism | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | Intracellular Signaling Peptides and Proteins - classification | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Sequence Alignment | Cell Cycle - physiology | Inhibitor of Growth Protein 1 | Trans-Activators - metabolism | Histones - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | DNA replication | Chromatin | Oncology, Experimental | Genomics | DNA | Development and progression | Research | Universities and colleges | Tumor proteins | Acetates | Tumors | Cancer | Index Medicus | Life Sciences
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 01/2012, Volume 19, Issue 1, pp. 117 - 122
The use of genetic mutations to study protein functions in vivo is a central paradigm of modern biology. Recent advances in reverse genetics such as RNA... 
TARGET | CELLS | SIGNALING PATHWAYS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRAP | DROSOPHILA | NONMUSCLE MYOSIN | CELL BIOLOGY | UBIQUITINATION | BIOPHYSICS | GENE | CELLULAR-PROTEINS | EFFICIENT | Drosophila melanogaster - embryology | Cytoskeletal Proteins - genetics | Homeodomain Proteins - metabolism | Humans | Embryo, Nonmammalian - metabolism | Molecular Sequence Data | Embryo, Nonmammalian - embryology | Green Fluorescent Proteins - genetics | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Recombinant Fusion Proteins - metabolism | Drosophila melanogaster - metabolism | POU Domain Factors - genetics | Proteolysis | Base Sequence | Antibodies - immunology | Cytoskeletal Proteins - metabolism | POU Domain Factors - metabolism | Wings, Animal - embryology | Amino Acid Sequence | Green Fluorescent Proteins - metabolism | Animals, Genetically Modified | Gene Knockout Techniques | Blotting, Western | Homeodomain Proteins - genetics | Microscopy, Confocal | Wings, Animal - metabolism | Animals | Green Fluorescent Proteins - immunology | Histones - genetics | Models, Biological | Recombinant Fusion Proteins - genetics | Luminescent Proteins - genetics | Drosophila Proteins - genetics | HeLa Cells | Histones - metabolism | Luminescent Proteins - metabolism | Ubiquitin | Physiological aspects | Research | Structure | Green fluorescent protein | Proteins | Genetics | Eukaryotes | Mutation | Insects | Molecular biology | Index Medicus
Journal Article
Neuron, ISSN 0896-6273, 02/2013, Volume 77, Issue 3, pp. 472 - 484
Major outputs of the neocortex are conveyed by corticothalamic axons (CTAs), which form reciprocal connections with thalamocortical axons, and... 
MUTANT MICE | CORTICAL AXONS | THALAMOCORTICAL AXONS | GROWTH | SEMAPHORIN 3E | CENTRAL-NERVOUS-SYSTEM | GUIDANCE | CHICK HINDLIMB | CAJAL-RETZIUS CELLS | NEUROSCIENCES | CEREBRAL-CORTEX | Thyroid Nuclear Factor 1 | Age Factors | Embryo, Mammalian | Leukocyte L1 Antigen Complex - metabolism | Gene Expression Regulation, Developmental - genetics | Axons - physiology | Cerebral Cortex - cytology | Neural Pathways - physiology | DNA-Binding Proteins - metabolism | POU Domain Factors - genetics | tau Proteins - genetics | Thalamus - physiology | Contactin 2 - metabolism | Repressor Proteins - metabolism | Glycoproteins - genetics | Tumor Suppressor Proteins - metabolism | Wnt3A Protein - genetics | Membrane Proteins - genetics | Mice, Inbred C57BL | Mice, Transgenic | Nuclear Proteins - metabolism | Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Homeodomain Proteins - genetics | Membrane Glycoproteins - genetics | Nerve Tissue Proteins - metabolism | S100 Calcium Binding Protein G - metabolism | Transcription Factors - metabolism | Animals | Calbindin 2 | Thalamus - cytology | Cerebral Cortex - physiology | Luminescent Proteins - genetics | Mice | Body Patterning - genetics | Luminescent Proteins - metabolism | Developmental biology | Neurons | Studies | Laboratories | Experiments | Index Medicus | Repressor Proteins | Cerebral Cortex | Cellular Biology | Neural Pathways | tau Proteins | Life Sciences | Contactin 2 | Gene Expression Regulation, Developmental | Body Patterning | Thalamus | Membrane Glycoproteins | Luminescent Proteins | DNA-Binding Proteins | POU Domain Factors | Calcium-Binding Protein, Vitamin D-Dependent | Glycoproteins | Nerve Tissue Proteins | Nuclear Proteins | Membrane Proteins | Axons | Homeodomain Proteins | Leukocyte L1 Antigen Complex | Transcription Factors | Wnt3A Protein | Tumor Suppressor Proteins | reciprocal connections | handshake | waiting period | PlexinD1 | axon guidance | Sema3E | thalamocortical | corticothalamic
Journal Article
Nature Cell Biology, ISSN 1465-7392, 05/2008, Volume 10, Issue 5, pp. 593 - 601
Journal Article