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JAMA : the journal of the American Medical Association, ISSN 0098-7484, 06/2018, Volume 319, Issue 22, pp. 2299 - 2307
Journal Article
British journal of cancer, ISSN 1532-1827, 2015, Volume 112, Issue 6, pp. 1042 - 1051
... Novel therapeutic strategy targeting the Hedgehog signalling and mTOR pathways in biliary tract cancer M Zuo1, A Rashid2, C Churi1, J-N Vauthey3, P Chang1, Y Li1, M... 
BTC | mTOR inhibitor | combination therapy | Hedgehog inhibitor | MAMMALIAN TARGET | RAPAMYCIN | CHOLANGIOCARCINOMA | INHIBITION | EVEROLIMUS | ONCOLOGY | GALLBLADDER CANCER | TOR Serine-Threonine Kinases - metabolism | Neoplastic Stem Cells - drug effects | Homeodomain Proteins - metabolism | Humans | Hedgehog Proteins - metabolism | Gene Expression Profiling | G1 Phase - drug effects | Octamer Transcription Factor-3 - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | TOR Serine-Threonine Kinases - genetics | Hedgehog Proteins - genetics | Neoplastic Stem Cells - metabolism | Biliary Tract Neoplasms - metabolism | Biliary Tract Neoplasms - drug therapy | G1 Phase - genetics | Biliary Tract Neoplasms - genetics | Biliary Tract Neoplasms - pathology | Cell Survival - drug effects | Nanog Homeobox Protein | Pyridines - administration & dosage | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Hedgehog Proteins - antagonists & inhibitors | Transcription Factors - genetics | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Sirolimus - administration & dosage | Animals | Anilides - administration & dosage | Signal Transduction - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice, Nude | Octamer Transcription Factor-3 - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Zinc Finger Protein GLI1 | Translational Therapeutics
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2014, Volume 124, Issue 1, pp. 222 - 236
.... Therapeutic inhibition of microRNA-21 and microRNA-196b inhibited in vitro leukemic colony forming activity and depleted in vivo leukemia-initiating cell activity of HOX-based leukemias, which led... 
HEMATOPOIETIC-CELLS | PROGENITOR CELLS | HOX | MEDICINE, RESEARCH & EXPERIMENTAL | ACUTE MYELOGENOUS LEUKEMIA | IN-VIVO | NPM1 MUTATIONS | ACUTE MYELOID-LEUKEMIA | GENE-EXPRESSION PROFILE | MLL | STEM | Phosphorothioate Oligonucleotides - genetics | Homeodomain Proteins - metabolism | Humans | Leukemia, Myeloid, Acute - metabolism | Regulatory Sequences, Nucleic Acid | Transcriptome | Induction Chemotherapy | MicroRNAs - metabolism | Neoplasm Proteins - metabolism | DNA-Binding Proteins - metabolism | Cell Transformation, Neoplastic - genetics | Base Sequence | Pre-B-Cell Leukemia Transcription Factor 1 | Binding Sites | Leukemia, Myeloid, Acute - therapy | Neoplastic Stem Cells - physiology | Doxorubicin - administration & dosage | Proto-Oncogene Proteins - metabolism | Leukemia, Myeloid, Acute - pathology | Mice, Inbred C57BL | Combined Modality Therapy | Gene Expression Regulation, Leukemic | Mice, SCID | Cell Transformation, Neoplastic - metabolism | Cytarabine - administration & dosage | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Protein Binding | Mice, Inbred NOD | Mice | MicroRNAs - genetics | Myeloid Ecotropic Viral Integration Site 1 Protein | MicroRNA | Genetic transcription | Research | Flow cytometry | Insects | Leukemia | Cloning | MicroRNAs | Cell cycle | Software | Signatures | Gene expression | Deoxyribonucleic acid--DNA | Children & youth
Journal Article
Journal of Translational Medicine, ISSN 1479-5876, 01/2011, Volume 9, Issue 1, pp. 8 - 8
... to play a key role in cancer, and Hsp90 has attracted considerable interest in recent years as a potential therapeutic target. Methods... 
BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | SNAP HELIX | SHOCK-PROTEIN 90 | MOLECULAR CHAPERONES | PANCREATIC-CANCER | HOP | TETRATRICOPEPTIDE REPEAT | DOMAINS | MOTIF | CANCER-THERAPY | Recombinant Fusion Proteins - pharmacology | Protein Interaction Domains and Motifs - physiology | Antineoplastic Agents - chemical synthesis | Homeodomain Proteins - metabolism | Humans | Recombinant Fusion Proteins - therapeutic use | Homeodomain Proteins - chemical synthesis | Antineoplastic Agents - therapeutic use | Molecular Targeted Therapy | Tumor Suppressor Proteins - chemistry | Antineoplastic Agents - pharmacology | Homeodomain Proteins - pharmacology | Tumor Suppressor Proteins - metabolism | Cells, Cultured | Models, Molecular | Recombinant Fusion Proteins - chemical synthesis | Recombinant Fusion Proteins - chemistry | Homeodomain Proteins - chemistry | Xenograft Model Antitumor Assays | Peptide Fragments - chemistry | Animals | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Homeodomain Proteins - therapeutic use | Mice, Nude | HSP90 Heat-Shock Proteins - metabolism | Mice | Antimitotic agents | Cell proliferation | Heat shock proteins | Physiological aspects | Research | Antineoplastic agents | Health aspects | Peptides | Protein folding | Amino acids | Kinases | Cancer therapies | Mass spectrometry | Adapter proteins | Apoptosis
Journal Article
Circulation (New York, N.Y.), ISSN 1524-4539, 2015, Volume 131, Issue 13, pp. 1171 - 1180
Background-Natural IgM antibodies represent a class of innate pattern recognition receptors that recognize danger-associated molecular patterns expressed on... 
Antibodies | Inflammation | Transplantation | Ischemia | Complement system proteins | ISCHEMIA/REPERFUSION INJURY | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | COMPLEMENT INHIBITION | MYOCARDIAL-ISCHEMIA | RECEPTOR | ischemia | complement system proteins | inflammation | transplantation | ENDOTHELIAL-CELLS | DISEASE | PERIPHERAL VASCULAR DISEASE | antibodies | MICE | EPSTEIN-BARR-VIRUS | Recombinant Fusion Proteins - immunology | Myocardium - immunology | Complement Activation | Self Tolerance - immunology | Recombinant Fusion Proteins - therapeutic use | Antibodies, Monoclonal - therapeutic use | Male | Antibodies, Bispecific - genetics | Immunoglobulin M - immunology | Epitopes - immunology | Transplantation Tolerance | Single-Chain Antibodies - genetics | Receptors, Complement - genetics | Single-Chain Antibodies - therapeutic use | Annexin A4 - immunology | Antibodies, Monoclonal - immunology | Immunoglobulin M - genetics | Myocardial Reperfusion Injury - immunology | Immunoglobulin M - deficiency | Mice, Inbred C57BL | Phospholipids - immunology | Genes, Synthetic | Heart Transplantation - adverse effects | Organ Specificity | Antibodies, Bispecific - immunology | Receptors, Complement - therapeutic use | Homeodomain Proteins - genetics | Mice, Knockout | Antibodies, Bispecific - therapeutic use | Antibodies, Monoclonal - genetics | Immunoglobulin M - therapeutic use | Myocardial Reperfusion - adverse effects | Animals | Recombinant Fusion Proteins - genetics | Mice | Mice, Inbred BALB C | Myocardial Reperfusion Injury - prevention & control | Single-Chain Antibodies - immunology
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2015, Volume 125, Issue 11, pp. 4255 - 4268
..., continued exploration of novel therapeutic options is imperative. Lung transplantation involves airway, arterial, and venous connections at the time of surgery (9... 
GRAFT-REJECTION | MEDICINE, RESEARCH & EXPERIMENTAL | BRONCHIOLITIS OBLITERANS SYNDROME | IN-VIVO | GROWTH FACTOR-C | GENE-THERAPY | HYALURONAN RECEPTOR LYVE-1 | TRANSPLANT RECIPIENTS | LYMPHATIC ENDOTHELIAL-CELLS | PULMONARY-FIBROSIS | T-CELLS | Molecular Weight | Humans | Immunosuppressive Agents - therapeutic use | Glycoproteins - metabolism | Male | Forced Expiratory Volume | Lung Transplantation | Allografts | Lung - metabolism | Vascular Endothelial Growth Factor Receptor-3 - drug effects | Vascular Endothelial Growth Factor C - therapeutic use | Graft Rejection - drug therapy | Acute Disease | Endothelial Cells - metabolism | Graft Rejection - physiopathology | Graft Rejection - therapy | Mice, Inbred C57BL | Hyaluronic Acid - chemistry | Lung - physiopathology | Vascular Endothelial Growth Factor Receptor-3 - metabolism | Vascular Endothelial Growth Factor C - genetics | Lymphangiogenesis - drug effects | Animals | Homeodomain Proteins - analysis | Hyaluronic Acid - metabolism | Lung - drug effects | Lymphatic Vessels - pathology | Protein Binding | Mice | Mice, Inbred BALB C | Lymphatic Vessels - surgery | Mutation | Prednisone - therapeutic use | Tumor Suppressor Proteins - analysis | Vascular Endothelial Growth Factor C - pharmacology | Prevention | Complications and side effects | Lungs | Transplantation | Neovascularization | Health aspects | Graft rejection
Journal Article
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1524-4636, 2007, Volume 27, Issue 12, pp. 2589 - 2596
OBJECTIVE—Aortic calcification is prevalent in type II diabetes (T2DM), enhancing morbidity and tracking metabolic syndrome parameters. Ldlr mice fed high-fat... 
Aortic calcification | Diabetes | TNF-α | Metabolic syndrome | Wnt | TNF-alpha | BONE MORPHOGENETIC PROTEIN-2 | MATRIX GLA PROTEIN | VASCULAR CALCIFICATION | aortic calcification | DEFICIENT MICE | metabolic syndrome | INFLAMMATION | IN-VIVO | ARTERIAL CALCIFICATION | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | DIFFERENTIATION | HEMATOLOGY | diabetes | EXPRESSION | Inflammation - pathology | Fibroblasts - enzymology | Homeodomain Proteins - metabolism | Tumor Necrosis Factor-alpha - blood | Tumor Necrosis Factor-alpha - genetics | Antibodies, Monoclonal - therapeutic use | Male | Aorta - metabolism | Haptoglobins - metabolism | RNA, Messenger - metabolism | Wnt Proteins - metabolism | Aortic Diseases - metabolism | Bone Morphogenetic Proteins - metabolism | Inflammation - metabolism | Calcinosis - etiology | Dietary Fats - administration & dosage | Anti-Inflammatory Agents - therapeutic use | Aortic Diseases - prevention & control | Disease Models, Animal | Fibroblasts - metabolism | Anti-Inflammatory Agents - pharmacology | Antibodies, Monoclonal - pharmacology | Receptors, LDL - metabolism | Mice, Transgenic | Mice, Knockout | Aorta - pathology | Muscle Proteins - genetics | Signal Transduction - drug effects | Wnt3 Protein | Calcinosis - prevention & control | Inflammation - prevention & control | Mice | Diabetes Mellitus, Type 2 - pathology | Calcinosis - pathology | Wnt3A Protein | Tumor Necrosis Factor-alpha - metabolism | Alkaline Phosphatase | Diabetes Mellitus, Type 2 - metabolism | DNA-Binding Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Wnt Proteins - genetics | Infliximab | Receptors, LDL - deficiency | Calcinosis - metabolism | Microfilament Proteins - genetics | Aorta - enzymology | Diabetes Mellitus, Type 2 - complications | Aortic Diseases - pathology | Promoter Regions, Genetic | Receptors, LDL - genetics | Bone Morphogenetic Protein 2 | Mice, Inbred C57BL | Cells, Cultured | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Animals | Diabetes Mellitus, Type 2 - chemically induced | Transforming Growth Factor beta - metabolism | Aortic Diseases - etiology | Tumor Necrosis Factor-alpha - antagonists & inhibitors
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 12/2010, Volume 16, Issue 24, pp. 6060 - 6070
Journal Article
Best Practice & Research: Clinical Haematology, ISSN 1521-6926, 2014, Volume 27, Issue 2, pp. 197 - 208
Agents targeting the JAK-STAT pathway have dominated the investigational therapeutic portfolio over the last five years resulting in the first and only approved agent for the treatment of patients with myelofibrosis (MF... 
Hematology, Oncology and Palliative Medicine | myelofibrosis | LDE225 | combination therapy | PRM-151 | ruxolitinib | decitabine | panobinostat | Panobinostat | Ruxolitinib | Myelofibrosis | Decitabine | Combination therapy | CHRONIC IDIOPATHIC MYELOFIBROSIS | INTERNATIONAL-WORKING-GROUP | BLAST PHASE | MYELOPROLIFERATIVE NEOPLASMS | ACUTE MYELOID-LEUKEMIA | BONE-MARROW FIBROSIS | PAN-DEACETYLASE INHIBITOR | JAK2 INHIBITOR | SERUM AMYLOID P | STEM-CELL TRANSPLANTATION | HEMATOLOGY | Recombinant Proteins - therapeutic use | Pyrazoles - therapeutic use | Humans | Hematopoietic Stem Cells - pathology | Primary Myelofibrosis - pathology | Biphenyl Compounds - therapeutic use | Serum Amyloid P-Component - therapeutic use | Drug Therapy, Combination | Janus Kinase 2 - antagonists & inhibitors | Pyridines - therapeutic use | Hematopoietic Stem Cells - drug effects | Primary Myelofibrosis - drug therapy | Gene Expression | Janus Kinase 2 - genetics | Azacitidine - analogs & derivatives | Clinical Trials as Topic | Hematopoietic Stem Cells - metabolism | Antimetabolites, Antineoplastic - therapeutic use | Primary Myelofibrosis - genetics | Homeodomain Proteins - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Hydroxamic Acids - therapeutic use | Indoles - therapeutic use | Mutation | Azacitidine - therapeutic use | Analysis | Hematopoietic stem cells
Journal Article
Journal Article
Genes chromosomes & cancer, ISSN 1045-2257, 2012, Volume 51, Issue 3, pp. 207 - 218
Journal Article
Cell metabolism, ISSN 1550-4131, 2014, Volume 20, Issue 2, pp. 280 - 294
The molecular mechanisms responsible for the failure of antiangiogenic therapies and how tumors adapt to these therapies are unclear. Here, we applied... 
INVASION | TARGETING CANCER METABOLISM | ANGIOGENESIS | ENDOCRINOLOGY & METABOLISM | SUNITINIB | RESISTANCE | SORAFENIB | INHIBITOR | EXPRESSION | RENAL-CELL CARCINOMA | DISEASE PROGRESSION |