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Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 10/2013, Volume 33, Issue 10, pp. 2444 - 2453
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 07/2015, Volume 35, Issue 7, pp. 1623 - 1634
Journal Article
Nature (London), ISSN 1476-4687, 2015, Volume 520, Issue 7546, pp. 192 - 197
The metabolism of endothelial cells during vessel sprouting remains poorly studied... 
OXIDATION | DISTRIBUTIONS | GLYCOLYSIS | REDUCTIVE GLUTAMINE-METABOLISM | ANGIOGENESIS | MULTIDISCIPLINARY SCIENCES | TUMOR | PROLIFERATION | GROWTH-FACTOR | CANCER | CULTURE | Carnitine O-Palmitoyltransferase - genetics | Human Umbilical Vein Endothelial Cells - metabolism | Blood Vessels - metabolism | Blood Vessels - pathology | Humans | Neovascularization, Pathologic - pathology | Nucleotides - chemistry | Carnitine O-Palmitoyltransferase - antagonists & inhibitors | Adenosine Triphosphate - metabolism | Carnitine O-Palmitoyltransferase - metabolism | Human Umbilical Vein Endothelial Cells - cytology | Nucleotides - biosynthesis | Nucleotides - pharmacology | Oxidation-Reduction - drug effects | DNA - biosynthesis | Carnitine O-Palmitoyltransferase - deficiency | Fatty Acids - metabolism | Disease Models, Animal | Carbon - metabolism | Fatty Acids - chemistry | Human Umbilical Vein Endothelial Cells - drug effects | Endothelial Cells - metabolism | Gene Silencing | Acetic Acid - pharmacology | Blood Vessels - cytology | Citric Acid Cycle | Animals | Retinopathy of Prematurity - drug therapy | Endothelial Cells - cytology | Neovascularization, Pathologic - drug therapy | Blood Vessels - drug effects | Cell Line, Tumor | Glucose - metabolism | Human Umbilical Vein Endothelial Cells - pathology | Cell Proliferation - drug effects | Mice | Neovascularization, Pathologic - metabolism | Retinopathy of Prematurity - metabolism | Endothelial Cells - enzymology | Endothelial Cells - drug effects | Retinopathy of Prematurity - pathology | Physiological aspects | Deoxyribonucleotides | Fatty acids | Carbon | Endothelium | Proteins | Angiogenesis | Protein synthesis | Glucose | Kinases | Deoxyribonucleic acid--DNA | Cells
Journal Article
PloS one, ISSN 1932-6203, 2018, Volume 13, Issue 7, p. e0199373
.... However, the underlying mechanism remains largely unknown. Here, we investigated human umbilical vein endothelial cells (HUVECs... 
NADPH OXIDASE | OXIDATIVE STRESS | CARBOXYPEPTIDASE | CARDIOVASCULAR INJURY | NITRIC-OXIDE SYNTHASE | ANTIOXIDANT | MULTIDISCIPLINARY SCIENCES | ANGIOTENSIN-CONVERTING ENZYME | HYPERTENSIVE-RATS | UP-REGULATION | EXPRESSION | Proto-Oncogene Proteins - metabolism | Angiotensin II - pharmacology | Human Umbilical Vein Endothelial Cells - drug effects | Human Umbilical Vein Endothelial Cells - metabolism | Receptors, G-Protein-Coupled - metabolism | Apoptosis - drug effects | Humans | Propofol - pharmacology | Animals | Protective Agents - pharmacology | Peptidyl-Dipeptidase A - metabolism | Nitric Oxide Synthase Type III - metabolism | Oxidative Stress - drug effects | Nitric Oxide - metabolism | Patient outcomes | Angiotensin converting enzyme | Genetic aspects | Propofol | Gene expression | Health aspects | Apoptosis | Oxidative stress | Phosphorylation | Laboratories | Angiotensin-converting enzyme 2--ACE2 | Antioxidants | Signal transduction | Ischemia | Vasoactive agents | Rodents | Penicillin | Tumor necrosis factor-TNF | Blood pressure | Pretreatment | Angiotensin II | Enzyme-linked immunosorbent assay | Hypertension | Enzymes | Immunoglobulins | Pulmonary arteries | Coronary artery | Nitric-oxide synthase | Endothelial cells | Endothelium | Injury prevention | Cell injury | Hospitals | Nitric oxide | Angiotensin | TNF inhibitors | Anesthesiology | Umbilical vein | Angiotensin-converting enzyme 2 | ACE2
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1524-4636, 2010, Volume 30, Issue 12, pp. 2621 - 2630
...) in protecting the activation and function of human umbilical vein endothelial cells (HUVECs) induced by proinflammatory stimulus and the mechanisms... 
atherosclerosis | endothelial function | regulatory T cells | immune system | oxidized lipids | endothelial cells adhesion molecules | MECHANISM | SUPPRESSION | TRYPTOPHAN CATABOLISM | KLF2 | IN-VITRO | INHIBITION | ADHESION MOLECULE | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | NF-KAPPA-B | EXPRESSION | T-Lymphocytes, Regulatory - metabolism | Coculture Techniques | Humans | NF-kappa B - metabolism | Antigens, CD - metabolism | T-Lymphocytes, Regulatory - immunology | Inflammation - metabolism | Time Factors | Kruppel-Like Transcription Factors - metabolism | Inflammation Mediators - metabolism | Interleukin-10 - metabolism | Chemokine CCL2 - metabolism | Lipoproteins, LDL - metabolism | Interleukin-6 - metabolism | Paracrine Communication | Umbilical Veins - immunology | Endothelial Cells - metabolism | Cells, Cultured | Inflammation - immunology | CD3 Complex - metabolism | CTLA-4 Antigen | Endothelial Cells - immunology | B7-2 Antigen - metabolism | Phenotype | T-Lymphocytes, Regulatory - drug effects | CD4 Antigens - analysis | Cell Communication - drug effects | Forkhead Transcription Factors - analysis | Lipopolysaccharides - pharmacology | Interleukin-2 Receptor alpha Subunit - analysis | Vascular Cell Adhesion Molecule-1 - metabolism | Transforming Growth Factor beta - metabolism | Endothelial Cells - drug effects
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 9, p. e107555
.... However, the underlying mechanism remains unknown. In this study, we observed the effect of salusins on inflammatory responses and the MAPK-NF-kappa B signaling pathway in human umbilical vein endothelial cells (HUVECs... 
RECEPTOR-DEFICIENT MICE | TUMOR-NECROSIS-FACTOR | MULTIDISCIPLINARY SCIENCES | ATHEROSCLEROSIS | MECHANISMS | SUPPRESSES | PROGRESSION | Tumor Necrosis Factor-alpha - metabolism | Vasculitis - metabolism | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Tumor Necrosis Factor-alpha - secretion | Cells, Cultured | Human Umbilical Vein Endothelial Cells - immunology | JNK Mitogen-Activated Protein Kinases - metabolism | NF-kappa B - metabolism | Human Umbilical Vein Endothelial Cells - secretion | Interleukin-6 - secretion | Intercellular Signaling Peptides and Proteins - physiology | MAP Kinase Signaling System | Inflammation Mediators - metabolism | Chemokine CCL2 - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Vascular Cell Adhesion Molecule-1 - metabolism | Interleukin-6 - metabolism | Phosphorylation | Vascular cell adhesion molecule 1 | Laboratories | Interleukin | mRNA | Kinases | Western blotting | Cell adhesion molecules | Cell adhesion & migration | Interleukin 6 | Proteins | Signal transduction | Apolipoprotein E | Rodents | Atherosclerosis | Cell adhesion | Tumor necrosis factor-TNF | Enzyme-linked immunosorbent assay | NF-κB protein | MAP kinase | Inflammation | Tumor necrosis factor-α | Apolipoproteins | Molecular chains | Endothelial cells | Endothelium | Polymerase chain reaction | Inhibitors | Monocyte chemoattractant protein | Arteriosclerosis | Pharmacy | TNF inhibitors | Anesthesiology | Umbilical vein | Monocyte chemoattractant protein 1
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 10, p. e110273
...) are not fully understood. In the current study, we demonstrated that irisin promoted Human Umbilical Vein Endothelial Cell (HUVEC) proliferation... 
SURVIVAL | BCL-2 | CIRCULATING IRISIN | MULTIDISCIPLINARY SCIENCES | KINASE | BAX | CYCLE | Caspase 9 - genetics | Caspase 9 - metabolism | Human Umbilical Vein Endothelial Cells - metabolism | Nitriles - pharmacology | Apoptosis - drug effects | Humans | Caspase 3 - metabolism | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Human Umbilical Vein Endothelial Cells - cytology | Caspase 3 - genetics | bcl-2-Associated X Protein - genetics | Recombinant Proteins - metabolism | Butadienes - pharmacology | Fibronectins - pharmacology | Human Umbilical Vein Endothelial Cells - drug effects | Signal Transduction | Gene Expression Regulation | bcl-2-Associated X Protein - metabolism | Glucose - pharmacology | Recombinant Proteins - genetics | Recombinant Proteins - pharmacology | Glucose - antagonists & inhibitors | Fibronectins - metabolism | Glucose - metabolism | Cell Proliferation - drug effects | Fibronectins - genetics | Protein Kinase Inhibitors - pharmacology | Proto-Oncogene Proteins c-bcl-2 - genetics | Glucose | Dextrose | Apoptosis | Endothelium | Reproductive health | Cell proliferation | Disease | Bax protein | Bcl-2 protein | Laboratories | Childrens health | Homeostasis | Biology | Kinases | Caspase-3 | Proteins | Signal transduction | Cell growth | Maternal & child health | Cell cycle | Extracellular signal-regulated kinase | Caspase | Breast cancer | Endothelial cells | Medicine | Studies | Glucose tolerance | Intolerance | Signaling | Hospitals | Stem cells | Caspase-9 | Diabetes | Umbilical vein | Metabolic disorders | Endocrinology | Veins & arteries
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, p. e0122398
...) was measured in KCl preconstricted human umbilical vein rings (wire myography) incubated in normal (5 mmol/L) or high (25 mmol/L) D-glucose... 
OXIDATIVE STRESS | HYPERGLYCEMIA | MULTIDISCIPLINARY SCIENCES | L-ARGININE TRANSPORT | GESTATIONAL DIABETES-MELLITUS | SLC29A1 PROMOTER ACTIVITY | DYSFUNCTION | TRANSCRIPTION FACTOR | EXPRESSION | CARDIOVASCULAR RISK | ADENOSINE TRANSPORT | Reactive Oxygen Species - metabolism | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Cationic Amino Acid Transporter 1 - metabolism | Spin Labels | Biopterin - analogs & derivatives | Proto-Oncogene Proteins c-akt - genetics | Reactive Oxygen Species - agonists | Biopterin - metabolism | Cyclic N-Oxides - pharmacology | Umbilical Veins - drug effects | Human Umbilical Vein Endothelial Cells - cytology | Mitogen-Activated Protein Kinase 1 - genetics | Acetophenones - pharmacology | Nitric Oxide Synthase Type III - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Vasoconstrictor Agents - pharmacology | Insulin - pharmacology | Human Umbilical Vein Endothelial Cells - drug effects | Signal Transduction | Calcitonin Gene-Related Peptide - pharmacology | Nitric Oxide - antagonists & inhibitors | Tissue Culture Techniques | Gene Expression Regulation | Glucose - pharmacology | Transcription Factors - genetics | Glucose - antagonists & inhibitors | Nitric Oxide Synthase Type III - genetics | Nitric Oxide - agonists | Transcription Factors - metabolism | Reactive Oxygen Species - antagonists & inhibitors | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology | Primary Cell Culture | Nitric Oxide - metabolism | Arginine - metabolism | Cationic Amino Acid Transporter 1 - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | Umbilical Veins - metabolism | Oxidases | Nitric oxide | Superoxide | Glucose | Insulin | Phosphotransferases | Dextrose | Endothelium | Oxidative stress | Reactive oxygen species | Phosphorylation | Laboratories | Oxidase | Tempol | Amino acids | AKT protein | Kinases | Contraction | NAD(P)H oxidase | Western blotting | Vasodilation | Proteins | Nerve conduction | Hyperglycemia | Synthesis | Arginine | Calcitonin | Physiology | Adenosine | Incubation | NADPH-diaphorase | Gynecology | Liquid chromatography | Bioavailability | Gene expression | Glucose transport | High-performance liquid chromatography | Obstetrics | Potassium chloride | Nitric-oxide synthase | Endothelial cells | Medicine | Calcitonin gene-related peptide | Pharmacy | Nicotinamide adenine dinucleotide | Insulin resistance | Nicotinamide | Diabetes | Transporter | Veins & arteries
Journal Article
Molecular cell, ISSN 1097-2765, 2017, Volume 67, Issue 3, pp. 387 - 399.e5
The DNA-mediated innate immune response underpins anti-microbial defenses and certain autoimmune diseases. Here we used immunoprecipitation, mass spectrometry,... 
HEXIM1 | DNA-PK | innate immune response | herpesvirus | paraspeckles | cGAS | NEAT1 | interferon stimulatory DNA | DEFENSE | PROTEIN | INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | SENSOR | POLYMERASE-II | 7SK RNA | BINDING | GMP-AMP SYNTHASE | P-TEFB | CELL BIOLOGY | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Octamer Transcription Factors - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Herpesvirus 8, Human - immunology | RNA, Long Noncoding - immunology | PTB-Associated Splicing Factor - genetics | RNA Interference | Calcium-Binding Proteins - immunology | Octamer Transcription Factors - genetics | Nucleotidyltransferases - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Signal Transduction | Membrane Proteins - genetics | RNA-Binding Proteins - immunology | PTB-Associated Splicing Factor - metabolism | Nuclear Matrix-Associated Proteins - metabolism | PTB-Associated Splicing Factor - immunology | DNA - metabolism | Host-Pathogen Interactions | Nuclear Matrix-Associated Proteins - genetics | HeLa Cells | RNA-Binding Proteins - metabolism | Calcium-Binding Proteins - genetics | RNA-Binding Proteins - genetics | Multiprotein Complexes | Human Umbilical Vein Endothelial Cells - immunology | Intracellular Signaling Peptides and Proteins - immunology | Human Umbilical Vein Endothelial Cells - virology | Interferon Regulatory Factor-3 - genetics | Ku Autoantigen - genetics | Transfection | HEK293 Cells | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Octamer Transcription Factors - metabolism | Interferon Regulatory Factor-3 - immunology | Calcium-Binding Proteins - metabolism | DNA - immunology | Nuclear Matrix-Associated Proteins - immunology | Ku Autoantigen - immunology | Membrane Proteins - immunology | Nuclear Proteins - metabolism | Ku Autoantigen - metabolism | RNA, Long Noncoding - genetics | Immunity, Innate | Nuclear Proteins - immunology | DNA - genetics | Interferon Regulatory Factor-3 - metabolism | Nucleotidyltransferases - genetics | Protein Binding | Nucleotidyltransferases - immunology | RNA, Long Noncoding - metabolism | RNA sequencing | Immune response | RNA | DNA | Genetic research | Interferon | Biological response modifiers | Mass spectrometry | Human Umbilical Vein Endothelial Cells | Nuclear Matrix-Associated Proteins | Herpesvirus 8, Human | RNA-Binding Proteins | Life Sciences | Interferon Regulatory Factor-3 | Genetics | Calcium-Binding Proteins | Intracellular Signaling Peptides and Proteins | PTB-Associated Splicing Factor | Nuclear Proteins | Membrane Proteins | Nucleotidyltransferases | Ku Autoantigen | Octamer Transcription Factors | RNA, Long Noncoding
Journal Article