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European Journal of Clinical Pharmacology, ISSN 0031-6970, 10/2011, Volume 67, Issue 10, pp. 993 - 1006
The objectives of this study were (1) to develop a population pharmacokinetic model of high-dose methotrexate (HD-MTX) in children with acute lymphoblastic... 
Population pharmacokinetics | Pharmacogenetics | Biomedicine | Toxicity | Acute lymphoblastic leukaemia | Children | Pharmacology/Toxicology | Methotrexate | THYMIDYLATE SYNTHASE | HIGH-DOSE METHOTREXATE | CARRIER GENE | RHEUMATOID-ARTHRITIS PATIENTS | METHYLENETETRAHYDROFOLATE REDUCTASE | BREAST-CANCER | METHIONINE SYNTHASE REDUCTASE | BFM 90 | PHARMACOLOGY & PHARMACY | PLASMA HOMOCYSTEINE | Antimetabolites, Antineoplastic - pharmacokinetics | Humans | Methotrexate - pharmacokinetics | Child, Preschool | Male | Lymphoma - metabolism | Thrombocytopenia - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Lymphoma - drug therapy | Methylenetetrahydrofolate Reductase (NADPH2) - genetics | Female | Retrospective Studies | Odds Ratio | Lymphoma - genetics | Reduced Folate Carrier Protein - genetics | Genotype | Methotrexate - blood | Polymorphism, Genetic | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Methotrexate - adverse effects | Metabolic Networks and Pathways | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Antimetabolites, Antineoplastic - adverse effects | Folic Acid - metabolism | ATP Binding Cassette Transporter, Sub-Family B | Mucositis - genetics | Folic Acid - genetics | Nonlinear Dynamics | Analysis | Genetic research | Lymphomas | Genetic aspects | Dosage and administration | Universities and colleges | Folic acid | Leukemia | Genetics | Pharmacology | Drug therapy | Children & youth | Index Medicus
Journal Article
Life Sciences, ISSN 0024-3205, 05/2018, Volume 200, pp. 15 - 25
Journal Article
World Journal of Gastroenterology, ISSN 1007-9327, 10/2017, Volume 23, Issue 40, pp. 7343 - 7346
S-Adenosyl-L-methionine (SAM) is a cofactor serving as a methyl donor in numerous enzymatic reactions. It has been reported that SAM has the potential to... 
Bioavailability | Concentration | Liver | S-Adenosyl-L-methionine | CELLS | METHYLATION | ADENOSYLMETHIONINE | MASS-SPECTROMETRY | ADENOSYLHOMOCYSTEINE | ERYTHROCYTES | METABOLISM | GLUTATHIONE | DISEASE | GASTROENTEROLOGY & HEPATOLOGY | PLASMA HOMOCYSTEINE | Antioxidants | Hepacivirus | S-Adenosylmethionine | Methionine | Glutathione | Methionine Adenosyltransferase | Index Medicus
Journal Article
British Journal of Cancer, ISSN 0007-0920, 10/2007, Volume 97, Issue 8, pp. 1071 - 1076
The purpose of this study was to investigate the utility of plasma pharmacokinetic and pharmacodynamic measures including plasma deoxynucleosides, homocysteine... 
Plasma deoxynucleosides | Thymidylate synthase inhibition | Anti-folates | Pharmacodynamic markers | Homocysteine | Pemetrexed | homocysteine | NOLATREXED DIHYDROCHLORIDE | pemetrexed | SOLID TUMORS | THYMIDYLATE SYNTHASE INHIBITOR | METHYLMALONIC ACID | thymidylate synthase inhibition | plasma deoxynucleosides | FOLIC-ACID | CELL LUNG-CANCER | PLASMA 2'-DEOXYURIDINE | HOMOCYSTEINE CONCENTRATIONS | ONCOLOGY | I TRIAL | pharmacodynamic markers | IONIZATION MASS-SPECTROMETRY | anti-folates | Lung Neoplasms - drug therapy | Folic Acid - therapeutic use | Glutamates - adverse effects | Area Under Curve | Guanine - analogs & derivatives | Methylmalonic Acid - blood | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Male | Vinblastine - administration & dosage | Vitamin B 12 - therapeutic use | Vinblastine - pharmacokinetics | Dose-Response Relationship, Drug | Vinblastine - analogs & derivatives | Thymidine - blood | Vinblastine - adverse effects | Thymidylate Synthase - drug effects | Adult | Female | Guanine - adverse effects | Deoxyuridine - blood | Guanine - pharmacokinetics | Homocysteine - blood | Glutamates - pharmacokinetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Glutamates - administration & dosage | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Dietary Supplements | Guanine - administration & dosage | Index Medicus | Clinical Studies
Journal Article
Journal Article
European Journal of Clinical Pharmacology, ISSN 0031-6970, 4/2008, Volume 64, Issue 4, pp. 347 - 355
Journal Article
Journal Article