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Journal Article
European Respiratory Journal, ISSN 0903-1936, 02/2012, Volume 39, Issue 2, pp. 439 - 445
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, pp. e64281 - e64281
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 07/2019, Volume 515, Issue 1, pp. 31 - 36
Journal Article
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 09/2017, Volume 32, Issue 3, pp. 360 - 376.e6
We define how chronic cigarette smoke-induced time-dependent epigenetic alterations can sensitize human bronchial epithelial cells for transformation by a... 
genetic | lung cancer | epigenetic | polycomb | addiction | DNA methylation | cigarette smoke exposure | Kras | human bronchial epithelial cells | oncogene | HBECs | LUNG-CANCER | TRANSLATIONAL IMPLICATIONS | GENOMIC LANDSCAPE | ONCOLOGY | DNA HYPERMETHYLATION | COLORECTAL-CANCER | EXPRESSION PROFILES | NEVER-SMOKERS | LARGE GENE LISTS | WNT | EPIGENETIC ALTERATIONS | CELL BIOLOGY | Sirtuin 1 - metabolism | Smoking - adverse effects | Chromatin - metabolism | Epithelial Cells - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | Male | Epithelial-Mesenchymal Transition - genetics | Promoter Regions, Genetic - genetics | DNA (Cytosine-5-)-Methyltransferases - metabolism | Cell Transformation, Neoplastic - genetics | Bronchi - pathology | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Cell Proliferation - genetics | Enhancer of Zeste Homolog 2 Protein - metabolism | Epigenomics | Carcinoma, Non-Small-Cell Lung - genetics | DNA (Cytosine-5-)-Methyltransferase 1 | Epithelial Cells - pathology | Smoking - genetics | DNA Methylation - genetics | Signal Transduction - genetics | Mutation - genetics | Phenotype | Animals | Mice | DNA Damage | Cell Transformation, Neoplastic - pathology | Genome, Human | Epigenetic inheritance | Chromatin | Gene mutations | Stem cells | Genetic aspects | Lung cancer, Non-small cell | Methylation | Smoking | Medical colleges | Anopheles | Genes | Cellular signal transduction | Index Medicus
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 11/2013, Volume 305, Issue 10, pp. L737 - L746
Mitochondria are dynamic organelles that continuously change their shape through fission and fusion. Disruption of mitochondrial dynamics is involved in... 
Mitochondria dynamics | Chronic obstructive pulmonary disease | GLOBAL BURDEN | OXIDATIVE STRESS | PHYSIOLOGY | FUSION | LIPID-PEROXIDATION | CREATINE-KINASE B | mitochondria dynamics | OBSTRUCTIVE PULMONARY-DISEASE | RESPIRATORY SYSTEM | DYNAMICS | FISSION | DYSFUNCTION | chronic obstructive pulmonary disease | COPD | RNA, Small Interfering - genetics | Epithelial Cells - metabolism | Reactive Oxygen Species - metabolism | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Epithelial Cells - drug effects | Humans | Cellular Senescence - drug effects | Mitochondrial Proteins - genetics | GTP Phosphohydrolases - antagonists & inhibitors | Immunoenzyme Techniques | Bronchi - drug effects | Mitochondrial Proteins - metabolism | Bronchi - metabolism | Membrane Proteins - metabolism | Bronchi - pathology | Membrane Proteins - genetics | Mitochondrial Proteins - antagonists & inhibitors | Cells, Cultured | Epithelial Cells - pathology | Mitochondria - metabolism | Microtubule-Associated Proteins - antagonists & inhibitors | Mitochondria - drug effects | Mitochondria - pathology | Microscopy, Electron | Blotting, Western | GTP Phosphohydrolases - metabolism | Membrane Proteins - antagonists & inhibitors | GTP Phosphohydrolases - genetics | Tobacco - adverse effects | Physiological aspects | Aging | Epithelial cells | Health aspects | Smoking | Proteins | Fluorescence | Oxygen | Mitochondria | Cells | Index Medicus | Acetylcysteine
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2014, Volume 9, Issue 6, pp. e100633 - e100633
Airway epithelial mucus hypersecretion and mucus plugging are prominent pathologic features of chronic inflammatory conditions of the airway (e.g. asthma and... 
MENSTRUAL-CYCLE | GOBLET CELLS | MUC5AC MUCIN | MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | RECEPTOR | ALPHA | CYSTIC-FIBROSIS | REGULATES MUCIN | IDENTIFICATION | EXPRESSION | Gene Expression Regulation, Enzymologic - drug effects | Epithelial Cells - metabolism | Apoptosis - drug effects | Cell Count | Epithelial Cells - drug effects | Humans | Middle Aged | Goblet Cells - drug effects | Mucus - drug effects | RNA, Messenger - metabolism | Estrogen Receptor beta - metabolism | Young Adult | Adult | Female | Mucus - metabolism | Bronchi - cytology | Estradiol - pharmacology | Fucosyltransferases - genetics | NFATC Transcription Factors - metabolism | Periodic Acid-Schiff Reaction | RNA, Messenger - genetics | Goblet Cells - metabolism | Adolescent | Mucin 5AC - metabolism | Cell Proliferation - drug effects | Goblet Cells - cytology | NFATC Transcription Factors - genetics | Prognosis | RNA | Mucins | Phenols | Cystic fibrosis | Comparative analysis | T cells | Estradiol | Asthma | Heart | Epithelial cells | Estrogens | Estrogen | Estrogen receptors | Lymphocytes T | Mucus | NF-AT protein | Respiratory tract | Proteins | Synthesis | Epidermal growth factor | Post-translation | Tumor necrosis factor-TNF | Goblet cells | Cytokines | Neutrophils | Cultures | Inflammation | Gene expression | Epithelium | Medicine | Sex hormones | Protein arrays | Fibrosis | Females | Fucose | Index Medicus
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 10/2015, Volume 288, Issue 1, pp. 33 - 39
Metals such as arsenic, cadmium, beryllium, and nickel are known human carcinogens; however, other transition metals, such as tungsten (W), remain relatively... 
Beas-2B | Nude mice | RNA-Seq | In vitro | Tungsten | Cancer | TRANSLOCATION | METHYLATION | BIOCONDUCTOR PACKAGE | BETA-RECEPTOR | LUNG-CANCER | NICKEL | GROWTH | GENE-EXPRESSION |